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Gene ID: 84433 | CARD11 Antibody Resource


CARD11 Antibody Resource
Gene Full Name: 
caspase recruitment domain family, member 11
Uniprot: 
Q9BXL7
Protein Name: 
caspase recruitment domain-containing protein 11
Nucleotide: 
NM_032415
Alias: 
PPBL;BENTA;BIMP3;IMD11;CARMA1;
Ensembl: 
ENSG00000198286
Location: 
7p22
HPRD: 
06234
NCBI Gene: 
84433
MIM: 
607210

Summary: 
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]
Function: 
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Subcellular location: 
Cytoplasm. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.
PTM: 
Phosphoprotein;
Disease: 
Persistent polyclonal B-cell lymphocytosis (PPBL) [MIM:606445]: An autosomal dominant condition characterized by onset in infancy of splenomegaly and polyclonal expansion of B cells, resulting in peripheral lymphocytosis. Affected individuals also show mild immune dysfunction, including some defective antibody responses and T-cell anergy. There may be a predisposition to the development of B-cell malignancy. Note: The disease is caused by mutations affecting the gene represented in this entry. CARD11 immunodeficiency (CARD11ID) [MIM:615206]: An autosomal recessive primary immunodeficiency characterized by normal numbers of T and B lymphocytes, but defective intracellular signaling. There is a block in B-cell differentiation with increased numbers of transitional B cells and hypogammaglobulinemia, as well as decreased numbers of regulatory T cells and defects in T-cell function. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OASA07115 CARD11 Antibody (OASA07115) Human IHC-FFPE, WB 0.1mg $355 Details
Polyclonal Antibody OASA07116 CARD11 Antibody (OASA07116) Human IHC-FFPE, WB 50ug $190 Details
Polyclonal Antibody OAEB02396 CARD11 Antibody (OAEB02396) Bovine, Dog, Guinea pig, Horse, Human, Mouse WB, IHC 0.1mg $289 Details
Polyclonal Antibody OAAB06304 CARD11 antibody - C-terminal region (OAAB06304) Human WB, FC, IHC 400ul $289 Details
Polyclonal Antibody ARP59834_P050 CARD11 Antibody (ARP59834_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rat, Zebrafish Not tested 50 ug $125 Details
Polyclonal Antibody ARP59835_P050 CARD11 Antibody (ARP59835_P050) Polyclonal Bovine, Dog, Guinea pig, Human, Mouse, Rat Not tested 50 ug $125 Details
Polyclonal Antibody OAAF02865 CARD11 Antibody (OAAF02865) Polyclonal Human, Mouse WB, ELISA 100 ug $229 Details

Show all CARD11 antibodies


Product Images
CARD11 Antibody (OAAF02865) in COLO205 cells using Western Blot

Sample Type: COLO205

CARD11 Antibody (OAEB02396) in CARD11 (RC222740) cells using Western Blot

Sample Type: CARD11 (RC222740)

CARD11 Antibody (OAEB02396) in human Jurkat cells using Western Blot

Sample Type: human Jurkat

CARD11 Antibody (OAEB02396) in Human spleen cells using Immunohistochemistry

Sample Type: Human spleen


CARD11 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP59834 African elephant CARD11 antibody; Loxodonta africana CARD11 antibody G3SUN2 93.0%
ARP59834 African elephant CARD11 antibody; Loxodonta africana CARD11 antibody G3UL74 93.0%
ARP59835 Bovine CARD11 antibody; Bos taurus CARD11 antibody A8E646 100.0%
ARP59834 Bovine CARD11 antibody; Bos taurus CARD11 antibody A8E646 86.0%
ARP59835 Cat CARD11 antibody; Felis catus CARD11 antibody M3W9U0 100.0%
ARP59834 Cat CARD11 antibody; Felis catus CARD11 antibody M3W9U0 85.0%
ARP59834 Chicken CARD11 antibody; Gallus gallus CARD11 antibody Q5F3W0 93.0%
ARP59834 Chimpanzee CARD11 antibody; Pan troglodytes CARD11 antibody H2QU43 100.0%
ARP59835 Chimpanzee CARD11 antibody; Pan troglodytes CARD11 antibody H2QU43 100.0%
ARP59834 Chinese softshell turtle CARD11 antibody; Pelodiscus sinensis CARD11 antibody K7FJ33 93.0%
ARP59834 Collared flycatcher CARD11 antibody; Ficedula albicollis CARD11 antibody U3KHH7 86.0%
ARP59834 Common turkey CARD11 antibody; Meleagris gallopavo CARD11 antibody G1MVL0 93.0%
ARP59834 Common turkey CARD11 antibody; Meleagris gallopavo CARD11 antibody G3UTY6 93.0%
ARP59835 Dog CARD11 antibody; Canis familiaris CARD11 antibody F1PZC8 93.0%
ARP59834 Dog CARD11 antibody; Canis familiaris CARD11 antibody F1PZC8 86.0%
ARP59834 Domestic duck CARD11 antibody; Anas platyrhynchos CARD11 antibody U3I7P8 100.0%
ARP59834 Duckbill platypus CARD11 antibody; Ornithorhynchus anatinus CARD11 antibody F6SYC2 86.0%
ARP59834 European domestic ferret CARD11 antibody; Mustela putorius furo CARD11 antibody M3Z2M7 93.0%
ARP59835 European domestic ferret CARD11 antibody; Mustela putorius furo CARD11 antibody M3Z2M7 86.0%
ARP59834 Gray short-tailed opossum CARD11 antibody; Monodelphis domestica CARD11 antibody F6SZN4 79.0%
ARP59834 Horse CARD11 antibody; Equus caballus CARD11 antibody F6VU19 93.0%
ARP59834 Human CARD11 antibody; Homo sapiens CARD11 antibody Q9BXL7 100.0%
ARP59835 Human CARD11 antibody; Homo sapiens CARD11 antibody Q9BXL7 100.0%
ARP59834 Mouse CARD11 antibody; Mus musculus CARD11 antibody Q8BVX8 93.0%
ARP59834 Mouse CARD11 antibody; Mus musculus CARD11 antibody Q8CIS0-2 93.0%
ARP59834 Mouse CARD11 antibody; Mus musculus CARD11 antibody Q8CIS0 93.0%
ARP59835 Mouse CARD11 antibody; Mus musculus CARD11 antibody Q8BVX8 83.0%
ARP59835 Mouse CARD11 antibody; Mus musculus CARD11 antibody Q8CIS0-2 83.0%
ARP59835 Mouse CARD11 antibody; Mus musculus CARD11 antibody Q8CIS0 83.0%
ARP59834 Northern white-cheeked gibbon CARD11 antibody; Nomascus leucogenys CARD11 antibody G1RI46 93.0%
ARP59835 Northern white-cheeked gibbon CARD11 antibody; Nomascus leucogenys CARD11 antibody G1RI46 93.0%
ARP59834 Rat CARD11 antibody; Rattus norvegicus CARD11 antibody F1M1I1 93.0%
ARP59835 Rat CARD11 antibody; Rattus norvegicus CARD11 antibody F1M1I1 83.0%
ARP59834 Rhesus macaque CARD11 antibody; Macaca mulatta CARD11 antibody H9YY19 100.0%
ARP59835 Rhesus macaque CARD11 antibody; Macaca mulatta CARD11 antibody H9YY19 100.0%
ARP59835 Small-eared galago CARD11 antibody; Otolemur garnettii CARD11 antibody H0WV32 93.0%
ARP59834 Small-eared galago CARD11 antibody; Otolemur garnettii CARD11 antibody H0WV32 86.0%
ARP59834 Southern platyfish CARD11 antibody; Xiphophorus maculatus CARD11 antibody M3ZFW0 79.0%
ARP59834 Sumatran orangutan CARD11 antibody; Pongo abelii CARD11 antibody H2PLD1 100.0%
ARP59835 Sumatran orangutan CARD11 antibody; Pongo abelii CARD11 antibody H2PLD1 100.0%
ARP59834 Tasmanian devil CARD11 antibody; Sarcophilus harrisii CARD11 antibody G3WLU9 86.0%
ARP59834 Tasmanian devil CARD11 antibody; Sarcophilus harrisii CARD11 antibody G3WLV0 86.0%
ARP59834 Thirteen-lined ground squirrel CARD11 antibody; Spermophilus tridecemlineatus CARD11 antibody I3MA41 100.0%
ARP59835 Thirteen-lined ground squirrel CARD11 antibody; Spermophilus tridecemlineatus CARD11 antibody I3MA41 79.0%
ARP59834 White-tufted-ear marmoset CARD11 antibody; Callithrix jacchus CARD11 antibody U3BZ84 100.0%
ARP59835 White-tufted-ear marmoset CARD11 antibody; Callithrix jacchus CARD11 antibody U3BZ84 100.0%
ARP59834 Zebra finch CARD11 antibody; Taeniopygia guttata CARD11 antibody H0ZCH5 79.0%

Tissue & Cell Line Gene Expression Data