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Gene ID: 50489 | CD207 Antibody Resource


CD207 Antibody Resource
Gene Full Name: 
CD207 molecule, langerin
Uniprot: 
Q9UJ71
Protein Name: 
C-type lectin domain family 4 member K
Nucleotide: 
NM_015717
Alias: 
CLEC4K;
Ensembl: 
ENSG00000116031
Location: 
2p13
HPRD: 
07278
NCBI Gene: 
50489
MIM: 
604862

Summary: 
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
Function: 
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation.
Subcellular location: 
Membrane; Single-pass type II membrane protein. Note: Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
PTM: 
Disulfide bond;
Disease: 
Birbeck granule deficiency (BIRGD) [MIM:613393]: A condition characterized by the absence of Birbeck granules in epidermal Langerhans cells. Despite the lack of Birbeck granules, Langerhans cells are present in normal numbers and have normal morphologic characteristics and antigen-presenting capacity. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP63502_P050 CD207 antibody - C-terminal region (ARP63502_P050) Bovine, Guinea pig, Horse, Mouse, Pig, Rat WB 50ug $289 Details
Polyclonal Antibody ARP63501_P050 CD207 Antibody (ARP63501_P050) Polyclonal Human Not tested 50 ug $125 Details

Show all CD207 antibodies


Product Images
CD207 antibody - C-terminal region (ARP63502_P050) in Human Fetal Kidney cells using Western Blot

Sample Type: Human Fetal Kidney


CD207 Protocols
Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP63502 Bovine CD207 antibody; Bos taurus CD207 antibody E1BB51 92.0%
ARP63502 Cat CD207 antibody; Felis catus CD207 antibody M3WIV5 86.0%
ARP63501 Chimpanzee CD207 antibody; Pan troglodytes CD207 antibody H2R8S3 100.0%
ARP63502 Chimpanzee CD207 antibody; Pan troglodytes CD207 antibody H2R8S3 100.0%
ARP63502 European domestic ferret CD207 antibody; Mustela putorius furo CD207 antibody M3Y7D9 86.0%
ARP63502 Horse CD207 antibody; Equus caballus CD207 antibody F6TZE3 79.0%
ARP63501 Human CD207 antibody; Homo sapiens CD207 antibody Q9UJ71 100.0%
ARP63502 Human CD207 antibody; Homo sapiens CD207 antibody Q9UJ71 100.0%
ARP63502 Mouse CD207 antibody; Mus musculus CD207 antibody Q8VBX4 93.0%
ARP63502 Mouse CD207 antibody; Mus musculus CD207 antibody Q8VDD4 93.0%
ARP63501 Northern white-cheeked gibbon CD207 antibody; Nomascus leucogenys CD207 antibody G1RGW2 100.0%
ARP63502 Northern white-cheeked gibbon CD207 antibody; Nomascus leucogenys CD207 antibody G1RGW2 100.0%
ARP63502 Pig CD207 antibody; Sus scrofa CD207 antibody B3FVQ1 79.0%
ARP63502 Rabbit CD207 antibody; Oryctolagus cuniculus CD207 antibody G1TDE9 83.0%
ARP63502 Rat CD207 antibody; Rattus norvegicus CD207 antibody D3ZBX0 79.0%
ARP63501 Rhesus macaque CD207 antibody; Macaca mulatta CD207 antibody F7A5P2 100.0%
ARP63502 Rhesus macaque CD207 antibody; Macaca mulatta CD207 antibody F7A5P2 100.0%
ARP63501 Rhesus macaque CD207 antibody; Macaca mulatta CD207 antibody F7HNH2 100.0%
ARP63502 Rhesus macaque CD207 antibody; Macaca mulatta CD207 antibody F7HNH2 100.0%
ARP63502 Small-eared galago CD207 antibody; Otolemur garnettii CD207 antibody H0WH23 83.0%
ARP63501 Sumatran orangutan CD207 antibody; Pongo abelii CD207 antibody H2P5W9 86.0%
ARP63502 Thirteen-lined ground squirrel CD207 antibody; Spermophilus tridecemlineatus CD207 antibody I3N0C4 100.0%
ARP63501 White-tufted-ear marmoset CD207 antibody; Callithrix jacchus CD207 antibody F7EFC9 100.0%
ARP63502 White-tufted-ear marmoset CD207 antibody; Callithrix jacchus CD207 antibody F7EFC9 86.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas220428_at721_B_lymphoblasts4.8003.950Details
BioGPS Gene Atlas220428_atAdipocyte3.8003.950Details
BioGPS Gene Atlas220428_atAdrenalCortex4.1003.950Details
BioGPS Gene Atlas220428_atAdrenalgland3.2503.950Details
BioGPS Gene Atlas220428_atAmygdala4.0503.950Details
BioGPS Gene Atlas220428_atAppendix5.5003.950Details
BioGPS Gene Atlas220428_atAtrioventricularNode3.0003.950Details
BioGPS Gene Atlas220428_atBDCA4+_DentriticCells4.2503.950Details
BioGPS Gene Atlas220428_atBonemarrow3.8003.950Details
BioGPS Gene Atlas220428_atBronchialEpithelialCells3.8503.950Details
BioGPS Gene Atlas220428_atCD105+_Endothelial3.9503.950Details
BioGPS Gene Atlas220428_atCD14+_Monocytes4.1503.950Details
BioGPS Gene Atlas220428_atCD19+_BCells(neg._sel.)4.1503.950Details
BioGPS Gene Atlas220428_atCD33+_Myeloid4.9503.950Details
BioGPS Gene Atlas220428_atCD34+4.9503.950Details
BioGPS Gene Atlas220428_atCD4+_Tcells4.2003.950Details
BioGPS Gene Atlas220428_atCD56+_NKCells4.6003.950Details
BioGPS Gene Atlas220428_atCD71+_EarlyErythroid3.8503.950Details
BioGPS Gene Atlas220428_atCD8+_Tcells3.7003.950Details
BioGPS Gene Atlas220428_atCardiacMyocytes5.0003.950Details
BioGPS Gene Atlas220428_atCaudatenucleus3.4503.950Details
BioGPS Gene Atlas220428_atCerebellum3.1503.950Details
BioGPS Gene Atlas220428_atCerebellumPeduncles4.4003.950Details
BioGPS Gene Atlas220428_atCiliaryGanglion2.8503.950Details
BioGPS Gene Atlas220428_atCingulateCortex4.0003.950Details
BioGPS Gene Atlas220428_atColorectaladenocarcinoma3.9003.950Details
BioGPS Gene Atlas220428_atDorsalRootGanglion3.0003.950Details
BioGPS Gene Atlas220428_atFetalThyroid3.7503.950Details
BioGPS Gene Atlas220428_atFetalbrain3.8503.950Details
BioGPS Gene Atlas220428_atFetalliver3.3503.950Details
BioGPS Gene Atlas220428_atFetallung3.1503.950Details
BioGPS Gene Atlas220428_atGlobusPallidus2.8503.950Details
BioGPS Gene Atlas220428_atHeart5.0503.950Details
BioGPS Gene Atlas220428_atHypothalamus4.2003.950Details
BioGPS Gene Atlas220428_atKidney3.1503.950Details
BioGPS Gene Atlas220428_atLeukemia_chronicMyelogenousK-5623.5503.950Details
BioGPS Gene Atlas220428_atLeukemia_promyelocytic-HL-603.4503.950Details
BioGPS Gene Atlas220428_atLeukemialymphoblastic(MOLT-4)3.1003.950Details
BioGPS Gene Atlas220428_atLiver5.1503.950Details
BioGPS Gene Atlas220428_atLung4.2503.950Details
BioGPS Gene Atlas220428_atLymphnode3.3503.950Details
BioGPS Gene Atlas220428_atLymphoma_burkitts(Daudi)4.9503.950Details
BioGPS Gene Atlas220428_atLymphoma_burkitts(Raji)5.4503.950Details
BioGPS Gene Atlas220428_atMedullaOblongata3.5503.950Details
BioGPS Gene Atlas220428_atOccipitalLobe3.4503.950Details
BioGPS Gene Atlas220428_atOlfactoryBulb3.1003.950Details
BioGPS Gene Atlas220428_atOvary2.6003.950Details
BioGPS Gene Atlas220428_atPancreas3.1003.950Details
BioGPS Gene Atlas220428_atPancreaticIslet4.1503.950Details
BioGPS Gene Atlas220428_atParietalLobe4.1503.950Details
BioGPS Gene Atlas220428_atPituitary4.5503.950Details
BioGPS Gene Atlas220428_atPlacenta4.0003.950Details
BioGPS Gene Atlas220428_atPons3.8003.950Details
BioGPS Gene Atlas220428_atPrefrontalCortex4.9003.950Details
BioGPS Gene Atlas220428_atProstate4.5003.950Details
BioGPS Gene Atlas220428_atSalivarygland3.1003.950Details
BioGPS Gene Atlas220428_atSkeletalMuscle4.5503.950Details
BioGPS Gene Atlas220428_atSkin3.0003.950Details
BioGPS Gene Atlas220428_atSmoothMuscle4.4003.950Details
BioGPS Gene Atlas220428_atSpinalcord4.1503.950Details
BioGPS Gene Atlas220428_atSubthalamicNucleus3.5503.950Details
BioGPS Gene Atlas220428_atSuperiorCervicalGanglion5.1503.950Details
BioGPS Gene Atlas220428_atTemporalLobe3.5503.950Details
BioGPS Gene Atlas220428_atTestis3.3003.950Details
BioGPS Gene Atlas220428_atTestisGermCell3.2503.950Details
BioGPS Gene Atlas220428_atTestisIntersitial3.2503.950Details
BioGPS Gene Atlas220428_atTestisLeydigCell3.8503.950Details
BioGPS Gene Atlas220428_atTestisSeminiferousTubule3.3503.950Details
BioGPS Gene Atlas220428_atThalamus3.9503.950Details
BioGPS Gene Atlas220428_atThymus3.0503.950Details
BioGPS Gene Atlas220428_atThyroid4.8503.950Details
BioGPS Gene Atlas220428_atTongue3.8503.950Details
BioGPS Gene Atlas220428_atTonsil3.8003.950Details
BioGPS Gene Atlas220428_atTrachea3.2003.950Details
BioGPS Gene Atlas220428_atTrigeminalGanglion3.9003.950Details
BioGPS Gene Atlas220428_atUterus3.2003.950Details
BioGPS Gene Atlas220428_atUterusCorpus3.5003.950Details
BioGPS Gene Atlas220428_atWholeBlood4.2003.950Details
BioGPS Gene Atlas220428_atWholebrain3.2503.950Details
BioGPS Gene Atlas220428_atcolon3.9003.950Details
BioGPS Gene Atlas220428_atpineal_day4.8803.950Details
BioGPS Gene Atlas220428_atpineal_night4.7803.950Details
BioGPS Gene Atlas220428_atretina4.7003.950Details
BioGPS Gene Atlas220428_atsmall_intestine3.7503.950Details
BioGPS NCI60220428_at7864.0573.970Details
BioGPS NCI60220428_atA1723.8043.970Details
BioGPS NCI60220428_atA2043.9563.970Details
BioGPS NCI60220428_atA3614.0023.970Details
BioGPS NCI60220428_atA4983.9563.970Details
BioGPS NCI60220428_atA5494.0223.970Details
BioGPS NCI60220428_atACC34.1173.970Details
BioGPS NCI60220428_atACHN3.7523.970Details
BioGPS NCI60220428_atALVA314.1603.970Details
BioGPS NCI60220428_atCAKI14.1143.970Details
BioGPS NCI60220428_atCCRT CEM4.3233.970Details
BioGPS NCI60220428_atCOLO2053.9953.970Details
BioGPS NCI60220428_atDLD13.8933.970Details
BioGPS NCI60220428_atDU1453.8063.970Details
BioGPS NCI60220428_atEKVX3.8263.970Details
BioGPS NCI60220428_atGM1334.0633.970Details
BioGPS NCI60220428_atGM16004.1223.970Details
BioGPS NCI60220428_atGM23134.0253.970Details
BioGPS NCI60220428_atGM23453.9933.970Details
BioGPS NCI60220428_atGM24934.1513.970Details
BioGPS NCI60220428_atGM974.4013.970Details
BioGPS NCI60220428_atHCC29983.6583.970Details
BioGPS NCI60220428_atHCT1163.9553.970Details
BioGPS NCI60220428_atHCT153.7733.970Details
BioGPS NCI60220428_atHEK 293 T-rex4.0453.970Details
BioGPS NCI60220428_atHEK 293T3.9453.970Details
BioGPS NCI60220428_atHEK2933.9343.970Details
BioGPS NCI60220428_atHELA3.7543.970Details
BioGPS NCI60220428_atHEPG23.9443.970Details
BioGPS NCI60220428_atHL604.2433.970Details
BioGPS NCI60220428_atHOP623.9623.970Details
BioGPS NCI60220428_atHOP923.8583.970Details
BioGPS NCI60220428_atHS578T3.8963.970Details
BioGPS NCI60220428_atHSG3.8493.970Details
BioGPS NCI60220428_atHT10803.9313.970Details
BioGPS NCI60220428_atHT294.1813.970Details
BioGPS NCI60220428_atIGROV13.9213.970Details
BioGPS NCI60220428_atIOSE803.9293.970Details
BioGPS NCI60220428_atJURKAT3.9533.970Details
BioGPS NCI60220428_atK5624.2283.970Details
BioGPS NCI60220428_atKM124.1353.970Details
BioGPS NCI60220428_atLN183.7713.970Details
BioGPS NCI60220428_atLNCAP3.9653.970Details
BioGPS NCI60220428_atLOX IMVI3.9573.970Details
BioGPS NCI60220428_atM143.9153.970Details
BioGPS NCI60220428_atMALME 3M4.2033.970Details
BioGPS NCI60220428_atMCF73.8413.970Details
BioGPS NCI60220428_atMD MB2313.9903.970Details
BioGPS NCI60220428_atMDA MB4354.1623.970Details
BioGPS NCI60220428_atMOLT44.0643.970Details
BioGPS NCI60220428_atNCI 4604.0623.970Details
BioGPS NCI60220428_atNCI H2264.0343.970Details
BioGPS NCI60220428_atNCI H233.9523.970Details
BioGPS NCI60220428_atNCI H322M3.9563.970Details
BioGPS NCI60220428_atNCVADR RES3.7793.970Details
BioGPS NCI60220428_atOVCAR34.1203.970Details
BioGPS NCI60220428_atOVCAR43.9413.970Details
BioGPS NCI60220428_atOVCAR53.9003.970Details
BioGPS NCI60220428_atOVCAR83.7573.970Details
BioGPS NCI60220428_atPANC14.0243.970Details
BioGPS NCI60220428_atRL74.0313.970Details
BioGPS NCI60220428_atRPMI 82264.0163.970Details
BioGPS NCI60220428_atRS118464.1233.970Details
BioGPS NCI60220428_atRXF3933.9333.970Details
BioGPS NCI60220428_atSAOS24.0183.970Details
BioGPS NCI60220428_atSF2683.9603.970Details
BioGPS NCI60220428_atSF2953.9023.970Details
BioGPS NCI60220428_atSF5393.7673.970Details
BioGPS NCI60220428_atSHSYSY+RA3.8653.970Details
BioGPS NCI60220428_atSHSYSY-RA3.9153.970Details
BioGPS NCI60220428_atSKMEL23.9413.970Details
BioGPS NCI60220428_atSKMEL283.9693.970Details
BioGPS NCI60220428_atSKMEL53.8493.970Details
BioGPS NCI60220428_atSKOV34.0553.970Details
BioGPS NCI60220428_atSN12C3.9243.970Details
BioGPS NCI60220428_atSNB193.7983.970Details
BioGPS NCI60220428_atSNB753.9403.970Details
BioGPS NCI60220428_atSR4.0343.970Details
BioGPS NCI60220428_atSW6204.0073.970Details
BioGPS NCI60220428_atT244.0733.970Details
BioGPS NCI60220428_atT3M44.1823.970Details
BioGPS NCI60220428_atTK103.9613.970Details
BioGPS NCI60220428_atU1183.8703.970Details
BioGPS NCI60220428_atU1383.7723.970Details
BioGPS NCI60220428_atU20S3.8453.970Details
BioGPS NCI60220428_atU2513.9063.970Details
BioGPS NCI60220428_atU873.8703.970Details
BioGPS NCI60220428_atUACC2573.8913.970Details
BioGPS NCI60220428_atUACC623.9903.970Details
BioGPS NCI60220428_atUO313.8403.970Details
BioGPS NCI60220428_atZR75_14.0663.970Details
BioGPS NCI60220428_atastrocytes3.9583.970Details
BioGPS NCI60220428_athuh-74.0533.970Details