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Gene ID: 117144 | CATSPER1 Antibody Resource


CATSPER1 Antibody Resource
Gene Full Name: 
cation channel, sperm associated 1
Uniprot: 
Q8NEC5
Protein Name: 
cation channel sperm-associated protein 1
Nucleotide: 
NM_053054
Alias: 
SPGF7;CATSPER;
Ensembl: 
ENSG00000175294
Location: 
11q12.1
HPRD: 
09396
NCBI Gene: 
117144
MIM: 
606389

Summary: 
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]
Function: 
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Subcellular location: 
Cell projection › cilium › flagellum membrane; Multi-pass membrane protein. Note: Specifically located in the principal piece of sperm tail.
PTM: 
Disease: 
Spermatogenic failure 7 (SPGF7) [MIM:612997]: An infertility disorder characterized by non-motile sperm or sperm motility below the normal threshold, low sperm count, increased abnormally structured spermatozoa, and reduced semen volume. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP35386_P050 CATSPER1 Antibody (ARP35386_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody ARP35387_P050 CATSPER1 Antibody (ARP35387_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAB09281 CATSPER1 antibody - N - terminal region (OAAB09281) Human WB 400ul $289 Details

Show all CATSPER1 antibodies


Product Images
CATSPER1 antibody - N - terminal region (OAAB09281) in HepG2 cells using Western Blot

Sample Type: HepG2


CATSPER1 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP35386 Angolan talapoin CATSPER1 antibody; Miopithecus talapoin CATSPER1 antibody Q6TYQ7 93.0%
ARP35387 Angolan talapoin CATSPER1 antibody; Miopithecus talapoin CATSPER1 antibody Q6TYQ7 92.0%
ARP35386 Bornean orangutan CATSPER1 antibody; Pongo pygmaeus CATSPER1 antibody Q6TYP9 93.0%
ARP35387 Bornean orangutan CATSPER1 antibody; Pongo pygmaeus CATSPER1 antibody Q6TYP9 93.0%
ARP35386 Chimpanzee CATSPER1 antibody; Pan troglodytes CATSPER1 antibody H2Q455 100.0%
ARP35387 Chimpanzee CATSPER1 antibody; Pan troglodytes CATSPER1 antibody H2Q455 100.0%
ARP35386 Chimpanzee CATSPER1 antibody; Pan troglodytes CATSPER1 antibody Q6TYQ2 100.0%
ARP35387 Chimpanzee CATSPER1 antibody; Pan troglodytes CATSPER1 antibody Q6TYQ2 100.0%
ARP35386 Green monkey CATSPER1 antibody; Chlorocebus aethiops CATSPER1 antibody Q6TYQ5 93.0%
ARP35387 Green monkey CATSPER1 antibody; Chlorocebus aethiops CATSPER1 antibody Q6TYQ5 91.0%
ARP35386 Hamadryas baboon CATSPER1 antibody; Papio hamadryas CATSPER1 antibody Q6TYQ4 93.0%
ARP35387 Hamadryas baboon CATSPER1 antibody; Papio hamadryas CATSPER1 antibody Q6TYQ4 92.0%
ARP35386 Human CATSPER1 antibody; Homo sapiens CATSPER1 antibody Q8NEC5 100.0%
ARP35387 Human CATSPER1 antibody; Homo sapiens CATSPER1 antibody Q8NEC5 100.0%
ARP35386 Mantled guereza CATSPER1 antibody; Colobus guereza CATSPER1 antibody Q6TYQ3 93.0%
ARP35386 Northern white-cheeked gibbon CATSPER1 antibody; Nomascus leucogenys CATSPER1 antibody G1R245 93.0%
ARP35387 Northern white-cheeked gibbon CATSPER1 antibody; Nomascus leucogenys CATSPER1 antibody G1R245 93.0%
ARP35386 Pygmy chimpanzee CATSPER1 antibody; Pan paniscus CATSPER1 antibody Q6TYQ1 100.0%
ARP35387 Pygmy chimpanzee CATSPER1 antibody; Pan paniscus CATSPER1 antibody Q6TYQ1 100.0%
ARP35387 Rhesus macaque CATSPER1 antibody; Macaca mulatta CATSPER1 antibody Q6TYQ6 92.0%
ARP35387 Rhesus macaque CATSPER1 antibody; Macaca mulatta CATSPER1 antibody F7B7J2 92.0%
ARP35386 Rhesus macaque CATSPER1 antibody; Macaca mulatta CATSPER1 antibody Q6TYQ6 86.0%
ARP35386 Rhesus macaque CATSPER1 antibody; Macaca mulatta CATSPER1 antibody F7B7J2 86.0%
ARP35386 Sumatran orangutan CATSPER1 antibody; Pongo abelii CATSPER1 antibody H2NCS7 93.0%
ARP35387 Sumatran orangutan CATSPER1 antibody; Pongo abelii CATSPER1 antibody H2NCS7 93.0%
ARP35387 western gorilla CATSPER1 antibody; Gorilla gorilla CATSPER1 antibody Q6TYQ0 100.0%
ARP35386 western gorilla CATSPER1 antibody; Gorilla gorilla CATSPER1 antibody Q6TYQ0 79.0%

Tissue & Cell Line Gene Expression Data