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Gene ID: 875 | CBS Antibody Resource


CBS Antibody Resource
Gene Full Name: 
cystathionine-beta-synthase
Uniprot: 
P35520
Protein Name: 
cystathionine beta-synthase
Nucleotide: 
NM_001178009
Alias: 
HIP4;
Ensembl: 
ENSG00000160200
Location: 
21q22.3
HPRD: 
01994
NCBI Gene: 
875
MIM: 
613381

Summary: 
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2010]
Function: 
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury .
Subcellular location: 
Cytoplasm. Nucleus .
PTM: 
Isopeptide bond;
Disease: 
Cystathionine beta-synthase deficiency (CBSD) [MIM:236200]: An enzymatic deficiency resulting in altered sulfur metabolism and homocystinuria. The clinical features of untreated homocystinuria due to CBS deficiency include myopia, ectopia lentis, mental retardation, skeletal anomalies resembling Marfan syndrome, and thromboembolic events. Light skin and hair can also be present. Biochemical features include increased urinary homocystine and methionine. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP45746_T100 CBS antibody - N-terminal region (ARP45746_T100) Polyclonal Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat, Zebrafish IHC, WB 100ug $229 Details
Protein Lysate APL10364 CBS Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
Protein Lysate APL10365 CBS Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
DNA/cDNA/RNA ANA10364 CBS (Human) cDNA (1ug) 1ug $189 Details
DNA/cDNA/RNA ANA10365 CBS (Human) cDNA (1ug) 1ug $189 Details
Polyclonal Antibody OAAB04080 CBS antibody - N-terminal region (OAAB04080) Human; Mouse WB, FC, IHC 400ul $289 Details
Polyclonal Antibody OAAB04081 CBS antibody - center region (OAAB04081) Human; Mouse WB, IHC, FC, ELISA 400ul $289 Details
Polyclonal Antibody ARP45747_P050 CBS Antibody (ARP45747_P050) Polyclonal Horse, Human Not tested 50 ug $125 Details
Polyclonal Antibody OAGA01010 CBS antibody (OAGA01010) Polyclonal Human ICC/IF, IHC (Formalin-fixed paraffin-embedded sections), WB 100 ul $340 Details

Show all CBS antibodies


Product Images
CBS antibody - N-terminal region (ARP45746_T100) in HepG2 cells using Western Blot

Sample Type: HepG2

CBS antibody - N-terminal region (ARP45746_T100) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2

CBS antibody - N-terminal region (ARP45746_T100) in Human kidney cells using Western Blot

Sample Type: Human kidney

CBS antibody - N-terminal region (ARP45746_T100) in Human Kidney cells using Immunohistochemistry

Sample Type: Human Kidney

CBS antibody - N-terminal region (ARP45746_T100) in Mouse Brain cells using Immunohistochemistry

Sample Type: Mouse Brain

CBS antibody - center region (OAAB04081) in 293 cells using Flow Cytometry

Sample Type: 293

CBS antibody - center region (OAAB04081) in CBS cells using Western Blot

Sample Type: CBS

CBS antibody - center region (OAAB04081) in human brain cells using Immunohistochemistry

Sample Type: human brain

CBS antibody - center region (OAAB04081) in Mouse Kidney cells using Western Blot

Sample Type: Mouse Kidney


CBS Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP45746 African clawed frog CBS antibody; Xenopus laevis CBS antibody Q6DDN9 93.0%
ARP45746 African clawed frog CBS antibody; Xenopus laevis CBS antibody Q7ZXW6 93.0%
ARP45746 Bovine CBS antibody; Bos taurus CBS antibody A7MBF8 100.0%
ARP45746 Bovine CBS antibody; Bos taurus CBS antibody F1MEW4 100.0%
ARP45746 Cat CBS antibody; Felis catus CBS antibody M3W1B1 93.0%
ARP45747 Cat CBS antibody; Felis catus CBS antibody M3W1B1 86.0%
ARP45746 Chicken CBS antibody; Gallus gallus CBS antibody E1BYG4 93.0%
ARP45746 Chimpanzee CBS antibody; Pan troglodytes CBS antibody H2QL34 100.0%
ARP45747 Chimpanzee CBS antibody; Pan troglodytes CBS antibody H2QL34 100.0%
ARP45746 Chinese softshell turtle CBS antibody; Pelodiscus sinensis CBS antibody K7GJP4 93.0%
ARP45746 Chinese softshell turtle CBS antibody; Pelodiscus sinensis CBS antibody K7GJP6 93.0%
ARP45747 Chinese softshell turtle CBS antibody; Pelodiscus sinensis CBS antibody K7GJP4 79.0%
ARP45747 Chinese softshell turtle CBS antibody; Pelodiscus sinensis CBS antibody K7GJP6 79.0%
ARP45746 Collared flycatcher CBS antibody; Ficedula albicollis CBS antibody U3JH19 93.0%
ARP45746 Common turkey CBS antibody; Meleagris gallopavo CBS antibody G1NP20 93.0%
ARP45746 Crab-eating macaque CBS antibody; Macaca fascicularis CBS antibody Q58H57 100.0%
ARP45747 Crab-eating macaque CBS antibody; Macaca fascicularis CBS antibody Q58H57 100.0%
ARP45746 Dog CBS antibody; Canis familiaris CBS antibody J9P469 100.0%
ARP45746 Dog CBS antibody; Canis familiaris CBS antibody E2QXN9 100.0%
ARP45746 Domestic duck CBS antibody; Anas platyrhynchos CBS antibody U3IQA5 93.0%
ARP45746 Duckbill platypus CBS antibody; Ornithorhynchus anatinus CBS antibody F6R4A4 86.0%
ARP45746 European domestic ferret CBS antibody; Mustela putorius furo CBS antibody M3YE56 93.0%
ARP45746 Giant panda CBS antibody; Ailuropoda melanoleuca CBS antibody G1L4P8 93.0%
ARP45746 Gray short-tailed opossum CBS antibody; Monodelphis domestica CBS antibody F6QYX0 100.0%
ARP45746 Green anole CBS antibody; Anolis carolinensis CBS antibody G1KUE6 100.0%
ARP45747 Green anole CBS antibody; Anolis carolinensis CBS antibody G1KUE6 79.0%
ARP45746 Human CBS antibody; Homo sapiens CBS antibody F5H2U1 100.0%
ARP45747 Human CBS antibody; Homo sapiens CBS antibody F5H2U1 100.0%
ARP45746 Human CBS antibody; Homo sapiens CBS antibody P35520-2 100.0%
ARP45746 Human CBS antibody; Homo sapiens CBS antibody P35520 100.0%
ARP45747 Human CBS antibody; Homo sapiens CBS antibody P35520 100.0%
ARP45746 Hydra CBS antibody; Hydra vulgaris CBS antibody T2MGI5 86.0%
ARP45746 Mouse CBS antibody; Mus musculus CBS antibody Q91WT9-2 100.0%
ARP45746 Mouse CBS antibody; Mus musculus CBS antibody Q91WT9 100.0%
ARP45746 Northern white-cheeked gibbon CBS antibody; Nomascus leucogenys CBS antibody G1RXD7 100.0%
ARP45747 Northern white-cheeked gibbon CBS antibody; Nomascus leucogenys CBS antibody G1RXD7 100.0%
ARP45746 Rabbit CBS antibody; Oryctolagus cuniculus CBS antibody Q9N0V7 100.0%
ARP45746 Rabbit CBS antibody; Oryctolagus cuniculus CBS antibody G1TE53 100.0%
ARP45746 Rat CBS antibody; Rattus norvegicus CBS antibody P32232-2 100.0%
ARP45746 Rat CBS antibody; Rattus norvegicus CBS antibody P32232-3 100.0%
ARP45746 Rat CBS antibody; Rattus norvegicus CBS antibody P32232 100.0%
ARP45746 Rhesus macaque CBS antibody; Macaca mulatta CBS antibody H9EWI7 100.0%
ARP45747 Rhesus macaque CBS antibody; Macaca mulatta CBS antibody H9EWI7 100.0%
ARP45746 Small-eared galago CBS antibody; Otolemur garnettii CBS antibody H0XFH6 100.0%
ARP45746 Small-eared galago CBS antibody; Otolemur garnettii CBS antibody H0XNC8 100.0%
ARP45747 Small-eared galago CBS antibody; Otolemur garnettii CBS antibody H0XFH6 79.0%
ARP45746 Tasmanian devil CBS antibody; Sarcophilus harrisii CBS antibody G3WXK3 93.0%
ARP45747 Tasmanian devil CBS antibody; Sarcophilus harrisii CBS antibody G3WXK3 79.0%
ARP45746 Thirteen-lined ground squirrel CBS antibody; Spermophilus tridecemlineatus CBS antibody I3MY56 100.0%
ARP45747 Thirteen-lined ground squirrel CBS antibody; Spermophilus tridecemlineatus CBS antibody I3MY56 79.0%
ARP45746 Western clawed frog CBS antibody; Xenopus tropicalis CBS antibody Q640V0 100.0%
ARP45747 Western clawed frog CBS antibody; Xenopus tropicalis CBS antibody F6PUJ6 83.0%
ARP45746 White-tufted-ear marmoset CBS antibody; Callithrix jacchus CBS antibody F6R0S5 93.0%
ARP45746 White-tufted-ear marmoset CBS antibody; Callithrix jacchus CBS antibody F6SUE8 93.0%
ARP45746 White-tufted-ear marmoset CBS antibody; Callithrix jacchus CBS antibody F7I7U8 93.0%
ARP45747 White-tufted-ear marmoset CBS antibody; Callithrix jacchus CBS antibody F6R0S5 79.0%
ARP45747 White-tufted-ear marmoset CBS antibody; Callithrix jacchus CBS antibody F6SUE8 79.0%
ARP45746 Yeast CBS antibody; Komagataella pastoris CBS antibody Q96V35 79.0%
ARP45746 Yeast CBS antibody; Komagataella pastoris CBS antibody Q8X1W5 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas212816_s_at721_B_lymphoblasts6.80013.220Details
BioGPS Gene Atlas212816_s_atAdipocyte7.60013.220Details
BioGPS Gene Atlas212816_s_atAdrenalCortex6.80013.220Details
BioGPS Gene Atlas212816_s_atAdrenalgland5.30013.220Details
BioGPS Gene Atlas212816_s_atAmygdala22.00013.220Details
BioGPS Gene Atlas212816_s_atAppendix6.30013.220Details
BioGPS Gene Atlas212816_s_atAtrioventricularNode5.25013.220Details
BioGPS Gene Atlas212816_s_atBDCA4+_DentriticCells6.05013.220Details
BioGPS Gene Atlas212816_s_atBonemarrow6.25013.220Details
BioGPS Gene Atlas212816_s_atBronchialEpithelialCells7.00013.220Details
BioGPS Gene Atlas212816_s_atCD105+_Endothelial6.10013.220Details
BioGPS Gene Atlas212816_s_atCD14+_Monocytes6.15013.220Details
BioGPS Gene Atlas212816_s_atCD19+_BCells(neg._sel.)6.30013.220Details
BioGPS Gene Atlas212816_s_atCD33+_Myeloid7.60013.220Details
BioGPS Gene Atlas212816_s_atCD34+7.20013.220Details
BioGPS Gene Atlas212816_s_atCD4+_Tcells6.35013.220Details
BioGPS Gene Atlas212816_s_atCD56+_NKCells6.95013.220Details
BioGPS Gene Atlas212816_s_atCD71+_EarlyErythroid5.80013.220Details
BioGPS Gene Atlas212816_s_atCD8+_Tcells5.45013.220Details
BioGPS Gene Atlas212816_s_atCardiacMyocytes22.50013.220Details
BioGPS Gene Atlas212816_s_atCaudatenucleus6.70013.220Details
BioGPS Gene Atlas212816_s_atCerebellum25.50013.220Details
BioGPS Gene Atlas212816_s_atCerebellumPeduncles22.70013.220Details
BioGPS Gene Atlas212816_s_atCiliaryGanglion4.35013.220Details
BioGPS Gene Atlas212816_s_atCingulateCortex8.60013.220Details
BioGPS Gene Atlas212816_s_atColorectaladenocarcinoma70.25013.220Details
BioGPS Gene Atlas212816_s_atDorsalRootGanglion4.70013.220Details
BioGPS Gene Atlas212816_s_atFetalThyroid6.30013.220Details
BioGPS Gene Atlas212816_s_atFetalbrain8.20013.220Details
BioGPS Gene Atlas212816_s_atFetalliver21.15013.220Details
BioGPS Gene Atlas212816_s_atFetallung5.95013.220Details
BioGPS Gene Atlas212816_s_atGlobusPallidus4.65013.220Details
BioGPS Gene Atlas212816_s_atHeart8.05013.220Details
BioGPS Gene Atlas212816_s_atHypothalamus9.80013.220Details
BioGPS Gene Atlas212816_s_atKidney5.05013.220Details
BioGPS Gene Atlas212816_s_atLeukemia_chronicMyelogenousK-562116.05013.220Details
BioGPS Gene Atlas212816_s_atLeukemia_promyelocytic-HL-6018.80013.220Details
BioGPS Gene Atlas212816_s_atLeukemialymphoblastic(MOLT-4)10.60013.220Details
BioGPS Gene Atlas212816_s_atLiver134.05013.220Details
BioGPS Gene Atlas212816_s_atLung7.15013.220Details
BioGPS Gene Atlas212816_s_atLymphnode5.10013.220Details
BioGPS Gene Atlas212816_s_atLymphoma_burkitts(Daudi)7.85013.220Details
BioGPS Gene Atlas212816_s_atLymphoma_burkitts(Raji)96.95013.220Details
BioGPS Gene Atlas212816_s_atMedullaOblongata7.05013.220Details
BioGPS Gene Atlas212816_s_atOccipitalLobe5.90013.220Details
BioGPS Gene Atlas212816_s_atOlfactoryBulb10.65013.220Details
BioGPS Gene Atlas212816_s_atOvary4.25013.220Details
BioGPS Gene Atlas212816_s_atPancreas32.55013.220Details
BioGPS Gene Atlas212816_s_atPancreaticIslet24.35013.220Details
BioGPS Gene Atlas212816_s_atParietalLobe9.20013.220Details
BioGPS Gene Atlas212816_s_atPituitary7.35013.220Details
BioGPS Gene Atlas212816_s_atPlacenta5.80013.220Details
BioGPS Gene Atlas212816_s_atPons6.05013.220Details
BioGPS Gene Atlas212816_s_atPrefrontalCortex15.30013.220Details
BioGPS Gene Atlas212816_s_atProstate17.20013.220Details
BioGPS Gene Atlas212816_s_atSalivarygland4.80013.220Details
BioGPS Gene Atlas212816_s_atSkeletalMuscle7.30013.220Details
BioGPS Gene Atlas212816_s_atSkin4.70013.220Details
BioGPS Gene Atlas212816_s_atSmoothMuscle12.70013.220Details
BioGPS Gene Atlas212816_s_atSpinalcord12.25013.220Details
BioGPS Gene Atlas212816_s_atSubthalamicNucleus7.80013.220Details
BioGPS Gene Atlas212816_s_atSuperiorCervicalGanglion7.35013.220Details
BioGPS Gene Atlas212816_s_atTemporalLobe5.80013.220Details
BioGPS Gene Atlas212816_s_atTestis5.00013.220Details
BioGPS Gene Atlas212816_s_atTestisGermCell4.90013.220Details
BioGPS Gene Atlas212816_s_atTestisIntersitial5.20013.220Details
BioGPS Gene Atlas212816_s_atTestisLeydigCell6.25013.220Details
BioGPS Gene Atlas212816_s_atTestisSeminiferousTubule5.20013.220Details
BioGPS Gene Atlas212816_s_atThalamus9.60013.220Details
BioGPS Gene Atlas212816_s_atThymus4.60013.220Details
BioGPS Gene Atlas212816_s_atThyroid15.80013.220Details
BioGPS Gene Atlas212816_s_atTongue6.05013.220Details
BioGPS Gene Atlas212816_s_atTonsil5.90013.220Details
BioGPS Gene Atlas212816_s_atTrachea5.45013.220Details
BioGPS Gene Atlas212816_s_atTrigeminalGanglion6.45013.220Details
BioGPS Gene Atlas212816_s_atUterus4.80013.220Details
BioGPS Gene Atlas212816_s_atUterusCorpus5.50013.220Details
BioGPS Gene Atlas212816_s_atWholeBlood6.55013.220Details
BioGPS Gene Atlas212816_s_atWholebrain20.90013.220Details
BioGPS Gene Atlas212816_s_atcolon6.05013.220Details
BioGPS Gene Atlas212816_s_atpineal_day7.74013.220Details
BioGPS Gene Atlas212816_s_atpineal_night7.46013.220Details
BioGPS Gene Atlas212816_s_atretina9.50013.220Details
BioGPS Gene Atlas212816_s_atsmall_intestine5.85013.220Details
BioGPS NCI60212816_s_at786187.224343.830Details
BioGPS NCI60212816_s_atA172674.335343.830Details
BioGPS NCI60212816_s_atA204415.237343.830Details
BioGPS NCI60212816_s_atA361181.176343.830Details
BioGPS NCI60212816_s_atA498136.907343.830Details
BioGPS NCI60212816_s_atA54967.672343.830Details
BioGPS NCI60212816_s_atACC320.986343.830Details
BioGPS NCI60212816_s_atACHN138.181343.830Details
BioGPS NCI60212816_s_atALVA3117.653343.830Details
BioGPS NCI60212816_s_atCAKI179.983343.830Details
BioGPS NCI60212816_s_atCCRT CEM26.406343.830Details
BioGPS NCI60212816_s_atCOLO20523.580343.830Details
BioGPS NCI60212816_s_atDLD17.325343.830Details
BioGPS NCI60212816_s_atDU145276.518343.830Details
BioGPS NCI60212816_s_atEKVX20.131343.830Details
BioGPS NCI60212816_s_atGM133154.020343.830Details
BioGPS NCI60212816_s_atGM160028.846343.830Details
BioGPS NCI60212816_s_atGM231332.427343.830Details
BioGPS NCI60212816_s_atGM234519.957343.830Details
BioGPS NCI60212816_s_atGM249368.505343.830Details
BioGPS NCI60212816_s_atGM978.311343.830Details
BioGPS NCI60212816_s_atHCC2998715.626343.830Details
BioGPS NCI60212816_s_atHCT11623.330343.830Details
BioGPS NCI60212816_s_atHCT157.107343.830Details
BioGPS NCI60212816_s_atHEK 293 T-rex67.752343.830Details
BioGPS NCI60212816_s_atHEK 293T1918.977343.830Details
BioGPS NCI60212816_s_atHEK293297.646343.830Details
BioGPS NCI60212816_s_atHELA58.851343.830Details
BioGPS NCI60212816_s_atHEPG2174.696343.830Details
BioGPS NCI60212816_s_atHL60151.142343.830Details
BioGPS NCI60212816_s_atHOP6223.325343.830Details
BioGPS NCI60212816_s_atHOP92254.895343.830Details
BioGPS NCI60212816_s_atHS578T264.942343.830Details
BioGPS NCI60212816_s_atHSG22.348343.830Details
BioGPS NCI60212816_s_atHT1080396.549343.830Details
BioGPS NCI60212816_s_atHT2925.255343.830Details
BioGPS NCI60212816_s_atIGROV11590.182343.830Details
BioGPS NCI60212816_s_atIOSE80340.854343.830Details
BioGPS NCI60212816_s_atJURKAT226.500343.830Details
BioGPS NCI60212816_s_atK5621194.765343.830Details
BioGPS NCI60212816_s_atKM1224.510343.830Details
BioGPS NCI60212816_s_atLN181683.303343.830Details
BioGPS NCI60212816_s_atLNCAP431.698343.830Details
BioGPS NCI60212816_s_atLOX IMVI88.096343.830Details
BioGPS NCI60212816_s_atM1493.839343.830Details
BioGPS NCI60212816_s_atMALME 3M58.260343.830Details
BioGPS NCI60212816_s_atMCF7892.121343.830Details
BioGPS NCI60212816_s_atMD MB23123.634343.830Details
BioGPS NCI60212816_s_atMDA MB435123.755343.830Details
BioGPS NCI60212816_s_atMOLT4237.053343.830Details
BioGPS NCI60212816_s_atNCI 460212.063343.830Details
BioGPS NCI60212816_s_atNCI H226762.460343.830Details
BioGPS NCI60212816_s_atNCI H23518.617343.830Details
BioGPS NCI60212816_s_atNCI H322M102.872343.830Details
BioGPS NCI60212816_s_atNCVADR RES2734.826343.830Details
BioGPS NCI60212816_s_atOVCAR3109.323343.830Details
BioGPS NCI60212816_s_atOVCAR41083.634343.830Details
BioGPS NCI60212816_s_atOVCAR5221.880343.830Details
BioGPS NCI60212816_s_atOVCAR8997.035343.830Details
BioGPS NCI60212816_s_atPANC1437.736343.830Details
BioGPS NCI60212816_s_atRL723.779343.830Details
BioGPS NCI60212816_s_atRPMI 8226504.317343.830Details
BioGPS NCI60212816_s_atRS1184624.718343.830Details
BioGPS NCI60212816_s_atRXF393145.569343.830Details
BioGPS NCI60212816_s_atSAOS2515.861343.830Details
BioGPS NCI60212816_s_atSF268263.232343.830Details
BioGPS NCI60212816_s_atSF29588.441343.830Details
BioGPS NCI60212816_s_atSF53922.009343.830Details
BioGPS NCI60212816_s_atSHSYSY+RA960.851343.830Details
BioGPS NCI60212816_s_atSHSYSY-RA467.190343.830Details
BioGPS NCI60212816_s_atSKMEL222.811343.830Details
BioGPS NCI60212816_s_atSKMEL28156.868343.830Details
BioGPS NCI60212816_s_atSKMEL5340.991343.830Details
BioGPS NCI60212816_s_atSKOV376.030343.830Details
BioGPS NCI60212816_s_atSN12C199.890343.830Details
BioGPS NCI60212816_s_atSNB1943.433343.830Details
BioGPS NCI60212816_s_atSNB75740.373343.830Details
BioGPS NCI60212816_s_atSR16.146343.830Details
BioGPS NCI60212816_s_atSW62032.733343.830Details
BioGPS NCI60212816_s_atT24134.045343.830Details
BioGPS NCI60212816_s_atT3M4216.963343.830Details
BioGPS NCI60212816_s_atTK1086.998343.830Details
BioGPS NCI60212816_s_atU11841.807343.830Details
BioGPS NCI60212816_s_atU138153.396343.830Details
BioGPS NCI60212816_s_atU20S191.280343.830Details
BioGPS NCI60212816_s_atU251146.999343.830Details
BioGPS NCI60212816_s_atU8787.329343.830Details
BioGPS NCI60212816_s_atUACC257154.092343.830Details
BioGPS NCI60212816_s_atUACC621016.807343.830Details
BioGPS NCI60212816_s_atUO3187.061343.830Details
BioGPS NCI60212816_s_atZR75_1135.135343.830Details
BioGPS NCI60212816_s_atastrocytes940.303343.830Details
BioGPS NCI60212816_s_athuh-7203.797343.830Details