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Gene ID: 55997 | CFC1 Antibody Resource


CFC1 Antibody Resource
Gene Full Name: 
cripto, FRL-1, cryptic family 1
Uniprot: 
P0CG37
Protein Name: 
cryptic protein
Nucleotide: 
NM_001270421
Alias: 
HTX2;CFC1B;DTGA2;CRYPTIC;
Ensembl: 
Location: 
2q21.1
HPRD: 
05548
NCBI Gene: 
55997
MIM: 
605194

Summary: 
This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Function: 
NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation.
Subcellular location: 
Cell membrane; Lipid-anchor › GPI-anchor. Secreted. Note: Does not exhibit a typical GPI-signal sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could lead to the production of an secreted unprocessed form. This extension is found only in primates.
PTM: 
Disulfide bond;
Disease: 
Heterotaxy, visceral, 2, autosomal (HTX2) [MIM:605376]: A form of visceral heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. Visceral heterotaxy or situs ambiguus results in randomization of the placement of visceral organs, including the heart, lungs, liver, spleen, and stomach. The organs are oriented randomly with respect to the left-right axis and with respect to one another. It can been associated with variety of congenital defects including cardiac malformations. Note: The disease is caused by mutations affecting the gene represented in this entry. Transposition of the great arteries dextro-looped 2 (DTGA2) [MIM:613853]: A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. The presence or absence of associated cardiac anomalies defines the clinical presentation and surgical management of patients with transposition of the great arteries. Note: The disease is caused by mutations affecting the gene represented in this entry. Conotruncal heart malformations (CTHM) [MIM:217095]: A group of congenital heart defects involving the outflow tracts. Examples include truncus arteriosus communis, double-outlet right ventricle and transposition of great arteries. Truncus arteriosus communis is characterized by a single outflow tract instead of a separate aorta and pulmonary artery. In transposition of the great arteries, the aorta arises from the right ventricle and the pulmonary artery from the left ventricle. In double outlet of the right ventricle, both the pulmonary artery and aorta arise from the right ventricle. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAEB00451 Goat Anti-CFC1 / Cripto-1 Antibody (OAEB00451) Human, Mouse, Rat ELISA 0.1mg $229 Details
Polyclonal Antibody ARP64298_P050 CFC1 antibody - N-terminal region (ARP64298_P050) Human WB 50ug $289 Details
Polyclonal Antibody ARP64299_P050 CFC1 Antibody (ARP64299_P050) Polyclonal Dog, Guinea pig, Horse, Human, Mouse, Rabbit Not tested 50 ug $125 Details

Show all CFC1 antibodies


Product Images
CFC1 antibody - N-terminal region (ARP64298_P050) in Hela cells using Western Blot

Sample Type: Hela


CFC1 Protocols
Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP64298 Chimpanzee CFC1 antibody; Pan troglodytes CFC1 antibody H2QIQ5 100.0%
ARP64299 Chimpanzee CFC1 antibody; Pan troglodytes CFC1 antibody H2QIQ5 100.0%
ARP64298 Human CFC1 antibody; Homo sapiens CFC1 antibody P0CG37 100.0%
ARP64299 Human CFC1 antibody; Homo sapiens CFC1 antibody P0CG37 100.0%
ARP64299 Mouse CFC1 antibody; Mus musculus CFC1 antibody P97766 79.0%
ARP64299 Rhesus macaque CFC1 antibody; Macaca mulatta CFC1 antibody F7DZD1 100.0%
ARP64299 Rhesus macaque CFC1 antibody; Macaca mulatta CFC1 antibody F7DZX2 100.0%
ARP64298 Rhesus macaque CFC1 antibody; Macaca mulatta CFC1 antibody F7DZD1 93.0%
ARP64298 Rhesus macaque CFC1 antibody; Macaca mulatta CFC1 antibody F7DZX2 93.0%

Tissue & Cell Line Gene Expression Data