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Gene ID: 375298 | CERKL Antibody Resource


CERKL Antibody Resource
Gene Full Name: 
ceramide kinase-like
Uniprot: 
Q49MI3
Protein Name: 
ceramide kinase-like protein
Nucleotide: 
NM_001030312
Alias: 
RP26;
Ensembl: 
ENSG00000188452
Location: 
2q31.3
HPRD: 
09757
NCBI Gene: 
375298
MIM: 
608381

Summary: 
This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010]
Function: 
Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions.
Subcellular location: 
Cytoplasm. Nucleus › nucleolus. Note: Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli. Isoform 2: Cytoplasm. Nucleus › nucleolus. Golgi apparatus › trans-Golgi network. Endoplasmic reticulum .
PTM: 
Phosphoprotein;
Disease: 
Retinitis pigmentosa 26 (RP26) [MIM:608380]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP59827_P050 CERKL antibody - C-terminal region (ARP59827_P050) Polyclonal Human, Rabbit WB 50ug $289 Details
Polyclonal Antibody ARP59828_P050 CERKL antibody - N-terminal region (ARP59828_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Pig, Rabbit WB 50ug $289 Details
Polyclonal Antibody OAAF02484 CERKL Antibody (OAAF02484) Polyclonal Human WB, ELISA 100 ug $229 Details

Show all CERKL antibodies


Product Images
CERKL antibody - C-terminal region (ARP59827_P050) in Human Heart cells using Western Blot

Sample Type: Human Heart

CERKL antibody - N-terminal region (ARP59828_P050) in Human ACHN cells using Western Blot

Sample Type: Human ACHN

CERKL Antibody (OAAF02484) in A549 cells using Western Blot

Sample Type: A549


CERKL Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP59828 Cat CERKL antibody; Felis catus CERKL antibody M3WPC4 100.0%
ARP59827 Chimpanzee CERKL antibody; Pan troglodytes CERKL antibody H2QJ30 100.0%
ARP59828 Chimpanzee CERKL antibody; Pan troglodytes CERKL antibody H2QJ30 100.0%
ARP59828 Dog CERKL antibody; Canis familiaris CERKL antibody F1PQ25 93.0%
ARP59828 Duckbill platypus CERKL antibody; Ornithorhynchus anatinus CERKL antibody F7FJP1 100.0%
ARP59828 European domestic ferret CERKL antibody; Mustela putorius furo CERKL antibody M3XT81 100.0%
ARP59828 Gray short-tailed opossum CERKL antibody; Monodelphis domestica CERKL antibody F7AV84 85.0%
ARP59828 Horse CERKL antibody; Equus caballus CERKL antibody F6W6F5 100.0%
ARP59827 Horse CERKL antibody; Equus caballus CERKL antibody F6W6F5 79.0%
ARP59828 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3-3 100.0%
ARP59827 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3-4 100.0%
ARP59828 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3-5 100.0%
ARP59828 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3-7 100.0%
ARP59827 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3-9 100.0%
ARP59827 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3 100.0%
ARP59828 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3 100.0%
ARP59827 Human CERKL antibody; Homo sapiens CERKL antibody G0XYD8 100.0%
ARP59827 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3-2 100.0%
ARP59828 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3-2 100.0%
ARP59827 Human CERKL antibody; Homo sapiens CERKL antibody Q49MI3-3 100.0%
ARP59828 Pig CERKL antibody; Sus scrofa CERKL antibody F1RYP2 100.0%
ARP59828 Pig CERKL antibody; Sus scrofa CERKL antibody F1RYP3 100.0%
ARP59828 Rabbit CERKL antibody; Oryctolagus cuniculus CERKL antibody U3KLX9 93.0%
ARP59828 Rabbit CERKL antibody; Oryctolagus cuniculus CERKL antibody G1SIV4 93.0%
ARP59827 Rabbit CERKL antibody; Oryctolagus cuniculus CERKL antibody U3KLX9 81.0%
ARP59827 Rabbit CERKL antibody; Oryctolagus cuniculus CERKL antibody G1SIV4 81.0%
ARP59828 Rhesus macaque CERKL antibody; Macaca mulatta CERKL antibody F6SPL3 100.0%
ARP59828 Rhesus macaque CERKL antibody; Macaca mulatta CERKL antibody F7FUC2 100.0%
ARP59828 Rhesus macaque CERKL antibody; Macaca mulatta CERKL antibody F7FUD1 100.0%
ARP59827 Rhesus macaque CERKL antibody; Macaca mulatta CERKL antibody F6SPL3 92.0%
ARP59827 Rhesus macaque CERKL antibody; Macaca mulatta CERKL antibody F7FUC2 92.0%
ARP59827 Rhesus macaque CERKL antibody; Macaca mulatta CERKL antibody F7FUC5 92.0%
ARP59828 Small-eared galago CERKL antibody; Otolemur garnettii CERKL antibody H0XEQ7 93.0%
ARP59828 Sumatran orangutan CERKL antibody; Pongo abelii CERKL antibody H2P812 100.0%
ARP59828 Thirteen-lined ground squirrel CERKL antibody; Spermophilus tridecemlineatus CERKL antibody I3MEE5 100.0%

Tissue & Cell Line Gene Expression Data