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Gene ID: 131474 | CHCHD4 Antibody Resource


CHCHD4 Antibody Resource
Gene Full Name: 
coiled-coil-helix-coiled-coil-helix domain containing 4
Uniprot: 
Q8N4Q1
Protein Name: 
mitochondrial intermembrane space import and assembly protein 40
Nucleotide: 
NM_001098502
Alias: 
MIA40;TIMM40;
Ensembl: 
ENSG00000163528
Location: 
3p25.1
HPRD: 
13045
NCBI Gene: 
131474
MIM: 
611077

Summary: 
CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008]
Function: 
Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system.
Subcellular location: 
Mitochondrion intermembrane space .
PTM: 
Disulfide bond;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP51895_P050 CHCHD4 antibody - N-terminal region (ARP51895_P050) Polyclonal Dog, Guinea pig, Horse, Pig, Rabbit, Zebrafish WB 50ug $289 Details
Polyclonal Antibody ARP51896_P050 CHCHD4 Antibody (ARP51896_P050) Polyclonal Dog, Guinea pig, Horse, Human, Mouse, Rat, Yeast, Zebrafish Not tested 50 ug $125 Details
Polyclonal Antibody OAAB07775 MIA40 antibody - C - terminal region (OAAB07775) Human WB, IHC 400ul $289 Details

Show all CHCHD4 antibodies


Product Images
CHCHD4 antibody - N-terminal region (ARP51895_P050) in Transfected 293T cells using Western Blot

Sample Type: Transfected 293T

MIA40 antibody - C - terminal region (OAAB07775) in Human Liver cells using Immunohistochemistry

Sample Type: Human Liver

MIA40 antibody - C - terminal region (OAAB07775) in MDA-MB231 cells using Western Blot

Sample Type: MDA-MB231


CHCHD4 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP51895 Bovine CHCHD4 antibody; Bos taurus CHCHD4 antibody Q2KHZ4 93.0%
ARP51895 Cat CHCHD4 antibody; Felis catus CHCHD4 antibody M3VXE8 93.0%
ARP51896 Cat CHCHD4 antibody; Felis catus CHCHD4 antibody M3VXE8 86.0%
ARP51895 Chicken CHCHD4 antibody; Gallus gallus CHCHD4 antibody E1BUJ8 100.0%
ARP51895 Chimpanzee CHCHD4 antibody; Pan troglodytes CHCHD4 antibody K7BAJ4 100.0%
ARP51896 Chimpanzee CHCHD4 antibody; Pan troglodytes CHCHD4 antibody K7BAJ4 100.0%
ARP51895 Chimpanzee CHCHD4 antibody; Pan troglodytes CHCHD4 antibody H2RBJ7 100.0%
ARP51896 Chimpanzee CHCHD4 antibody; Pan troglodytes CHCHD4 antibody H2RBJ7 100.0%
ARP51895 Chinese softshell turtle CHCHD4 antibody; Pelodiscus sinensis CHCHD4 antibody K7G880 100.0%
ARP51895 Collared flycatcher CHCHD4 antibody; Ficedula albicollis CHCHD4 antibody U3KDT0 86.0%
ARP51895 Dog CHCHD4 antibody; Canis familiaris CHCHD4 antibody E2RDS4 93.0%
ARP51896 Dog CHCHD4 antibody; Canis familiaris CHCHD4 antibody E2RDS4 79.0%
ARP51895 Domestic duck CHCHD4 antibody; Anas platyrhynchos CHCHD4 antibody U3J2P1 100.0%
ARP51895 Duckbill platypus CHCHD4 antibody; Ornithorhynchus anatinus CHCHD4 antibody F6W9M7 100.0%
ARP51895 Duckbill platypus CHCHD4 antibody; Ornithorhynchus anatinus CHCHD4 antibody F6W9N3 100.0%
ARP51895 Giant panda CHCHD4 antibody; Ailuropoda melanoleuca CHCHD4 antibody G1LS95 93.0%
ARP51896 Giant panda CHCHD4 antibody; Ailuropoda melanoleuca CHCHD4 antibody G1LS95 79.0%
ARP51895 Horse CHCHD4 antibody; Equus caballus CHCHD4 antibody F6T393 93.0%
ARP51895 Human CHCHD4 antibody; Homo sapiens CHCHD4 antibody Q8N4Q1-2 100.0%
ARP51896 Human CHCHD4 antibody; Homo sapiens CHCHD4 antibody Q8N4Q1-2 100.0%
ARP51895 Human CHCHD4 antibody; Homo sapiens CHCHD4 antibody Q8N4Q1 100.0%
ARP51896 Human CHCHD4 antibody; Homo sapiens CHCHD4 antibody Q8N4Q1 100.0%
ARP51895 Mouse CHCHD4 antibody; Mus musculus CHCHD4 antibody Q8VEA4 100.0%
ARP51895 Pig CHCHD4 antibody; Sus scrofa CHCHD4 antibody F1SPI0 93.0%
ARP51895 Rabbit CHCHD4 antibody; Oryctolagus cuniculus CHCHD4 antibody G1TF72 93.0%
ARP51895 Rat CHCHD4 antibody; Rattus norvegicus CHCHD4 antibody Q5BJN5 100.0%
ARP51896 Rhesus macaque CHCHD4 antibody; Macaca mulatta CHCHD4 antibody F7DGV0 100.0%
ARP51896 Rhesus macaque CHCHD4 antibody; Macaca mulatta CHCHD4 antibody H9EVC9 100.0%
ARP51895 Rhesus macaque CHCHD4 antibody; Macaca mulatta CHCHD4 antibody F7DGV0 93.0%
ARP51895 Rhesus macaque CHCHD4 antibody; Macaca mulatta CHCHD4 antibody H9EVC9 93.0%
ARP51895 Spotted green pufferfish CHCHD4 antibody; Tetraodon nigroviridis CHCHD4 antibody H3CNR6 86.0%
ARP51895 Sumatran orangutan CHCHD4 antibody; Pongo abelii CHCHD4 antibody H2PXM4 100.0%
ARP51896 Sumatran orangutan CHCHD4 antibody; Pongo abelii CHCHD4 antibody H2PXM4 100.0%
ARP51895 Tasmanian devil CHCHD4 antibody; Sarcophilus harrisii CHCHD4 antibody G3VKZ1 93.0%
ARP51895 Thirteen-lined ground squirrel CHCHD4 antibody; Spermophilus tridecemlineatus CHCHD4 antibody I3NET5 93.0%
ARP51895 Three-spined stickleback CHCHD4 antibody; Gasterosteus aculeatus CHCHD4 antibody G3N6Z8 86.0%
ARP51895 Western clawed frog CHCHD4 antibody; Xenopus tropicalis CHCHD4 antibody Q6PBC3 100.0%
ARP51895 White-tufted-ear marmoset CHCHD4 antibody; Callithrix jacchus CHCHD4 antibody F7IRW6 93.0%
ARP51895 White-tufted-ear marmoset CHCHD4 antibody; Callithrix jacchus CHCHD4 antibody U3EA41 93.0%
ARP51896 White-tufted-ear marmoset CHCHD4 antibody; Callithrix jacchus CHCHD4 antibody U3EA41 93.0%
ARP51895 Zebra finch CHCHD4 antibody; Taeniopygia guttata CHCHD4 antibody H0ZD63 93.0%
ARP51895 Zebrafish CHCHD4 antibody; Danio rerio CHCHD4 antibody Q6DEI8 86.0%
ARP51895 Zebrafish CHCHD4 antibody; Danio rerio CHCHD4 antibody E9QDT6 86.0%
ARP51895 Zebrafish CHCHD4 antibody; Danio rerio CHCHD4 antibody F1QKE2 86.0%

Tissue & Cell Line Gene Expression Data