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Gene ID: 732 | C8B Antibody Resource


C8B Antibody Resource
Gene Full Name: 
complement component 8, beta polypeptide
Uniprot: 
P07358
Protein Name: 
complement component C8 beta chain
Nucleotide: 
XM_005271166
Alias: 
C82;
Ensembl: 
ENSG00000021852
Location: 
1p32.2
HPRD: 
00410
NCBI Gene: 
732
MIM: 
120960

Summary: 
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Function: 
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Subcellular location: 
Secreted.
PTM: 
Disulfide bond;
Disease: 
Complement component 8 deficiency, 2 (C8D2) [MIM:613789]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP44211_P050 C8B antibody - C-terminal region (ARP44211_P050) Polyclonal Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat IHC, WB 50ug $289 Details
Polyclonal Antibody ARP44210_P050 C8B antibody - middle region (ARP44210_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat IHC, WB 50ug $289 Details
Polyclonal Antibody OAAB15255 C8B antibody - C - terminal region (OAAB15255) Human WB 400ul $289 Details

Show all C8B antibodies


Product Images
C8B antibody - middle region (ARP44210_P050) in Human Fetal liver cells using Western Blot

Sample Type: Human Fetal liver

C8B antibody - middle region (ARP44210_P050) in Human Intestine cells using Immunohistochemistry

Sample Type: Human Intestine

C8B antibody - C-terminal region (ARP44211_P050) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2

C8B antibody - C-terminal region (ARP44211_P050) in Human Liver cells using Immunohistochemistry

Sample Type: Human Liver

C8B antibody - C - terminal region (OAAB15255) in CEM cells using Western Blot

Sample Type: CEM


C8B Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP44211 African elephant C8B antibody; Loxodonta africana C8B antibody G3SS44 93.0%
ARP44210 African elephant C8B antibody; Loxodonta africana C8B antibody G3SS44 86.0%
ARP44210 Bastard halibut C8B antibody; Paralichthys olivaceus C8B antibody Q9PVW7 79.0%
ARP44210 Bovine C8B antibody; Bos taurus C8B antibody F1MX86 100.0%
ARP44210 Bovine C8B antibody; Bos taurus C8B antibody F1N102 100.0%
ARP44211 Bovine C8B antibody; Bos taurus C8B antibody F1N102 100.0%
ARP44210 Bovine C8B antibody; Bos taurus C8B antibody Q2KIK9 100.0%
ARP44210 Cat C8B antibody; Felis catus C8B antibody M3W159 100.0%
ARP44211 Cat C8B antibody; Felis catus C8B antibody M3W159 100.0%
ARP44210 Chicken C8B antibody; Gallus gallus C8B antibody E1C7C1 86.0%
ARP44210 Chimpanzee C8B antibody; Pan troglodytes C8B antibody H2PZ47 100.0%
ARP44211 Chimpanzee C8B antibody; Pan troglodytes C8B antibody H2PZ47 100.0%
ARP44210 Chinese softshell turtle C8B antibody; Pelodiscus sinensis C8B antibody K7F7M3 93.0%
ARP44210 Chinese softshell turtle C8B antibody; Pelodiscus sinensis C8B antibody K7F7M5 93.0%
ARP44210 Collared flycatcher C8B antibody; Ficedula albicollis C8B antibody U3KCU0 79.0%
ARP44210 Dog C8B antibody; Canis familiaris C8B antibody E2R141 100.0%
ARP44211 Dog C8B antibody; Canis familiaris C8B antibody E2R141 100.0%
ARP44210 Domestic duck C8B antibody; Anas platyrhynchos C8B antibody U3IKF3 86.0%
ARP44210 European domestic ferret C8B antibody; Mustela putorius furo C8B antibody M3Y7D2 100.0%
ARP44210 Giant panda C8B antibody; Ailuropoda melanoleuca C8B antibody G1LKE1 93.0%
ARP44210 Green anole C8B antibody; Anolis carolinensis C8B antibody G1KFX8 86.0%
ARP44210 Horse C8B antibody; Equus caballus C8B antibody F7AXF6 100.0%
ARP44211 Horse C8B antibody; Equus caballus C8B antibody F7AXF6 93.0%
ARP44210 Human C8B antibody; Homo sapiens C8B antibody B7Z550 100.0%
ARP44211 Human C8B antibody; Homo sapiens C8B antibody B7Z550 100.0%
ARP44210 Human C8B antibody; Homo sapiens C8B antibody F5GY80 100.0%
ARP44211 Human C8B antibody; Homo sapiens C8B antibody F5GY80 100.0%
ARP44210 Human C8B antibody; Homo sapiens C8B antibody F5H7G1 100.0%
ARP44211 Human C8B antibody; Homo sapiens C8B antibody F5H7G1 100.0%
ARP44210 Human C8B antibody; Homo sapiens C8B antibody P07358 100.0%
ARP44211 Human C8B antibody; Homo sapiens C8B antibody P07358 100.0%
ARP44210 Human C8B antibody; Homo sapiens C8B antibody Q05CV3 100.0%
ARP44211 Mouse C8B antibody; Mus musculus C8B antibody Q8BH35-2 100.0%
ARP44211 Mouse C8B antibody; Mus musculus C8B antibody Q8BH35 100.0%
ARP44210 Mouse C8B antibody; Mus musculus C8B antibody Q8BH35 93.0%
ARP44210 Mouse C8B antibody; Mus musculus C8B antibody Q8BH35-2 93.0%
ARP44210 Northern white-cheeked gibbon C8B antibody; Nomascus leucogenys C8B antibody G1RXE4 100.0%
ARP44211 Northern white-cheeked gibbon C8B antibody; Nomascus leucogenys C8B antibody G1RXE4 100.0%
ARP44210 Pig C8B antibody; Sus scrofa C8B antibody F1S790 93.0%
ARP44211 Pig C8B antibody; Sus scrofa C8B antibody F1S790 92.0%
ARP44210 Rabbit C8B antibody; Oryctolagus cuniculus C8B antibody P98137 93.0%
ARP44211 Rabbit C8B antibody; Oryctolagus cuniculus C8B antibody G1U8Y5 92.0%
ARP44211 Rabbit C8B antibody; Oryctolagus cuniculus C8B antibody P98137 92.0%
ARP44210 Rainbow trout C8B antibody; Oncorhynchus mykiss C8B antibody Q90X85 86.0%
ARP44211 Rat C8B antibody; Rattus norvegicus C8B antibody P55314 100.0%
ARP44210 Rat C8B antibody; Rattus norvegicus C8B antibody P55314 93.0%
ARP44210 Rhesus macaque C8B antibody; Macaca mulatta C8B antibody F6TP36 100.0%
ARP44211 Rhesus macaque C8B antibody; Macaca mulatta C8B antibody F6TP36 100.0%
ARP44210 Small-eared galago C8B antibody; Otolemur garnettii C8B antibody H0XEI3 100.0%
ARP44211 Small-eared galago C8B antibody; Otolemur garnettii C8B antibody H0XEI3 92.0%
ARP44210 Spotted green pufferfish C8B antibody; Tetraodon nigroviridis C8B antibody H3BXN7 79.0%
ARP44210 Spotted green pufferfish C8B antibody; Tetraodon nigroviridis C8B antibody H3CR06 79.0%
ARP44210 Sumatran orangutan C8B antibody; Pongo abelii C8B antibody H2N790 100.0%
ARP44211 Sumatran orangutan C8B antibody; Pongo abelii C8B antibody H2N790 100.0%
ARP44210 Thirteen-lined ground squirrel C8B antibody; Spermophilus tridecemlineatus C8B antibody I3MBV4 100.0%
ARP44211 Thirteen-lined ground squirrel C8B antibody; Spermophilus tridecemlineatus C8B antibody I3MBV4 100.0%
ARP44210 Western clawed frog C8B antibody; Xenopus tropicalis C8B antibody F6R5H7 86.0%
ARP44210 White-tufted-ear marmoset C8B antibody; Callithrix jacchus C8B antibody F7IA58 100.0%
ARP44211 White-tufted-ear marmoset C8B antibody; Callithrix jacchus C8B antibody F7IA58 100.0%
ARP44210 White-tufted-ear marmoset C8B antibody; Callithrix jacchus C8B antibody F7ICE0 100.0%
ARP44211 White-tufted-ear marmoset C8B antibody; Callithrix jacchus C8B antibody F7ICE0 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas206979_at721_B_lymphoblasts8.50014.320Details
BioGPS Gene Atlas206979_atAdipocyte7.30014.320Details
BioGPS Gene Atlas206979_atAdrenalCortex8.65014.320Details
BioGPS Gene Atlas206979_atAdrenalgland6.45014.320Details
BioGPS Gene Atlas206979_atAmygdala7.80014.320Details
BioGPS Gene Atlas206979_atAppendix7.50014.320Details
BioGPS Gene Atlas206979_atAtrioventricularNode5.80014.320Details
BioGPS Gene Atlas206979_atBDCA4+_DentriticCells7.50014.320Details
BioGPS Gene Atlas206979_atBonemarrow7.35014.320Details
BioGPS Gene Atlas206979_atBronchialEpithelialCells7.30014.320Details
BioGPS Gene Atlas206979_atCD105+_Endothelial7.50014.320Details
BioGPS Gene Atlas206979_atCD14+_Monocytes7.85014.320Details
BioGPS Gene Atlas206979_atCD19+_BCells(neg._sel.)7.55014.320Details
BioGPS Gene Atlas206979_atCD33+_Myeloid9.10014.320Details
BioGPS Gene Atlas206979_atCD34+8.65014.320Details
BioGPS Gene Atlas206979_atCD4+_Tcells7.15014.320Details
BioGPS Gene Atlas206979_atCD56+_NKCells8.90014.320Details
BioGPS Gene Atlas206979_atCD71+_EarlyErythroid6.85014.320Details
BioGPS Gene Atlas206979_atCD8+_Tcells6.25014.320Details
BioGPS Gene Atlas206979_atCardiacMyocytes9.80014.320Details
BioGPS Gene Atlas206979_atCaudatenucleus7.15014.320Details
BioGPS Gene Atlas206979_atCerebellum6.00014.320Details
BioGPS Gene Atlas206979_atCerebellumPeduncles8.60014.320Details
BioGPS Gene Atlas206979_atCiliaryGanglion5.35014.320Details
BioGPS Gene Atlas206979_atCingulateCortex8.55014.320Details
BioGPS Gene Atlas206979_atColorectaladenocarcinoma7.45014.320Details
BioGPS Gene Atlas206979_atDorsalRootGanglion5.75014.320Details
BioGPS Gene Atlas206979_atFetalThyroid7.20014.320Details
BioGPS Gene Atlas206979_atFetalbrain7.45014.320Details
BioGPS Gene Atlas206979_atFetalliver142.20014.320Details
BioGPS Gene Atlas206979_atFetallung7.00014.320Details
BioGPS Gene Atlas206979_atGlobusPallidus5.45014.320Details
BioGPS Gene Atlas206979_atHeart10.00014.320Details
BioGPS Gene Atlas206979_atHypothalamus8.05014.320Details
BioGPS Gene Atlas206979_atKidney8.70014.320Details
BioGPS Gene Atlas206979_atLeukemia_chronicMyelogenousK-5626.70014.320Details
BioGPS Gene Atlas206979_atLeukemia_promyelocytic-HL-606.50014.320Details
BioGPS Gene Atlas206979_atLeukemialymphoblastic(MOLT-4)6.00014.320Details
BioGPS Gene Atlas206979_atLiver471.55014.320Details
BioGPS Gene Atlas206979_atLung8.15014.320Details
BioGPS Gene Atlas206979_atLymphnode6.45014.320Details
BioGPS Gene Atlas206979_atLymphoma_burkitts(Daudi)9.50014.320Details
BioGPS Gene Atlas206979_atLymphoma_burkitts(Raji)10.55014.320Details
BioGPS Gene Atlas206979_atMedullaOblongata6.80014.320Details
BioGPS Gene Atlas206979_atOccipitalLobe6.60014.320Details
BioGPS Gene Atlas206979_atOlfactoryBulb5.80014.320Details
BioGPS Gene Atlas206979_atOvary4.95014.320Details
BioGPS Gene Atlas206979_atPancreas5.95014.320Details
BioGPS Gene Atlas206979_atPancreaticIslet7.90014.320Details
BioGPS Gene Atlas206979_atParietalLobe7.95014.320Details
BioGPS Gene Atlas206979_atPituitary8.75014.320Details
BioGPS Gene Atlas206979_atPlacenta7.60014.320Details
BioGPS Gene Atlas206979_atPons7.25014.320Details
BioGPS Gene Atlas206979_atPrefrontalCortex9.25014.320Details
BioGPS Gene Atlas206979_atProstate8.75014.320Details
BioGPS Gene Atlas206979_atSalivarygland5.90014.320Details
BioGPS Gene Atlas206979_atSkeletalMuscle8.75014.320Details
BioGPS Gene Atlas206979_atSkin5.75014.320Details
BioGPS Gene Atlas206979_atSmoothMuscle8.25014.320Details
BioGPS Gene Atlas206979_atSpinalcord8.10014.320Details
BioGPS Gene Atlas206979_atSubthalamicNucleus7.00014.320Details
BioGPS Gene Atlas206979_atSuperiorCervicalGanglion8.85014.320Details
BioGPS Gene Atlas206979_atTemporalLobe6.75014.320Details
BioGPS Gene Atlas206979_atTestis6.40014.320Details
BioGPS Gene Atlas206979_atTestisGermCell6.20014.320Details
BioGPS Gene Atlas206979_atTestisIntersitial6.25014.320Details
BioGPS Gene Atlas206979_atTestisLeydigCell7.35014.320Details
BioGPS Gene Atlas206979_atTestisSeminiferousTubule6.30014.320Details
BioGPS Gene Atlas206979_atThalamus9.05014.320Details
BioGPS Gene Atlas206979_atThymus5.90014.320Details
BioGPS Gene Atlas206979_atThyroid9.15014.320Details
BioGPS Gene Atlas206979_atTongue7.35014.320Details
BioGPS Gene Atlas206979_atTonsil7.15014.320Details
BioGPS Gene Atlas206979_atTrachea6.20014.320Details
BioGPS Gene Atlas206979_atTrigeminalGanglion7.30014.320Details
BioGPS Gene Atlas206979_atUterus6.10014.320Details
BioGPS Gene Atlas206979_atUterusCorpus6.70014.320Details
BioGPS Gene Atlas206979_atWholeBlood8.05014.320Details
BioGPS Gene Atlas206979_atWholebrain6.20014.320Details
BioGPS Gene Atlas206979_atcolon7.40014.320Details
BioGPS Gene Atlas206979_atpineal_day8.94014.320Details
BioGPS Gene Atlas206979_atpineal_night9.04014.320Details
BioGPS Gene Atlas206979_atretina8.92514.320Details
BioGPS Gene Atlas206979_atsmall_intestine7.10014.320Details
BioGPS NCI60206979_at7864.1124.090Details
BioGPS NCI60206979_atA1723.9144.090Details
BioGPS NCI60206979_atA2044.0524.090Details
BioGPS NCI60206979_atA3614.1704.090Details
BioGPS NCI60206979_atA4984.0584.090Details
BioGPS NCI60206979_atA5494.1314.090Details
BioGPS NCI60206979_atACC34.2934.090Details
BioGPS NCI60206979_atACHN3.8104.090Details
BioGPS NCI60206979_atALVA314.2244.090Details
BioGPS NCI60206979_atCAKI14.2234.090Details
BioGPS NCI60206979_atCCRT CEM4.5284.090Details
BioGPS NCI60206979_atCOLO2054.0994.090Details
BioGPS NCI60206979_atDLD13.9874.090Details
BioGPS NCI60206979_atDU1453.9044.090Details
BioGPS NCI60206979_atEKVX3.9194.090Details
BioGPS NCI60206979_atGM1334.1384.090Details
BioGPS NCI60206979_atGM16004.2544.090Details
BioGPS NCI60206979_atGM23134.1064.090Details
BioGPS NCI60206979_atGM23454.0774.090Details
BioGPS NCI60206979_atGM24934.2664.090Details
BioGPS NCI60206979_atGM974.6404.090Details
BioGPS NCI60206979_atHCC29983.7104.090Details
BioGPS NCI60206979_atHCT1164.0544.090Details
BioGPS NCI60206979_atHCT153.8574.090Details
BioGPS NCI60206979_atHEK 293 T-rex4.1524.090Details
BioGPS NCI60206979_atHEK 293T4.0774.090Details
BioGPS NCI60206979_atHEK2934.0374.090Details
BioGPS NCI60206979_atHELA3.7954.090Details
BioGPS NCI60206979_atHEPG24.6494.090Details
BioGPS NCI60206979_atHL604.6684.090Details
BioGPS NCI60206979_atHOP624.0724.090Details
BioGPS NCI60206979_atHOP923.9824.090Details
BioGPS NCI60206979_atHS578T3.9954.090Details
BioGPS NCI60206979_atHSG3.9634.090Details
BioGPS NCI60206979_atHT10803.9714.090Details
BioGPS NCI60206979_atHT294.2584.090Details
BioGPS NCI60206979_atIGROV14.0254.090Details
BioGPS NCI60206979_atIOSE804.0484.090Details
BioGPS NCI60206979_atJURKAT4.0514.090Details
BioGPS NCI60206979_atK5624.3454.090Details
BioGPS NCI60206979_atKM124.1594.090Details
BioGPS NCI60206979_atLN183.8614.090Details
BioGPS NCI60206979_atLNCAP4.0554.090Details
BioGPS NCI60206979_atLOX IMVI4.0244.090Details
BioGPS NCI60206979_atM144.0354.090Details
BioGPS NCI60206979_atMALME 3M4.3664.090Details
BioGPS NCI60206979_atMCF73.9304.090Details
BioGPS NCI60206979_atMD MB2314.1114.090Details
BioGPS NCI60206979_atMDA MB4354.3414.090Details
BioGPS NCI60206979_atMOLT44.2044.090Details
BioGPS NCI60206979_atNCI 4604.1704.090Details
BioGPS NCI60206979_atNCI H2264.1184.090Details
BioGPS NCI60206979_atNCI H234.0594.090Details
BioGPS NCI60206979_atNCI H322M4.0464.090Details
BioGPS NCI60206979_atNCVADR RES3.8414.090Details
BioGPS NCI60206979_atOVCAR34.2604.090Details
BioGPS NCI60206979_atOVCAR44.0454.090Details
BioGPS NCI60206979_atOVCAR53.9924.090Details
BioGPS NCI60206979_atOVCAR83.8274.090Details
BioGPS NCI60206979_atPANC14.0874.090Details
BioGPS NCI60206979_atRL74.1334.090Details
BioGPS NCI60206979_atRPMI 82264.1234.090Details
BioGPS NCI60206979_atRS118464.2774.090Details
BioGPS NCI60206979_atRXF3934.0524.090Details
BioGPS NCI60206979_atSAOS24.1194.090Details
BioGPS NCI60206979_atSF2684.0194.090Details
BioGPS NCI60206979_atSF2953.9834.090Details
BioGPS NCI60206979_atSF5393.8124.090Details
BioGPS NCI60206979_atSHSYSY+RA3.9464.090Details
BioGPS NCI60206979_atSHSYSY-RA4.0074.090Details
BioGPS NCI60206979_atSKMEL24.0604.090Details
BioGPS NCI60206979_atSKMEL284.0724.090Details
BioGPS NCI60206979_atSKMEL53.9314.090Details
BioGPS NCI60206979_atSKOV34.4624.090Details
BioGPS NCI60206979_atSN12C4.0194.090Details
BioGPS NCI60206979_atSNB193.8654.090Details
BioGPS NCI60206979_atSNB754.0264.090Details
BioGPS NCI60206979_atSR4.1204.090Details
BioGPS NCI60206979_atSW6204.1124.090Details
BioGPS NCI60206979_atT244.1184.090Details
BioGPS NCI60206979_atT3M44.2424.090Details
BioGPS NCI60206979_atTK104.0224.090Details
BioGPS NCI60206979_atU1183.9604.090Details
BioGPS NCI60206979_atU1383.8444.090Details
BioGPS NCI60206979_atU20S4.0564.090Details
BioGPS NCI60206979_atU2513.9994.090Details
BioGPS NCI60206979_atU873.9994.090Details
BioGPS NCI60206979_atUACC2573.9844.090Details
BioGPS NCI60206979_atUACC624.1034.090Details
BioGPS NCI60206979_atUO313.9304.090Details
BioGPS NCI60206979_atZR75_14.1754.090Details
BioGPS NCI60206979_atastrocytes4.1254.090Details
BioGPS NCI60206979_athuh-74.2824.090Details