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Gene ID: 1121 | CHM Antibody Resource


CHM Antibody Resource
Gene Full Name: 
choroideremia (Rab escort protein 1)
Uniprot: 
P24386
Protein Name: 
rab proteins geranylgeranyltransferase component A 1
Nucleotide: 
NM_000390
Alias: 
TCD;GGTA;REP-1;DXS540;HSD-32;
Ensembl: 
ENSG00000188419
Location: 
Xq21.2
HPRD: 
02312
NCBI Gene: 
1121
MIM: 
300390

Summary: 
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
Function: 
Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.
Subcellular location: 
PTM: 
Disease: 
Choroideremia (CHM) [MIM:303100]: An X-linked recessive disease characterized by a slowly progressive degeneration of the choroid, photoreceptors, and retinal pigment epithelium. Affected males develop night blindness in their teenage years followed by loss of peripheral vision and complete blindness at middle age. Carrier females are generally asymptomatic but funduscopic examination often shows patchy areas of chorioretinal atrophy. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody AVARP13011_P050 CHM antibody - N-terminal region (AVARP13011_P050) Polyclonal Horse, Human WB 50ug $289 Details
Polyclonal Antibody ARP30666_P050 CHM Antibody (ARP30666_P050) Polyclonal Horse, Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAB15484 CHM antibody - center region (OAAB15484) Human WB 400ul $289 Details

Show all CHM antibodies


Product Images
CHM antibody - N-terminal region (AVARP13011_P050) in Human Thymus cells using Western Blot

Sample Type: Human Thymus

CHM antibody - center region (OAAB15484) in 293 cells using Western Blot

Sample Type: 293


CHM Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP30666 Chimpanzee CHM antibody; Pan troglodytes CHM antibody H2QYV2 100.0%
ARP30666 European domestic ferret CHM antibody; Mustela putorius furo CHM antibody M3XQ32 80.0%
ARP30666 Giant panda CHM antibody; Ailuropoda melanoleuca CHM antibody G1LUI9 80.0%
ARP30666 Horse CHM antibody; Equus caballus CHM antibody F7A2B6 80.0%
ARP30666 Human CHM antibody; Homo sapiens CHM antibody P24386-2 100.0%
ARP30666 Human CHM antibody; Homo sapiens CHM antibody P24386 100.0%
ARP30666 Northern white-cheeked gibbon CHM antibody; Nomascus leucogenys CHM antibody G1QR06 93.0%
ARP30666 Rhesus macaque CHM antibody; Macaca mulatta CHM antibody F7DAV9 80.0%
ARP30666 Rhesus macaque CHM antibody; Macaca mulatta CHM antibody G7NSD9 80.0%
ARP30666 Sumatran orangutan CHM antibody; Pongo abelii CHM antibody H2PW61 100.0%
ARP30666 White-tufted-ear marmoset CHM antibody; Callithrix jacchus CHM antibody U3C1F5 93.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas207099_s_at721_B_lymphoblasts6.1505.610Details
BioGPS Gene Atlas207099_s_atAdipocyte5.5005.610Details
BioGPS Gene Atlas207099_s_atAdrenalCortex5.9005.610Details
BioGPS Gene Atlas207099_s_atAdrenalgland4.8005.610Details
BioGPS Gene Atlas207099_s_atAmygdala5.7505.610Details
BioGPS Gene Atlas207099_s_atAppendix5.9505.610Details
BioGPS Gene Atlas207099_s_atAtrioventricularNode4.3005.610Details
BioGPS Gene Atlas207099_s_atBDCA4+_DentriticCells5.5505.610Details
BioGPS Gene Atlas207099_s_atBonemarrow5.8505.610Details
BioGPS Gene Atlas207099_s_atBronchialEpithelialCells5.4505.610Details
BioGPS Gene Atlas207099_s_atCD105+_Endothelial5.4505.610Details
BioGPS Gene Atlas207099_s_atCD14+_Monocytes5.9005.610Details
BioGPS Gene Atlas207099_s_atCD19+_BCells(neg._sel.)5.7005.610Details
BioGPS Gene Atlas207099_s_atCD33+_Myeloid6.8505.610Details
BioGPS Gene Atlas207099_s_atCD34+6.7005.610Details
BioGPS Gene Atlas207099_s_atCD4+_Tcells5.6505.610Details
BioGPS Gene Atlas207099_s_atCD56+_NKCells6.3005.610Details
BioGPS Gene Atlas207099_s_atCD71+_EarlyErythroid5.2505.610Details
BioGPS Gene Atlas207099_s_atCD8+_Tcells5.2505.610Details
BioGPS Gene Atlas207099_s_atCardiacMyocytes7.3005.610Details
BioGPS Gene Atlas207099_s_atCaudatenucleus5.0005.610Details
BioGPS Gene Atlas207099_s_atCerebellum4.5005.610Details
BioGPS Gene Atlas207099_s_atCerebellumPeduncles6.4505.610Details
BioGPS Gene Atlas207099_s_atCiliaryGanglion4.1005.610Details
BioGPS Gene Atlas207099_s_atCingulateCortex5.6505.610Details
BioGPS Gene Atlas207099_s_atColorectaladenocarcinoma5.5505.610Details
BioGPS Gene Atlas207099_s_atDorsalRootGanglion4.3505.610Details
BioGPS Gene Atlas207099_s_atFetalThyroid5.4005.610Details
BioGPS Gene Atlas207099_s_atFetalbrain5.4505.610Details
BioGPS Gene Atlas207099_s_atFetalliver4.9005.610Details
BioGPS Gene Atlas207099_s_atFetallung4.5005.610Details
BioGPS Gene Atlas207099_s_atGlobusPallidus4.2005.610Details
BioGPS Gene Atlas207099_s_atHeart7.7005.610Details
BioGPS Gene Atlas207099_s_atHypothalamus5.9005.610Details
BioGPS Gene Atlas207099_s_atKidney4.7005.610Details
BioGPS Gene Atlas207099_s_atLeukemia_chronicMyelogenousK-5625.0005.610Details
BioGPS Gene Atlas207099_s_atLeukemia_promyelocytic-HL-604.9005.610Details
BioGPS Gene Atlas207099_s_atLeukemialymphoblastic(MOLT-4)4.4505.610Details
BioGPS Gene Atlas207099_s_atLiver8.1505.610Details
BioGPS Gene Atlas207099_s_atLung6.0005.610Details
BioGPS Gene Atlas207099_s_atLymphnode4.7505.610Details
BioGPS Gene Atlas207099_s_atLymphoma_burkitts(Daudi)7.1005.610Details
BioGPS Gene Atlas207099_s_atLymphoma_burkitts(Raji)8.1505.610Details
BioGPS Gene Atlas207099_s_atMedullaOblongata5.0505.610Details
BioGPS Gene Atlas207099_s_atOccipitalLobe4.9005.610Details
BioGPS Gene Atlas207099_s_atOlfactoryBulb4.4005.610Details
BioGPS Gene Atlas207099_s_atOvary3.7005.610Details
BioGPS Gene Atlas207099_s_atPancreas4.5005.610Details
BioGPS Gene Atlas207099_s_atPancreaticIslet5.9505.610Details
BioGPS Gene Atlas207099_s_atParietalLobe6.1005.610Details
BioGPS Gene Atlas207099_s_atPituitary6.5005.610Details
BioGPS Gene Atlas207099_s_atPlacenta5.7005.610Details
BioGPS Gene Atlas207099_s_atPons5.2505.610Details
BioGPS Gene Atlas207099_s_atPrefrontalCortex6.7505.610Details
BioGPS Gene Atlas207099_s_atProstate6.4505.610Details
BioGPS Gene Atlas207099_s_atSalivarygland4.4505.610Details
BioGPS Gene Atlas207099_s_atSkeletalMuscle6.9505.610Details
BioGPS Gene Atlas207099_s_atSkin4.4505.610Details
BioGPS Gene Atlas207099_s_atSmoothMuscle6.3005.610Details
BioGPS Gene Atlas207099_s_atSpinalcord5.9505.610Details
BioGPS Gene Atlas207099_s_atSubthalamicNucleus5.1005.610Details
BioGPS Gene Atlas207099_s_atSuperiorCervicalGanglion6.4505.610Details
BioGPS Gene Atlas207099_s_atTemporalLobe5.1505.610Details
BioGPS Gene Atlas207099_s_atTestis4.7005.610Details
BioGPS Gene Atlas207099_s_atTestisGermCell4.5005.610Details
BioGPS Gene Atlas207099_s_atTestisIntersitial4.6505.610Details
BioGPS Gene Atlas207099_s_atTestisLeydigCell5.5005.610Details
BioGPS Gene Atlas207099_s_atTestisSeminiferousTubule4.6505.610Details
BioGPS Gene Atlas207099_s_atThalamus5.6505.610Details
BioGPS Gene Atlas207099_s_atThymus4.3005.610Details
BioGPS Gene Atlas207099_s_atThyroid6.8005.610Details
BioGPS Gene Atlas207099_s_atTongue5.6005.610Details
BioGPS Gene Atlas207099_s_atTonsil5.4505.610Details
BioGPS Gene Atlas207099_s_atTrachea4.6505.610Details
BioGPS Gene Atlas207099_s_atTrigeminalGanglion6.2005.610Details
BioGPS Gene Atlas207099_s_atUterus4.5005.610Details
BioGPS Gene Atlas207099_s_atUterusCorpus5.1505.610Details
BioGPS Gene Atlas207099_s_atWholeBlood6.1005.610Details
BioGPS Gene Atlas207099_s_atWholebrain4.6005.610Details
BioGPS Gene Atlas207099_s_atcolon5.5505.610Details
BioGPS Gene Atlas207099_s_atpineal_day6.8005.610Details
BioGPS Gene Atlas207099_s_atpineal_night6.6605.610Details
BioGPS Gene Atlas207099_s_atretina6.7005.610Details
BioGPS Gene Atlas207099_s_atsmall_intestine5.3005.610Details
BioGPS NCI60207099_s_at7865.7285.870Details
BioGPS NCI60207099_s_atA1725.3705.870Details
BioGPS NCI60207099_s_atA2045.4615.870Details
BioGPS NCI60207099_s_atA3615.6375.870Details
BioGPS NCI60207099_s_atA4985.5485.870Details
BioGPS NCI60207099_s_atA5495.6565.870Details
BioGPS NCI60207099_s_atACC35.8155.870Details
BioGPS NCI60207099_s_atACHN5.6045.870Details
BioGPS NCI60207099_s_atALVA316.1155.870Details
BioGPS NCI60207099_s_atCAKI15.8315.870Details
BioGPS NCI60207099_s_atCCRT CEM6.5275.870Details
BioGPS NCI60207099_s_atCOLO2055.5475.870Details
BioGPS NCI60207099_s_atDLD15.4605.870Details
BioGPS NCI60207099_s_atDU1455.0965.870Details
BioGPS NCI60207099_s_atEKVX5.3695.870Details
BioGPS NCI60207099_s_atGM1335.7325.870Details
BioGPS NCI60207099_s_atGM16005.8615.870Details
BioGPS NCI60207099_s_atGM23136.0695.870Details
BioGPS NCI60207099_s_atGM23457.8295.870Details
BioGPS NCI60207099_s_atGM24935.8545.870Details
BioGPS NCI60207099_s_atGM9712.0785.870Details
BioGPS NCI60207099_s_atHCC299814.8105.870Details
BioGPS NCI60207099_s_atHCT1165.5105.870Details
BioGPS NCI60207099_s_atHCT155.2945.870Details
BioGPS NCI60207099_s_atHEK 293 T-rex5.6675.870Details
BioGPS NCI60207099_s_atHEK 293T5.5405.870Details
BioGPS NCI60207099_s_atHEK2935.5285.870Details
BioGPS NCI60207099_s_atHELA7.1395.870Details
BioGPS NCI60207099_s_atHEPG25.4815.870Details
BioGPS NCI60207099_s_atHL605.7925.870Details
BioGPS NCI60207099_s_atHOP625.5975.870Details
BioGPS NCI60207099_s_atHOP925.3445.870Details
BioGPS NCI60207099_s_atHS578T5.4065.870Details
BioGPS NCI60207099_s_atHSG5.3225.870Details
BioGPS NCI60207099_s_atHT10809.5705.870Details
BioGPS NCI60207099_s_atHT295.9225.870Details
BioGPS NCI60207099_s_atIGROV15.5015.870Details
BioGPS NCI60207099_s_atIOSE805.5505.870Details
BioGPS NCI60207099_s_atJURKAT5.4655.870Details
BioGPS NCI60207099_s_atK5625.9215.870Details
BioGPS NCI60207099_s_atKM125.7965.870Details
BioGPS NCI60207099_s_atLN185.4045.870Details
BioGPS NCI60207099_s_atLNCAP5.5695.870Details
BioGPS NCI60207099_s_atLOX IMVI5.4755.870Details
BioGPS NCI60207099_s_atM145.5045.870Details
BioGPS NCI60207099_s_atMALME 3M6.0355.870Details
BioGPS NCI60207099_s_atMCF75.3885.870Details
BioGPS NCI60207099_s_atMD MB2315.6695.870Details
BioGPS NCI60207099_s_atMDA MB4355.8945.870Details
BioGPS NCI60207099_s_atMOLT45.6435.870Details
BioGPS NCI60207099_s_atNCI 4605.6565.870Details
BioGPS NCI60207099_s_atNCI H2265.6705.870Details
BioGPS NCI60207099_s_atNCI H235.5045.870Details
BioGPS NCI60207099_s_atNCI H322M5.4775.870Details
BioGPS NCI60207099_s_atNCVADR RES5.4765.870Details
BioGPS NCI60207099_s_atOVCAR35.8145.870Details
BioGPS NCI60207099_s_atOVCAR45.5565.870Details
BioGPS NCI60207099_s_atOVCAR55.3715.870Details
BioGPS NCI60207099_s_atOVCAR84.9745.870Details
BioGPS NCI60207099_s_atPANC15.6825.870Details
BioGPS NCI60207099_s_atRL75.6505.870Details
BioGPS NCI60207099_s_atRPMI 82265.6525.870Details
BioGPS NCI60207099_s_atRS118465.8225.870Details
BioGPS NCI60207099_s_atRXF3935.4975.870Details
BioGPS NCI60207099_s_atSAOS212.3955.870Details
BioGPS NCI60207099_s_atSF2685.5495.870Details
BioGPS NCI60207099_s_atSF2955.3765.870Details
BioGPS NCI60207099_s_atSF5395.2295.870Details
BioGPS NCI60207099_s_atSHSYSY+RA5.4055.870Details
BioGPS NCI60207099_s_atSHSYSY-RA5.5325.870Details
BioGPS NCI60207099_s_atSKMEL25.5305.870Details
BioGPS NCI60207099_s_atSKMEL285.5725.870Details
BioGPS NCI60207099_s_atSKMEL55.2035.870Details
BioGPS NCI60207099_s_atSKOV35.6455.870Details
BioGPS NCI60207099_s_atSN12C6.4855.870Details
BioGPS NCI60207099_s_atSNB195.3615.870Details
BioGPS NCI60207099_s_atSNB755.5855.870Details
BioGPS NCI60207099_s_atSR5.6545.870Details
BioGPS NCI60207099_s_atSW6205.6505.870Details
BioGPS NCI60207099_s_atT245.6435.870Details
BioGPS NCI60207099_s_atT3M45.8155.870Details
BioGPS NCI60207099_s_atTK105.5565.870Details
BioGPS NCI60207099_s_atU1185.3755.870Details
BioGPS NCI60207099_s_atU1385.4525.870Details
BioGPS NCI60207099_s_atU20S5.4025.870Details
BioGPS NCI60207099_s_atU2515.5635.870Details
BioGPS NCI60207099_s_atU875.4865.870Details
BioGPS NCI60207099_s_atUACC2575.6615.870Details
BioGPS NCI60207099_s_atUACC625.6855.870Details
BioGPS NCI60207099_s_atUO315.1925.870Details
BioGPS NCI60207099_s_atZR75_15.7025.870Details
BioGPS NCI60207099_s_atastrocytes5.5705.870Details
BioGPS NCI60207099_s_athuh-75.7265.870Details