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Gene ID: 1025 | CDK9 Antibody Resource


CDK9 Antibody Resource
Gene Full Name: 
cyclin-dependent kinase 9
Uniprot: 
P50750
Protein Name: 
cyclin-dependent kinase 9
Nucleotide: 
NM_001261
Alias: 
TAK;C-2k;CTK1;CDC2L4;PITALRE;
Ensembl: 
ENSG00000136807
Location: 
9q34.1
HPRD: 
16016
NCBI Gene: 
1025
MIM: 
603251

Summary: 
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
Function: 
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3; integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein; the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth. DSIF and NELF phosphorylation promotes transcription by inhibiting their negative effect. The phosphorylation of MYOD1 enhances its transcriptional activity and thus promotes muscle differentiation.
Subcellular location: 
Nucleus. Cytoplasm. Nucleus › PML body. Note: Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated.
PTM: 
Acetylation;
Disease: 
Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy, and confers predisposition to heart failure.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody AVARP03004_T100 CDK9 antibody - N-terminal region (AVARP03004_T100) Polyclonal Bovine, Dog, Human, Mouse, Pig, Rat, Zebrafish WB 100ug $229 Details
Polyclonal Antibody AVARP03004_P050 CDK9 antibody - N-terminal region (AVARP03004_P050) Polyclonal Bovine, Dog, Human, Mouse, Pig, Rat, Zebrafish IHC, WB 50ug $289 Details
DNA/cDNA/RNA ANA00002-P001 CDK9 (Human) cDNA (1ug) 1ug $189 Details
Polyclonal Antibody OASA07138 CDK9 Antibody (OASA07138) Human IHC-AFF, ELISA, IP, IHC-FFPE, WB 0.1ml $735 Details
Polyclonal Antibody OAMA03586 Rabbit anti cdk9 PITALRE Antibody (0.1ml) ELISA, IHC-FFPE, WB 0.1ml $725 Details
DNA/cDNA/RNA ANA10661 CDK9 (Human) cDNA (1ug) 1ug $189 Details
Protein Lysate APL10661 CDK9 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
Polyclonal Antibody OARA02817 CDK9 Antibody (OARA02817) Human; Mouse; Rat ELISA, WB, IP 100ug $475 Details
Polyclonal Antibody OAAB10190 CDK9 antibody - C - terminal region (OAAB10190) Human WB, IF 400ul $289 Details
Polyclonal Antibody OAAB11560 Mouse Cdk9 antibody - C - terminal region (OAAB11560) Human; Mouse WB 400ul $289 Details
Polyclonal Antibody OAAB17086 CDK9 antibody - C - terminal region (OAAB17086) Human WB, IHC, IF 400ul $289 Details
Polyclonal Antibody OAAF00216 CDK9 (Phospho-Thr186) Antibody (OAAF00216) Polyclonal Human, Mouse, Rat WB, ELISA 100 ug $229 Details

Show all CDK9 antibodies


Product Images
CDK9 antibody - N-terminal region (AVARP03004_P050) in Human 293T cells using Western Blot

Sample Type: Human 293T

CDK9 antibody - N-terminal region (AVARP03004_P050) in Human Uterus cells using Immunohistochemistry

Sample Type: Human Uterus

CDK9 antibody - N-terminal region (AVARP03004_T100) in Human 293T cells using Western Blot

Sample Type: Human 293T

Mouse Cdk9 antibody - C - terminal region (OAAB11560) in 293 cells using Western Blot

Sample Type: 293

Mouse Cdk9 antibody - C - terminal region (OAAB11560) in Mouse NIH-3T3 cells using Western Blot

Sample Type: Mouse NIH-3T3

CDK9 (Phospho-Thr186) Antibody (OAAF00216) in 3T3 cells using Western Blot

Sample Type: 3T3


CDK9 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP30157 Atlantic salmon CDK9 antibody; Salmo salar CDK9 antibody B5X0Q0 85.0%
ARP30157 Bovine CDK9 antibody; Bos taurus CDK9 antibody Q5EAB2 92.0%
ARP30157 Cat CDK9 antibody; Felis catus CDK9 antibody M3X943 92.0%
ARP30157 Chicken CDK9 antibody; Gallus gallus CDK9 antibody Q5ZKN1 100.0%
ARP30157 Chimpanzee CDK9 antibody; Pan troglodytes CDK9 antibody H2QXX8 100.0%
ARP30157 Collared flycatcher CDK9 antibody; Ficedula albicollis CDK9 antibody U3JF41 100.0%
ARP30157 Dog CDK9 antibody; Canis familiaris CDK9 antibody J9NWT0 100.0%
ARP30157 European domestic ferret CDK9 antibody; Mustela putorius furo CDK9 antibody M3YQG9 92.0%
ARP30157 Giant panda CDK9 antibody; Ailuropoda melanoleuca CDK9 antibody G1M948 100.0%
ARP30157 Gray short-tailed opossum CDK9 antibody; Monodelphis domestica CDK9 antibody F7FH38 92.0%
ARP30157 Honeybee CDK9 antibody; Apis mellifera CDK9 antibody H9KMX1 85.0%
ARP30157 Human CDK9 antibody; Homo sapiens CDK9 antibody B5BU53 100.0%
ARP30157 Human CDK9 antibody; Homo sapiens CDK9 antibody P50750-2 100.0%
ARP30157 Human CDK9 antibody; Homo sapiens CDK9 antibody P50750 100.0%
ARP30157 Mouse CDK9 antibody; Mus musculus CDK9 antibody Q99J95 92.0%
ARP30157 Mouse CDK9 antibody; Mus musculus CDK9 antibody D6RGN3 92.0%
ARP30157 Mouse CDK9 antibody; Mus musculus CDK9 antibody D6RHP4 92.0%
ARP30157 Pig CDK9 antibody; Sus scrofa CDK9 antibody C9E1C9 92.0%
ARP30157 Rat CDK9 antibody; Rattus norvegicus CDK9 antibody Q641Z4 92.0%
ARP30157 Rhesus macaque CDK9 antibody; Macaca mulatta CDK9 antibody F6XP46 100.0%
ARP30157 Rhesus macaque CDK9 antibody; Macaca mulatta CDK9 antibody H9FNK6 100.0%
ARP30157 Savannah tsetse fly CDK9 antibody; Glossina morsitans morsitans CDK9 antibody Q2PQN8 85.0%
ARP30157 Silk moth CDK9 antibody; Bombyx mori CDK9 antibody H9JJ80 85.0%
ARP30157 Small-eared galago CDK9 antibody; Otolemur garnettii CDK9 antibody H0WXQ5 92.0%
ARP30157 Thirteen-lined ground squirrel CDK9 antibody; Spermophilus tridecemlineatus CDK9 antibody I3MBB8 92.0%
ARP30157 Western clawed frog CDK9 antibody; Xenopus tropicalis CDK9 antibody Q6GLD8 92.0%
ARP30157 White-tufted-ear marmoset CDK9 antibody; Callithrix jacchus CDK9 antibody U3DPZ7 92.0%
ARP30157 Zebrafish CDK9 antibody; Danio rerio CDK9 antibody Q7SXE8 92.0%
ARP30157 Zebrafish CDK9 antibody; Danio rerio CDK9 antibody Q7T3L5 92.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas203198_at721_B_lymphoblasts34.50010.210Details
BioGPS Gene Atlas203198_atAdipocyte6.20010.210Details
BioGPS Gene Atlas203198_atAdrenalCortex7.25010.210Details
BioGPS Gene Atlas203198_atAdrenalgland6.00010.210Details
BioGPS Gene Atlas203198_atAmygdala10.15010.210Details
BioGPS Gene Atlas203198_atAppendix7.00010.210Details
BioGPS Gene Atlas203198_atAtrioventricularNode4.35010.210Details
BioGPS Gene Atlas203198_atBDCA4+_DentriticCells48.00010.210Details
BioGPS Gene Atlas203198_atBonemarrow6.85010.210Details
BioGPS Gene Atlas203198_atBronchialEpithelialCells7.10010.210Details
BioGPS Gene Atlas203198_atCD105+_Endothelial10.70010.210Details
BioGPS Gene Atlas203198_atCD14+_Monocytes12.20010.210Details
BioGPS Gene Atlas203198_atCD19+_BCells(neg._sel.)27.00010.210Details
BioGPS Gene Atlas203198_atCD33+_Myeloid19.40010.210Details
BioGPS Gene Atlas203198_atCD34+26.05010.210Details
BioGPS Gene Atlas203198_atCD4+_Tcells23.05010.210Details
BioGPS Gene Atlas203198_atCD56+_NKCells60.65010.210Details
BioGPS Gene Atlas203198_atCD71+_EarlyErythroid10.20010.210Details
BioGPS Gene Atlas203198_atCD8+_Tcells33.40010.210Details
BioGPS Gene Atlas203198_atCardiacMyocytes9.00010.210Details
BioGPS Gene Atlas203198_atCaudatenucleus6.50010.210Details
BioGPS Gene Atlas203198_atCerebellum5.65010.210Details
BioGPS Gene Atlas203198_atCerebellumPeduncles8.05010.210Details
BioGPS Gene Atlas203198_atCiliaryGanglion4.05010.210Details
BioGPS Gene Atlas203198_atCingulateCortex8.40010.210Details
BioGPS Gene Atlas203198_atColorectaladenocarcinoma7.20010.210Details
BioGPS Gene Atlas203198_atDorsalRootGanglion4.70010.210Details
BioGPS Gene Atlas203198_atFetalThyroid6.80010.210Details
BioGPS Gene Atlas203198_atFetalbrain7.70010.210Details
BioGPS Gene Atlas203198_atFetalliver6.10010.210Details
BioGPS Gene Atlas203198_atFetallung6.40010.210Details
BioGPS Gene Atlas203198_atGlobusPallidus4.30010.210Details
BioGPS Gene Atlas203198_atHeart9.30010.210Details
BioGPS Gene Atlas203198_atHypothalamus11.55010.210Details
BioGPS Gene Atlas203198_atKidney5.65010.210Details
BioGPS Gene Atlas203198_atLeukemia_chronicMyelogenousK-5626.55010.210Details
BioGPS Gene Atlas203198_atLeukemia_promyelocytic-HL-606.05010.210Details
BioGPS Gene Atlas203198_atLeukemialymphoblastic(MOLT-4)5.85010.210Details
BioGPS Gene Atlas203198_atLiver13.40010.210Details
BioGPS Gene Atlas203198_atLung11.15010.210Details
BioGPS Gene Atlas203198_atLymphnode6.80010.210Details
BioGPS Gene Atlas203198_atLymphoma_burkitts(Daudi)8.90010.210Details
BioGPS Gene Atlas203198_atLymphoma_burkitts(Raji)12.10010.210Details
BioGPS Gene Atlas203198_atMedullaOblongata6.60010.210Details
BioGPS Gene Atlas203198_atOccipitalLobe6.45010.210Details
BioGPS Gene Atlas203198_atOlfactoryBulb5.65010.210Details
BioGPS Gene Atlas203198_atOvary5.25010.210Details
BioGPS Gene Atlas203198_atPancreas5.70010.210Details
BioGPS Gene Atlas203198_atPancreaticIslet7.05010.210Details
BioGPS Gene Atlas203198_atParietalLobe7.40010.210Details
BioGPS Gene Atlas203198_atPituitary8.25010.210Details
BioGPS Gene Atlas203198_atPlacenta7.85010.210Details
BioGPS Gene Atlas203198_atPons6.70010.210Details
BioGPS Gene Atlas203198_atPrefrontalCortex9.15010.210Details
BioGPS Gene Atlas203198_atProstate8.55010.210Details
BioGPS Gene Atlas203198_atSalivarygland5.70010.210Details
BioGPS Gene Atlas203198_atSkeletalMuscle7.85010.210Details
BioGPS Gene Atlas203198_atSkin3.60010.210Details
BioGPS Gene Atlas203198_atSmoothMuscle9.70010.210Details
BioGPS Gene Atlas203198_atSpinalcord7.70010.210Details
BioGPS Gene Atlas203198_atSubthalamicNucleus5.00010.210Details
BioGPS Gene Atlas203198_atSuperiorCervicalGanglion7.85010.210Details
BioGPS Gene Atlas203198_atTemporalLobe6.45010.210Details
BioGPS Gene Atlas203198_atTestis7.65010.210Details
BioGPS Gene Atlas203198_atTestisGermCell6.50010.210Details
BioGPS Gene Atlas203198_atTestisIntersitial6.00010.210Details
BioGPS Gene Atlas203198_atTestisLeydigCell7.05010.210Details
BioGPS Gene Atlas203198_atTestisSeminiferousTubule6.15010.210Details
BioGPS Gene Atlas203198_atThalamus7.25010.210Details
BioGPS Gene Atlas203198_atThymus6.50010.210Details
BioGPS Gene Atlas203198_atThyroid14.50010.210Details
BioGPS Gene Atlas203198_atTongue6.80010.210Details
BioGPS Gene Atlas203198_atTonsil5.90010.210Details
BioGPS Gene Atlas203198_atTrachea6.00010.210Details
BioGPS Gene Atlas203198_atTrigeminalGanglion6.90010.210Details
BioGPS Gene Atlas203198_atUterus7.20010.210Details
BioGPS Gene Atlas203198_atUterusCorpus6.35010.210Details
BioGPS Gene Atlas203198_atWholeBlood8.00010.210Details
BioGPS Gene Atlas203198_atWholebrain10.65010.210Details
BioGPS Gene Atlas203198_atcolon7.25010.210Details
BioGPS Gene Atlas203198_atpineal_day12.56010.210Details
BioGPS Gene Atlas203198_atpineal_night14.56010.210Details
BioGPS Gene Atlas203198_atretina8.75010.210Details
BioGPS Gene Atlas203198_atsmall_intestine5.80010.210Details
BioGPS NCI60203198_at78637.00890.470Details
BioGPS NCI60203198_atA172203.17790.470Details
BioGPS NCI60203198_atA20436.01190.470Details
BioGPS NCI60203198_atA36156.08990.470Details
BioGPS NCI60203198_atA49836.31090.470Details
BioGPS NCI60203198_atA54936.76990.470Details
BioGPS NCI60203198_atACC3126.70790.470Details
BioGPS NCI60203198_atACHN117.90690.470Details
BioGPS NCI60203198_atALVA3137.55890.470Details
BioGPS NCI60203198_atCAKI156.80590.470Details
BioGPS NCI60203198_atCCRT CEM57.81990.470Details
BioGPS NCI60203198_atCOLO20535.44290.470Details
BioGPS NCI60203198_atDLD1256.71490.470Details
BioGPS NCI60203198_atDU145230.45090.470Details
BioGPS NCI60203198_atEKVX60.24990.470Details
BioGPS NCI60203198_atGM13360.48590.470Details
BioGPS NCI60203198_atGM160068.44290.470Details
BioGPS NCI60203198_atGM231365.29490.470Details
BioGPS NCI60203198_atGM234555.97090.470Details
BioGPS NCI60203198_atGM249370.49390.470Details
BioGPS NCI60203198_atGM9798.61390.470Details
BioGPS NCI60203198_atHCC299864.85390.470Details
BioGPS NCI60203198_atHCT11667.01490.470Details
BioGPS NCI60203198_atHCT1565.78790.470Details
BioGPS NCI60203198_atHEK 293 T-rex68.22290.470Details
BioGPS NCI60203198_atHEK 293T81.01390.470Details
BioGPS NCI60203198_atHEK29362.97290.470Details
BioGPS NCI60203198_atHELA41.37490.470Details
BioGPS NCI60203198_atHEPG236.15990.470Details
BioGPS NCI60203198_atHL6054.83790.470Details
BioGPS NCI60203198_atHOP6267.80190.470Details
BioGPS NCI60203198_atHOP92149.13690.470Details
BioGPS NCI60203198_atHS578T67.27790.470Details
BioGPS NCI60203198_atHSG81.55490.470Details
BioGPS NCI60203198_atHT108063.09190.470Details
BioGPS NCI60203198_atHT2971.35790.470Details
BioGPS NCI60203198_atIGROV169.11590.470Details
BioGPS NCI60203198_atIOSE8067.74390.470Details
BioGPS NCI60203198_atJURKAT67.39590.470Details
BioGPS NCI60203198_atK56256.93190.470Details
BioGPS NCI60203198_atKM1237.24190.470Details
BioGPS NCI60203198_atLN18195.72190.470Details
BioGPS NCI60203198_atLNCAP133.36890.470Details
BioGPS NCI60203198_atLOX IMVI68.87890.470Details
BioGPS NCI60203198_atM1435.89790.470Details
BioGPS NCI60203198_atMALME 3M44.48390.470Details
BioGPS NCI60203198_atMCF761.19990.470Details
BioGPS NCI60203198_atMD MB23150.65090.470Details
BioGPS NCI60203198_atMDA MB43556.72390.470Details
BioGPS NCI60203198_atMOLT452.58990.470Details
BioGPS NCI60203198_atNCI 46036.92990.470Details
BioGPS NCI60203198_atNCI H22646.51090.470Details
BioGPS NCI60203198_atNCI H2358.33690.470Details
BioGPS NCI60203198_atNCI H322M33.42090.470Details
BioGPS NCI60203198_atNCVADR RES64.23890.470Details
BioGPS NCI60203198_atOVCAR358.70590.470Details
BioGPS NCI60203198_atOVCAR436.11490.470Details
BioGPS NCI60203198_atOVCAR528.90790.470Details
BioGPS NCI60203198_atOVCAR8150.57790.470Details
BioGPS NCI60203198_atPANC168.43290.470Details
BioGPS NCI60203198_atRL736.73390.470Details
BioGPS NCI60203198_atRPMI 8226110.03190.470Details
BioGPS NCI60203198_atRS1184652.65090.470Details
BioGPS NCI60203198_atRXF39380.62490.470Details
BioGPS NCI60203198_atSAOS265.00390.470Details
BioGPS NCI60203198_atSF26852.78390.470Details
BioGPS NCI60203198_atSF29590.90090.470Details
BioGPS NCI60203198_atSF53965.76490.470Details
BioGPS NCI60203198_atSHSYSY+RA136.29990.470Details
BioGPS NCI60203198_atSHSYSY-RA261.22390.470Details
BioGPS NCI60203198_atSKMEL296.38990.470Details
BioGPS NCI60203198_atSKMEL2846.42690.470Details
BioGPS NCI60203198_atSKMEL565.50790.470Details
BioGPS NCI60203198_atSKOV337.00290.470Details
BioGPS NCI60203198_atSN12C135.18390.470Details
BioGPS NCI60203198_atSNB19134.56090.470Details
BioGPS NCI60203198_atSNB75158.74390.470Details
BioGPS NCI60203198_atSR116.54190.470Details
BioGPS NCI60203198_atSW62036.25190.470Details
BioGPS NCI60203198_atT2468.10690.470Details
BioGPS NCI60203198_atT3M4333.01690.470Details
BioGPS NCI60203198_atTK1023.44690.470Details
BioGPS NCI60203198_atU118222.53790.470Details
BioGPS NCI60203198_atU138121.21990.470Details
BioGPS NCI60203198_atU20S233.92690.470Details
BioGPS NCI60203198_atU251110.14990.470Details
BioGPS NCI60203198_atU87172.08290.470Details
BioGPS NCI60203198_atUACC25755.28890.470Details
BioGPS NCI60203198_atUACC6253.48990.470Details
BioGPS NCI60203198_atUO31114.55990.470Details
BioGPS NCI60203198_atZR75_135.60790.470Details
BioGPS NCI60203198_atastrocytes148.38290.470Details
BioGPS NCI60203198_athuh-768.70490.470Details