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Gene ID: 100506742 | CASP12 Antibody Resource


CASP12 Antibody Resource
Gene Full Name: 
caspase 12 (gene/pseudogene)
Uniprot: 
Q6UXS9
Protein Name: 
inactive caspase-12
Nucleotide: 
NM_001191016
Alias: 
CASP-12;CASP12P1;
Ensembl: 
ENSG00000204403
Location: 
11q22.3
HPRD: 
NCBI Gene: 
100506742
MIM: 
608633

Summary: 
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
Function: 
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Subcellular location: 
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OASA07117 Casp12 Antibody (OASA07117) Mouse IHC-FFPE, WB 0.1mg $310 Details
Polyclonal Antibody OASA07118 Casp12 Antibody (OASA07118) Mouse IHC-FFPE, WB 50ug $220 Details
Polyclonal Antibody OASA07119 Casp12 Antibody (OASA07119) Mouse IHC-FFPE, WB 0.1mg $360 Details
Polyclonal Antibody OASA07120 Casp12 Antibody (OASA07120) Mouse IHC-FFPE, WB 50ug $265 Details
Polyclonal Antibody OAMA03410 Rabbit anti Caspase 12 (N-terminal) Antibody (0.1mg) WB, IHC 0.1mg $500 Details
Polyclonal Antibody OARA02087 CASP12 Antibody (OARA02087) ELISA, WB, IHC 100ug $450 Details
Polyclonal Antibody OAAB08271 CASP12 antibody - center region (OAAB08271) Human WB, IHC, FC, IF 400ul $289 Details

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Product Images
CASP12 antibody - center region (OAAB08271) in 293 cells using Immunofluorescence

Sample Type: 293

CASP12 antibody - center region (OAAB08271) in HL-60 cells using Flow Cytometry

Sample Type: HL-60

CASP12 antibody - center region (OAAB08271) in HL-60 cells using Western Blot

Sample Type: HL-60

CASP12 antibody - center region (OAAB08271) in Human Stomach cells using Immunohistochemistry

Sample Type: Human Stomach

Casp12 Antibody (OASA07117) in Mouse Liver cells using Immunohistochemistry

Sample Type: Mouse Liver

Casp12 Antibody (OASA07118) in Mouse Liver cells using Immunohistochemistry

Sample Type: Mouse Liver

Casp12 Antibody (OASA07119) in human heart cells using Immunohistochemistry

Sample Type: human heart

Casp12 Antibody (OASA07120) in human heart cells using Immunohistochemistry

Sample Type: human heart


CASP12 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP58984 Sumatran orangutan CASP12 antibody; Pongo abelii CASP12 antibody H2NF43 85.0%

Tissue & Cell Line Gene Expression Data