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Gene ID: 22794 | CASC3 Antibody Resource


CASC3 Antibody Resource
Gene Full Name: 
cancer susceptibility candidate 3
Uniprot: 
O15234
Protein Name: 
protein CASC3
Nucleotide: 
NM_007359
Alias: 
BTZ;MLN51;
Ensembl: 
ENSG00000108349
Location: 
17q21.1
HPRD: 
16225
NCBI Gene: 
22794
MIM: 
606504

Summary: 
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]
Function: 
Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons . May play a role in mRNA transport . Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer.
Subcellular location: 
Cytoplasm › perinuclear region. Nucleus. Nucleus speckle. Note: Predominantly found in the perinuclear region . Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress.
PTM: 
ADP-ribosylation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP54817_P050 CASC3 antibody - N-terminal region (ARP54817_P050) Polyclonal Bovine, Dog, Human, Mouse, Pig, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody OAAB02053 Casc3 Antibody (OAAB02053) Human DB, ELISA 400ul $289 Details
Polyclonal Antibody OAAB04220 Casc3 antibody - C-terminal region (OAAB04220) Human WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody OAAB04221 Casc3 Antibody (OAAB04221) Human WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody ARP54818_P050 CASC3 Antibody (ARP54818_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Not tested 50 ug $125 Details

Show all CASC3 antibodies


Product Images
CASC3 antibody - N-terminal region (ARP54817_P050) in Human ACHN cells using Western Blot

Sample Type: Human ACHN

Casc3 antibody - C-terminal region (OAAB04220) in CASC3 cells using Western Blot

Sample Type: CASC3

Casc3 antibody - C-terminal region (OAAB04220) in human brain carcinoma cells using Immunohistochemistry

Sample Type: human brain carcinoma

Casc3 Antibody (OAAB04221) in human brain carcinoma cells using Immunohistochemistry

Sample Type: human brain carcinoma

Casc3 Antibody (OAAB04221) in NCI-H460 cells using Western Blot

Sample Type: NCI-H460


CASC3 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP54818 African clawed frog CASC3 antibody; Xenopus laevis CASC3 antibody A0JMU8 100.0%
ARP54818 African clawed frog CASC3 antibody; Xenopus laevis CASC3 antibody Q801T5 93.0%
ARP54817 Bovine CASC3 antibody; Bos taurus CASC3 antibody A5D7H5 100.0%
ARP54818 Bovine CASC3 antibody; Bos taurus CASC3 antibody A5D7H5 100.0%
ARP54817 Cat CASC3 antibody; Felis catus CASC3 antibody M3WLR6 100.0%
ARP54818 Cat CASC3 antibody; Felis catus CASC3 antibody M3WLR6 100.0%
ARP54818 Chimpanzee CASC3 antibody; Pan troglodytes CASC3 antibody H2QCW0 100.0%
ARP54817 Chimpanzee CASC3 antibody; Pan troglodytes CASC3 antibody K7CMY7 100.0%
ARP54818 Chimpanzee CASC3 antibody; Pan troglodytes CASC3 antibody K7CMY7 100.0%
ARP54818 Chinese softshell turtle CASC3 antibody; Pelodiscus sinensis CASC3 antibody K7F2V4 100.0%
ARP54818 Collared flycatcher CASC3 antibody; Ficedula albicollis CASC3 antibody U3JCC2 100.0%
ARP54817 Dog CASC3 antibody; Canis familiaris CASC3 antibody E2R5K5 100.0%
ARP54818 Dog CASC3 antibody; Canis familiaris CASC3 antibody E2R5K5 100.0%
ARP54818 Domestic duck CASC3 antibody; Anas platyrhynchos CASC3 antibody U3IX98 100.0%
ARP54817 European domestic ferret CASC3 antibody; Mustela putorius furo CASC3 antibody M3YTY2 100.0%
ARP54818 European domestic ferret CASC3 antibody; Mustela putorius furo CASC3 antibody M3YTY2 100.0%
ARP54817 Giant panda CASC3 antibody; Ailuropoda melanoleuca CASC3 antibody G1LMI1 100.0%
ARP54818 Giant panda CASC3 antibody; Ailuropoda melanoleuca CASC3 antibody G1LMI1 100.0%
ARP54817 Gray short-tailed opossum CASC3 antibody; Monodelphis domestica CASC3 antibody F7G173 100.0%
ARP54818 Gray short-tailed opossum CASC3 antibody; Monodelphis domestica CASC3 antibody F7G173 100.0%
ARP54818 Green anole CASC3 antibody; Anolis carolinensis CASC3 antibody G1KB37 100.0%
ARP54817 Horse CASC3 antibody; Equus caballus CASC3 antibody F7BTY7 100.0%
ARP54818 Horse CASC3 antibody; Equus caballus CASC3 antibody F7BTY7 100.0%
ARP54817 Human CASC3 antibody; Homo sapiens CASC3 antibody O15234 100.0%
ARP54818 Human CASC3 antibody; Homo sapiens CASC3 antibody O15234 100.0%
ARP54817 Mouse CASC3 antibody; Mus musculus CASC3 antibody Q8K3W3 100.0%
ARP54818 Mouse CASC3 antibody; Mus musculus CASC3 antibody Q8K3W3 100.0%
ARP54818 Pig CASC3 antibody; Sus scrofa CASC3 antibody F1RXC7 100.0%
ARP54817 Rabbit CASC3 antibody; Oryctolagus cuniculus CASC3 antibody G1TNQ2 100.0%
ARP54818 Rabbit CASC3 antibody; Oryctolagus cuniculus CASC3 antibody G1TNQ2 100.0%
ARP54818 Rat CASC3 antibody; Rattus norvegicus CASC3 antibody G3V793 100.0%
ARP54817 Rat CASC3 antibody; Rattus norvegicus CASC3 antibody Q8K3X0 100.0%
ARP54818 Rat CASC3 antibody; Rattus norvegicus CASC3 antibody Q8K3X0 100.0%
ARP54817 Rat CASC3 antibody; Rattus norvegicus CASC3 antibody G3V793 100.0%
ARP54817 Rhesus macaque CASC3 antibody; Macaca mulatta CASC3 antibody H9FRD9 100.0%
ARP54818 Rhesus macaque CASC3 antibody; Macaca mulatta CASC3 antibody H9FRD9 100.0%
ARP54817 Rhesus macaque CASC3 antibody; Macaca mulatta CASC3 antibody F6XDK9 100.0%
ARP54818 Rhesus macaque CASC3 antibody; Macaca mulatta CASC3 antibody F6XDK9 100.0%
ARP54817 Small-eared galago CASC3 antibody; Otolemur garnettii CASC3 antibody H0XWE6 100.0%
ARP54818 Small-eared galago CASC3 antibody; Otolemur garnettii CASC3 antibody H0XWE6 100.0%
ARP54818 Spotted green pufferfish CASC3 antibody; Tetraodon nigroviridis CASC3 antibody H3CC16 93.0%
ARP54817 Sumatran orangutan CASC3 antibody; Pongo abelii CASC3 antibody H2NU84 100.0%
ARP54818 Sumatran orangutan CASC3 antibody; Pongo abelii CASC3 antibody H2NU84 100.0%
ARP54818 Tasmanian devil CASC3 antibody; Sarcophilus harrisii CASC3 antibody G3WJP9 100.0%
ARP54818 Western clawed frog CASC3 antibody; Xenopus tropicalis CASC3 antibody Q5CZI8 100.0%
ARP54818 Western clawed frog CASC3 antibody; Xenopus tropicalis CASC3 antibody F6X519 100.0%
ARP54817 White-tufted-ear marmoset CASC3 antibody; Callithrix jacchus CASC3 antibody U3C5Z9 100.0%
ARP54818 White-tufted-ear marmoset CASC3 antibody; Callithrix jacchus CASC3 antibody U3C5Z9 100.0%
ARP54817 White-tufted-ear marmoset CASC3 antibody; Callithrix jacchus CASC3 antibody U3F3U6 100.0%
ARP54818 White-tufted-ear marmoset CASC3 antibody; Callithrix jacchus CASC3 antibody U3F3U6 100.0%
ARP54818 White-tufted-ear marmoset CASC3 antibody; Callithrix jacchus CASC3 antibody F7IH43 100.0%
ARP54818 Zebra finch CASC3 antibody; Taeniopygia guttata CASC3 antibody H0YVQ2 100.0%
ARP54818 Zebrafish CASC3 antibody; Danio rerio CASC3 antibody Q1ECZ4 85.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas207842_s_at721_B_lymphoblasts183.450148.460Details
BioGPS Gene Atlas207842_s_atAdipocyte63.250148.460Details
BioGPS Gene Atlas207842_s_atAdrenalCortex77.850148.460Details
BioGPS Gene Atlas207842_s_atAdrenalgland92.100148.460Details
BioGPS Gene Atlas207842_s_atAmygdala140.550148.460Details
BioGPS Gene Atlas207842_s_atAppendix72.150148.460Details
BioGPS Gene Atlas207842_s_atAtrioventricularNode44.600148.460Details
BioGPS Gene Atlas207842_s_atBDCA4+_DentriticCells178.750148.460Details
BioGPS Gene Atlas207842_s_atBonemarrow66.850148.460Details
BioGPS Gene Atlas207842_s_atBronchialEpithelialCells50.850148.460Details
BioGPS Gene Atlas207842_s_atCD105+_Endothelial133.300148.460Details
BioGPS Gene Atlas207842_s_atCD14+_Monocytes165.000148.460Details
BioGPS Gene Atlas207842_s_atCD19+_BCells(neg._sel.)173.850148.460Details
BioGPS Gene Atlas207842_s_atCD33+_Myeloid177.750148.460Details
BioGPS Gene Atlas207842_s_atCD34+177.700148.460Details
BioGPS Gene Atlas207842_s_atCD4+_Tcells231.450148.460Details
BioGPS Gene Atlas207842_s_atCD56+_NKCells230.900148.460Details
BioGPS Gene Atlas207842_s_atCD71+_EarlyErythroid103.600148.460Details
BioGPS Gene Atlas207842_s_atCD8+_Tcells186.700148.460Details
BioGPS Gene Atlas207842_s_atCardiacMyocytes61.400148.460Details
BioGPS Gene Atlas207842_s_atCaudatenucleus105.550148.460Details
BioGPS Gene Atlas207842_s_atCerebellum154.600148.460Details
BioGPS Gene Atlas207842_s_atCerebellumPeduncles174.850148.460Details
BioGPS Gene Atlas207842_s_atCiliaryGanglion58.100148.460Details
BioGPS Gene Atlas207842_s_atCingulateCortex168.950148.460Details
BioGPS Gene Atlas207842_s_atColorectaladenocarcinoma64.400148.460Details
BioGPS Gene Atlas207842_s_atDorsalRootGanglion59.350148.460Details
BioGPS Gene Atlas207842_s_atFetalThyroid162.400148.460Details
BioGPS Gene Atlas207842_s_atFetalbrain162.500148.460Details
BioGPS Gene Atlas207842_s_atFetalliver41.300148.460Details
BioGPS Gene Atlas207842_s_atFetallung124.350148.460Details
BioGPS Gene Atlas207842_s_atGlobusPallidus81.950148.460Details
BioGPS Gene Atlas207842_s_atHeart81.550148.460Details
BioGPS Gene Atlas207842_s_atHypothalamus323.750148.460Details
BioGPS Gene Atlas207842_s_atKidney76.950148.460Details
BioGPS Gene Atlas207842_s_atLeukemia_chronicMyelogenousK-56281.800148.460Details
BioGPS Gene Atlas207842_s_atLeukemia_promyelocytic-HL-6083.700148.460Details
BioGPS Gene Atlas207842_s_atLeukemialymphoblastic(MOLT-4)181.850148.460Details
BioGPS Gene Atlas207842_s_atLiver49.200148.460Details
BioGPS Gene Atlas207842_s_atLung166.300148.460Details
BioGPS Gene Atlas207842_s_atLymphnode114.700148.460Details
BioGPS Gene Atlas207842_s_atLymphoma_burkitts(Daudi)146.450148.460Details
BioGPS Gene Atlas207842_s_atLymphoma_burkitts(Raji)83.350148.460Details
BioGPS Gene Atlas207842_s_atMedullaOblongata125.800148.460Details
BioGPS Gene Atlas207842_s_atOccipitalLobe124.750148.460Details
BioGPS Gene Atlas207842_s_atOlfactoryBulb235.450148.460Details
BioGPS Gene Atlas207842_s_atOvary67.650148.460Details
BioGPS Gene Atlas207842_s_atPancreas63.450148.460Details
BioGPS Gene Atlas207842_s_atPancreaticIslet162.750148.460Details
BioGPS Gene Atlas207842_s_atParietalLobe134.750148.460Details
BioGPS Gene Atlas207842_s_atPituitary163.500148.460Details
BioGPS Gene Atlas207842_s_atPlacenta169.950148.460Details
BioGPS Gene Atlas207842_s_atPons79.350148.460Details
BioGPS Gene Atlas207842_s_atPrefrontalCortex354.400148.460Details
BioGPS Gene Atlas207842_s_atProstate151.300148.460Details
BioGPS Gene Atlas207842_s_atSalivarygland84.450148.460Details
BioGPS Gene Atlas207842_s_atSkeletalMuscle50.750148.460Details
BioGPS Gene Atlas207842_s_atSkin72.250148.460Details
BioGPS Gene Atlas207842_s_atSmoothMuscle113.900148.460Details
BioGPS Gene Atlas207842_s_atSpinalcord178.300148.460Details
BioGPS Gene Atlas207842_s_atSubthalamicNucleus130.250148.460Details
BioGPS Gene Atlas207842_s_atSuperiorCervicalGanglion68.300148.460Details
BioGPS Gene Atlas207842_s_atTemporalLobe70.400148.460Details
BioGPS Gene Atlas207842_s_atTestis233.000148.460Details
BioGPS Gene Atlas207842_s_atTestisGermCell259.600148.460Details
BioGPS Gene Atlas207842_s_atTestisIntersitial152.600148.460Details
BioGPS Gene Atlas207842_s_atTestisLeydigCell146.400148.460Details
BioGPS Gene Atlas207842_s_atTestisSeminiferousTubule184.150148.460Details
BioGPS Gene Atlas207842_s_atThalamus171.050148.460Details
BioGPS Gene Atlas207842_s_atThymus148.200148.460Details
BioGPS Gene Atlas207842_s_atThyroid182.400148.460Details
BioGPS Gene Atlas207842_s_atTongue67.350148.460Details
BioGPS Gene Atlas207842_s_atTonsil83.200148.460Details
BioGPS Gene Atlas207842_s_atTrachea78.550148.460Details
BioGPS Gene Atlas207842_s_atTrigeminalGanglion45.300148.460Details
BioGPS Gene Atlas207842_s_atUterus134.600148.460Details
BioGPS Gene Atlas207842_s_atUterusCorpus109.400148.460Details
BioGPS Gene Atlas207842_s_atWholeBlood377.400148.460Details
BioGPS Gene Atlas207842_s_atWholebrain164.650148.460Details
BioGPS Gene Atlas207842_s_atcolon64.900148.460Details
BioGPS Gene Atlas207842_s_atpineal_day385.840148.460Details
BioGPS Gene Atlas207842_s_atpineal_night326.600148.460Details
BioGPS Gene Atlas207842_s_atretina325.850148.460Details
BioGPS Gene Atlas207842_s_atsmall_intestine66.950148.460Details
BioGPS NCI60207842_s_at786486.436659.260Details
BioGPS NCI60207842_s_atA172879.577659.260Details
BioGPS NCI60207842_s_atA204632.845659.260Details
BioGPS NCI60207842_s_atA361644.835659.260Details
BioGPS NCI60207842_s_atA498486.690659.260Details
BioGPS NCI60207842_s_atA5491043.971659.260Details
BioGPS NCI60207842_s_atACC3877.099659.260Details
BioGPS NCI60207842_s_atACHN639.798659.260Details
BioGPS NCI60207842_s_atALVA31170.265659.260Details
BioGPS NCI60207842_s_atCAKI1653.901659.260Details
BioGPS NCI60207842_s_atCCRT CEM338.033659.260Details
BioGPS NCI60207842_s_atCOLO205818.193659.260Details
BioGPS NCI60207842_s_atDLD1555.464659.260Details
BioGPS NCI60207842_s_atDU1451073.232659.260Details
BioGPS NCI60207842_s_atEKVX630.863659.260Details
BioGPS NCI60207842_s_atGM133325.489659.260Details
BioGPS NCI60207842_s_atGM1600591.542659.260Details
BioGPS NCI60207842_s_atGM2313644.841659.260Details
BioGPS NCI60207842_s_atGM2345521.235659.260Details
BioGPS NCI60207842_s_atGM2493655.857659.260Details
BioGPS NCI60207842_s_atGM97522.212659.260Details
BioGPS NCI60207842_s_atHCC2998677.439659.260Details
BioGPS NCI60207842_s_atHCT116890.759659.260Details
BioGPS NCI60207842_s_atHCT15655.929659.260Details
BioGPS NCI60207842_s_atHEK 293 T-rex721.043659.260Details
BioGPS NCI60207842_s_atHEK 293T737.806659.260Details
BioGPS NCI60207842_s_atHEK293683.405659.260Details
BioGPS NCI60207842_s_atHELA801.314659.260Details
BioGPS NCI60207842_s_atHEPG2935.168659.260Details
BioGPS NCI60207842_s_atHL60439.207659.260Details
BioGPS NCI60207842_s_atHOP62584.135659.260Details
BioGPS NCI60207842_s_atHOP92626.695659.260Details
BioGPS NCI60207842_s_atHS578T681.944659.260Details
BioGPS NCI60207842_s_atHSG788.722659.260Details
BioGPS NCI60207842_s_atHT1080884.783659.260Details
BioGPS NCI60207842_s_atHT29392.047659.260Details
BioGPS NCI60207842_s_atIGROV1696.085659.260Details
BioGPS NCI60207842_s_atIOSE80840.697659.260Details
BioGPS NCI60207842_s_atJURKAT639.303659.260Details
BioGPS NCI60207842_s_atK562424.545659.260Details
BioGPS NCI60207842_s_atKM12422.536659.260Details
BioGPS NCI60207842_s_atLN18931.593659.260Details
BioGPS NCI60207842_s_atLNCAP379.863659.260Details
BioGPS NCI60207842_s_atLOX IMVI1145.794659.260Details
BioGPS NCI60207842_s_atM14992.495659.260Details
BioGPS NCI60207842_s_atMALME 3M554.568659.260Details
BioGPS NCI60207842_s_atMCF7428.866659.260Details
BioGPS NCI60207842_s_atMD MB231534.392659.260Details
BioGPS NCI60207842_s_atMDA MB435597.950659.260Details
BioGPS NCI60207842_s_atMOLT41258.428659.260Details
BioGPS NCI60207842_s_atNCI 460879.567659.260Details
BioGPS NCI60207842_s_atNCI H226842.534659.260Details
BioGPS NCI60207842_s_atNCI H23634.992659.260Details
BioGPS NCI60207842_s_atNCI H322M643.144659.260Details
BioGPS NCI60207842_s_atNCVADR RES499.534659.260Details
BioGPS NCI60207842_s_atOVCAR31129.704659.260Details
BioGPS NCI60207842_s_atOVCAR4405.227659.260Details
BioGPS NCI60207842_s_atOVCAR5791.785659.260Details
BioGPS NCI60207842_s_atOVCAR8624.700659.260Details
BioGPS NCI60207842_s_atPANC1254.738659.260Details
BioGPS NCI60207842_s_atRL71024.563659.260Details
BioGPS NCI60207842_s_atRPMI 8226982.009659.260Details
BioGPS NCI60207842_s_atRS11846546.143659.260Details
BioGPS NCI60207842_s_atRXF393352.039659.260Details
BioGPS NCI60207842_s_atSAOS2338.833659.260Details
BioGPS NCI60207842_s_atSF268652.485659.260Details
BioGPS NCI60207842_s_atSF295721.092659.260Details
BioGPS NCI60207842_s_atSF539670.092659.260Details
BioGPS NCI60207842_s_atSHSYSY+RA755.472659.260Details
BioGPS NCI60207842_s_atSHSYSY-RA702.445659.260Details
BioGPS NCI60207842_s_atSKMEL2882.217659.260Details
BioGPS NCI60207842_s_atSKMEL28471.769659.260Details
BioGPS NCI60207842_s_atSKMEL5347.466659.260Details
BioGPS NCI60207842_s_atSKOV3647.585659.260Details
BioGPS NCI60207842_s_atSN12C562.791659.260Details
BioGPS NCI60207842_s_atSNB19700.724659.260Details
BioGPS NCI60207842_s_atSNB75439.726659.260Details
BioGPS NCI60207842_s_atSR701.471659.260Details
BioGPS NCI60207842_s_atSW620801.286659.260Details
BioGPS NCI60207842_s_atT24599.090659.260Details
BioGPS NCI60207842_s_atT3M4399.146659.260Details
BioGPS NCI60207842_s_atTK101009.787659.260Details
BioGPS NCI60207842_s_atU118630.646659.260Details
BioGPS NCI60207842_s_atU138496.463659.260Details
BioGPS NCI60207842_s_atU20S789.005659.260Details
BioGPS NCI60207842_s_atU251498.344659.260Details
BioGPS NCI60207842_s_atU87523.205659.260Details
BioGPS NCI60207842_s_atUACC257451.915659.260Details
BioGPS NCI60207842_s_atUACC62516.156659.260Details
BioGPS NCI60207842_s_atUO31674.769659.260Details
BioGPS NCI60207842_s_atZR75_1746.425659.260Details
BioGPS NCI60207842_s_atastrocytes624.250659.260Details
BioGPS NCI60207842_s_athuh-7435.230659.260Details