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Gene ID: 57082 | CASC5 Antibody Resource


CASC5 Antibody Resource
Gene Full Name: 
cancer susceptibility candidate 5
Uniprot: 
Q8NG31
Protein Name: 
protein CASC5
Nucleotide: 
NM_170589
Alias: 
D40;CT29;KNL1;Spc7;hKNL-1;AF15Q14;PPP1R55;hSpc105;
Ensembl: 
ENSG00000137812
Location: 
15q14
HPRD: 
10634
NCBI Gene: 
57082
MIM: 
609173

Summary: 
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11;15)(q23;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013]
Function: 
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
Subcellular location: 
Nucleus. Chromosome › centromere › kinetochore. Note: Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle.
PTM: 
Phosphoprotein;
Disease: 
A chromosomal aberration involving CASC5 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with KMT2A/MLL1. May give rise to a KMT2A/MLL1-CASC5 fusion protein.Microcephaly 4, primary, autosomal recessive (MCPH4) [MIM:604321]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP49092_P050 CASC5 Antibody (ARP49092_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody ARP49093_P050 CASC5 Antibody (ARP49093_P050) Polyclonal Horse, Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAB14791 Mouse Casc5 antibody - C - terminal region (OAAB14791) Mouse WB 400ul $289 Details

Show all CASC5 antibodies


Product Images
Mouse Casc5 antibody - C - terminal region (OAAB14791) in Mouse Kidney cells using Western Blot

Sample Type: Mouse Kidney


CASC5 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP49093 Chimpanzee CASC5 antibody; Pan troglodytes CASC5 antibody H2QZH8 100.0%
ARP49093 Horse CASC5 antibody; Equus caballus CASC5 antibody F6ZH89 83.0%
ARP49093 Human CASC5 antibody; Homo sapiens CASC5 antibody H0YCZ2 100.0%
ARP49093 Human CASC5 antibody; Homo sapiens CASC5 antibody Q8NG31-2 100.0%
ARP49093 Human CASC5 antibody; Homo sapiens CASC5 antibody Q8NG31-3 100.0%
ARP49093 Human CASC5 antibody; Homo sapiens CASC5 antibody Q8NG31-4 100.0%
ARP49092 Human CASC5 antibody; Homo sapiens CASC5 antibody Q8NG31 100.0%
ARP49093 Human CASC5 antibody; Homo sapiens CASC5 antibody Q8NG31 100.0%
ARP49093 Little brown bat CASC5 antibody; Myotis lucifugus CASC5 antibody G1PQP6 79.0%
ARP49093 Little brown bat CASC5 antibody; Myotis lucifugus CASC5 antibody G1Q5F0 79.0%
ARP49093 Northern white-cheeked gibbon CASC5 antibody; Nomascus leucogenys CASC5 antibody G1QS69 100.0%
ARP49092 Northern white-cheeked gibbon CASC5 antibody; Nomascus leucogenys CASC5 antibody G1QS69 86.0%
ARP49092 Sumatran orangutan CASC5 antibody; Pongo abelii CASC5 antibody H2NMU8 92.0%
ARP49093 Sumatran orangutan CASC5 antibody; Pongo abelii CASC5 antibody H2NMU8 86.0%
ARP49093 White-tufted-ear marmoset CASC5 antibody; Callithrix jacchus CASC5 antibody F7IG50 86.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas220247_at721_B_lymphoblasts8.8009.360Details
BioGPS Gene Atlas220247_atAdipocyte8.0509.360Details
BioGPS Gene Atlas220247_atAdrenalCortex13.3009.360Details
BioGPS Gene Atlas220247_atAdrenalgland7.8509.360Details
BioGPS Gene Atlas220247_atAmygdala7.7009.360Details
BioGPS Gene Atlas220247_atAppendix19.2509.360Details
BioGPS Gene Atlas220247_atAtrioventricularNode13.1009.360Details
BioGPS Gene Atlas220247_atBDCA4+_DentriticCells8.1509.360Details
BioGPS Gene Atlas220247_atBonemarrow9.8509.360Details
BioGPS Gene Atlas220247_atBronchialEpithelialCells7.7009.360Details
BioGPS Gene Atlas220247_atCD105+_Endothelial8.4009.360Details
BioGPS Gene Atlas220247_atCD14+_Monocytes9.1009.360Details
BioGPS Gene Atlas220247_atCD19+_BCells(neg._sel.)8.7009.360Details
BioGPS Gene Atlas220247_atCD33+_Myeloid11.1009.360Details
BioGPS Gene Atlas220247_atCD34+9.6509.360Details
BioGPS Gene Atlas220247_atCD4+_Tcells8.5009.360Details
BioGPS Gene Atlas220247_atCD56+_NKCells9.5009.360Details
BioGPS Gene Atlas220247_atCD71+_EarlyErythroid8.6009.360Details
BioGPS Gene Atlas220247_atCD8+_Tcells7.2009.360Details
BioGPS Gene Atlas220247_atCardiacMyocytes16.5509.360Details
BioGPS Gene Atlas220247_atCaudatenucleus7.8009.360Details
BioGPS Gene Atlas220247_atCerebellum7.0509.360Details
BioGPS Gene Atlas220247_atCerebellumPeduncles11.1509.360Details
BioGPS Gene Atlas220247_atCiliaryGanglion8.3009.360Details
BioGPS Gene Atlas220247_atCingulateCortex9.0509.360Details
BioGPS Gene Atlas220247_atColorectaladenocarcinoma8.2009.360Details
BioGPS Gene Atlas220247_atDorsalRootGanglion8.6009.360Details
BioGPS Gene Atlas220247_atFetalThyroid8.5009.360Details
BioGPS Gene Atlas220247_atFetalbrain8.1009.360Details
BioGPS Gene Atlas220247_atFetalliver7.4009.360Details
BioGPS Gene Atlas220247_atFetallung5.7509.360Details
BioGPS Gene Atlas220247_atGlobusPallidus7.4009.360Details
BioGPS Gene Atlas220247_atHeart15.0009.360Details
BioGPS Gene Atlas220247_atHypothalamus8.6009.360Details
BioGPS Gene Atlas220247_atKidney8.3009.360Details
BioGPS Gene Atlas220247_atLeukemia_chronicMyelogenousK-5627.6009.360Details
BioGPS Gene Atlas220247_atLeukemia_promyelocytic-HL-607.5009.360Details
BioGPS Gene Atlas220247_atLeukemialymphoblastic(MOLT-4)6.4009.360Details
BioGPS Gene Atlas220247_atLiver16.0509.360Details
BioGPS Gene Atlas220247_atLung9.2009.360Details
BioGPS Gene Atlas220247_atLymphnode7.0009.360Details
BioGPS Gene Atlas220247_atLymphoma_burkitts(Daudi)11.5009.360Details
BioGPS Gene Atlas220247_atLymphoma_burkitts(Raji)14.2009.360Details
BioGPS Gene Atlas220247_atMedullaOblongata7.3509.360Details
BioGPS Gene Atlas220247_atOccipitalLobe7.6509.360Details
BioGPS Gene Atlas220247_atOlfactoryBulb6.5009.360Details
BioGPS Gene Atlas220247_atOvary7.5509.360Details
BioGPS Gene Atlas220247_atPancreas7.3009.360Details
BioGPS Gene Atlas220247_atPancreaticIslet9.3509.360Details
BioGPS Gene Atlas220247_atParietalLobe10.3009.360Details
BioGPS Gene Atlas220247_atPituitary9.8009.360Details
BioGPS Gene Atlas220247_atPlacenta7.8509.360Details
BioGPS Gene Atlas220247_atPons8.9009.360Details
BioGPS Gene Atlas220247_atPrefrontalCortex9.6009.360Details
BioGPS Gene Atlas220247_atProstate9.3509.360Details
BioGPS Gene Atlas220247_atSalivarygland7.3509.360Details
BioGPS Gene Atlas220247_atSkeletalMuscle16.4009.360Details
BioGPS Gene Atlas220247_atSkin11.9009.360Details
BioGPS Gene Atlas220247_atSmoothMuscle9.6009.360Details
BioGPS Gene Atlas220247_atSpinalcord9.0509.360Details
BioGPS Gene Atlas220247_atSubthalamicNucleus10.4509.360Details
BioGPS Gene Atlas220247_atSuperiorCervicalGanglion21.4509.360Details
BioGPS Gene Atlas220247_atTemporalLobe8.4509.360Details
BioGPS Gene Atlas220247_atTestis7.1509.360Details
BioGPS Gene Atlas220247_atTestisGermCell6.4509.360Details
BioGPS Gene Atlas220247_atTestisIntersitial7.2509.360Details
BioGPS Gene Atlas220247_atTestisLeydigCell9.0509.360Details
BioGPS Gene Atlas220247_atTestisSeminiferousTubule7.2509.360Details
BioGPS Gene Atlas220247_atThalamus9.4509.360Details
BioGPS Gene Atlas220247_atThymus6.0009.360Details
BioGPS Gene Atlas220247_atThyroid9.1009.360Details
BioGPS Gene Atlas220247_atTongue9.9009.360Details
BioGPS Gene Atlas220247_atTonsil8.9509.360Details
BioGPS Gene Atlas220247_atTrachea7.0009.360Details
BioGPS Gene Atlas220247_atTrigeminalGanglion14.3009.360Details
BioGPS Gene Atlas220247_atUterus6.3509.360Details
BioGPS Gene Atlas220247_atUterusCorpus8.9009.360Details
BioGPS Gene Atlas220247_atWholeBlood8.6509.360Details
BioGPS Gene Atlas220247_atWholebrain6.0509.360Details
BioGPS Gene Atlas220247_atcolon7.9509.360Details
BioGPS Gene Atlas220247_atpineal_day10.1609.360Details
BioGPS Gene Atlas220247_atpineal_night9.9809.360Details
BioGPS Gene Atlas220247_atretina10.2759.360Details
BioGPS Gene Atlas220247_atsmall_intestine7.5009.360Details
BioGPS NCI60220247_at7869.4799.280Details
BioGPS NCI60220247_atA1727.5019.280Details
BioGPS NCI60220247_atA2048.7199.280Details
BioGPS NCI60220247_atA3619.0109.280Details
BioGPS NCI60220247_atA4988.5529.280Details
BioGPS NCI60220247_atA5499.1069.280Details
BioGPS NCI60220247_atACC310.6629.280Details
BioGPS NCI60220247_atACHN7.3599.280Details
BioGPS NCI60220247_atALVA3111.8049.280Details
BioGPS NCI60220247_atCAKI110.1549.280Details
BioGPS NCI60220247_atCCRT CEM23.1599.280Details
BioGPS NCI60220247_atCOLO2058.8709.280Details
BioGPS NCI60220247_atDLD18.4209.280Details
BioGPS NCI60220247_atDU1457.8879.280Details
BioGPS NCI60220247_atEKVX7.6269.280Details
BioGPS NCI60220247_atGM1339.9409.280Details
BioGPS NCI60220247_atGM160010.7969.280Details
BioGPS NCI60220247_atGM231310.2399.280Details
BioGPS NCI60220247_atGM23458.5909.280Details
BioGPS NCI60220247_atGM249311.1979.280Details
BioGPS NCI60220247_atGM9719.3339.280Details
BioGPS NCI60220247_atHCC29986.4899.280Details
BioGPS NCI60220247_atHCT1168.9179.280Details
BioGPS NCI60220247_atHCT157.5169.280Details
BioGPS NCI60220247_atHEK 293 T-rex11.9279.280Details
BioGPS NCI60220247_atHEK 293T8.4509.280Details
BioGPS NCI60220247_atHEK2938.3299.280Details
BioGPS NCI60220247_atHELA7.1379.280Details
BioGPS NCI60220247_atHEPG29.0669.280Details
BioGPS NCI60220247_atHL6014.6959.280Details
BioGPS NCI60220247_atHOP628.8199.280Details
BioGPS NCI60220247_atHOP927.8089.280Details
BioGPS NCI60220247_atHS578T8.6079.280Details
BioGPS NCI60220247_atHSG7.9019.280Details
BioGPS NCI60220247_atHT10808.4389.280Details
BioGPS NCI60220247_atHT2912.3459.280Details
BioGPS NCI60220247_atIGROV18.5599.280Details
BioGPS NCI60220247_atIOSE808.7129.280Details
BioGPS NCI60220247_atJURKAT8.6589.280Details
BioGPS NCI60220247_atK56212.2269.280Details
BioGPS NCI60220247_atKM1210.2049.280Details
BioGPS NCI60220247_atLN186.9569.280Details
BioGPS NCI60220247_atLNCAP8.7859.280Details
BioGPS NCI60220247_atLOX IMVI8.6339.280Details
BioGPS NCI60220247_atM148.8179.280Details
BioGPS NCI60220247_atMALME 3M11.1249.280Details
BioGPS NCI60220247_atMCF78.1909.280Details
BioGPS NCI60220247_atMD MB2319.2469.280Details
BioGPS NCI60220247_atMDA MB43512.2699.280Details
BioGPS NCI60220247_atMOLT412.8119.280Details
BioGPS NCI60220247_atNCI 4609.4099.280Details
BioGPS NCI60220247_atNCI H2269.7649.280Details
BioGPS NCI60220247_atNCI H238.8149.280Details
BioGPS NCI60220247_atNCI H322M8.5689.280Details
BioGPS NCI60220247_atNCVADR RES7.5739.280Details
BioGPS NCI60220247_atOVCAR312.3409.280Details
BioGPS NCI60220247_atOVCAR48.5529.280Details
BioGPS NCI60220247_atOVCAR58.1669.280Details
BioGPS NCI60220247_atOVCAR87.1579.280Details
BioGPS NCI60220247_atPANC19.1709.280Details
BioGPS NCI60220247_atRL79.9329.280Details
BioGPS NCI60220247_atRPMI 82269.5679.280Details
BioGPS NCI60220247_atRS1184610.6879.280Details
BioGPS NCI60220247_atRXF3938.7909.280Details
BioGPS NCI60220247_atSAOS28.8989.280Details
BioGPS NCI60220247_atSF2688.5819.280Details
BioGPS NCI60220247_atSF2957.8349.280Details
BioGPS NCI60220247_atSF5397.5689.280Details
BioGPS NCI60220247_atSHSYSY+RA7.9199.280Details
BioGPS NCI60220247_atSHSYSY-RA8.3969.280Details
BioGPS NCI60220247_atSKMEL28.6519.280Details
BioGPS NCI60220247_atSKMEL288.7949.280Details
BioGPS NCI60220247_atSKMEL57.4059.280Details
BioGPS NCI60220247_atSKOV39.8839.280Details
BioGPS NCI60220247_atSN12C8.5169.280Details
BioGPS NCI60220247_atSNB197.2849.280Details
BioGPS NCI60220247_atSNB758.4479.280Details
BioGPS NCI60220247_atSR9.8739.280Details
BioGPS NCI60220247_atSW6209.4159.280Details
BioGPS NCI60220247_atT249.2229.280Details
BioGPS NCI60220247_atT3M410.3049.280Details
BioGPS NCI60220247_atTK108.5809.280Details
BioGPS NCI60220247_atU1187.9369.280Details
BioGPS NCI60220247_atU1387.3249.280Details
BioGPS NCI60220247_atU20S8.1399.280Details
BioGPS NCI60220247_atU2518.3579.280Details
BioGPS NCI60220247_atU877.5769.280Details
BioGPS NCI60220247_atUACC2577.7819.280Details
BioGPS NCI60220247_atUACC629.1129.280Details
BioGPS NCI60220247_atUO317.6899.280Details
BioGPS NCI60220247_atZR75_111.7409.280Details
BioGPS NCI60220247_atastrocytes8.7709.280Details
BioGPS NCI60220247_athuh-79.4639.280Details