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Gene ID: 725 | C4BPB Antibody Resource


C4BPB Antibody Resource
Gene Full Name: 
complement component 4 binding protein, beta
Uniprot: 
P20851
Protein Name: 
C4b-binding protein beta chain
Nucleotide: 
XM_005273253
Alias: 
C4BP;
Ensembl: 
ENSG00000123843
Location: 
1q32
HPRD: 
00404
NCBI Gene: 
725
MIM: 
120831

Summary: 
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]
Function: 
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
Subcellular location: 
Secreted.
PTM: 
Disulfide bond;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP33814_P050 C4BPB antibody - N-terminal region (ARP33814_P050) Polyclonal Dog, Human IHC, WB 50ug $289 Details
Polyclonal Antibody OAAB11455 C4BPB antibody - center region (OAAB11455) Human WB 400ul $289 Details

Show all C4BPB antibodies


Product Images
C4BPB antibody - N-terminal region (ARP33814_P050) in Human 721_B cells using Western Blot

Sample Type: Human 721_B

C4BPB antibody - N-terminal region (ARP33814_P050) in Human kidney cells using Immunohistochemistry

Sample Type: Human kidney

C4BPB antibody - N-terminal region (ARP33814_P050) in Human Liver cells using Western Blot

Sample Type: Human Liver

C4BPB antibody - center region (OAAB11455) in 293 cells using Western Blot

Sample Type: 293

C4BPB antibody - center region (OAAB11455) in A549 cells using Western Blot

Sample Type: A549


C4BPB Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP33814 Cat C4BPB antibody; Felis catus C4BPB antibody M3WJK2 87.0%
ARP33814 Chimpanzee C4BPB antibody; Pan troglodytes C4BPB antibody H2R859 100.0%
ARP33814 Dog C4BPB antibody; Canis familiaris C4BPB antibody F1PVL0 86.0%
ARP33814 Dog C4BPB antibody; Canis familiaris C4BPB antibody J9NYG8 86.0%
ARP33814 Human C4BPB antibody; Homo sapiens C4BPB antibody E7EQT9 100.0%
ARP33814 Human C4BPB antibody; Homo sapiens C4BPB antibody P20851-2 100.0%
ARP33814 Human C4BPB antibody; Homo sapiens C4BPB antibody P20851 100.0%
ARP33814 Human C4BPB antibody; Homo sapiens C4BPB antibody Q5VVQ7 100.0%
ARP33814 Pig C4BPB antibody; Sus scrofa C4BPB antibody F1S0J3 93.0%
ARP33814 Rhesus macaque C4BPB antibody; Macaca mulatta C4BPB antibody F6XIH5 80.0%
ARP33814 Sumatran orangutan C4BPB antibody; Pongo abelii C4BPB antibody H2N3W1 100.0%
ARP33814 White-tufted-ear marmoset C4BPB antibody; Callithrix jacchus C4BPB antibody F7BUT1 100.0%
ARP33814 White-tufted-ear marmoset C4BPB antibody; Callithrix jacchus C4BPB antibody F7BUV9 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas208209_s_at721_B_lymphoblasts6.0505.900Details
BioGPS Gene Atlas208209_s_atAdipocyte5.0505.900Details
BioGPS Gene Atlas208209_s_atAdrenalCortex5.7005.900Details
BioGPS Gene Atlas208209_s_atAdrenalgland4.4505.900Details
BioGPS Gene Atlas208209_s_atAmygdala5.2005.900Details
BioGPS Gene Atlas208209_s_atAppendix5.5505.900Details
BioGPS Gene Atlas208209_s_atAtrioventricularNode4.3505.900Details
BioGPS Gene Atlas208209_s_atBDCA4+_DentriticCells5.3505.900Details
BioGPS Gene Atlas208209_s_atBonemarrow5.3505.900Details
BioGPS Gene Atlas208209_s_atBronchialEpithelialCells4.9505.900Details
BioGPS Gene Atlas208209_s_atCD105+_Endothelial5.1505.900Details
BioGPS Gene Atlas208209_s_atCD14+_Monocytes5.3505.900Details
BioGPS Gene Atlas208209_s_atCD19+_BCells(neg._sel.)5.2505.900Details
BioGPS Gene Atlas208209_s_atCD33+_Myeloid6.5005.900Details
BioGPS Gene Atlas208209_s_atCD34+6.2005.900Details
BioGPS Gene Atlas208209_s_atCD4+_Tcells5.3505.900Details
BioGPS Gene Atlas208209_s_atCD56+_NKCells5.8505.900Details
BioGPS Gene Atlas208209_s_atCD71+_EarlyErythroid4.8505.900Details
BioGPS Gene Atlas208209_s_atCD8+_Tcells4.8005.900Details
BioGPS Gene Atlas208209_s_atCardiacMyocytes7.3005.900Details
BioGPS Gene Atlas208209_s_atCaudatenucleus4.6005.900Details
BioGPS Gene Atlas208209_s_atCerebellum4.2005.900Details
BioGPS Gene Atlas208209_s_atCerebellumPeduncles5.9505.900Details
BioGPS Gene Atlas208209_s_atCiliaryGanglion3.9005.900Details
BioGPS Gene Atlas208209_s_atCingulateCortex5.3005.900Details
BioGPS Gene Atlas208209_s_atColorectaladenocarcinoma5.1505.900Details
BioGPS Gene Atlas208209_s_atDorsalRootGanglion4.2005.900Details
BioGPS Gene Atlas208209_s_atFetalThyroid5.0005.900Details
BioGPS Gene Atlas208209_s_atFetalbrain5.0005.900Details
BioGPS Gene Atlas208209_s_atFetalliver15.0005.900Details
BioGPS Gene Atlas208209_s_atFetallung4.1005.900Details
BioGPS Gene Atlas208209_s_atGlobusPallidus3.9005.900Details
BioGPS Gene Atlas208209_s_atHeart7.4005.900Details
BioGPS Gene Atlas208209_s_atHypothalamus5.4005.900Details
BioGPS Gene Atlas208209_s_atKidney4.3505.900Details
BioGPS Gene Atlas208209_s_atLeukemia_chronicMyelogenousK-5624.6005.900Details
BioGPS Gene Atlas208209_s_atLeukemia_promyelocytic-HL-604.5505.900Details
BioGPS Gene Atlas208209_s_atLeukemialymphoblastic(MOLT-4)4.0505.900Details
BioGPS Gene Atlas208209_s_atLiver49.6005.900Details
BioGPS Gene Atlas208209_s_atLung5.5505.900Details
BioGPS Gene Atlas208209_s_atLymphnode4.3005.900Details
BioGPS Gene Atlas208209_s_atLymphoma_burkitts(Daudi)6.7005.900Details
BioGPS Gene Atlas208209_s_atLymphoma_burkitts(Raji)7.5505.900Details
BioGPS Gene Atlas208209_s_atMedullaOblongata4.6005.900Details
BioGPS Gene Atlas208209_s_atOccipitalLobe4.5505.900Details
BioGPS Gene Atlas208209_s_atOlfactoryBulb4.0505.900Details
BioGPS Gene Atlas208209_s_atOvary3.7005.900Details
BioGPS Gene Atlas208209_s_atPancreas4.3005.900Details
BioGPS Gene Atlas208209_s_atPancreaticIslet12.7505.900Details
BioGPS Gene Atlas208209_s_atParietalLobe5.6005.900Details
BioGPS Gene Atlas208209_s_atPituitary5.9005.900Details
BioGPS Gene Atlas208209_s_atPlacenta5.3005.900Details
BioGPS Gene Atlas208209_s_atPons4.9505.900Details
BioGPS Gene Atlas208209_s_atPrefrontalCortex6.2505.900Details
BioGPS Gene Atlas208209_s_atProstate5.9505.900Details
BioGPS Gene Atlas208209_s_atSalivarygland4.2005.900Details
BioGPS Gene Atlas208209_s_atSkeletalMuscle6.5005.900Details
BioGPS Gene Atlas208209_s_atSkin4.3005.900Details
BioGPS Gene Atlas208209_s_atSmoothMuscle5.8005.900Details
BioGPS Gene Atlas208209_s_atSpinalcord5.4005.900Details
BioGPS Gene Atlas208209_s_atSubthalamicNucleus4.8005.900Details
BioGPS Gene Atlas208209_s_atSuperiorCervicalGanglion6.4005.900Details
BioGPS Gene Atlas208209_s_atTemporalLobe4.7505.900Details
BioGPS Gene Atlas208209_s_atTestis4.4005.900Details
BioGPS Gene Atlas208209_s_atTestisGermCell4.1505.900Details
BioGPS Gene Atlas208209_s_atTestisIntersitial4.3005.900Details
BioGPS Gene Atlas208209_s_atTestisLeydigCell5.1505.900Details
BioGPS Gene Atlas208209_s_atTestisSeminiferousTubule4.3505.900Details
BioGPS Gene Atlas208209_s_atThalamus5.2505.900Details
BioGPS Gene Atlas208209_s_atThymus3.9505.900Details
BioGPS Gene Atlas208209_s_atThyroid6.3005.900Details
BioGPS Gene Atlas208209_s_atTongue5.2005.900Details
BioGPS Gene Atlas208209_s_atTonsil5.0005.900Details
BioGPS Gene Atlas208209_s_atTrachea4.2505.900Details
BioGPS Gene Atlas208209_s_atTrigeminalGanglion5.5005.900Details
BioGPS Gene Atlas208209_s_atUterus4.1005.900Details
BioGPS Gene Atlas208209_s_atUterusCorpus4.8505.900Details
BioGPS Gene Atlas208209_s_atWholeBlood5.5505.900Details
BioGPS Gene Atlas208209_s_atWholebrain4.1505.900Details
BioGPS Gene Atlas208209_s_atcolon5.1505.900Details
BioGPS Gene Atlas208209_s_atpineal_day6.3405.900Details
BioGPS Gene Atlas208209_s_atpineal_night6.2005.900Details
BioGPS Gene Atlas208209_s_atretina6.1755.900Details
BioGPS Gene Atlas208209_s_atsmall_intestine4.9005.900Details
BioGPS NCI60208209_s_at7865.43029.070Details
BioGPS NCI60208209_s_atA1724.83729.070Details
BioGPS NCI60208209_s_atA2045.16929.070Details
BioGPS NCI60208209_s_atA3615.29329.070Details
BioGPS NCI60208209_s_atA4985.19329.070Details
BioGPS NCI60208209_s_atA5495.36529.070Details
BioGPS NCI60208209_s_atACC3571.25829.070Details
BioGPS NCI60208209_s_atACHN4.92929.070Details
BioGPS NCI60208209_s_atALVA315.69629.070Details
BioGPS NCI60208209_s_atCAKI15.57129.070Details
BioGPS NCI60208209_s_atCCRT CEM6.42429.070Details
BioGPS NCI60208209_s_atCOLO2055.30729.070Details
BioGPS NCI60208209_s_atDLD1266.49329.070Details
BioGPS NCI60208209_s_atDU1454.89629.070Details
BioGPS NCI60208209_s_atEKVX5.05229.070Details
BioGPS NCI60208209_s_atGM1335.38029.070Details
BioGPS NCI60208209_s_atGM16005.54229.070Details
BioGPS NCI60208209_s_atGM23135.37129.070Details
BioGPS NCI60208209_s_atGM23455.22229.070Details
BioGPS NCI60208209_s_atGM24935.61529.070Details
BioGPS NCI60208209_s_atGM976.25829.070Details
BioGPS NCI60208209_s_atHCC29984.79829.070Details
BioGPS NCI60208209_s_atHCT1165.25329.070Details
BioGPS NCI60208209_s_atHCT15111.82729.070Details
BioGPS NCI60208209_s_atHEK 293 T-rex5.46029.070Details
BioGPS NCI60208209_s_atHEK 293T5.18629.070Details
BioGPS NCI60208209_s_atHEK2935.18129.070Details
BioGPS NCI60208209_s_atHELA132.45629.070Details
BioGPS NCI60208209_s_atHEPG2252.65529.070Details
BioGPS NCI60208209_s_atHL605.54329.070Details
BioGPS NCI60208209_s_atHOP625.20729.070Details
BioGPS NCI60208209_s_atHOP925.22729.070Details
BioGPS NCI60208209_s_atHS578T5.09629.070Details
BioGPS NCI60208209_s_atHSG1143.97529.070Details
BioGPS NCI60208209_s_atHT10805.08029.070Details
BioGPS NCI60208209_s_atHT296.03529.070Details
BioGPS NCI60208209_s_atIGROV15.09129.070Details
BioGPS NCI60208209_s_atIOSE805.17929.070Details
BioGPS NCI60208209_s_atJURKAT5.24029.070Details
BioGPS NCI60208209_s_atK5625.82729.070Details
BioGPS NCI60208209_s_atKM127.75329.070Details
BioGPS NCI60208209_s_atLN184.74429.070Details
BioGPS NCI60208209_s_atLNCAP5.23429.070Details
BioGPS NCI60208209_s_atLOX IMVI5.25429.070Details
BioGPS NCI60208209_s_atM145.16229.070Details
BioGPS NCI60208209_s_atMALME 3M5.85429.070Details
BioGPS NCI60208209_s_atMCF74.98529.070Details
BioGPS NCI60208209_s_atMD MB2319.35129.070Details
BioGPS NCI60208209_s_atMDA MB4355.83129.070Details
BioGPS NCI60208209_s_atMOLT45.51229.070Details
BioGPS NCI60208209_s_atNCI 4605.39829.070Details
BioGPS NCI60208209_s_atNCI H2265.52229.070Details
BioGPS NCI60208209_s_atNCI H235.19229.070Details
BioGPS NCI60208209_s_atNCI H322M5.18129.070Details
BioGPS NCI60208209_s_atNCVADR RES4.80729.070Details
BioGPS NCI60208209_s_atOVCAR35.54929.070Details
BioGPS NCI60208209_s_atOVCAR45.17629.070Details
BioGPS NCI60208209_s_atOVCAR55.06529.070Details
BioGPS NCI60208209_s_atOVCAR84.75329.070Details
BioGPS NCI60208209_s_atPANC15.35929.070Details
BioGPS NCI60208209_s_atRL75.35429.070Details
BioGPS NCI60208209_s_atRPMI 82265.37929.070Details
BioGPS NCI60208209_s_atRS118465.66129.070Details
BioGPS NCI60208209_s_atRXF3935.16029.070Details
BioGPS NCI60208209_s_atSAOS25.30129.070Details
BioGPS NCI60208209_s_atSF2686.22329.070Details
BioGPS NCI60208209_s_atSF2954.99929.070Details
BioGPS NCI60208209_s_atSF5394.80629.070Details
BioGPS NCI60208209_s_atSHSYSY+RA4.91329.070Details
BioGPS NCI60208209_s_atSHSYSY-RA5.07329.070Details
BioGPS NCI60208209_s_atSKMEL25.18629.070Details
BioGPS NCI60208209_s_atSKMEL285.21929.070Details
BioGPS NCI60208209_s_atSKMEL54.87329.070Details
BioGPS NCI60208209_s_atSKOV35.49829.070Details
BioGPS NCI60208209_s_atSN12C121.90629.070Details
BioGPS NCI60208209_s_atSNB194.81829.070Details
BioGPS NCI60208209_s_atSNB755.12329.070Details
BioGPS NCI60208209_s_atSR5.43629.070Details
BioGPS NCI60208209_s_atSW6205.39229.070Details
BioGPS NCI60208209_s_atT245.38329.070Details
BioGPS NCI60208209_s_atT3M45.54829.070Details
BioGPS NCI60208209_s_atTK105.15829.070Details
BioGPS NCI60208209_s_atU1185.01329.070Details
BioGPS NCI60208209_s_atU1384.73829.070Details
BioGPS NCI60208209_s_atU20S5.05829.070Details
BioGPS NCI60208209_s_atU2515.14229.070Details
BioGPS NCI60208209_s_atU874.97329.070Details
BioGPS NCI60208209_s_atUACC2575.12829.070Details
BioGPS NCI60208209_s_atUACC625.32529.070Details
BioGPS NCI60208209_s_atUO314.96929.070Details
BioGPS NCI60208209_s_atZR75_15.40429.070Details
BioGPS NCI60208209_s_atastrocytes5.24029.070Details
BioGPS NCI60208209_s_athuh-75.86729.070Details