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Gene ID: 83605 | CCM2 Antibody Resource


CCM2 Antibody Resource
Gene Full Name: 
cerebral cavernous malformation 2
Uniprot: 
Q9BSQ5
Protein Name: 
malcavernin
Nucleotide: 
NR_030770
Alias: 
OSM;C7orf22;PP10187;
Ensembl: 
ENSG00000136280
Location: 
7p13
HPRD: 
09719
NCBI Gene: 
83605
MIM: 
607929

Summary: 
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Function: 
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions . May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock .
Subcellular location: 
Cytoplasm.
PTM: 
Phosphoprotein;
Disease: 
Cerebral cavernous malformations 2 (CCM2) [MIM:603284]: A congenital vascular anomaly of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAEB01193 CCM2 Antibody (OAEB01193) Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish WB 0.1mg $289 Details
Polyclonal Antibody OAAB03986 CCM2 antibody - N-terminal region (OAAB03986) Human WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody ARP60630_P050 CCM2 Antibody (ARP60630_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Not tested 50 ug $125 Details
Polyclonal Antibody OAAB13588 CCM2 antibody - C - terminal region (OAAB13588) Human WB 400ul $289 Details

Show all CCM2 antibodies


Product Images
CCM2 Antibody (OAEB01193) in Human Heart cells using Western Blot

Sample Type: Human Heart


CCM2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60630 Bovine CCM2 antibody; Bos taurus CCM2 antibody E1B8H2 100.0%
ARP60630 Cat CCM2 antibody; Felis catus CCM2 antibody M3WFG3 100.0%
ARP60630 Chicken CCM2 antibody; Gallus gallus CCM2 antibody E1C144 86.0%
ARP60630 Chimpanzee CCM2 antibody; Pan troglodytes CCM2 antibody H2QUJ0 100.0%
ARP60630 Chimpanzee CCM2 antibody; Pan troglodytes CCM2 antibody K7BA80 100.0%
ARP60630 Chimpanzee CCM2 antibody; Pan troglodytes CCM2 antibody K7BXD2 100.0%
ARP60630 Chimpanzee CCM2 antibody; Pan troglodytes CCM2 antibody K7BYQ0 100.0%
ARP60630 Chimpanzee CCM2 antibody; Pan troglodytes CCM2 antibody K7D555 100.0%
ARP60630 Chinese softshell turtle CCM2 antibody; Pelodiscus sinensis CCM2 antibody K7FE94 86.0%
ARP60630 Chinese softshell turtle CCM2 antibody; Pelodiscus sinensis CCM2 antibody K7FEA4 86.0%
ARP60630 Collared flycatcher CCM2 antibody; Ficedula albicollis CCM2 antibody U3KE02 86.0%
ARP60630 Dog CCM2 antibody; Canis familiaris CCM2 antibody F1PI83 100.0%
ARP60630 Dog CCM2 antibody; Canis familiaris CCM2 antibody F1Q1Q9 100.0%
ARP60630 Domestic duck CCM2 antibody; Anas platyrhynchos CCM2 antibody U3J0F3 86.0%
ARP60630 Duckbill platypus CCM2 antibody; Ornithorhynchus anatinus CCM2 antibody F7G409 86.0%
ARP60630 European domestic ferret CCM2 antibody; Mustela putorius furo CCM2 antibody M3Z3B3 100.0%
ARP60630 Gray short-tailed opossum CCM2 antibody; Monodelphis domestica CCM2 antibody F7G883 93.0%
ARP60630 Horse CCM2 antibody; Equus caballus CCM2 antibody F6Z7I5 100.0%
ARP60630 Human CCM2 antibody; Homo sapiens CCM2 antibody C9JUH3 100.0%
ARP60630 Human CCM2 antibody; Homo sapiens CCM2 antibody E9PEC4 100.0%
ARP60630 Human CCM2 antibody; Homo sapiens CCM2 antibody Q6P456 100.0%
ARP60630 Human CCM2 antibody; Homo sapiens CCM2 antibody Q9BSQ5-2 100.0%
ARP60630 Human CCM2 antibody; Homo sapiens CCM2 antibody Q9BSQ5-3 100.0%
ARP60630 Human CCM2 antibody; Homo sapiens CCM2 antibody Q9BSQ5 100.0%
ARP60630 Mouse CCM2 antibody; Mus musculus CCM2 antibody E0CXR5 100.0%
ARP60630 Mouse CCM2 antibody; Mus musculus CCM2 antibody E0CYY2 100.0%
ARP60630 Mouse CCM2 antibody; Mus musculus CCM2 antibody Q8K2Y9-2 100.0%
ARP60630 Mouse CCM2 antibody; Mus musculus CCM2 antibody Q8K2Y9 100.0%
ARP60630 Northern white-cheeked gibbon CCM2 antibody; Nomascus leucogenys CCM2 antibody G1QVN9 100.0%
ARP60630 Pig CCM2 antibody; Sus scrofa CCM2 antibody F1ST61 100.0%
ARP60630 Rabbit CCM2 antibody; Oryctolagus cuniculus CCM2 antibody G1T9C9 100.0%
ARP60630 Rat CCM2 antibody; Rattus norvegicus CCM2 antibody B1H273 100.0%
ARP60630 Rhesus macaque CCM2 antibody; Macaca mulatta CCM2 antibody H9G0F7 100.0%
ARP60630 Rhesus macaque CCM2 antibody; Macaca mulatta CCM2 antibody H9G0F8 100.0%
ARP60630 Rhesus macaque CCM2 antibody; Macaca mulatta CCM2 antibody F7GGE7 100.0%
ARP60630 Small-eared galago CCM2 antibody; Otolemur garnettii CCM2 antibody H0WW12 100.0%
ARP60630 Spotted green pufferfish CCM2 antibody; Tetraodon nigroviridis CCM2 antibody H3CEX3 85.0%
ARP60630 Sumatran orangutan CCM2 antibody; Pongo abelii CCM2 antibody H2PM69 100.0%
ARP60630 Tasmanian devil CCM2 antibody; Sarcophilus harrisii CCM2 antibody G3VYU4 93.0%
ARP60630 Tasmanian devil CCM2 antibody; Sarcophilus harrisii CCM2 antibody G3VYU5 93.0%
ARP60630 Thirteen-lined ground squirrel CCM2 antibody; Spermophilus tridecemlineatus CCM2 antibody I3ND06 100.0%
ARP60630 White-tufted-ear marmoset CCM2 antibody; Callithrix jacchus CCM2 antibody F6RW31 100.0%
ARP60630 White-tufted-ear marmoset CCM2 antibody; Callithrix jacchus CCM2 antibody F6S5C3 100.0%
ARP60630 White-tufted-ear marmoset CCM2 antibody; Callithrix jacchus CCM2 antibody F6SS51 100.0%
ARP60630 White-tufted-ear marmoset CCM2 antibody; Callithrix jacchus CCM2 antibody F6SSD4 100.0%
ARP60630 White-tufted-ear marmoset CCM2 antibody; Callithrix jacchus CCM2 antibody F6ST97 100.0%
ARP60630 White-tufted-ear marmoset CCM2 antibody; Callithrix jacchus CCM2 antibody U3DVT3 100.0%
ARP60630 White-tufted-ear marmoset CCM2 antibody; Callithrix jacchus CCM2 antibody U3EKL2 100.0%
ARP60630 Zebra finch CCM2 antibody; Taeniopygia guttata CCM2 antibody H0ZXP2 86.0%
ARP60630 Zebrafish CCM2 antibody; Danio rerio CCM2 antibody B5DDE0 85.0%
ARP60630 Zebrafish CCM2 antibody; Danio rerio CCM2 antibody Q6DRP4-2 85.0%
ARP60630 Zebrafish CCM2 antibody; Danio rerio CCM2 antibody Q6DRP4 85.0%

Tissue & Cell Line Gene Expression Data