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Gene ID: 255022 | CALHM1 Antibody Resource


CALHM1 Antibody Resource
Gene Full Name: 
calcium homeostasis modulator 1
Uniprot: 
Q8IU99
Protein Name: 
calcium homeostasis modulator protein 1
Nucleotide: 
NM_001001412
Alias: 
FAM26C;
Ensembl: 
ENSG00000185933
Location: 
10q24.33
HPRD: 
16879
NCBI Gene: 
255022
MIM: 
612234

Summary: 
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]
Function: 
Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner.
Subcellular location: 
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Colocalizes with HSPA5 at the endoplasmic reticulum.
PTM: 
Glycoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP44397_P050 EG546729 antibody - C-terminal region (ARP44397_P050) Polyclonal Human; mouse WB 50ug $289 Details
Polyclonal Antibody OAAB04421 CALHM1 antibody - N-terminal region (OAAB04421) Human WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody OAAB04422 CALHM1 antibody - center region (OAAB04422) Human WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody OAPB01039 CALHM1 Antibody (OAPB01039) Polyclonal Human; Mouse; Rat ELISA, WB, IHC 0.1 mg $355 Details
Polyclonal Antibody ARP44395_P050 CALHM1 Antibody (ARP44395_P050) Polyclonal Dog, Human, Rabbit Not tested 50 ug $125 Details
Polyclonal Antibody ARP44396_P050 CALHM1 Antibody (ARP44396_P050) Polyclonal Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details

Show all CALHM1 antibodies


Product Images
EG546729 antibody - C-terminal region (ARP44397_P050) in Mouse Intestine cells using Western Blot

Sample Type: Mouse Intestine


CALHM1 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP44396 African elephant CALHM1 antibody; Loxodonta africana CALHM1 antibody G3T1R6 100.0%
ARP44397 African elephant CALHM1 antibody; Loxodonta africana CALHM1 antibody G3T1R6 100.0%
ARP44396 Bovine CALHM1 antibody; Bos taurus CALHM1 antibody G3X6M4 100.0%
ARP44397 Bovine CALHM1 antibody; Bos taurus CALHM1 antibody G3X6M4 93.0%
ARP44396 Cat CALHM1 antibody; Felis catus CALHM1 antibody M3VYF2 100.0%
ARP44397 Cat CALHM1 antibody; Felis catus CALHM1 antibody M3VYF2 86.0%
ARP44395 Cat CALHM1 antibody; Felis catus CALHM1 antibody M3VYF2 79.0%
ARP44395 Chimpanzee CALHM1 antibody; Pan troglodytes CALHM1 antibody H2Q2J0 100.0%
ARP44396 Chimpanzee CALHM1 antibody; Pan troglodytes CALHM1 antibody H2Q2J0 100.0%
ARP44397 Chimpanzee CALHM1 antibody; Pan troglodytes CALHM1 antibody H2Q2J0 100.0%
ARP44397 Dog CALHM1 antibody; Canis familiaris CALHM1 antibody F1PLK6 93.0%
ARP44396 Dog CALHM1 antibody; Canis familiaris CALHM1 antibody F1PLK6 92.0%
ARP44395 Dog CALHM1 antibody; Canis familiaris CALHM1 antibody F1PLK6 86.0%
ARP44396 Gray short-tailed opossum CALHM1 antibody; Monodelphis domestica CALHM1 antibody F7F4B0 92.0%
ARP44396 Horse CALHM1 antibody; Equus caballus CALHM1 antibody F7C2X9 92.0%
ARP44397 Horse CALHM1 antibody; Equus caballus CALHM1 antibody F7C2X9 85.0%
ARP44395 Human CALHM1 antibody; Homo sapiens CALHM1 antibody Q8IU99 100.0%
ARP44396 Human CALHM1 antibody; Homo sapiens CALHM1 antibody Q8IU99 100.0%
ARP44397 Human CALHM1 antibody; Homo sapiens CALHM1 antibody Q8IU99 100.0%
ARP44397 Mouse CALHM1 antibody; Mus musculus CALHM1 antibody D3Z291 93.0%
ARP44396 Mouse CALHM1 antibody; Mus musculus CALHM1 antibody D3Z291 92.0%
ARP44395 Northern white-cheeked gibbon CALHM1 antibody; Nomascus leucogenys CALHM1 antibody G1RZ46 100.0%
ARP44396 Northern white-cheeked gibbon CALHM1 antibody; Nomascus leucogenys CALHM1 antibody G1RZ46 100.0%
ARP44397 Northern white-cheeked gibbon CALHM1 antibody; Nomascus leucogenys CALHM1 antibody G1RZ46 93.0%
ARP44396 Pig CALHM1 antibody; Sus scrofa CALHM1 antibody F1S840 92.0%
ARP44397 Pig CALHM1 antibody; Sus scrofa CALHM1 antibody F1S840 86.0%
ARP44397 Rabbit CALHM1 antibody; Oryctolagus cuniculus CALHM1 antibody G1TIH4 93.0%
ARP44397 Rabbit CALHM1 antibody; Oryctolagus cuniculus CALHM1 antibody G1U6U2 93.0%
ARP44396 Rabbit CALHM1 antibody; Oryctolagus cuniculus CALHM1 antibody G1TIH4 92.0%
ARP44396 Rabbit CALHM1 antibody; Oryctolagus cuniculus CALHM1 antibody G1U6U2 92.0%
ARP44395 Rabbit CALHM1 antibody; Oryctolagus cuniculus CALHM1 antibody G1TIH4 86.0%
ARP44395 Rabbit CALHM1 antibody; Oryctolagus cuniculus CALHM1 antibody G1U6U2 86.0%
ARP44397 Rat CALHM1 antibody; Rattus norvegicus CALHM1 antibody D4AE44 100.0%
ARP44396 Rat CALHM1 antibody; Rattus norvegicus CALHM1 antibody D4AE44 92.0%
ARP44397 Rhesus macaque CALHM1 antibody; Macaca mulatta CALHM1 antibody F7EX80 100.0%
ARP44395 Rhesus macaque CALHM1 antibody; Macaca mulatta CALHM1 antibody F7EX80 93.0%
ARP44396 Rhesus macaque CALHM1 antibody; Macaca mulatta CALHM1 antibody F7EX80 86.0%
ARP44396 Small-eared galago CALHM1 antibody; Otolemur garnettii CALHM1 antibody H0Y232 83.0%
ARP44397 Small-eared galago CALHM1 antibody; Otolemur garnettii CALHM1 antibody H0Y232 79.0%
ARP44395 Sumatran orangutan CALHM1 antibody; Pongo abelii CALHM1 antibody H2NBH8 100.0%
ARP44396 Sumatran orangutan CALHM1 antibody; Pongo abelii CALHM1 antibody H2NBH8 100.0%
ARP44397 Sumatran orangutan CALHM1 antibody; Pongo abelii CALHM1 antibody H2NBH8 100.0%
ARP44396 Tasmanian devil CALHM1 antibody; Sarcophilus harrisii CALHM1 antibody G3X1F4 83.0%
ARP44397 Thirteen-lined ground squirrel CALHM1 antibody; Spermophilus tridecemlineatus CALHM1 antibody I3MN82 100.0%
ARP44396 Thirteen-lined ground squirrel CALHM1 antibody; Spermophilus tridecemlineatus CALHM1 antibody I3MN82 86.0%
ARP44397 White-tufted-ear marmoset CALHM1 antibody; Callithrix jacchus CALHM1 antibody F6QMY0 93.0%
ARP44396 White-tufted-ear marmoset CALHM1 antibody; Callithrix jacchus CALHM1 antibody F6QMY0 92.0%

Tissue & Cell Line Gene Expression Data