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Gene ID: 81494 | CFHR5 Antibody Resource


CFHR5 Antibody Resource
Gene Full Name: 
complement factor H-related 5
Uniprot: 
Q9BXR6
Protein Name: 
complement factor H-related protein 5
Nucleotide: 
NM_030787
Alias: 
FHR5;CFHL5;FHR-5;CFHR5D;
Ensembl: 
ENSG00000134389
Location: 
1q31.3
HPRD: 
06508
NCBI Gene: 
81494
MIM: 
608593

Summary: 
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq, Jan 2010]
Function: 
Involved in complement regulation.
Subcellular location: 
Secreted.
PTM: 
Disulfide bond;
Disease: 
Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. Atypical hemolytic uremic syndrome is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.CFHR5 deficiency (CFHR5D) [MIM:614809]: A progressive disease characterized by glomerulonephritis, hematuria, renal failure, end-stage renal disease, subendothelial and mesangial glomerular C3 deposits, mesangial matrix expansion, increased glomerular cellularity, and segmental capillary wall thickening. Hematuria may become apparent after respiratory infections. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB03097 CFHR5 antibody - center region (OAAB03097) Human WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody ARP65643_P050 CFHR5 Antibody - N-terminal region (ARP65643_P050) Human WB 50ug $289 Details
Polyclonal Antibody ARP65644_P050 CFHR5 Antibody (ARP65644_P050) Polyclonal Bovine, Horse, Human Not tested 50 ug $125 Details

Show all CFHR5 antibodies


Product Images
CFHR5 Antibody - N-terminal region (ARP65643_P050) in Human THP-1 cells using Western Blot

Sample Type: Human THP-1

CFHR5 antibody - center region (OAAB03097) in CEM, K562 cells using Western Blot

Sample Type: CEM, K562

CFHR5 antibody - center region (OAAB03097) in human hepatocarcinoma cells using Immunohistochemistry

Sample Type: human hepatocarcinoma


CFHR5 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP65643 Chimpanzee CFHR5 antibody; Pan troglodytes CFHR5 antibody H2Q0U2 100.0%
ARP65644 Chimpanzee CFHR5 antibody; Pan troglodytes CFHR5 antibody H2Q0U2 93.0%
ARP62261 Chimpanzee CFHR5 antibody; Pan troglodytes CFHR5 antibody H2Q0U2 79.0%
ARP65643 Human CFHR5 antibody; Homo sapiens CFHR5 antibody Q05CF5 100.0%
ARP65644 Human CFHR5 antibody; Homo sapiens CFHR5 antibody Q05CF5 100.0%
ARP65643 Human CFHR5 antibody; Homo sapiens CFHR5 antibody Q5VYL6 100.0%
ARP65644 Human CFHR5 antibody; Homo sapiens CFHR5 antibody Q5VYL6 100.0%
ARP65643 Human CFHR5 antibody; Homo sapiens CFHR5 antibody Q9BXR6 100.0%
ARP65644 Human CFHR5 antibody; Homo sapiens CFHR5 antibody Q9BXR6 100.0%
ARP62261 Human CFHR5 antibody; Homo sapiens CFHR5 antibody Q05CF5 79.0%
ARP62261 Human CFHR5 antibody; Homo sapiens CFHR5 antibody Q5VYL6 79.0%
ARP62261 Human CFHR5 antibody; Homo sapiens CFHR5 antibody Q9BXR6 79.0%
ARP65644 Northern white-cheeked gibbon CFHR5 antibody; Nomascus leucogenys CFHR5 antibody G1S8U6 100.0%
ARP65643 Northern white-cheeked gibbon CFHR5 antibody; Nomascus leucogenys CFHR5 antibody G1S8U6 92.0%
ARP62261 Northern white-cheeked gibbon CFHR5 antibody; Nomascus leucogenys CFHR5 antibody G1S8U6 86.0%
ARP65643 White-tufted-ear marmoset CFHR5 antibody; Callithrix jacchus CFHR5 antibody F7GHA7 86.0%
ARP62261 White-tufted-ear marmoset CFHR5 antibody; Callithrix jacchus CFHR5 antibody F7GHA7 79.0%
ARP62261 White-tufted-ear marmoset CFHR5 antibody; Callithrix jacchus CFHR5 antibody F7IMG0 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas208088_s_at721_B_lymphoblasts6.5505.590Details
BioGPS Gene Atlas208088_s_atAdipocyte5.4005.590Details
BioGPS Gene Atlas208088_s_atAdrenalCortex6.1005.590Details
BioGPS Gene Atlas208088_s_atAdrenalgland4.8505.590Details
BioGPS Gene Atlas208088_s_atAmygdala5.6505.590Details
BioGPS Gene Atlas208088_s_atAppendix5.6005.590Details
BioGPS Gene Atlas208088_s_atAtrioventricularNode4.6005.590Details
BioGPS Gene Atlas208088_s_atBDCA4+_DentriticCells5.8505.590Details
BioGPS Gene Atlas208088_s_atBonemarrow5.8005.590Details
BioGPS Gene Atlas208088_s_atBronchialEpithelialCells5.3505.590Details
BioGPS Gene Atlas208088_s_atCD105+_Endothelial5.5005.590Details
BioGPS Gene Atlas208088_s_atCD14+_Monocytes5.8505.590Details
BioGPS Gene Atlas208088_s_atCD19+_BCells(neg._sel.)5.8505.590Details
BioGPS Gene Atlas208088_s_atCD33+_Myeloid6.9505.590Details
BioGPS Gene Atlas208088_s_atCD34+7.0005.590Details
BioGPS Gene Atlas208088_s_atCD4+_Tcells5.7005.590Details
BioGPS Gene Atlas208088_s_atCD56+_NKCells6.4005.590Details
BioGPS Gene Atlas208088_s_atCD71+_EarlyErythroid5.2505.590Details
BioGPS Gene Atlas208088_s_atCD8+_Tcells5.2005.590Details
BioGPS Gene Atlas208088_s_atCardiacMyocytes7.5505.590Details
BioGPS Gene Atlas208088_s_atCaudatenucleus4.9505.590Details
BioGPS Gene Atlas208088_s_atCerebellum4.4505.590Details
BioGPS Gene Atlas208088_s_atCerebellumPeduncles6.4505.590Details
BioGPS Gene Atlas208088_s_atCiliaryGanglion4.1005.590Details
BioGPS Gene Atlas208088_s_atCingulateCortex5.6505.590Details
BioGPS Gene Atlas208088_s_atColorectaladenocarcinoma5.4505.590Details
BioGPS Gene Atlas208088_s_atDorsalRootGanglion4.5005.590Details
BioGPS Gene Atlas208088_s_atFetalThyroid5.4005.590Details
BioGPS Gene Atlas208088_s_atFetalbrain5.4505.590Details
BioGPS Gene Atlas208088_s_atFetalliver4.8005.590Details
BioGPS Gene Atlas208088_s_atFetallung4.4505.590Details
BioGPS Gene Atlas208088_s_atGlobusPallidus4.0505.590Details
BioGPS Gene Atlas208088_s_atHeart8.0505.590Details
BioGPS Gene Atlas208088_s_atHypothalamus5.7005.590Details
BioGPS Gene Atlas208088_s_atKidney4.8505.590Details
BioGPS Gene Atlas208088_s_atLeukemia_chronicMyelogenousK-5624.9005.590Details
BioGPS Gene Atlas208088_s_atLeukemia_promyelocytic-HL-604.8005.590Details
BioGPS Gene Atlas208088_s_atLeukemialymphoblastic(MOLT-4)4.3505.590Details
BioGPS Gene Atlas208088_s_atLiver9.7005.590Details
BioGPS Gene Atlas208088_s_atLung5.9505.590Details
BioGPS Gene Atlas208088_s_atLymphnode4.6505.590Details
BioGPS Gene Atlas208088_s_atLymphoma_burkitts(Daudi)7.0505.590Details
BioGPS Gene Atlas208088_s_atLymphoma_burkitts(Raji)7.7005.590Details
BioGPS Gene Atlas208088_s_atMedullaOblongata4.9505.590Details
BioGPS Gene Atlas208088_s_atOccipitalLobe4.9505.590Details
BioGPS Gene Atlas208088_s_atOlfactoryBulb4.3005.590Details
BioGPS Gene Atlas208088_s_atOvary3.9005.590Details
BioGPS Gene Atlas208088_s_atPancreas4.5005.590Details
BioGPS Gene Atlas208088_s_atPancreaticIslet5.9505.590Details
BioGPS Gene Atlas208088_s_atParietalLobe6.0005.590Details
BioGPS Gene Atlas208088_s_atPituitary6.3005.590Details
BioGPS Gene Atlas208088_s_atPlacenta5.6005.590Details
BioGPS Gene Atlas208088_s_atPons5.2505.590Details
BioGPS Gene Atlas208088_s_atPrefrontalCortex6.6505.590Details
BioGPS Gene Atlas208088_s_atProstate6.3505.590Details
BioGPS Gene Atlas208088_s_atSalivarygland4.5005.590Details
BioGPS Gene Atlas208088_s_atSkeletalMuscle6.5505.590Details
BioGPS Gene Atlas208088_s_atSkin4.7005.590Details
BioGPS Gene Atlas208088_s_atSmoothMuscle6.2005.590Details
BioGPS Gene Atlas208088_s_atSpinalcord5.8005.590Details
BioGPS Gene Atlas208088_s_atSubthalamicNucleus5.0505.590Details
BioGPS Gene Atlas208088_s_atSuperiorCervicalGanglion6.4005.590Details
BioGPS Gene Atlas208088_s_atTemporalLobe5.1005.590Details
BioGPS Gene Atlas208088_s_atTestis4.7005.590Details
BioGPS Gene Atlas208088_s_atTestisGermCell4.4505.590Details
BioGPS Gene Atlas208088_s_atTestisIntersitial4.6005.590Details
BioGPS Gene Atlas208088_s_atTestisLeydigCell5.4505.590Details
BioGPS Gene Atlas208088_s_atTestisSeminiferousTubule4.7005.590Details
BioGPS Gene Atlas208088_s_atThalamus5.6005.590Details
BioGPS Gene Atlas208088_s_atThymus4.2505.590Details
BioGPS Gene Atlas208088_s_atThyroid6.7505.590Details
BioGPS Gene Atlas208088_s_atTongue5.5505.590Details
BioGPS Gene Atlas208088_s_atTonsil5.3005.590Details
BioGPS Gene Atlas208088_s_atTrachea4.5505.590Details
BioGPS Gene Atlas208088_s_atTrigeminalGanglion5.7505.590Details
BioGPS Gene Atlas208088_s_atUterus4.4005.590Details
BioGPS Gene Atlas208088_s_atUterusCorpus4.9505.590Details
BioGPS Gene Atlas208088_s_atWholeBlood5.9505.590Details
BioGPS Gene Atlas208088_s_atWholebrain4.6005.590Details
BioGPS Gene Atlas208088_s_atcolon5.4505.590Details
BioGPS Gene Atlas208088_s_atpineal_day6.7205.590Details
BioGPS Gene Atlas208088_s_atpineal_night6.5605.590Details
BioGPS Gene Atlas208088_s_atretina6.5505.590Details
BioGPS Gene Atlas208088_s_atsmall_intestine5.2505.590Details
BioGPS NCI60208088_s_at7865.0424.870Details
BioGPS NCI60208088_s_atA1724.5294.870Details
BioGPS NCI60208088_s_atA2044.8424.870Details
BioGPS NCI60208088_s_atA3614.9474.870Details
BioGPS NCI60208088_s_atA4984.8504.870Details
BioGPS NCI60208088_s_atA5494.9794.870Details
BioGPS NCI60208088_s_atACC35.1874.870Details
BioGPS NCI60208088_s_atACHN4.4004.870Details
BioGPS NCI60208088_s_atALVA315.2864.870Details
BioGPS NCI60208088_s_atCAKI15.1204.870Details
BioGPS NCI60208088_s_atCCRT CEM5.6874.870Details
BioGPS NCI60208088_s_atCOLO2054.9204.870Details
BioGPS NCI60208088_s_atDLD14.7444.870Details
BioGPS NCI60208088_s_atDU1454.5764.870Details
BioGPS NCI60208088_s_atEKVX4.5564.870Details
BioGPS NCI60208088_s_atGM1334.9844.870Details
BioGPS NCI60208088_s_atGM16005.1424.870Details
BioGPS NCI60208088_s_atGM23135.0534.870Details
BioGPS NCI60208088_s_atGM23454.8814.870Details
BioGPS NCI60208088_s_atGM24935.2124.870Details
BioGPS NCI60208088_s_atGM975.6344.870Details
BioGPS NCI60208088_s_atHCC29984.3904.870Details
BioGPS NCI60208088_s_atHCT1164.8644.870Details
BioGPS NCI60208088_s_atHCT154.4864.870Details
BioGPS NCI60208088_s_atHEK 293 T-rex5.0404.870Details
BioGPS NCI60208088_s_atHEK 293T4.8334.870Details
BioGPS NCI60208088_s_atHEK2934.8784.870Details
BioGPS NCI60208088_s_atHELA4.4574.870Details
BioGPS NCI60208088_s_atHEPG24.8514.870Details
BioGPS NCI60208088_s_atHL605.1144.870Details
BioGPS NCI60208088_s_atHOP624.8724.870Details
BioGPS NCI60208088_s_atHOP924.6384.870Details
BioGPS NCI60208088_s_atHS578T4.7644.870Details
BioGPS NCI60208088_s_atHSG4.5744.870Details
BioGPS NCI60208088_s_atHT10804.7464.870Details
BioGPS NCI60208088_s_atHT295.5084.870Details
BioGPS NCI60208088_s_atIGROV14.7524.870Details
BioGPS NCI60208088_s_atIOSE804.8254.870Details
BioGPS NCI60208088_s_atJURKAT4.8504.870Details
BioGPS NCI60208088_s_atK5625.3204.870Details
BioGPS NCI60208088_s_atKM125.1334.870Details
BioGPS NCI60208088_s_atLN184.5454.870Details
BioGPS NCI60208088_s_atLNCAP4.8704.870Details
BioGPS NCI60208088_s_atLOX IMVI4.8474.870Details
BioGPS NCI60208088_s_atM144.8034.870Details
BioGPS NCI60208088_s_atMALME 3M5.2664.870Details
BioGPS NCI60208088_s_atMCF74.6574.870Details
BioGPS NCI60208088_s_atMD MB2314.9724.870Details
BioGPS NCI60208088_s_atMDA MB4355.5104.870Details
BioGPS NCI60208088_s_atMOLT45.2034.870Details
BioGPS NCI60208088_s_atNCI 4605.0014.870Details
BioGPS NCI60208088_s_atNCI H2265.0214.870Details
BioGPS NCI60208088_s_atNCI H234.8514.870Details
BioGPS NCI60208088_s_atNCI H322M4.8424.870Details
BioGPS NCI60208088_s_atNCVADR RES4.4674.870Details
BioGPS NCI60208088_s_atOVCAR35.1494.870Details
BioGPS NCI60208088_s_atOVCAR44.8384.870Details
BioGPS NCI60208088_s_atOVCAR54.7164.870Details
BioGPS NCI60208088_s_atOVCAR84.4434.870Details
BioGPS NCI60208088_s_atPANC14.9504.870Details
BioGPS NCI60208088_s_atRL74.9804.870Details
BioGPS NCI60208088_s_atRPMI 82264.9854.870Details
BioGPS NCI60208088_s_atRS118465.2084.870Details
BioGPS NCI60208088_s_atRXF3934.8294.870Details
BioGPS NCI60208088_s_atSAOS24.9284.870Details
BioGPS NCI60208088_s_atSF2684.8514.870Details
BioGPS NCI60208088_s_atSF2954.6464.870Details
BioGPS NCI60208088_s_atSF5394.4654.870Details
BioGPS NCI60208088_s_atSHSYSY+RA4.5944.870Details
BioGPS NCI60208088_s_atSHSYSY-RA4.7804.870Details
BioGPS NCI60208088_s_atSKMEL24.8414.870Details
BioGPS NCI60208088_s_atSKMEL284.8744.870Details
BioGPS NCI60208088_s_atSKMEL54.6764.870Details
BioGPS NCI60208088_s_atSKOV35.0934.870Details
BioGPS NCI60208088_s_atSN12C4.8064.870Details
BioGPS NCI60208088_s_atSNB194.4764.870Details
BioGPS NCI60208088_s_atSNB754.7844.870Details
BioGPS NCI60208088_s_atSR5.0094.870Details
BioGPS NCI60208088_s_atSW6204.9434.870Details
BioGPS NCI60208088_s_atT245.0104.870Details
BioGPS NCI60208088_s_atT3M45.1124.870Details
BioGPS NCI60208088_s_atTK104.8164.870Details
BioGPS NCI60208088_s_atU1184.6994.870Details
BioGPS NCI60208088_s_atU1384.4594.870Details
BioGPS NCI60208088_s_atU20S4.7024.870Details
BioGPS NCI60208088_s_atU2514.7414.870Details
BioGPS NCI60208088_s_atU874.6394.870Details
BioGPS NCI60208088_s_atUACC2574.6844.870Details
BioGPS NCI60208088_s_atUACC624.9434.870Details
BioGPS NCI60208088_s_atUO314.6404.870Details
BioGPS NCI60208088_s_atZR75_15.0394.870Details
BioGPS NCI60208088_s_atastrocytes4.9034.870Details
BioGPS NCI60208088_s_athuh-75.0754.870Details