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Gene ID: 1021 | CDK6 Antibody Resource


CDK6 Antibody Resource
Gene Full Name: 
cyclin-dependent kinase 6
Uniprot: 
Q00534
Protein Name: 
cyclin-dependent kinase 6
Nucleotide: 
NM_001145306
Alias: 
PLSTIRE;
Ensembl: 
ENSG00000105810
Location: 
7q21-q22
HPRD: 
04533
NCBI Gene: 
1021
MIM: 
603368

Summary: 
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
Function: 
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.
Subcellular location: 
Cytoplasm. Nucleus. Cell projection › ruffle. Note: Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus.
PTM: 
Acetylation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody AVARP03005_T100 CDK6 antibody - C-terminal region (AVARP03005_T100) Polyclonal Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit WB 100ug $229 Details
Monoclonal Antibody OASA02602 CDK6 Antibody (OASA02602) Human IHC-AFF, IP, WB 0.1mg $555 Details
Polyclonal Antibody OAAB04572 CDK6 antibody - center region (OAAB04572) Human WB, ELISA 400ul $289 Details
Polyclonal Antibody OASC00170 CDK6 Antibody (OASC00170) Human; Mouse IHC, IF 50 ug $215 Details
Polyclonal Antibody OASC00171 CDK6 Antibody (OASC00171) Human; Mouse IHC, IF 50 ug $215 Details
Polyclonal Antibody OASC00367 CDK6 Antibody (OASC00367) Human; Mouse IHC, IF 50 ug $180 Details
Polyclonal Antibody OASC00368 CDK6 Antibody (OASC00368) Human; Mouse IHC 50 ug $180 Details
Polyclonal Antibody OAAB14550 Mouse Cdk6 antibody - C - terminal region (OAAB14550) Human WB 400ul $289 Details
Polyclonal Antibody OAAB17083 CDK6 antibody - C - terminal region (OAAB17083) Human WB, IHC 400ul $289 Details
Polyclonal Antibody OAEC00318 CDK6 (phospho-Tyr13) Antibody (OAEC00318) Human; Mouse IHC, IF 50ug $229 Details
Polyclonal Antibody OAEC00319 CDK6 (phospho-Tyr24) Antibody (OAEC00319) Human; Mouse IHC 50ug $229 Details
Polyclonal Antibody OAEC00681 CDK6 (Ab-13) Antibody (OAEC00681) Human; Mouse IHC 50ug $229 Details
Polyclonal Antibody OAEC00682 CDK6 (Ab-24) Antibody (OAEC00682) Human; Mouse IHC 50ug $229 Details
Polyclonal Antibody OAEC01036 CDK6 (phospho-Tyr13) Antibody (OAEC01036) Human; Mouse IHC: 1:50~100 IF:1:100~1:200 100ug $195 Details
Polyclonal Antibody OAEC01037 CDK6 (phospho-Tyr24) Antibody (OAEC01037) Human; Mouse IHC: 1:50~100 100ug $195 Details
Polyclonal Antibody OAEC01413 CDK6 (Ab-13) Antibody (OAEC01413) Human; Mouse IHC: 1:50~1:100 100ug $229 Details
Polyclonal Antibody OAEC01414 CDK6 (Ab-24) Antibody (OAEC01414) Human; Mouse IHC: 1:50~1:100 100ug $229 Details

Show all CDK6 antibodies


Product Images
CDK6 antibody - C-terminal region (AVARP03005_T100) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

Mouse Cdk6 antibody - C - terminal region (OAAB14550) in CDK6, HepG2, Mouse cells using Western Blot

Sample Type: CDK6, HepG2, Mouse

CDK6 (phospho-Tyr13) Antibody (OAEC00318) in Human breast carcinoma cells using Immunohistochemistry

Sample Type: Human breast carcinoma

CDK6 (phospho-Tyr13) Antibody (OAEC00318) in Human Hela cells using Immunofluorescence

Sample Type: Human Hela

CDK6 (phospho-Tyr24) Antibody (OAEC00319) in Human colon carcinoma cells using Immunohistochemistry

Sample Type: Human colon carcinoma

CDK6 (Ab-13) Antibody (OAEC00681) in Human colon carcinoma cells using Immunohistochemistry

Sample Type: Human colon carcinoma

CDK6 (Ab-24) Antibody (OAEC00682) in Human colon carcinoma cells using Immunohistochemistry

Sample Type: Human colon carcinoma

CDK6 Antibody (OASC00170) in Hela cells using Immunofluorescence

Sample Type: Hela

CDK6 Antibody (OASC00170) in human brain carcinoma cells using Immunohistochemistry

Sample Type: human brain carcinoma

CDK6 Antibody (OASC00171) in Hela cells using Immunofluorescence

Sample Type: Hela

CDK6 Antibody (OASC00171) in human colon carcinoma cells using Immunohistochemistry

Sample Type: human colon carcinoma

CDK6 Antibody (OASC00367) in Hela cells using Immunofluorescence

Sample Type: Hela

CDK6 Antibody (OASC00367) in human colon carcinoma cells using Immunohistochemistry

Sample Type: human colon carcinoma

CDK6 Antibody (OASC00368) in human colon carcinoma cells using Immunohistochemistry

Sample Type: human colon carcinoma


CDK6 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP30155 African elephant CDK6 antibody; Loxodonta africana CDK6 antibody G3TL01 92.0%
ARP30155 Bovine CDK6 antibody; Bos taurus CDK6 antibody E1BC36 85.0%
ARP30155 Cat CDK6 antibody; Felis catus CDK6 antibody M3VZ21 85.0%
ARP30155 Chimpanzee CDK6 antibody; Pan troglodytes CDK6 antibody H2QUX4 100.0%
ARP30155 Dog CDK6 antibody; Canis familiaris CDK6 antibody E2RLM4 85.0%
ARP30155 Giant panda CDK6 antibody; Ailuropoda melanoleuca CDK6 antibody G1MHH7 85.0%
ARP30155 Horse CDK6 antibody; Equus caballus CDK6 antibody F6XCT7 85.0%
ARP30155 Human CDK6 antibody; Homo sapiens CDK6 antibody A4D1G0 100.0%
ARP30155 Human CDK6 antibody; Homo sapiens CDK6 antibody Q00534 100.0%
ARP62168 Hydra CDK6 antibody; Hydra vulgaris CDK6 antibody T2MEA4 83.0%
ARP30155 Northern white-cheeked gibbon CDK6 antibody; Nomascus leucogenys CDK6 antibody G1RZD7 100.0%
ARP30155 Pig CDK6 antibody; Sus scrofa CDK6 antibody K7GSW3 85.0%
ARP30155 Rabbit CDK6 antibody; Oryctolagus cuniculus CDK6 antibody G1T0K2 85.0%
ARP30155 Rhesus macaque CDK6 antibody; Macaca mulatta CDK6 antibody F7E5V8 100.0%
ARP30155 Small-eared galago CDK6 antibody; Otolemur garnettii CDK6 antibody H0XQI5 100.0%
ARP30155 Sumatran orangutan CDK6 antibody; Pongo abelii CDK6 antibody H2PMX6 100.0%
ARP30155 Thirteen-lined ground squirrel CDK6 antibody; Spermophilus tridecemlineatus CDK6 antibody I3MM51 92.0%
ARP30155 White-tufted-ear marmoset CDK6 antibody; Callithrix jacchus CDK6 antibody F6YF92 92.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas207143_at721_B_lymphoblasts5.8004.690Details
BioGPS Gene Atlas207143_atAdipocyte4.5504.690Details
BioGPS Gene Atlas207143_atAdrenalCortex4.8504.690Details
BioGPS Gene Atlas207143_atAdrenalgland3.9004.690Details
BioGPS Gene Atlas207143_atAmygdala4.8504.690Details
BioGPS Gene Atlas207143_atAppendix4.7004.690Details
BioGPS Gene Atlas207143_atAtrioventricularNode3.6004.690Details
BioGPS Gene Atlas207143_atBDCA4+_DentriticCells4.9004.690Details
BioGPS Gene Atlas207143_atBonemarrow4.5504.690Details
BioGPS Gene Atlas207143_atBronchialEpithelialCells4.6004.690Details
BioGPS Gene Atlas207143_atCD105+_Endothelial4.7004.690Details
BioGPS Gene Atlas207143_atCD14+_Monocytes4.8504.690Details
BioGPS Gene Atlas207143_atCD19+_BCells(neg._sel.)4.8004.690Details
BioGPS Gene Atlas207143_atCD33+_Myeloid6.0004.690Details
BioGPS Gene Atlas207143_atCD34+9.0504.690Details
BioGPS Gene Atlas207143_atCD4+_Tcells5.0004.690Details
BioGPS Gene Atlas207143_atCD56+_NKCells5.4004.690Details
BioGPS Gene Atlas207143_atCD71+_EarlyErythroid4.2504.690Details
BioGPS Gene Atlas207143_atCD8+_Tcells4.4504.690Details
BioGPS Gene Atlas207143_atCardiacMyocytes6.3004.690Details
BioGPS Gene Atlas207143_atCaudatenucleus4.1004.690Details
BioGPS Gene Atlas207143_atCerebellum3.7504.690Details
BioGPS Gene Atlas207143_atCerebellumPeduncles5.2004.690Details
BioGPS Gene Atlas207143_atCiliaryGanglion3.2504.690Details
BioGPS Gene Atlas207143_atCingulateCortex4.7004.690Details
BioGPS Gene Atlas207143_atColorectaladenocarcinoma4.6004.690Details
BioGPS Gene Atlas207143_atDorsalRootGanglion3.5504.690Details
BioGPS Gene Atlas207143_atFetalThyroid4.5004.690Details
BioGPS Gene Atlas207143_atFetalbrain4.5504.690Details
BioGPS Gene Atlas207143_atFetalliver4.1004.690Details
BioGPS Gene Atlas207143_atFetallung3.8504.690Details
BioGPS Gene Atlas207143_atGlobusPallidus3.4004.690Details
BioGPS Gene Atlas207143_atHeart6.2504.690Details
BioGPS Gene Atlas207143_atHypothalamus4.9504.690Details
BioGPS Gene Atlas207143_atKidney3.8004.690Details
BioGPS Gene Atlas207143_atLeukemia_chronicMyelogenousK-5624.2504.690Details
BioGPS Gene Atlas207143_atLeukemia_promyelocytic-HL-604.1004.690Details
BioGPS Gene Atlas207143_atLeukemialymphoblastic(MOLT-4)3.7004.690Details
BioGPS Gene Atlas207143_atLiver6.1504.690Details
BioGPS Gene Atlas207143_atLung5.0504.690Details
BioGPS Gene Atlas207143_atLymphnode3.9504.690Details
BioGPS Gene Atlas207143_atLymphoma_burkitts(Daudi)5.9004.690Details
BioGPS Gene Atlas207143_atLymphoma_burkitts(Raji)6.6004.690Details
BioGPS Gene Atlas207143_atMedullaOblongata4.2504.690Details
BioGPS Gene Atlas207143_atOccipitalLobe4.1504.690Details
BioGPS Gene Atlas207143_atOlfactoryBulb3.6004.690Details
BioGPS Gene Atlas207143_atOvary3.0504.690Details
BioGPS Gene Atlas207143_atPancreas3.7004.690Details
BioGPS Gene Atlas207143_atPancreaticIslet4.9504.690Details
BioGPS Gene Atlas207143_atParietalLobe5.0504.690Details
BioGPS Gene Atlas207143_atPituitary5.4004.690Details
BioGPS Gene Atlas207143_atPlacenta4.7504.690Details
BioGPS Gene Atlas207143_atPons4.4004.690Details
BioGPS Gene Atlas207143_atPrefrontalCortex5.6004.690Details
BioGPS Gene Atlas207143_atProstate5.3004.690Details
BioGPS Gene Atlas207143_atSalivarygland3.6504.690Details
BioGPS Gene Atlas207143_atSkeletalMuscle5.5504.690Details
BioGPS Gene Atlas207143_atSkin3.5504.690Details
BioGPS Gene Atlas207143_atSmoothMuscle5.2504.690Details
BioGPS Gene Atlas207143_atSpinalcord4.9004.690Details
BioGPS Gene Atlas207143_atSubthalamicNucleus4.2004.690Details
BioGPS Gene Atlas207143_atSuperiorCervicalGanglion5.4004.690Details
BioGPS Gene Atlas207143_atTemporalLobe4.2004.690Details
BioGPS Gene Atlas207143_atTestis4.0504.690Details
BioGPS Gene Atlas207143_atTestisGermCell3.8504.690Details
BioGPS Gene Atlas207143_atTestisIntersitial3.9004.690Details
BioGPS Gene Atlas207143_atTestisLeydigCell4.6004.690Details
BioGPS Gene Atlas207143_atTestisSeminiferousTubule3.9504.690Details
BioGPS Gene Atlas207143_atThalamus4.6504.690Details
BioGPS Gene Atlas207143_atThymus3.8504.690Details
BioGPS Gene Atlas207143_atThyroid5.8004.690Details
BioGPS Gene Atlas207143_atTongue4.5004.690Details
BioGPS Gene Atlas207143_atTonsil4.5004.690Details
BioGPS Gene Atlas207143_atTrachea3.8504.690Details
BioGPS Gene Atlas207143_atTrigeminalGanglion4.6004.690Details
BioGPS Gene Atlas207143_atUterus3.7504.690Details
BioGPS Gene Atlas207143_atUterusCorpus4.1504.690Details
BioGPS Gene Atlas207143_atWholeBlood5.0504.690Details
BioGPS Gene Atlas207143_atWholebrain3.9504.690Details
BioGPS Gene Atlas207143_atcolon4.6004.690Details
BioGPS Gene Atlas207143_atpineal_day5.5804.690Details
BioGPS Gene Atlas207143_atpineal_night5.5004.690Details
BioGPS Gene Atlas207143_atretina5.5004.690Details
BioGPS Gene Atlas207143_atsmall_intestine4.4504.690Details
BioGPS NCI60207143_at7864.7245.480Details
BioGPS NCI60207143_atA1724.4635.480Details
BioGPS NCI60207143_atA2044.5805.480Details
BioGPS NCI60207143_atA3614.6785.480Details
BioGPS NCI60207143_atA4984.6115.480Details
BioGPS NCI60207143_atA5494.6955.480Details
BioGPS NCI60207143_atACC34.8015.480Details
BioGPS NCI60207143_atACHN4.4625.480Details
BioGPS NCI60207143_atALVA314.8515.480Details
BioGPS NCI60207143_atCAKI14.7375.480Details
BioGPS NCI60207143_atCCRT CEM27.3065.480Details
BioGPS NCI60207143_atCOLO2054.5715.480Details
BioGPS NCI60207143_atDLD14.5445.480Details
BioGPS NCI60207143_atDU1454.4465.480Details
BioGPS NCI60207143_atEKVX4.3755.480Details
BioGPS NCI60207143_atGM1334.7335.480Details
BioGPS NCI60207143_atGM160018.2225.480Details
BioGPS NCI60207143_atGM23134.7155.480Details
BioGPS NCI60207143_atGM23454.5495.480Details
BioGPS NCI60207143_atGM24934.9465.480Details
BioGPS NCI60207143_atGM974.8725.480Details
BioGPS NCI60207143_atHCC29986.5685.480Details
BioGPS NCI60207143_atHCT1164.6165.480Details
BioGPS NCI60207143_atHCT154.4025.480Details
BioGPS NCI60207143_atHEK 293 T-rex4.7505.480Details
BioGPS NCI60207143_atHEK 293T4.6335.480Details
BioGPS NCI60207143_atHEK2934.6105.480Details
BioGPS NCI60207143_atHELA4.4995.480Details
BioGPS NCI60207143_atHEPG24.5825.480Details
BioGPS NCI60207143_atHL604.9865.480Details
BioGPS NCI60207143_atHOP624.5095.480Details
BioGPS NCI60207143_atHOP924.2885.480Details
BioGPS NCI60207143_atHS578T4.6235.480Details
BioGPS NCI60207143_atHSG4.5575.480Details
BioGPS NCI60207143_atHT10806.9465.480Details
BioGPS NCI60207143_atHT295.0555.480Details
BioGPS NCI60207143_atIGROV14.6005.480Details
BioGPS NCI60207143_atIOSE804.6205.480Details
BioGPS NCI60207143_atJURKAT9.2345.480Details
BioGPS NCI60207143_atK5625.0445.480Details
BioGPS NCI60207143_atKM124.7855.480Details
BioGPS NCI60207143_atLN184.3965.480Details
BioGPS NCI60207143_atLNCAP4.6165.480Details
BioGPS NCI60207143_atLOX IMVI4.6205.480Details
BioGPS NCI60207143_atM144.4895.480Details
BioGPS NCI60207143_atMALME 3M5.0035.480Details
BioGPS NCI60207143_atMCF74.2685.480Details
BioGPS NCI60207143_atMD MB2314.6575.480Details
BioGPS NCI60207143_atMDA MB4354.8035.480Details
BioGPS NCI60207143_atMOLT410.2755.480Details
BioGPS NCI60207143_atNCI 4604.7025.480Details
BioGPS NCI60207143_atNCI H2264.7665.480Details
BioGPS NCI60207143_atNCI H234.5885.480Details
BioGPS NCI60207143_atNCI H322M4.6145.480Details
BioGPS NCI60207143_atNCVADR RES4.0155.480Details
BioGPS NCI60207143_atOVCAR34.8045.480Details
BioGPS NCI60207143_atOVCAR44.6145.480Details
BioGPS NCI60207143_atOVCAR54.5815.480Details
BioGPS NCI60207143_atOVCAR84.5855.480Details
BioGPS NCI60207143_atPANC14.6915.480Details
BioGPS NCI60207143_atRL75.1915.480Details
BioGPS NCI60207143_atRPMI 82264.6735.480Details
BioGPS NCI60207143_atRS118464.7685.480Details
BioGPS NCI60207143_atRXF3934.8445.480Details
BioGPS NCI60207143_atSAOS24.6785.480Details
BioGPS NCI60207143_atSF2685.6935.480Details
BioGPS NCI60207143_atSF2954.5855.480Details
BioGPS NCI60207143_atSF5394.3945.480Details
BioGPS NCI60207143_atSHSYSY+RA9.4695.480Details
BioGPS NCI60207143_atSHSYSY-RA5.4775.480Details
BioGPS NCI60207143_atSKMEL24.5965.480Details
BioGPS NCI60207143_atSKMEL284.6395.480Details
BioGPS NCI60207143_atSKMEL54.4915.480Details
BioGPS NCI60207143_atSKOV34.5905.480Details
BioGPS NCI60207143_atSN12C4.5485.480Details
BioGPS NCI60207143_atSNB198.1015.480Details
BioGPS NCI60207143_atSNB755.3585.480Details
BioGPS NCI60207143_atSR11.9775.480Details
BioGPS NCI60207143_atSW6204.8455.480Details
BioGPS NCI60207143_atT244.6965.480Details
BioGPS NCI60207143_atT3M45.6555.480Details
BioGPS NCI60207143_atTK1023.7585.480Details
BioGPS NCI60207143_atU1184.4925.480Details
BioGPS NCI60207143_atU1384.4265.480Details
BioGPS NCI60207143_atU20S4.5195.480Details
BioGPS NCI60207143_atU2514.5075.480Details
BioGPS NCI60207143_atU874.4425.480Details
BioGPS NCI60207143_atUACC2574.5775.480Details
BioGPS NCI60207143_atUACC626.0985.480Details
BioGPS NCI60207143_atUO315.7985.480Details
BioGPS NCI60207143_atZR75_14.7215.480Details
BioGPS NCI60207143_atastrocytes4.6105.480Details
BioGPS NCI60207143_athuh-74.7375.480Details