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Gene ID: 3426 | CFI Antibody Resource


CFI Antibody Resource
Gene Full Name: 
complement factor I
Uniprot: 
P05156
Protein Name: 
complement factor I
Nucleotide: 
XM_005262976
Alias: 
FI;IF;KAF;AHUS3;ARMD13;C3BINA;C3b-INA;
Ensembl: 
ENSG00000205403
Location: 
4q25
HPRD: 
01955
NCBI Gene: 
3426
MIM: 
217030

Summary: 
This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq, Jul 2008]
Function: 
Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively.
Subcellular location: 
Secreted › extracellular space.
PTM: 
Cleavage on pair of basic residues;
Disease: 
Hemolytic uremic syndrome atypical 3 (AHUS3) [MIM:612923]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype. Complement factor I deficiency (CFI deficiency) [MIM:610984]: Autosomal recessive condition associated with a propensity to pyogenic infections. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Monoclonal Antibody OASA02640 CFI Antibody (OASA02640) Human IHC-AFF, ELISA, WB 0.1mg $635 Details
Monoclonal Antibody OASA02641 MOUSE ANTI HUMAN COMPLEMENT FACTOR I Antibody (0.1mg) IHC-AFF, ELISA, WB 0.1mg $460 Details
Monoclonal Antibody OASA02642 CFI Antibody (OASA02642) Human ELISA, IP, WB 5ml $400 Details
Polyclonal Antibody OASA09169 CFI Antibody (OASA09169) Human ID 1ml $545 Details
Polyclonal Antibody ARP63227_P050 CFI antibody - N-terminal region (ARP63227_P050) Human WB 50ug $289 Details
Polyclonal Antibody ARP63226_P050 CFI Antibody (ARP63226_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAF03524 CFI Antibody (OAAF03524) Polyclonal Human WB, IHC, ELISA 100 ug $229 Details
Polyclonal Antibody ARP71464_P050 CFI Antibody - C-terminal region (ARP71464_P050) Human WB 50ug $289 Details

Show all CFI antibodies


Product Images
CFI antibody - N-terminal region (ARP63227_P050) in Human HeLa cells using Western Blot

Sample Type: Human HeLa

CFI Antibody (OAAF03524) in Jurkat cells using Western Blot

Sample Type: Jurkat


CFI Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP71464 African clawed frog CFI antibody; Xenopus laevis CFI antibody Q03711 83.0%
ARP71464 African clawed frog CFI antibody; Xenopus laevis CFI antibody Q7ZTR2 83.0%
ARP71464 African elephant CFI antibody; Loxodonta africana CFI antibody G3T7Z9 85.0%
ARP71464 Chicken CFI antibody; Gallus gallus CFI antibody F1NF64 83.0%
ARP63226 Chimpanzee CFI antibody; Pan troglodytes CFI antibody K7ABU9 100.0%
ARP63227 Chimpanzee CFI antibody; Pan troglodytes CFI antibody K7ABU9 100.0%
ARP63226 Chimpanzee CFI antibody; Pan troglodytes CFI antibody H2R9Z9 100.0%
ARP63227 Chimpanzee CFI antibody; Pan troglodytes CFI antibody H2R9Z9 100.0%
ARP71464 Chimpanzee CFI antibody; Pan troglodytes CFI antibody K7ABU9 83.0%
ARP71464 Chimpanzee CFI antibody; Pan troglodytes CFI antibody H2R9Z9 83.0%
ARP71464 Chinese softshell turtle CFI antibody; Pelodiscus sinensis CFI antibody K7F513 83.0%
ARP71464 Chinese softshell turtle CFI antibody; Pelodiscus sinensis CFI antibody K7F516 83.0%
ARP71464 Collared flycatcher CFI antibody; Ficedula albicollis CFI antibody U3JVB4 83.0%
ARP71464 Common turkey CFI antibody; Meleagris gallopavo CFI antibody G1NEZ6 83.0%
ARP42663 Dog CFI antibody; Canis familiaris CFI antibody F1Q036 100.0%
ARP71464 European domestic ferret CFI antibody; Mustela putorius furo CFI antibody M3YB47 85.0%
ARP63226 Giant panda CFI antibody; Ailuropoda melanoleuca CFI antibody G1LD59 79.0%
ARP71464 Horse CFI antibody; Equus caballus CFI antibody F7APU2 83.0%
ARP71464 Horse CFI antibody; Equus caballus CFI antibody F7AU56 83.0%
ARP63226 Human CFI antibody; Homo sapiens CFI antibody E7ETH0 100.0%
ARP63227 Human CFI antibody; Homo sapiens CFI antibody E7ETH0 100.0%
ARP63226 Human CFI antibody; Homo sapiens CFI antibody P05156 100.0%
ARP63227 Human CFI antibody; Homo sapiens CFI antibody P05156 100.0%
ARP63226 Human CFI antibody; Homo sapiens CFI antibody G3XAM2 100.0%
ARP63227 Human CFI antibody; Homo sapiens CFI antibody G3XAM2 100.0%
ARP63227 Human CFI antibody; Homo sapiens CFI antibody Q8WW88 100.0%
ARP71464 Human CFI antibody; Homo sapiens CFI antibody E7ETH0 83.0%
ARP71464 Human CFI antibody; Homo sapiens CFI antibody P05156 83.0%
ARP71464 Human CFI antibody; Homo sapiens CFI antibody G3XAM2 83.0%
ARP71464 Mouse CFI antibody; Mus musculus CFI antibody Q61129 83.0%
ARP42663 Rabbit CFI antibody; Oryctolagus cuniculus CFI antibody G1T628 100.0%
ARP71464 Rabbit CFI antibody; Oryctolagus cuniculus CFI antibody G1SKM9 83.0%
ARP71464 Rat CFI antibody; Rattus norvegicus CFI antibody D3ZIX5 83.0%
ARP71464 Rat CFI antibody; Rattus norvegicus CFI antibody Q9WUW3 83.0%
ARP63226 Rhesus macaque CFI antibody; Macaca mulatta CFI antibody I0FMF7 86.0%
ARP63227 Rhesus macaque CFI antibody; Macaca mulatta CFI antibody I0FMF7 86.0%
ARP63226 Rhesus macaque CFI antibody; Macaca mulatta CFI antibody H9F2U2 86.0%
ARP63227 Rhesus macaque CFI antibody; Macaca mulatta CFI antibody H9F2U2 86.0%
ARP71464 Rhesus macaque CFI antibody; Macaca mulatta CFI antibody I0FMF7 83.0%
ARP71464 Rhesus macaque CFI antibody; Macaca mulatta CFI antibody H9F2U2 83.0%
ARP63227 Rhesus macaque CFI antibody; Macaca mulatta CFI antibody F7HTT9 79.0%
ARP71464 Small-eared galago CFI antibody; Otolemur garnettii CFI antibody H0WQG5 83.0%
ARP71464 Spotted green pufferfish CFI antibody; Tetraodon nigroviridis CFI antibody H3CAX3 83.0%
ARP63226 Sumatran orangutan CFI antibody; Pongo abelii CFI antibody Q5R5A4 100.0%
ARP63227 Sumatran orangutan CFI antibody; Pongo abelii CFI antibody Q5R5A4 93.0%
ARP71464 Sumatran orangutan CFI antibody; Pongo abelii CFI antibody Q5R5A4 83.0%
ARP71464 Thirteen-lined ground squirrel CFI antibody; Spermophilus tridecemlineatus CFI antibody I3MKU9 83.0%
ARP71464 Western clawed frog CFI antibody; Xenopus tropicalis CFI antibody Q4V785 83.0%
ARP71464 Zebra finch CFI antibody; Taeniopygia guttata CFI antibody H0Z161 83.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas203854_at721_B_lymphoblasts4.7505.100Details
BioGPS Gene Atlas203854_atAdipocyte3.8005.100Details
BioGPS Gene Atlas203854_atAdrenalCortex4.1005.100Details
BioGPS Gene Atlas203854_atAdrenalgland3.3005.100Details
BioGPS Gene Atlas203854_atAmygdala4.0005.100Details
BioGPS Gene Atlas203854_atAppendix4.0005.100Details
BioGPS Gene Atlas203854_atAtrioventricularNode2.9505.100Details
BioGPS Gene Atlas203854_atBDCA4+_DentriticCells4.1505.100Details
BioGPS Gene Atlas203854_atBonemarrow3.7505.100Details
BioGPS Gene Atlas203854_atBronchialEpithelialCells3.7505.100Details
BioGPS Gene Atlas203854_atCD105+_Endothelial3.9005.100Details
BioGPS Gene Atlas203854_atCD14+_Monocytes4.1005.100Details
BioGPS Gene Atlas203854_atCD19+_BCells(neg._sel.)4.0505.100Details
BioGPS Gene Atlas203854_atCD33+_Myeloid4.8505.100Details
BioGPS Gene Atlas203854_atCD34+4.8505.100Details
BioGPS Gene Atlas203854_atCD4+_Tcells4.1505.100Details
BioGPS Gene Atlas203854_atCD56+_NKCells4.6005.100Details
BioGPS Gene Atlas203854_atCD71+_EarlyErythroid3.5505.100Details
BioGPS Gene Atlas203854_atCD8+_Tcells3.7005.100Details
BioGPS Gene Atlas203854_atCardiacMyocytes4.9505.100Details
BioGPS Gene Atlas203854_atCaudatenucleus3.4505.100Details
BioGPS Gene Atlas203854_atCerebellum3.1005.100Details
BioGPS Gene Atlas203854_atCerebellumPeduncles4.3005.100Details
BioGPS Gene Atlas203854_atCiliaryGanglion2.7505.100Details
BioGPS Gene Atlas203854_atCingulateCortex3.9005.100Details
BioGPS Gene Atlas203854_atColorectaladenocarcinoma3.8005.100Details
BioGPS Gene Atlas203854_atDorsalRootGanglion2.9505.100Details
BioGPS Gene Atlas203854_atFetalThyroid4.2005.100Details
BioGPS Gene Atlas203854_atFetalbrain3.7505.100Details
BioGPS Gene Atlas203854_atFetalliver70.7005.100Details
BioGPS Gene Atlas203854_atFetallung17.5005.100Details
BioGPS Gene Atlas203854_atGlobusPallidus2.8005.100Details
BioGPS Gene Atlas203854_atHeart4.8505.100Details
BioGPS Gene Atlas203854_atHypothalamus4.1505.100Details
BioGPS Gene Atlas203854_atKidney6.0005.100Details
BioGPS Gene Atlas203854_atLeukemia_chronicMyelogenousK-5623.4505.100Details
BioGPS Gene Atlas203854_atLeukemia_promyelocytic-HL-603.4005.100Details
BioGPS Gene Atlas203854_atLeukemialymphoblastic(MOLT-4)3.1005.100Details
BioGPS Gene Atlas203854_atLiver5.0505.100Details
BioGPS Gene Atlas203854_atLung4.2005.100Details
BioGPS Gene Atlas203854_atLymphnode3.9505.100Details
BioGPS Gene Atlas203854_atLymphoma_burkitts(Daudi)4.9005.100Details
BioGPS Gene Atlas203854_atLymphoma_burkitts(Raji)5.3005.100Details
BioGPS Gene Atlas203854_atMedullaOblongata3.4505.100Details
BioGPS Gene Atlas203854_atOccipitalLobe3.4505.100Details
BioGPS Gene Atlas203854_atOlfactoryBulb3.1505.100Details
BioGPS Gene Atlas203854_atOvary2.5505.100Details
BioGPS Gene Atlas203854_atPancreas3.1505.100Details
BioGPS Gene Atlas203854_atPancreaticIslet24.1005.100Details
BioGPS Gene Atlas203854_atParietalLobe4.0505.100Details
BioGPS Gene Atlas203854_atPituitary4.4505.100Details
BioGPS Gene Atlas203854_atPlacenta3.9005.100Details
BioGPS Gene Atlas203854_atPons3.6005.100Details
BioGPS Gene Atlas203854_atPrefrontalCortex4.7505.100Details
BioGPS Gene Atlas203854_atProstate4.4005.100Details
BioGPS Gene Atlas203854_atSalivarygland3.1005.100Details
BioGPS Gene Atlas203854_atSkeletalMuscle4.4505.100Details
BioGPS Gene Atlas203854_atSkin2.9505.100Details
BioGPS Gene Atlas203854_atSmoothMuscle4.3505.100Details
BioGPS Gene Atlas203854_atSpinalcord5.1005.100Details
BioGPS Gene Atlas203854_atSubthalamicNucleus3.5005.100Details
BioGPS Gene Atlas203854_atSuperiorCervicalGanglion4.4505.100Details
BioGPS Gene Atlas203854_atTemporalLobe3.5505.100Details
BioGPS Gene Atlas203854_atTestis3.3005.100Details
BioGPS Gene Atlas203854_atTestisGermCell3.1505.100Details
BioGPS Gene Atlas203854_atTestisIntersitial3.2005.100Details
BioGPS Gene Atlas203854_atTestisLeydigCell3.8005.100Details
BioGPS Gene Atlas203854_atTestisSeminiferousTubule3.3005.100Details
BioGPS Gene Atlas203854_atThalamus3.9005.100Details
BioGPS Gene Atlas203854_atThymus3.0005.100Details
BioGPS Gene Atlas203854_atThyroid4.8005.100Details
BioGPS Gene Atlas203854_atTongue3.7505.100Details
BioGPS Gene Atlas203854_atTonsil3.7005.100Details
BioGPS Gene Atlas203854_atTrachea3.2005.100Details
BioGPS Gene Atlas203854_atTrigeminalGanglion3.9005.100Details
BioGPS Gene Atlas203854_atUterus3.4005.100Details
BioGPS Gene Atlas203854_atUterusCorpus3.4005.100Details
BioGPS Gene Atlas203854_atWholeBlood4.2005.100Details
BioGPS Gene Atlas203854_atWholebrain3.2505.100Details
BioGPS Gene Atlas203854_atcolon3.8505.100Details
BioGPS Gene Atlas203854_atpineal_day4.8005.100Details
BioGPS Gene Atlas203854_atpineal_night4.7005.100Details
BioGPS Gene Atlas203854_atretina5.5255.100Details
BioGPS Gene Atlas203854_atsmall_intestine3.7005.100Details
BioGPS NCI60203854_at7863.888127.840Details
BioGPS NCI60203854_atA1723.650127.840Details
BioGPS NCI60203854_atA2043.757127.840Details
BioGPS NCI60203854_atA3613.789127.840Details
BioGPS NCI60203854_atA49830.587127.840Details
BioGPS NCI60203854_atA5493.818127.840Details
BioGPS NCI60203854_atACC3422.614127.840Details
BioGPS NCI60203854_atACHN3.749127.840Details
BioGPS NCI60203854_atALVA313.955127.840Details
BioGPS NCI60203854_atCAKI1414.469127.840Details
BioGPS NCI60203854_atCCRT CEM4.168127.840Details
BioGPS NCI60203854_atCOLO2053.756127.840Details
BioGPS NCI60203854_atDLD13.710127.840Details
BioGPS NCI60203854_atDU1453.631127.840Details
BioGPS NCI60203854_atEKVX769.370127.840Details
BioGPS NCI60203854_atGM1333.866127.840Details
BioGPS NCI60203854_atGM16003.926127.840Details
BioGPS NCI60203854_atGM23132341.998127.840Details
BioGPS NCI60203854_atGM2345699.176127.840Details
BioGPS NCI60203854_atGM24933.940127.840Details
BioGPS NCI60203854_atGM974.108127.840Details
BioGPS NCI60203854_atHCC29983.477127.840Details
BioGPS NCI60203854_atHCT1163.743127.840Details
BioGPS NCI60203854_atHCT153.596127.840Details
BioGPS NCI60203854_atHEK 293 T-rex3.821127.840Details
BioGPS NCI60203854_atHEK 293T3.749127.840Details
BioGPS NCI60203854_atHEK2933.745127.840Details
BioGPS NCI60203854_atHELA3.641127.840Details
BioGPS NCI60203854_atHEPG23175.366127.840Details
BioGPS NCI60203854_atHL603.851127.840Details
BioGPS NCI60203854_atHOP623.767127.840Details
BioGPS NCI60203854_atHOP92643.697127.840Details
BioGPS NCI60203854_atHS578T3.715127.840Details
BioGPS NCI60203854_atHSG3.687127.840Details
BioGPS NCI60203854_atHT10803.741127.840Details
BioGPS NCI60203854_atHT293.986127.840Details
BioGPS NCI60203854_atIGROV13.734127.840Details
BioGPS NCI60203854_atIOSE8014.324127.840Details
BioGPS NCI60203854_atJURKAT3.758127.840Details
BioGPS NCI60203854_atK5623.989127.840Details
BioGPS NCI60203854_atKM123.900127.840Details
BioGPS NCI60203854_atLN183.596127.840Details
BioGPS NCI60203854_atLNCAP3.764127.840Details
BioGPS NCI60203854_atLOX IMVI3.756127.840Details
BioGPS NCI60203854_atM143.723127.840Details
BioGPS NCI60203854_atMALME 3M3.964127.840Details
BioGPS NCI60203854_atMCF73.671127.840Details
BioGPS NCI60203854_atMD MB2313.789127.840Details
BioGPS NCI60203854_atMDA MB4353.951127.840Details
BioGPS NCI60203854_atMOLT43.857127.840Details
BioGPS NCI60203854_atNCI 4603.849127.840Details
BioGPS NCI60203854_atNCI H2263.836127.840Details
BioGPS NCI60203854_atNCI H233.760127.840Details
BioGPS NCI60203854_atNCI H322M3.763127.840Details
BioGPS NCI60203854_atNCVADR RES3.617127.840Details
BioGPS NCI60203854_atOVCAR33.949127.840Details
BioGPS NCI60203854_atOVCAR43.756127.840Details
BioGPS NCI60203854_atOVCAR53.729127.840Details
BioGPS NCI60203854_atOVCAR83.593127.840Details
BioGPS NCI60203854_atPANC13.800127.840Details
BioGPS NCI60203854_atRL73.810127.840Details
BioGPS NCI60203854_atRPMI 82263.808127.840Details
BioGPS NCI60203854_atRS118463.920127.840Details
BioGPS NCI60203854_atRXF3933.747127.840Details
BioGPS NCI60203854_atSAOS21039.625127.840Details
BioGPS NCI60203854_atSF2683.763127.840Details
BioGPS NCI60203854_atSF2953.712127.840Details
BioGPS NCI60203854_atSF5393.621127.840Details
BioGPS NCI60203854_atSHSYSY+RA3.674127.840Details
BioGPS NCI60203854_atSHSYSY-RA3.731127.840Details
BioGPS NCI60203854_atSKMEL23.756127.840Details
BioGPS NCI60203854_atSKMEL283.768127.840Details
BioGPS NCI60203854_atSKMEL53.663127.840Details
BioGPS NCI60203854_atSKOV34.213127.840Details
BioGPS NCI60203854_atSN12C3.740127.840Details
BioGPS NCI60203854_atSNB19469.665127.840Details
BioGPS NCI60203854_atSNB7568.485127.840Details
BioGPS NCI60203854_atSR1818.706127.840Details
BioGPS NCI60203854_atSW6203.769127.840Details
BioGPS NCI60203854_atT243.830127.840Details
BioGPS NCI60203854_atT3M43.890127.840Details
BioGPS NCI60203854_atTK103.766127.840Details
BioGPS NCI60203854_atU1183.745127.840Details
BioGPS NCI60203854_atU1383.592127.840Details
BioGPS NCI60203854_atU20S3.665127.840Details
BioGPS NCI60203854_atU251811.153127.840Details
BioGPS NCI60203854_atU876.680127.840Details
BioGPS NCI60203854_atUACC2573.707127.840Details
BioGPS NCI60203854_atUACC625.461127.840Details
BioGPS NCI60203854_atUO313.660127.840Details
BioGPS NCI60203854_atZR75_13.849127.840Details
BioGPS NCI60203854_atastrocytes13.265127.840Details
BioGPS NCI60203854_athuh-7356.716127.840Details