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Gene ID: 51652 | CHMP3 Antibody Resource


CHMP3 Antibody Resource
Gene Full Name: 
charged multivesicular body protein 3
Uniprot: 
Q9Y3E7
Protein Name: 
charged multivesicular body protein 3
Nucleotide: 
NR_036454
Alias: 
NEDF;VPS24;CGI-149;
Ensembl: 
ENSG00000115561
Location: 
2p11.2
HPRD: 
15650
NCBI Gene: 
51652
MIM: 
610052

Summary: 
This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]
Function: 
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.
Subcellular location: 
Cytoplasm › cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane Probable. Note: Localizes to the midbody of dividing cells.
PTM: 
Isopeptide bond;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP34452_P050 VPS24 antibody - N-terminal region (ARP34452_P050) Polyclonal WB 50ug $289 Details
Polyclonal Antibody ARP34453_P050 CHMP3 Antibody (ARP34453_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Not tested 50 ug $125 Details

Show all CHMP3 antibodies


Product Images
VPS24 antibody - N-terminal region (ARP34452_P050) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2


CHMP3 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP34453 African clawed frog CHMP3 antibody; Xenopus laevis CHMP3 antibody Q6NRM7 100.0%
ARP34453 Atlantic salmon CHMP3 antibody; Salmo salar CHMP3 antibody B5X3V9 100.0%
ARP34453 Atlantic salmon CHMP3 antibody; Salmo salar CHMP3 antibody B5XA18 100.0%
ARP34453 Atlantic salmon CHMP3 antibody; Salmo salar CHMP3 antibody B5XBI9 100.0%
ARP34452 Atlantic salmon CHMP3 antibody; Salmo salar CHMP3 antibody B5X3V9 93.0%
ARP34452 Atlantic salmon CHMP3 antibody; Salmo salar CHMP3 antibody B5X4Y7 93.0%
ARP34452 Atlantic salmon CHMP3 antibody; Salmo salar CHMP3 antibody B5XA18 93.0%
ARP34452 Bovine CHMP3 antibody; Bos taurus CHMP3 antibody Q58CS7 100.0%
ARP34453 Bovine CHMP3 antibody; Bos taurus CHMP3 antibody Q58CS7 100.0%
ARP34453 Channel catfish CHMP3 antibody; Ictalurus punctatus CHMP3 antibody E3TE96 100.0%
ARP34452 Channel catfish CHMP3 antibody; Ictalurus punctatus CHMP3 antibody E3TE96 93.0%
ARP65451 Channel catfish CHMP3 antibody; Ictalurus punctatus CHMP3 antibody E3TE96 89.0%
ARP34452 Chimpanzee CHMP3 antibody; Pan troglodytes CHMP3 antibody K7AR37 100.0%
ARP34453 Chimpanzee CHMP3 antibody; Pan troglodytes CHMP3 antibody K7AR37 100.0%
ARP34452 Crab-eating macaque CHMP3 antibody; Macaca fascicularis CHMP3 antibody Q4R574 100.0%
ARP34453 Crab-eating macaque CHMP3 antibody; Macaca fascicularis CHMP3 antibody Q4R574 100.0%
ARP34452 Dog CHMP3 antibody; Canis familiaris CHMP3 antibody E2RDX0 100.0%
ARP34453 Dog CHMP3 antibody; Canis familiaris CHMP3 antibody E2RDX0 100.0%
ARP34452 European domestic ferret CHMP3 antibody; Mustela putorius furo CHMP3 antibody M3YCZ1 100.0%
ARP34453 European domestic ferret CHMP3 antibody; Mustela putorius furo CHMP3 antibody M3YCZ1 100.0%
ARP34453 Human CHMP3 antibody; Homo sapiens CHMP3 antibody Q9Y3E7-2 100.0%
ARP34452 Human CHMP3 antibody; Homo sapiens CHMP3 antibody Q9Y3E7-3 100.0%
ARP34453 Human CHMP3 antibody; Homo sapiens CHMP3 antibody Q9Y3E7-3 100.0%
ARP34452 Human CHMP3 antibody; Homo sapiens CHMP3 antibody Q9Y3E7-4 100.0%
ARP34453 Human CHMP3 antibody; Homo sapiens CHMP3 antibody Q9Y3E7-4 100.0%
ARP34452 Human CHMP3 antibody; Homo sapiens CHMP3 antibody Q9Y3E7 100.0%
ARP34453 Human CHMP3 antibody; Homo sapiens CHMP3 antibody Q9Y3E7 100.0%
ARP34452 Mouse CHMP3 antibody; Mus musculus CHMP3 antibody Q9CQ10 100.0%
ARP34453 Mouse CHMP3 antibody; Mus musculus CHMP3 antibody Q9CQ10 100.0%
ARP34453 Rainbow smelt CHMP3 antibody; Osmerus mordax CHMP3 antibody C1BL73 100.0%
ARP34452 Rainbow smelt CHMP3 antibody; Osmerus mordax CHMP3 antibody C1BL73 93.0%
ARP65451 Rainbow smelt CHMP3 antibody; Osmerus mordax CHMP3 antibody C1BL73 89.0%
ARP34453 Rainbow trout CHMP3 antibody; Oncorhynchus mykiss CHMP3 antibody C1BGP2 100.0%
ARP34452 Rainbow trout CHMP3 antibody; Oncorhynchus mykiss CHMP3 antibody C1BGP2 93.0%
ARP34452 Rat CHMP3 antibody; Rattus norvegicus CHMP3 antibody Q8CGS4 100.0%
ARP34453 Rat CHMP3 antibody; Rattus norvegicus CHMP3 antibody Q8CGS4 100.0%
ARP34453 Sablefish CHMP3 antibody; Anoplopoma fimbria CHMP3 antibody C3KI02 100.0%
ARP34452 Sablefish CHMP3 antibody; Anoplopoma fimbria CHMP3 antibody C3KI02 92.0%
ARP34452 Sumatran orangutan CHMP3 antibody; Pongo abelii CHMP3 antibody Q5RAU5 100.0%
ARP34453 Sumatran orangutan CHMP3 antibody; Pongo abelii CHMP3 antibody Q5RAU5 100.0%
ARP34453 Western clawed frog CHMP3 antibody; Xenopus tropicalis CHMP3 antibody Q5BKM3 100.0%
ARP34453 White-tufted-ear marmoset CHMP3 antibody; Callithrix jacchus CHMP3 antibody F6R3G0 100.0%
ARP34453 White-tufted-ear marmoset CHMP3 antibody; Callithrix jacchus CHMP3 antibody F6SH13 100.0%
ARP34452 White-tufted-ear marmoset CHMP3 antibody; Callithrix jacchus CHMP3 antibody F7GN92 100.0%
ARP34453 White-tufted-ear marmoset CHMP3 antibody; Callithrix jacchus CHMP3 antibody F7GN92 100.0%
ARP34452 Zebrafish CHMP3 antibody; Danio rerio CHMP3 antibody Q6NY88 93.0%
ARP34453 Zebrafish CHMP3 antibody; Danio rerio CHMP3 antibody Q6NY88 86.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas217837_s_at721_B_lymphoblasts24.85063.290Details
BioGPS Gene Atlas217837_s_atAdipocyte99.65063.290Details
BioGPS Gene Atlas217837_s_atAdrenalCortex15.70063.290Details
BioGPS Gene Atlas217837_s_atAdrenalgland24.30063.290Details
BioGPS Gene Atlas217837_s_atAmygdala215.15063.290Details
BioGPS Gene Atlas217837_s_atAppendix23.20063.290Details
BioGPS Gene Atlas217837_s_atAtrioventricularNode13.95063.290Details
BioGPS Gene Atlas217837_s_atBDCA4+_DentriticCells64.90063.290Details
BioGPS Gene Atlas217837_s_atBonemarrow34.60063.290Details
BioGPS Gene Atlas217837_s_atBronchialEpithelialCells186.20063.290Details
BioGPS Gene Atlas217837_s_atCD105+_Endothelial83.10063.290Details
BioGPS Gene Atlas217837_s_atCD14+_Monocytes107.25063.290Details
BioGPS Gene Atlas217837_s_atCD19+_BCells(neg._sel.)86.25063.290Details
BioGPS Gene Atlas217837_s_atCD33+_Myeloid211.00063.290Details
BioGPS Gene Atlas217837_s_atCD34+87.20063.290Details
BioGPS Gene Atlas217837_s_atCD4+_Tcells36.15063.290Details
BioGPS Gene Atlas217837_s_atCD56+_NKCells122.55063.290Details
BioGPS Gene Atlas217837_s_atCD71+_EarlyErythroid80.75063.290Details
BioGPS Gene Atlas217837_s_atCD8+_Tcells34.60063.290Details
BioGPS Gene Atlas217837_s_atCardiacMyocytes30.35063.290Details
BioGPS Gene Atlas217837_s_atCaudatenucleus105.10063.290Details
BioGPS Gene Atlas217837_s_atCerebellum55.10063.290Details
BioGPS Gene Atlas217837_s_atCerebellumPeduncles40.35063.290Details
BioGPS Gene Atlas217837_s_atCiliaryGanglion12.30063.290Details
BioGPS Gene Atlas217837_s_atCingulateCortex34.25063.290Details
BioGPS Gene Atlas217837_s_atColorectaladenocarcinoma106.80063.290Details
BioGPS Gene Atlas217837_s_atDorsalRootGanglion63.30063.290Details
BioGPS Gene Atlas217837_s_atFetalThyroid50.60063.290Details
BioGPS Gene Atlas217837_s_atFetalbrain39.35063.290Details
BioGPS Gene Atlas217837_s_atFetalliver23.60063.290Details
BioGPS Gene Atlas217837_s_atFetallung48.35063.290Details
BioGPS Gene Atlas217837_s_atGlobusPallidus54.90063.290Details
BioGPS Gene Atlas217837_s_atHeart16.00063.290Details
BioGPS Gene Atlas217837_s_atHypothalamus53.70063.290Details
BioGPS Gene Atlas217837_s_atKidney12.20063.290Details
BioGPS Gene Atlas217837_s_atLeukemia_chronicMyelogenousK-56213.40063.290Details
BioGPS Gene Atlas217837_s_atLeukemia_promyelocytic-HL-6012.65063.290Details
BioGPS Gene Atlas217837_s_atLeukemialymphoblastic(MOLT-4)11.45063.290Details
BioGPS Gene Atlas217837_s_atLiver7.45063.290Details
BioGPS Gene Atlas217837_s_atLung118.00063.290Details
BioGPS Gene Atlas217837_s_atLymphnode21.75063.290Details
BioGPS Gene Atlas217837_s_atLymphoma_burkitts(Daudi)10.20063.290Details
BioGPS Gene Atlas217837_s_atLymphoma_burkitts(Raji)20.85063.290Details
BioGPS Gene Atlas217837_s_atMedullaOblongata28.85063.290Details
BioGPS Gene Atlas217837_s_atOccipitalLobe57.65063.290Details
BioGPS Gene Atlas217837_s_atOlfactoryBulb40.20063.290Details
BioGPS Gene Atlas217837_s_atOvary14.30063.290Details
BioGPS Gene Atlas217837_s_atPancreas64.40063.290Details
BioGPS Gene Atlas217837_s_atPancreaticIslet71.85063.290Details
BioGPS Gene Atlas217837_s_atParietalLobe22.25063.290Details
BioGPS Gene Atlas217837_s_atPituitary39.80063.290Details
BioGPS Gene Atlas217837_s_atPlacenta44.50063.290Details
BioGPS Gene Atlas217837_s_atPons26.05063.290Details
BioGPS Gene Atlas217837_s_atPrefrontalCortex82.90063.290Details
BioGPS Gene Atlas217837_s_atProstate134.40063.290Details
BioGPS Gene Atlas217837_s_atSalivarygland39.45063.290Details
BioGPS Gene Atlas217837_s_atSkeletalMuscle13.30063.290Details
BioGPS Gene Atlas217837_s_atSkin50.00063.290Details
BioGPS Gene Atlas217837_s_atSmoothMuscle66.95063.290Details
BioGPS Gene Atlas217837_s_atSpinalcord39.00063.290Details
BioGPS Gene Atlas217837_s_atSubthalamicNucleus40.05063.290Details
BioGPS Gene Atlas217837_s_atSuperiorCervicalGanglion15.60063.290Details
BioGPS Gene Atlas217837_s_atTemporalLobe22.20063.290Details
BioGPS Gene Atlas217837_s_atTestis6.05063.290Details
BioGPS Gene Atlas217837_s_atTestisGermCell31.60063.290Details
BioGPS Gene Atlas217837_s_atTestisIntersitial12.95063.290Details
BioGPS Gene Atlas217837_s_atTestisLeydigCell12.70063.290Details
BioGPS Gene Atlas217837_s_atTestisSeminiferousTubule12.75063.290Details
BioGPS Gene Atlas217837_s_atThalamus18.20063.290Details
BioGPS Gene Atlas217837_s_atThymus7.70063.290Details
BioGPS Gene Atlas217837_s_atThyroid278.40063.290Details
BioGPS Gene Atlas217837_s_atTongue37.90063.290Details
BioGPS Gene Atlas217837_s_atTonsil11.35063.290Details
BioGPS Gene Atlas217837_s_atTrachea63.70063.290Details
BioGPS Gene Atlas217837_s_atTrigeminalGanglion29.40063.290Details
BioGPS Gene Atlas217837_s_atUterus123.05063.290Details
BioGPS Gene Atlas217837_s_atUterusCorpus32.05063.290Details
BioGPS Gene Atlas217837_s_atWholeBlood218.95063.290Details
BioGPS Gene Atlas217837_s_atWholebrain92.70063.290Details
BioGPS Gene Atlas217837_s_atcolon205.80063.290Details
BioGPS Gene Atlas217837_s_atpineal_day108.22063.290Details
BioGPS Gene Atlas217837_s_atpineal_night105.60063.290Details
BioGPS Gene Atlas217837_s_atretina117.67563.290Details
BioGPS Gene Atlas217837_s_atsmall_intestine177.20063.290Details
BioGPS NCI60217837_s_at786759.230676.730Details
BioGPS NCI60217837_s_atA1721128.952676.730Details
BioGPS NCI60217837_s_atA204125.419676.730Details
BioGPS NCI60217837_s_atA361542.158676.730Details
BioGPS NCI60217837_s_atA4981038.671676.730Details
BioGPS NCI60217837_s_atA5491247.139676.730Details
BioGPS NCI60217837_s_atACC3670.825676.730Details
BioGPS NCI60217837_s_atACHN878.204676.730Details
BioGPS NCI60217837_s_atALVA31366.497676.730Details
BioGPS NCI60217837_s_atCAKI1702.231676.730Details
BioGPS NCI60217837_s_atCCRT CEM30.632676.730Details
BioGPS NCI60217837_s_atCOLO2051039.742676.730Details
BioGPS NCI60217837_s_atDLD1484.399676.730Details
BioGPS NCI60217837_s_atDU145253.218676.730Details
BioGPS NCI60217837_s_atEKVX975.286676.730Details
BioGPS NCI60217837_s_atGM133716.391676.730Details
BioGPS NCI60217837_s_atGM16001941.166676.730Details
BioGPS NCI60217837_s_atGM23131147.046676.730Details
BioGPS NCI60217837_s_atGM23451341.894676.730Details
BioGPS NCI60217837_s_atGM24931322.501676.730Details
BioGPS NCI60217837_s_atGM971656.356676.730Details
BioGPS NCI60217837_s_atHCC2998721.323676.730Details
BioGPS NCI60217837_s_atHCT116476.538676.730Details
BioGPS NCI60217837_s_atHCT15574.776676.730Details
BioGPS NCI60217837_s_atHEK 293 T-rex316.921676.730Details
BioGPS NCI60217837_s_atHEK 293T487.901676.730Details
BioGPS NCI60217837_s_atHEK293662.060676.730Details
BioGPS NCI60217837_s_atHELA322.129676.730Details
BioGPS NCI60217837_s_atHEPG2616.699676.730Details
BioGPS NCI60217837_s_atHL6023.242676.730Details
BioGPS NCI60217837_s_atHOP62888.873676.730Details
BioGPS NCI60217837_s_atHOP92557.447676.730Details
BioGPS NCI60217837_s_atHS578T736.015676.730Details
BioGPS NCI60217837_s_atHSG300.954676.730Details
BioGPS NCI60217837_s_atHT1080531.261676.730Details
BioGPS NCI60217837_s_atHT29884.481676.730Details
BioGPS NCI60217837_s_atIGROV1546.334676.730Details
BioGPS NCI60217837_s_atIOSE80596.047676.730Details
BioGPS NCI60217837_s_atJURKAT193.148676.730Details
BioGPS NCI60217837_s_atK562139.068676.730Details
BioGPS NCI60217837_s_atKM12434.726676.730Details
BioGPS NCI60217837_s_atLN18999.912676.730Details
BioGPS NCI60217837_s_atLNCAP128.515676.730Details
BioGPS NCI60217837_s_atLOX IMVI718.158676.730Details
BioGPS NCI60217837_s_atM14526.732676.730Details
BioGPS NCI60217837_s_atMALME 3M333.553676.730Details
BioGPS NCI60217837_s_atMCF7593.435676.730Details
BioGPS NCI60217837_s_atMD MB2311080.432676.730Details
BioGPS NCI60217837_s_atMDA MB435227.126676.730Details
BioGPS NCI60217837_s_atMOLT4103.679676.730Details
BioGPS NCI60217837_s_atNCI 460541.795676.730Details
BioGPS NCI60217837_s_atNCI H226553.792676.730Details
BioGPS NCI60217837_s_atNCI H231064.938676.730Details
BioGPS NCI60217837_s_atNCI H322M1024.878676.730Details
BioGPS NCI60217837_s_atNCVADR RES241.911676.730Details
BioGPS NCI60217837_s_atOVCAR3875.746676.730Details
BioGPS NCI60217837_s_atOVCAR4724.591676.730Details
BioGPS NCI60217837_s_atOVCAR5909.343676.730Details
BioGPS NCI60217837_s_atOVCAR8348.432676.730Details
BioGPS NCI60217837_s_atPANC1473.349676.730Details
BioGPS NCI60217837_s_atRL7190.721676.730Details
BioGPS NCI60217837_s_atRPMI 822622.311676.730Details
BioGPS NCI60217837_s_atRS11846181.432676.730Details
BioGPS NCI60217837_s_atRXF393874.907676.730Details
BioGPS NCI60217837_s_atSAOS2228.009676.730Details
BioGPS NCI60217837_s_atSF268551.392676.730Details
BioGPS NCI60217837_s_atSF295672.922676.730Details
BioGPS NCI60217837_s_atSF539444.927676.730Details
BioGPS NCI60217837_s_atSHSYSY+RA439.388676.730Details
BioGPS NCI60217837_s_atSHSYSY-RA599.266676.730Details
BioGPS NCI60217837_s_atSKMEL2134.103676.730Details
BioGPS NCI60217837_s_atSKMEL28227.089676.730Details
BioGPS NCI60217837_s_atSKMEL5562.433676.730Details
BioGPS NCI60217837_s_atSKOV31177.488676.730Details
BioGPS NCI60217837_s_atSN12C753.790676.730Details
BioGPS NCI60217837_s_atSNB19825.826676.730Details
BioGPS NCI60217837_s_atSNB75631.222676.730Details
BioGPS NCI60217837_s_atSR48.251676.730Details
BioGPS NCI60217837_s_atSW620816.362676.730Details
BioGPS NCI60217837_s_atT24563.202676.730Details
BioGPS NCI60217837_s_atT3M4307.402676.730Details
BioGPS NCI60217837_s_atTK10788.038676.730Details
BioGPS NCI60217837_s_atU1181560.512676.730Details
BioGPS NCI60217837_s_atU1382473.151676.730Details
BioGPS NCI60217837_s_atU20S260.188676.730Details
BioGPS NCI60217837_s_atU251517.487676.730Details
BioGPS NCI60217837_s_atU871673.772676.730Details
BioGPS NCI60217837_s_atUACC257531.471676.730Details
BioGPS NCI60217837_s_atUACC62376.263676.730Details
BioGPS NCI60217837_s_atUO31486.437676.730Details
BioGPS NCI60217837_s_atZR75_1302.972676.730Details
BioGPS NCI60217837_s_atastrocytes434.384676.730Details
BioGPS NCI60217837_s_athuh-7732.749676.730Details