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Gene ID: 997 | CDC34 Antibody Resource


CDC34 Antibody Resource
Gene Full Name: 
cell division cycle 34
Uniprot: 
P49427
Protein Name: 
ubiquitin-conjugating enzyme E2 R1
Nucleotide: 
XM_005259690
Alias: 
UBC3;UBCH3;UBE2R1;E2-CDC34;
Ensembl: 
ENSG00000099804
Location: 
19p13.3
HPRD: 
00306
NCBI Gene: 
997
MIM: 
116948

Summary: 
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]
Function: 
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.
Subcellular location: 
Cytoplasm. Nucleus. Note: The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.
PTM: 
Phosphoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody AVARP03048_P050 CDC34 antibody - middle region (AVARP03048_P050) Polyclonal Bovine, Dog, Rat WB 50ug $289 Details
Protein OPPA01522 CDC34 Human - Recombinant Cell Division Cycle 34 (5ug) 5ug $100 Details
Polyclonal Antibody ARP30152_P050 CDC34 Antibody (ARP30152_P050) Polyclonal Bovine, Dog, Human, Mouse, Rat, Zebrafish Not tested 50 ug $125 Details
Polyclonal Antibody OAAB15352 CDC34 antibody - center region (OAAB15352) Human WB 400ul $289 Details
Polyclonal Antibody OAAB15710 CDC34 antibody - N - terminal region (OAAB15710) Human; Mouse WB, IHC 400ul $289 Details
Polyclonal Antibody OAAB15711 CDC34 antibody - C - terminal region (OAAB15711) Human WB 400ul $289 Details

Show all CDC34 antibodies


Product Images
CDC34 antibody - middle region (AVARP03048_P050) in Human Thymus cells using Western Blot

Sample Type: Human Thymus


CDC34 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP58403 Candida albicans CDC34 antibody Q5AH09 86.0%
ARP43015 Candida albicans CDC34 antibody Q5AH09 83.0%
ARP30152 Bovine CDC34 antibody; Bos taurus CDC34 antibody F1N4D3 100.0%
ARP30152 Cat CDC34 antibody; Felis catus CDC34 antibody M3W8G8 93.0%
ARP30152 Chicken CDC34 antibody; Gallus gallus CDC34 antibody F1NL19 79.0%
ARP30152 Chimpanzee CDC34 antibody; Pan troglodytes CDC34 antibody H2QES2 93.0%
ARP30152 Chimpanzee CDC34 antibody; Pan troglodytes CDC34 antibody K7D195 93.0%
ARP30152 Chinese softshell turtle CDC34 antibody; Pelodiscus sinensis CDC34 antibody K7F6K9 79.0%
ARP30152 Collared flycatcher CDC34 antibody; Ficedula albicollis CDC34 antibody U3KHK6 79.0%
ARP30152 Dog CDC34 antibody; Canis familiaris CDC34 antibody J9P0N9 93.0%
ARP30152 Duckbill platypus CDC34 antibody; Ornithorhynchus anatinus CDC34 antibody F7F5T2 79.0%
ARP30152 European domestic ferret CDC34 antibody; Mustela putorius furo CDC34 antibody M3YEX8 93.0%
ARP30152 Giant panda CDC34 antibody; Ailuropoda melanoleuca CDC34 antibody G1L7G5 93.0%
ARP30152 Gray short-tailed opossum CDC34 antibody; Monodelphis domestica CDC34 antibody F7BV64 93.0%
ARP30152 Human CDC34 antibody; Homo sapiens CDC34 antibody U3KPV8 100.0%
ARP30152 Human CDC34 antibody; Homo sapiens CDC34 antibody U3KQP9 100.0%
ARP30152 Human CDC34 antibody; Homo sapiens CDC34 antibody P49427 100.0%
ARP30152 Mouse CDC34 antibody; Mus musculus CDC34 antibody Q8CFI2 93.0%
ARP30152 Rabbit CDC34 antibody; Oryctolagus cuniculus CDC34 antibody G1TQD7 80.0%
ARP30152 Rat CDC34 antibody; Rattus norvegicus CDC34 antibody D4A453 93.0%
ARP30152 Rhesus macaque CDC34 antibody; Macaca mulatta CDC34 antibody H9FMP3 100.0%
ARP30152 Small-eared galago CDC34 antibody; Otolemur garnettii CDC34 antibody H0WQA0 86.0%
ARP30152 Sumatran orangutan CDC34 antibody; Pongo abelii CDC34 antibody H2NWP9 100.0%
ARP30152 Tasmanian devil CDC34 antibody; Sarcophilus harrisii CDC34 antibody G3WAI7 93.0%
ARP30152 Thirteen-lined ground squirrel CDC34 antibody; Spermophilus tridecemlineatus CDC34 antibody I3NHU2 100.0%
ARP30152 White-tufted-ear marmoset CDC34 antibody; Callithrix jacchus CDC34 antibody U3FKL5 100.0%
ARP30152 White-tufted-ear marmoset CDC34 antibody; Callithrix jacchus CDC34 antibody F7GX42 100.0%
ARP30152 White-tufted-ear marmoset CDC34 antibody; Callithrix jacchus CDC34 antibody F7I3V6 100.0%
ARP30152 White-tufted-ear marmoset CDC34 antibody; Callithrix jacchus CDC34 antibody F7I3W0 100.0%
ARP58403 Yeast CDC34 antibody; Candida albicans CDC34 antibody G1UA80 86.0%
ARP43015 Yeast CDC34 antibody; Candida albicans CDC34 antibody G1UA80 83.0%
ARP30152 Zebra finch CDC34 antibody; Taeniopygia guttata CDC34 antibody H0YQR3 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas212540_at721_B_lymphoblasts18.55015.770Details
BioGPS Gene Atlas212540_atAdipocyte6.20015.770Details
BioGPS Gene Atlas212540_atAdrenalCortex6.60015.770Details
BioGPS Gene Atlas212540_atAdrenalgland5.45015.770Details
BioGPS Gene Atlas212540_atAmygdala14.30015.770Details
BioGPS Gene Atlas212540_atAppendix5.50015.770Details
BioGPS Gene Atlas212540_atAtrioventricularNode4.65015.770Details
BioGPS Gene Atlas212540_atBDCA4+_DentriticCells12.70015.770Details
BioGPS Gene Atlas212540_atBonemarrow12.60015.770Details
BioGPS Gene Atlas212540_atBronchialEpithelialCells8.80015.770Details
BioGPS Gene Atlas212540_atCD105+_Endothelial60.70015.770Details
BioGPS Gene Atlas212540_atCD14+_Monocytes11.50015.770Details
BioGPS Gene Atlas212540_atCD19+_BCells(neg._sel.)7.05015.770Details
BioGPS Gene Atlas212540_atCD33+_Myeloid9.95015.770Details
BioGPS Gene Atlas212540_atCD34+23.05015.770Details
BioGPS Gene Atlas212540_atCD4+_Tcells7.25015.770Details
BioGPS Gene Atlas212540_atCD56+_NKCells52.55015.770Details
BioGPS Gene Atlas212540_atCD71+_EarlyErythroid370.70015.770Details
BioGPS Gene Atlas212540_atCD8+_Tcells9.80015.770Details
BioGPS Gene Atlas212540_atCardiacMyocytes8.15015.770Details
BioGPS Gene Atlas212540_atCaudatenucleus5.85015.770Details
BioGPS Gene Atlas212540_atCerebellum5.30015.770Details
BioGPS Gene Atlas212540_atCerebellumPeduncles8.80015.770Details
BioGPS Gene Atlas212540_atCiliaryGanglion3.55015.770Details
BioGPS Gene Atlas212540_atCingulateCortex6.35015.770Details
BioGPS Gene Atlas212540_atColorectaladenocarcinoma14.40015.770Details
BioGPS Gene Atlas212540_atDorsalRootGanglion2.75015.770Details
BioGPS Gene Atlas212540_atFetalThyroid6.00015.770Details
BioGPS Gene Atlas212540_atFetalbrain6.95015.770Details
BioGPS Gene Atlas212540_atFetalliver7.30015.770Details
BioGPS Gene Atlas212540_atFetallung6.55015.770Details
BioGPS Gene Atlas212540_atGlobusPallidus4.60015.770Details
BioGPS Gene Atlas212540_atHeart17.60015.770Details
BioGPS Gene Atlas212540_atHypothalamus7.25015.770Details
BioGPS Gene Atlas212540_atKidney4.70015.770Details
BioGPS Gene Atlas212540_atLeukemia_chronicMyelogenousK-56228.45015.770Details
BioGPS Gene Atlas212540_atLeukemia_promyelocytic-HL-607.70015.770Details
BioGPS Gene Atlas212540_atLeukemialymphoblastic(MOLT-4)5.30015.770Details
BioGPS Gene Atlas212540_atLiver34.55015.770Details
BioGPS Gene Atlas212540_atLung19.45015.770Details
BioGPS Gene Atlas212540_atLymphnode5.15015.770Details
BioGPS Gene Atlas212540_atLymphoma_burkitts(Daudi)7.55015.770Details
BioGPS Gene Atlas212540_atLymphoma_burkitts(Raji)37.95015.770Details
BioGPS Gene Atlas212540_atMedullaOblongata6.05015.770Details
BioGPS Gene Atlas212540_atOccipitalLobe5.90015.770Details
BioGPS Gene Atlas212540_atOlfactoryBulb5.05015.770Details
BioGPS Gene Atlas212540_atOvary2.95015.770Details
BioGPS Gene Atlas212540_atPancreas5.20015.770Details
BioGPS Gene Atlas212540_atPancreaticIslet7.00015.770Details
BioGPS Gene Atlas212540_atParietalLobe6.75015.770Details
BioGPS Gene Atlas212540_atPituitary7.60015.770Details
BioGPS Gene Atlas212540_atPlacenta10.10015.770Details
BioGPS Gene Atlas212540_atPons4.80015.770Details
BioGPS Gene Atlas212540_atPrefrontalCortex14.40015.770Details
BioGPS Gene Atlas212540_atProstate14.35015.770Details
BioGPS Gene Atlas212540_atSalivarygland4.25015.770Details
BioGPS Gene Atlas212540_atSkeletalMuscle7.20015.770Details
BioGPS Gene Atlas212540_atSkin4.90015.770Details
BioGPS Gene Atlas212540_atSmoothMuscle7.75015.770Details
BioGPS Gene Atlas212540_atSpinalcord7.00015.770Details
BioGPS Gene Atlas212540_atSubthalamicNucleus4.35015.770Details
BioGPS Gene Atlas212540_atSuperiorCervicalGanglion7.10015.770Details
BioGPS Gene Atlas212540_atTemporalLobe6.00015.770Details
BioGPS Gene Atlas212540_atTestis56.20015.770Details
BioGPS Gene Atlas212540_atTestisGermCell15.45015.770Details
BioGPS Gene Atlas212540_atTestisIntersitial6.80015.770Details
BioGPS Gene Atlas212540_atTestisLeydigCell6.50015.770Details
BioGPS Gene Atlas212540_atTestisSeminiferousTubule15.25015.770Details
BioGPS Gene Atlas212540_atThalamus6.65015.770Details
BioGPS Gene Atlas212540_atThymus5.20015.770Details
BioGPS Gene Atlas212540_atThyroid21.00015.770Details
BioGPS Gene Atlas212540_atTongue4.80015.770Details
BioGPS Gene Atlas212540_atTonsil6.05015.770Details
BioGPS Gene Atlas212540_atTrachea4.20015.770Details
BioGPS Gene Atlas212540_atTrigeminalGanglion6.30015.770Details
BioGPS Gene Atlas212540_atUterus5.45015.770Details
BioGPS Gene Atlas212540_atUterusCorpus5.80015.770Details
BioGPS Gene Atlas212540_atWholeBlood12.50015.770Details
BioGPS Gene Atlas212540_atWholebrain15.85015.770Details
BioGPS Gene Atlas212540_atcolon6.60015.770Details
BioGPS Gene Atlas212540_atpineal_day22.18015.770Details
BioGPS Gene Atlas212540_atpineal_night20.42015.770Details
BioGPS Gene Atlas212540_atretina12.70015.770Details
BioGPS Gene Atlas212540_atsmall_intestine6.35015.770Details
BioGPS NCI60212540_at786183.842332.710Details
BioGPS NCI60212540_atA172413.382332.710Details
BioGPS NCI60212540_atA204172.488332.710Details
BioGPS NCI60212540_atA361411.485332.710Details
BioGPS NCI60212540_atA498298.463332.710Details
BioGPS NCI60212540_atA549143.533332.710Details
BioGPS NCI60212540_atACC3194.974332.710Details
BioGPS NCI60212540_atACHN358.819332.710Details
BioGPS NCI60212540_atALVA3189.228332.710Details
BioGPS NCI60212540_atCAKI166.070332.710Details
BioGPS NCI60212540_atCCRT CEM173.469332.710Details
BioGPS NCI60212540_atCOLO20567.714332.710Details
BioGPS NCI60212540_atDLD1388.308332.710Details
BioGPS NCI60212540_atDU145400.687332.710Details
BioGPS NCI60212540_atEKVX252.777332.710Details
BioGPS NCI60212540_atGM133130.019332.710Details
BioGPS NCI60212540_atGM1600175.613332.710Details
BioGPS NCI60212540_atGM2313154.677332.710Details
BioGPS NCI60212540_atGM2345163.747332.710Details
BioGPS NCI60212540_atGM249358.520332.710Details
BioGPS NCI60212540_atGM97132.265332.710Details
BioGPS NCI60212540_atHCC2998691.043332.710Details
BioGPS NCI60212540_atHCT116536.534332.710Details
BioGPS NCI60212540_atHCT15328.426332.710Details
BioGPS NCI60212540_atHEK 293 T-rex246.687332.710Details
BioGPS NCI60212540_atHEK 293T517.617332.710Details
BioGPS NCI60212540_atHEK293772.170332.710Details
BioGPS NCI60212540_atHELA288.960332.710Details
BioGPS NCI60212540_atHEPG2683.912332.710Details
BioGPS NCI60212540_atHL60185.384332.710Details
BioGPS NCI60212540_atHOP62326.884332.710Details
BioGPS NCI60212540_atHOP92213.481332.710Details
BioGPS NCI60212540_atHS578T333.475332.710Details
BioGPS NCI60212540_atHSG297.239332.710Details
BioGPS NCI60212540_atHT1080620.781332.710Details
BioGPS NCI60212540_atHT29126.407332.710Details
BioGPS NCI60212540_atIGROV1439.045332.710Details
BioGPS NCI60212540_atIOSE80305.635332.710Details
BioGPS NCI60212540_atJURKAT203.128332.710Details
BioGPS NCI60212540_atK562392.579332.710Details
BioGPS NCI60212540_atKM12496.828332.710Details
BioGPS NCI60212540_atLN18411.889332.710Details
BioGPS NCI60212540_atLNCAP156.222332.710Details
BioGPS NCI60212540_atLOX IMVI468.444332.710Details
BioGPS NCI60212540_atM14291.015332.710Details
BioGPS NCI60212540_atMALME 3M82.126332.710Details
BioGPS NCI60212540_atMCF7262.814332.710Details
BioGPS NCI60212540_atMD MB231257.331332.710Details
BioGPS NCI60212540_atMDA MB435321.468332.710Details
BioGPS NCI60212540_atMOLT4278.826332.710Details
BioGPS NCI60212540_atNCI 46087.670332.710Details
BioGPS NCI60212540_atNCI H226370.300332.710Details
BioGPS NCI60212540_atNCI H23439.680332.710Details
BioGPS NCI60212540_atNCI H322M304.675332.710Details
BioGPS NCI60212540_atNCVADR RES768.077332.710Details
BioGPS NCI60212540_atOVCAR3237.450332.710Details
BioGPS NCI60212540_atOVCAR4175.009332.710Details
BioGPS NCI60212540_atOVCAR5168.036332.710Details
BioGPS NCI60212540_atOVCAR8759.067332.710Details
BioGPS NCI60212540_atPANC1201.117332.710Details
BioGPS NCI60212540_atRL7300.049332.710Details
BioGPS NCI60212540_atRPMI 8226268.734332.710Details
BioGPS NCI60212540_atRS11846237.462332.710Details
BioGPS NCI60212540_atRXF393192.582332.710Details
BioGPS NCI60212540_atSAOS2186.638332.710Details
BioGPS NCI60212540_atSF268504.503332.710Details
BioGPS NCI60212540_atSF2951157.637332.710Details
BioGPS NCI60212540_atSF539288.287332.710Details
BioGPS NCI60212540_atSHSYSY+RA679.576332.710Details
BioGPS NCI60212540_atSHSYSY-RA390.627332.710Details
BioGPS NCI60212540_atSKMEL2458.267332.710Details
BioGPS NCI60212540_atSKMEL28230.407332.710Details
BioGPS NCI60212540_atSKMEL5292.225332.710Details
BioGPS NCI60212540_atSKOV381.089332.710Details
BioGPS NCI60212540_atSN12C219.109332.710Details
BioGPS NCI60212540_atSNB19443.431332.710Details
BioGPS NCI60212540_atSNB75271.490332.710Details
BioGPS NCI60212540_atSR232.268332.710Details
BioGPS NCI60212540_atSW620407.187332.710Details
BioGPS NCI60212540_atT24284.136332.710Details
BioGPS NCI60212540_atT3M4265.737332.710Details
BioGPS NCI60212540_atTK10158.704332.710Details
BioGPS NCI60212540_atU118578.885332.710Details
BioGPS NCI60212540_atU138357.899332.710Details
BioGPS NCI60212540_atU20S250.839332.710Details
BioGPS NCI60212540_atU251308.005332.710Details
BioGPS NCI60212540_atU87481.820332.710Details
BioGPS NCI60212540_atUACC257260.772332.710Details
BioGPS NCI60212540_atUACC62207.831332.710Details
BioGPS NCI60212540_atUO31333.579332.710Details
BioGPS NCI60212540_atZR75_1162.648332.710Details
BioGPS NCI60212540_atastrocytes342.031332.710Details
BioGPS NCI60212540_athuh-7357.776332.710Details