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Gene ID: 727 | C5 Antibody Resource


C5 Antibody Resource
Gene Full Name: 
complement component 5
Uniprot: 
P01031
Protein Name: 
complement C5
Nucleotide: 
NM_001735
Alias: 
C5a;C5b;CPAMD4;
Ensembl: 
ENSG00000106804
Location: 
9q33-q34
HPRD: 
00405
NCBI Gene: 
727
MIM: 
120900

Summary: 
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Function: 
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
Subcellular location: 
Secreted.
PTM: 
Cleavage on pair of basic residues;
Disease: 
Complement component 5 deficiency (C5D) [MIM:609536]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note: The disease is caused by mutations affecting the gene represented in this entry.An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele ().
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Monoclonal Antibody OASA01016 C5 Antibody (OASA01016) ELISA, FN, WB 0.1mg $475 Details
Monoclonal Antibody OASA01017 C5 Antibody (OASA01017) Human ELISA, WB 0.1mg $515 Details
Polyclonal Antibody OASA09148 C5 Antibody (OASA09148) Human ID 1ml $385 Details
Polyclonal Antibody OAMA03463 Sheep anti Complement-C5 Antibody (1ml) 1ml $275 Details
Polyclonal Antibody OAAB05170 C5 antibody - N-terminal region (OAAB05170) Human WB, IHC, FC, ELISA 400ul $289 Details
Polyclonal Antibody ARP41976_P050 C5 Antibody (ARP41976_P050) Polyclonal Guinea pig, Human, Rat Not tested 50 ug $125 Details
Polyclonal Antibody OAGA00917 C5 antibody (OAGA00917) Polyclonal Human IHC (Formalin-fixed paraffin-embedded sections), WB 100 ul $340 Details

Show all C5 antibodies


Product Images
C5 antibody - N-terminal region (OAAB05170) in HL-60 cells using Western Blot

Sample Type: HL-60

C5 antibody - N-terminal region (OAAB05170) in human brain carcinoma cells using Immunohistochemistry

Sample Type: human brain carcinoma

C5 antibody - N-terminal region (OAAB05170) in MDA-231 cells using Flow Cytometry

Sample Type: MDA-231


C5 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP41976 Cat C5 antibody; Felis catus C5 antibody M3VV58 85.0%
ARP41976 Chimpanzee C5 antibody; Pan troglodytes C5 antibody H2QXT1 100.0%
ARP41976 Human C5 antibody; Homo sapiens C5 antibody P01031 100.0%
ARP41976 Northern white-cheeked gibbon C5 antibody; Nomascus leucogenys C5 antibody G1S5G0 93.0%
ARP41976 Small-eared galago C5 antibody; Otolemur garnettii C5 antibody H0XZG5 83.0%
ARP41976 Sumatran orangutan C5 antibody; Pongo abelii C5 antibody H2PT89 100.0%
ARP41976 White-tufted-ear marmoset C5 antibody; Callithrix jacchus C5 antibody F6WH83 92.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas205500_at721_B_lymphoblasts9.45017.530Details
BioGPS Gene Atlas205500_atAdipocyte10.20017.530Details
BioGPS Gene Atlas205500_atAdrenalCortex16.70017.530Details
BioGPS Gene Atlas205500_atAdrenalgland9.00017.530Details
BioGPS Gene Atlas205500_atAmygdala11.15017.530Details
BioGPS Gene Atlas205500_atAppendix14.75017.530Details
BioGPS Gene Atlas205500_atAtrioventricularNode9.90017.530Details
BioGPS Gene Atlas205500_atBDCA4+_DentriticCells9.10017.530Details
BioGPS Gene Atlas205500_atBonemarrow11.50017.530Details
BioGPS Gene Atlas205500_atBronchialEpithelialCells10.20017.530Details
BioGPS Gene Atlas205500_atCD105+_Endothelial10.00017.530Details
BioGPS Gene Atlas205500_atCD14+_Monocytes10.85017.530Details
BioGPS Gene Atlas205500_atCD19+_BCells(neg._sel.)9.85017.530Details
BioGPS Gene Atlas205500_atCD33+_Myeloid13.15017.530Details
BioGPS Gene Atlas205500_atCD34+15.25017.530Details
BioGPS Gene Atlas205500_atCD4+_Tcells9.60017.530Details
BioGPS Gene Atlas205500_atCD56+_NKCells11.35017.530Details
BioGPS Gene Atlas205500_atCD71+_EarlyErythroid9.85017.530Details
BioGPS Gene Atlas205500_atCD8+_Tcells8.30017.530Details
BioGPS Gene Atlas205500_atCardiacMyocytes13.15017.530Details
BioGPS Gene Atlas205500_atCaudatenucleus10.95017.530Details
BioGPS Gene Atlas205500_atCerebellum9.55017.530Details
BioGPS Gene Atlas205500_atCerebellumPeduncles12.10017.530Details
BioGPS Gene Atlas205500_atCiliaryGanglion8.20017.530Details
BioGPS Gene Atlas205500_atCingulateCortex10.90017.530Details
BioGPS Gene Atlas205500_atColorectaladenocarcinoma10.20017.530Details
BioGPS Gene Atlas205500_atDorsalRootGanglion11.35017.530Details
BioGPS Gene Atlas205500_atFetalThyroid10.40017.530Details
BioGPS Gene Atlas205500_atFetalbrain10.30017.530Details
BioGPS Gene Atlas205500_atFetalliver503.95017.530Details
BioGPS Gene Atlas205500_atFetallung20.75017.530Details
BioGPS Gene Atlas205500_atGlobusPallidus8.05017.530Details
BioGPS Gene Atlas205500_atHeart15.85017.530Details
BioGPS Gene Atlas205500_atHypothalamus12.30017.530Details
BioGPS Gene Atlas205500_atKidney9.75017.530Details
BioGPS Gene Atlas205500_atLeukemia_chronicMyelogenousK-5629.40017.530Details
BioGPS Gene Atlas205500_atLeukemia_promyelocytic-HL-609.45017.530Details
BioGPS Gene Atlas205500_atLeukemialymphoblastic(MOLT-4)7.95017.530Details
BioGPS Gene Atlas205500_atLiver42.35017.530Details
BioGPS Gene Atlas205500_atLung10.50017.530Details
BioGPS Gene Atlas205500_atLymphnode8.30017.530Details
BioGPS Gene Atlas205500_atLymphoma_burkitts(Daudi)13.95017.530Details
BioGPS Gene Atlas205500_atLymphoma_burkitts(Raji)14.95017.530Details
BioGPS Gene Atlas205500_atMedullaOblongata13.05017.530Details
BioGPS Gene Atlas205500_atOccipitalLobe10.35017.530Details
BioGPS Gene Atlas205500_atOlfactoryBulb8.25017.530Details
BioGPS Gene Atlas205500_atOvary7.55017.530Details
BioGPS Gene Atlas205500_atPancreas14.05017.530Details
BioGPS Gene Atlas205500_atPancreaticIslet22.85017.530Details
BioGPS Gene Atlas205500_atParietalLobe14.30017.530Details
BioGPS Gene Atlas205500_atPituitary12.60017.530Details
BioGPS Gene Atlas205500_atPlacenta9.15017.530Details
BioGPS Gene Atlas205500_atPons18.10017.530Details
BioGPS Gene Atlas205500_atPrefrontalCortex12.85017.530Details
BioGPS Gene Atlas205500_atProstate10.90017.530Details
BioGPS Gene Atlas205500_atSalivarygland10.10017.530Details
BioGPS Gene Atlas205500_atSkeletalMuscle20.50017.530Details
BioGPS Gene Atlas205500_atSkin12.60017.530Details
BioGPS Gene Atlas205500_atSmoothMuscle11.10017.530Details
BioGPS Gene Atlas205500_atSpinalcord14.40017.530Details
BioGPS Gene Atlas205500_atSubthalamicNucleus9.90017.530Details
BioGPS Gene Atlas205500_atSuperiorCervicalGanglion19.45017.530Details
BioGPS Gene Atlas205500_atTemporalLobe12.30017.530Details
BioGPS Gene Atlas205500_atTestis8.95017.530Details
BioGPS Gene Atlas205500_atTestisGermCell10.45017.530Details
BioGPS Gene Atlas205500_atTestisIntersitial8.65017.530Details
BioGPS Gene Atlas205500_atTestisLeydigCell10.80017.530Details
BioGPS Gene Atlas205500_atTestisSeminiferousTubule10.95017.530Details
BioGPS Gene Atlas205500_atThalamus10.85017.530Details
BioGPS Gene Atlas205500_atThymus7.65017.530Details
BioGPS Gene Atlas205500_atThyroid11.70017.530Details
BioGPS Gene Atlas205500_atTongue13.20017.530Details
BioGPS Gene Atlas205500_atTonsil10.10017.530Details
BioGPS Gene Atlas205500_atTrachea9.00017.530Details
BioGPS Gene Atlas205500_atTrigeminalGanglion14.85017.530Details
BioGPS Gene Atlas205500_atUterus7.65017.530Details
BioGPS Gene Atlas205500_atUterusCorpus9.80017.530Details
BioGPS Gene Atlas205500_atWholeBlood10.60017.530Details
BioGPS Gene Atlas205500_atWholebrain7.95017.530Details
BioGPS Gene Atlas205500_atcolon10.10017.530Details
BioGPS Gene Atlas205500_atpineal_day12.58017.530Details
BioGPS Gene Atlas205500_atpineal_night11.54017.530Details
BioGPS Gene Atlas205500_atretina14.87517.530Details
BioGPS Gene Atlas205500_atsmall_intestine9.95017.530Details
BioGPS NCI60205500_at78610.72137.470Details
BioGPS NCI60205500_atA17210.23237.470Details
BioGPS NCI60205500_atA20429.61837.470Details
BioGPS NCI60205500_atA36110.37537.470Details
BioGPS NCI60205500_atA49811.65737.470Details
BioGPS NCI60205500_atA549889.57237.470Details
BioGPS NCI60205500_atACC311.27437.470Details
BioGPS NCI60205500_atACHN10.04637.470Details
BioGPS NCI60205500_atALVA31311.42437.470Details
BioGPS NCI60205500_atCAKI110.82837.470Details
BioGPS NCI60205500_atCCRT CEM34.99737.470Details
BioGPS NCI60205500_atCOLO20561.76837.470Details
BioGPS NCI60205500_atDLD110.63837.470Details
BioGPS NCI60205500_atDU1459.69037.470Details
BioGPS NCI60205500_atEKVX26.12837.470Details
BioGPS NCI60205500_atGM13310.45637.470Details
BioGPS NCI60205500_atGM160013.47537.470Details
BioGPS NCI60205500_atGM231313.74737.470Details
BioGPS NCI60205500_atGM234510.26437.470Details
BioGPS NCI60205500_atGM249310.96637.470Details
BioGPS NCI60205500_atGM9712.34237.470Details
BioGPS NCI60205500_atHCC29989.92537.470Details
BioGPS NCI60205500_atHCT11610.43737.470Details
BioGPS NCI60205500_atHCT1510.14637.470Details
BioGPS NCI60205500_atHEK 293 T-rex11.64937.470Details
BioGPS NCI60205500_atHEK 293T10.50837.470Details
BioGPS NCI60205500_atHEK2939.56737.470Details
BioGPS NCI60205500_atHELA7.36437.470Details
BioGPS NCI60205500_atHEPG2214.57037.470Details
BioGPS NCI60205500_atHL6044.04137.470Details
BioGPS NCI60205500_atHOP6210.44537.470Details
BioGPS NCI60205500_atHOP928.98737.470Details
BioGPS NCI60205500_atHS578T9.86737.470Details
BioGPS NCI60205500_atHSG10.43737.470Details
BioGPS NCI60205500_atHT108010.00937.470Details
BioGPS NCI60205500_atHT2911.33837.470Details
BioGPS NCI60205500_atIGROV110.01737.470Details
BioGPS NCI60205500_atIOSE809.81537.470Details
BioGPS NCI60205500_atJURKAT10.67037.470Details
BioGPS NCI60205500_atK56214.57437.470Details
BioGPS NCI60205500_atKM1211.84637.470Details
BioGPS NCI60205500_atLN188.74937.470Details
BioGPS NCI60205500_atLNCAP10.23237.470Details
BioGPS NCI60205500_atLOX IMVI9.89837.470Details
BioGPS NCI60205500_atM1410.42237.470Details
BioGPS NCI60205500_atMALME 3M12.47137.470Details
BioGPS NCI60205500_atMCF78.14237.470Details
BioGPS NCI60205500_atMD MB23115.64237.470Details
BioGPS NCI60205500_atMDA MB43516.28137.470Details
BioGPS NCI60205500_atMOLT410.68437.470Details
BioGPS NCI60205500_atNCI 46010.69637.470Details
BioGPS NCI60205500_atNCI H22610.72337.470Details
BioGPS NCI60205500_atNCI H2315.28937.470Details
BioGPS NCI60205500_atNCI H322M10.86337.470Details
BioGPS NCI60205500_atNCVADR RES8.25737.470Details
BioGPS NCI60205500_atOVCAR310.89137.470Details
BioGPS NCI60205500_atOVCAR410.47737.470Details
BioGPS NCI60205500_atOVCAR510.40137.470Details
BioGPS NCI60205500_atOVCAR88.76537.470Details
BioGPS NCI60205500_atPANC110.60237.470Details
BioGPS NCI60205500_atRL710.64937.470Details
BioGPS NCI60205500_atRPMI 822610.67937.470Details
BioGPS NCI60205500_atRS1184610.86337.470Details
BioGPS NCI60205500_atRXF39310.10837.470Details
BioGPS NCI60205500_atSAOS210.05537.470Details
BioGPS NCI60205500_atSF26810.19237.470Details
BioGPS NCI60205500_atSF29510.40737.470Details
BioGPS NCI60205500_atSF5399.45937.470Details
BioGPS NCI60205500_atSHSYSY+RA12.92637.470Details
BioGPS NCI60205500_atSHSYSY-RA13.15737.470Details
BioGPS NCI60205500_atSKMEL215.15937.470Details
BioGPS NCI60205500_atSKMEL2810.22737.470Details
BioGPS NCI60205500_atSKMEL59.67937.470Details
BioGPS NCI60205500_atSKOV310.70337.470Details
BioGPS NCI60205500_atSN12C8.76437.470Details
BioGPS NCI60205500_atSNB199.49637.470Details
BioGPS NCI60205500_atSNB7510.50737.470Details
BioGPS NCI60205500_atSR10.75737.470Details
BioGPS NCI60205500_atSW62010.68637.470Details
BioGPS NCI60205500_atT2410.60337.470Details
BioGPS NCI60205500_atT3M410.87437.470Details
BioGPS NCI60205500_atTK1011.02337.470Details
BioGPS NCI60205500_atU1189.71337.470Details
BioGPS NCI60205500_atU13810.19537.470Details
BioGPS NCI60205500_atU20S9.01437.470Details
BioGPS NCI60205500_atU2519.13037.470Details
BioGPS NCI60205500_atU8710.34637.470Details
BioGPS NCI60205500_atUACC25710.40137.470Details
BioGPS NCI60205500_atUACC6210.42737.470Details
BioGPS NCI60205500_atUO317.95137.470Details
BioGPS NCI60205500_atZR75_112.05837.470Details
BioGPS NCI60205500_atastrocytes10.20537.470Details
BioGPS NCI60205500_athuh-7677.01537.470Details