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Gene ID: 731 | C8A Antibody Resource


C8A Antibody Resource
Gene Full Name: 
complement component 8, alpha polypeptide
Uniprot: 
P07357
Protein Name: 
complement component C8 alpha chain
Nucleotide: 
NM_000562
Alias: 
Ensembl: 
ENSG00000157131
Location: 
1p32
HPRD: 
00409
NCBI Gene: 
731
MIM: 
120950

Summary: 
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]
Function: 
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.
Subcellular location: 
Secreted. Cell membrane; Multi-pass membrane protein. Note: Secreted as soluble protein. Inserts into the cell membrane of target cells.
PTM: 
Cleavage on pair of basic residues;
Disease: 
Complement component 8 deficiency, 1 (C8D1) [MIM:613790]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OASA09149 C8A Antibody (OASA09149) Human IHC-AFF, ELISA 1ml $420 Details
Polyclonal Antibody ARP60082_P050 C8A Antibody (ARP60082_P050) Polyclonal Human Not tested 50 ug $125 Details

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C8A Protocols
Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60082 Chimpanzee C8A antibody; Pan troglodytes C8A antibody H2R3U7 100.0%
ARP60082 Human C8A antibody; Homo sapiens C8A antibody P07357 100.0%
ARP60082 Human C8A antibody; Homo sapiens C8A antibody Q05CV2 100.0%
ARP60082 Northern white-cheeked gibbon C8A antibody; Nomascus leucogenys C8A antibody G1RXC0 100.0%
ARP60082 Rhesus macaque C8A antibody; Macaca mulatta C8A antibody F6U5Q9 93.0%
ARP60082 Sumatran orangutan C8A antibody; Pongo abelii C8A antibody H2N791 100.0%
ARP60082 White-tufted-ear marmoset C8A antibody; Callithrix jacchus C8A antibody F7IEW5 85.0%
ARP60082 White-tufted-ear marmoset C8A antibody; Callithrix jacchus C8A antibody F7IEW8 85.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas206305_s_at721_B_lymphoblasts9.85012.340Details
BioGPS Gene Atlas206305_s_atAdipocyte8.95012.340Details
BioGPS Gene Atlas206305_s_atAdrenalCortex14.25012.340Details
BioGPS Gene Atlas206305_s_atAdrenalgland8.40012.340Details
BioGPS Gene Atlas206305_s_atAmygdala8.95012.340Details
BioGPS Gene Atlas206305_s_atAppendix9.55012.340Details
BioGPS Gene Atlas206305_s_atAtrioventricularNode12.40012.340Details
BioGPS Gene Atlas206305_s_atBDCA4+_DentriticCells8.25012.340Details
BioGPS Gene Atlas206305_s_atBonemarrow9.80012.340Details
BioGPS Gene Atlas206305_s_atBronchialEpithelialCells8.55012.340Details
BioGPS Gene Atlas206305_s_atCD105+_Endothelial8.40012.340Details
BioGPS Gene Atlas206305_s_atCD14+_Monocytes9.35012.340Details
BioGPS Gene Atlas206305_s_atCD19+_BCells(neg._sel.)8.95012.340Details
BioGPS Gene Atlas206305_s_atCD33+_Myeloid10.45012.340Details
BioGPS Gene Atlas206305_s_atCD34+10.25012.340Details
BioGPS Gene Atlas206305_s_atCD4+_Tcells8.95012.340Details
BioGPS Gene Atlas206305_s_atCD56+_NKCells9.95012.340Details
BioGPS Gene Atlas206305_s_atCD71+_EarlyErythroid8.20012.340Details
BioGPS Gene Atlas206305_s_atCD8+_Tcells7.75012.340Details
BioGPS Gene Atlas206305_s_atCardiacMyocytes12.85012.340Details
BioGPS Gene Atlas206305_s_atCaudatenucleus8.60012.340Details
BioGPS Gene Atlas206305_s_atCerebellum9.50012.340Details
BioGPS Gene Atlas206305_s_atCerebellumPeduncles11.85012.340Details
BioGPS Gene Atlas206305_s_atCiliaryGanglion9.95012.340Details
BioGPS Gene Atlas206305_s_atCingulateCortex9.95012.340Details
BioGPS Gene Atlas206305_s_atColorectaladenocarcinoma8.95012.340Details
BioGPS Gene Atlas206305_s_atDorsalRootGanglion8.15012.340Details
BioGPS Gene Atlas206305_s_atFetalThyroid9.30012.340Details
BioGPS Gene Atlas206305_s_atFetalbrain8.70012.340Details
BioGPS Gene Atlas206305_s_atFetalliver52.45012.340Details
BioGPS Gene Atlas206305_s_atFetallung7.30012.340Details
BioGPS Gene Atlas206305_s_atGlobusPallidus7.65012.340Details
BioGPS Gene Atlas206305_s_atHeart19.60012.340Details
BioGPS Gene Atlas206305_s_atHypothalamus9.80012.340Details
BioGPS Gene Atlas206305_s_atKidney8.65012.340Details
BioGPS Gene Atlas206305_s_atLeukemia_chronicMyelogenousK-5628.30012.340Details
BioGPS Gene Atlas206305_s_atLeukemia_promyelocytic-HL-608.15012.340Details
BioGPS Gene Atlas206305_s_atLeukemialymphoblastic(MOLT-4)7.40012.340Details
BioGPS Gene Atlas206305_s_atLiver190.95012.340Details
BioGPS Gene Atlas206305_s_atLung10.00012.340Details
BioGPS Gene Atlas206305_s_atLymphnode7.55012.340Details
BioGPS Gene Atlas206305_s_atLymphoma_burkitts(Daudi)13.80012.340Details
BioGPS Gene Atlas206305_s_atLymphoma_burkitts(Raji)14.00012.340Details
BioGPS Gene Atlas206305_s_atMedullaOblongata9.90012.340Details
BioGPS Gene Atlas206305_s_atOccipitalLobe7.95012.340Details
BioGPS Gene Atlas206305_s_atOlfactoryBulb7.40012.340Details
BioGPS Gene Atlas206305_s_atOvary7.45012.340Details
BioGPS Gene Atlas206305_s_atPancreas7.45012.340Details
BioGPS Gene Atlas206305_s_atPancreaticIslet9.60012.340Details
BioGPS Gene Atlas206305_s_atParietalLobe10.80012.340Details
BioGPS Gene Atlas206305_s_atPituitary10.55012.340Details
BioGPS Gene Atlas206305_s_atPlacenta8.55012.340Details
BioGPS Gene Atlas206305_s_atPons10.15012.340Details
BioGPS Gene Atlas206305_s_atPrefrontalCortex11.00012.340Details
BioGPS Gene Atlas206305_s_atProstate10.60012.340Details
BioGPS Gene Atlas206305_s_atSalivarygland7.95012.340Details
BioGPS Gene Atlas206305_s_atSkeletalMuscle20.45012.340Details
BioGPS Gene Atlas206305_s_atSkin9.35012.340Details
BioGPS Gene Atlas206305_s_atSmoothMuscle10.30012.340Details
BioGPS Gene Atlas206305_s_atSpinalcord9.75012.340Details
BioGPS Gene Atlas206305_s_atSubthalamicNucleus8.40012.340Details
BioGPS Gene Atlas206305_s_atSuperiorCervicalGanglion17.05012.340Details
BioGPS Gene Atlas206305_s_atTemporalLobe8.45012.340Details
BioGPS Gene Atlas206305_s_atTestis7.65012.340Details
BioGPS Gene Atlas206305_s_atTestisGermCell7.40012.340Details
BioGPS Gene Atlas206305_s_atTestisIntersitial7.65012.340Details
BioGPS Gene Atlas206305_s_atTestisLeydigCell10.50012.340Details
BioGPS Gene Atlas206305_s_atTestisSeminiferousTubule8.85012.340Details
BioGPS Gene Atlas206305_s_atThalamus9.50012.340Details
BioGPS Gene Atlas206305_s_atThymus7.10012.340Details
BioGPS Gene Atlas206305_s_atThyroid11.10012.340Details
BioGPS Gene Atlas206305_s_atTongue9.15012.340Details
BioGPS Gene Atlas206305_s_atTonsil12.70012.340Details
BioGPS Gene Atlas206305_s_atTrachea7.65012.340Details
BioGPS Gene Atlas206305_s_atTrigeminalGanglion10.00012.340Details
BioGPS Gene Atlas206305_s_atUterus7.55012.340Details
BioGPS Gene Atlas206305_s_atUterusCorpus12.25012.340Details
BioGPS Gene Atlas206305_s_atWholeBlood9.70012.340Details
BioGPS Gene Atlas206305_s_atWholebrain7.60012.340Details
BioGPS Gene Atlas206305_s_atcolon8.80012.340Details
BioGPS Gene Atlas206305_s_atpineal_day10.56012.340Details
BioGPS Gene Atlas206305_s_atpineal_night10.30012.340Details
BioGPS Gene Atlas206305_s_atretina11.45012.340Details
BioGPS Gene Atlas206305_s_atsmall_intestine8.30012.340Details
BioGPS NCI60206305_s_at7869.3839.400Details
BioGPS NCI60206305_s_atA1728.4539.400Details
BioGPS NCI60206305_s_atA2048.9529.400Details
BioGPS NCI60206305_s_atA3619.1519.400Details
BioGPS NCI60206305_s_atA4988.9489.400Details
BioGPS NCI60206305_s_atA5499.2739.400Details
BioGPS NCI60206305_s_atACC39.4349.400Details
BioGPS NCI60206305_s_atACHN7.9989.400Details
BioGPS NCI60206305_s_atALVA3110.2299.400Details
BioGPS NCI60206305_s_atCAKI19.3619.400Details
BioGPS NCI60206305_s_atCCRT CEM22.6859.400Details
BioGPS NCI60206305_s_atCOLO2059.0939.400Details
BioGPS NCI60206305_s_atDLD18.8509.400Details
BioGPS NCI60206305_s_atDU1458.5699.400Details
BioGPS NCI60206305_s_atEKVX8.4559.400Details
BioGPS NCI60206305_s_atGM1339.2459.400Details
BioGPS NCI60206305_s_atGM16009.4359.400Details
BioGPS NCI60206305_s_atGM23139.1569.400Details
BioGPS NCI60206305_s_atGM23458.9229.400Details
BioGPS NCI60206305_s_atGM24939.3429.400Details
BioGPS NCI60206305_s_atGM9710.0269.400Details
BioGPS NCI60206305_s_atHCC29987.7059.400Details
BioGPS NCI60206305_s_atHCT1169.3419.400Details
BioGPS NCI60206305_s_atHCT158.2019.400Details
BioGPS NCI60206305_s_atHEK 293 T-rex10.7129.400Details
BioGPS NCI60206305_s_atHEK 293T9.1699.400Details
BioGPS NCI60206305_s_atHEK2939.0079.400Details
BioGPS NCI60206305_s_atHELA8.1619.400Details
BioGPS NCI60206305_s_atHEPG29.7529.400Details
BioGPS NCI60206305_s_atHL6013.3169.400Details
BioGPS NCI60206305_s_atHOP629.0289.400Details
BioGPS NCI60206305_s_atHOP928.4909.400Details
BioGPS NCI60206305_s_atHS578T8.8639.400Details
BioGPS NCI60206305_s_atHSG8.7129.400Details
BioGPS NCI60206305_s_atHT10808.8629.400Details
BioGPS NCI60206305_s_atHT299.9709.400Details
BioGPS NCI60206305_s_atIGROV18.7799.400Details
BioGPS NCI60206305_s_atIOSE808.9409.400Details
BioGPS NCI60206305_s_atJURKAT8.9979.400Details
BioGPS NCI60206305_s_atK56210.2479.400Details
BioGPS NCI60206305_s_atKM129.6869.400Details
BioGPS NCI60206305_s_atLN188.3359.400Details
BioGPS NCI60206305_s_atLNCAP9.0339.400Details
BioGPS NCI60206305_s_atLOX IMVI9.0049.400Details
BioGPS NCI60206305_s_atM148.9209.400Details
BioGPS NCI60206305_s_atMALME 3M9.8099.400Details
BioGPS NCI60206305_s_atMCF78.6619.400Details
BioGPS NCI60206305_s_atMD MB2319.1829.400Details
BioGPS NCI60206305_s_atMDA MB43510.3349.400Details
BioGPS NCI60206305_s_atMOLT412.6389.400Details
BioGPS NCI60206305_s_atNCI 4609.3399.400Details
BioGPS NCI60206305_s_atNCI H2269.3289.400Details
BioGPS NCI60206305_s_atNCI H239.0509.400Details
BioGPS NCI60206305_s_atNCI H322M8.9499.400Details
BioGPS NCI60206305_s_atNCVADR RES8.1609.400Details
BioGPS NCI60206305_s_atOVCAR39.5999.400Details
BioGPS NCI60206305_s_atOVCAR48.9289.400Details
BioGPS NCI60206305_s_atOVCAR58.8059.400Details
BioGPS NCI60206305_s_atOVCAR88.3229.400Details
BioGPS NCI60206305_s_atPANC19.1749.400Details
BioGPS NCI60206305_s_atRL79.1729.400Details
BioGPS NCI60206305_s_atRPMI 822610.1999.400Details
BioGPS NCI60206305_s_atRS118469.7019.400Details
BioGPS NCI60206305_s_atRXF3938.9469.400Details
BioGPS NCI60206305_s_atSAOS29.1809.400Details
BioGPS NCI60206305_s_atSF2688.9509.400Details
BioGPS NCI60206305_s_atSF2958.7919.400Details
BioGPS NCI60206305_s_atSF5398.1239.400Details
BioGPS NCI60206305_s_atSHSYSY+RA8.5479.400Details
BioGPS NCI60206305_s_atSHSYSY-RA8.8249.400Details
BioGPS NCI60206305_s_atSKMEL28.9099.400Details
BioGPS NCI60206305_s_atSKMEL289.0419.400Details
BioGPS NCI60206305_s_atSKMEL58.7349.400Details
BioGPS NCI60206305_s_atSKOV39.3669.400Details
BioGPS NCI60206305_s_atSN12C8.8869.400Details
BioGPS NCI60206305_s_atSNB197.5949.400Details
BioGPS NCI60206305_s_atSNB758.8189.400Details
BioGPS NCI60206305_s_atSR9.3339.400Details
BioGPS NCI60206305_s_atSW6209.6349.400Details
BioGPS NCI60206305_s_atT249.3379.400Details
BioGPS NCI60206305_s_atT3M49.6519.400Details
BioGPS NCI60206305_s_atTK108.9789.400Details
BioGPS NCI60206305_s_atU1188.7129.400Details
BioGPS NCI60206305_s_atU1388.2099.400Details
BioGPS NCI60206305_s_atU20S8.7719.400Details
BioGPS NCI60206305_s_atU2518.7969.400Details
BioGPS NCI60206305_s_atU878.6659.400Details
BioGPS NCI60206305_s_atUACC2578.9019.400Details
BioGPS NCI60206305_s_atUACC629.0849.400Details
BioGPS NCI60206305_s_atUO318.0149.400Details
BioGPS NCI60206305_s_atZR75_19.5589.400Details
BioGPS NCI60206305_s_atastrocytes9.0909.400Details
BioGPS NCI60206305_s_athuh-715.8509.400Details