Gene ID: 100506742 | CASP12 Antibody Resource
CASP12 Antibody Resource
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Summary: | Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011] |
Function: | Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. |
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Antibodies
| Type | Catalog | Name | Clonality | Species Reactivity | Application | Size | Price | More Info |
|---|---|---|---|---|---|---|---|---|
| Polyclonal Antibody | OASA07117 | Casp12 Antibody (OASA07117) | Mouse | IHC-FFPE, WB | 0.1mg | $310 | Details | |
| Polyclonal Antibody | OASA07118 | Casp12 Antibody (OASA07118) | Mouse | IHC-FFPE, WB | 50ug | $220 | Details | |
| Polyclonal Antibody | OASA07119 | Casp12 Antibody (OASA07119) | Mouse | IHC-FFPE, WB | 0.1mg | $360 | Details | |
| Polyclonal Antibody | OASA07120 | Casp12 Antibody (OASA07120) | Mouse | IHC-FFPE, WB | 50ug | $265 | Details | |
| Polyclonal Antibody | OAMA03410 | Rabbit anti Caspase 12 (N-terminal) Antibody (0.1mg) | WB, IHC | 0.1mg | $500 | Details | ||
| Polyclonal Antibody | OARA02087 | CASP12 Antibody (OARA02087) | ELISA, WB, IHC | 100ug | $450 | Details | ||
| Polyclonal Antibody | OAAB08271 | CASP12 antibody - center region (OAAB08271) | Human | WB, IHC, FC, IF | 400ul | $289 | Details |
Product Images
 Sample Type: 293 |
 Sample Type: HL-60 |
 Sample Type: HL-60 |
 Sample Type: Human Stomach |
 Sample Type: Mouse Liver |
 Sample Type: Mouse Liver |
 Sample Type: human heart |
 Sample Type: human heart |
CASP12 Protocols
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Publications
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Related Gene Trend Categories
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Species
| Catalog | Predicted Species & Target | Target Reference | Predicted Homology |
|---|---|---|---|
| ARP58984 | Sumatran orangutan CASP12 antibody; Pongo abelii CASP12 antibody | H2NF43 | 85.0% |
Tissue & Cell Line Gene Expression Data