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Gene ID: 718 | C3 Antibody Resource


C3 Antibody Resource
Gene Full Name: 
complement component 3
Uniprot: 
P01024
Protein Name: 
complement C3
Nucleotide: 
NM_000064
Alias: 
ASP;C3a;C3b;AHUS5;ARMD9;CPAMD1;
Ensembl: 
ENSG00000125730
Location: 
19p13.3-p13.2
HPRD: 
00400
NCBI Gene: 
718
MIM: 
120700

Summary: 
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Feb 2009]
Function: 
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. Acylation stimulating protein (ASP): adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.
Subcellular location: 
Secreted.
PTM: 
Cleavage on pair of basic residues;
Disease: 
Complement component 3 deficiency (C3D) [MIM:613779]: A rare defect of the complement classical pathway. Patients develop recurrent, severe, pyogenic infections because of ineffective opsonization of pathogens. Some patients may also develop autoimmune disorders, such as arthralgia and vasculitic rashes, lupus-like syndrome and membranoproliferative glomerulonephritis. Note: The disease is caused by mutations affecting the gene represented in this entry. Macular degeneration, age-related, 9 (ARMD9) [MIM:611378]: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.Hemolytic uremic syndrome atypical 5 (AHUS5) [MIM:612925]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype. Increased levels of C3 and its cleavage product ASP, are associated with obesity, diabetes and coronary heart disease. Short-term endurance training reduces baseline ASP levels and subsequently fat storage.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Monoclonal Antibody OASA00997 C3 Antibody (OASA00997) Human IHC-AFF, ELISA, WB 50ug $755 Details
Monoclonal Antibody OASA00998 C3 Antibody (OASA00998) Human ELISA, WB 0.1ml $515 Details
Monoclonal Antibody OASA00999 MOUSE ANTI HUMAN C3a Antibody (50ug) IHC-AFF, ELISA, WB 50ug $390 Details
Monoclonal Antibody OASA01005 C3 Antibody (OASA01005) Human IHC-AFF, WB 50ug $810 Details
Monoclonal Antibody OASA01006 C3 Antibody (OASA01006) Human ELISA 0.1mg $810 Details
Monoclonal Antibody OASA01007 C3 Antibody (OASA01007) Human IHC-AFF, ELISA, FC, WB 0.1mg $515 Details
Monoclonal Antibody OASA01008 C3 Antibody (OASA01008) Human IHC-AFF, ELISA, FC, WB 0.1ml $515 Details
Monoclonal Antibody OASA01009 C3 Antibody (OASA01009) Human IHC-AFF, ELISA, FC 0.1mg $670 Details
Monoclonal Antibody OASA02912 C3 Antibody (OASA02912) Human IHC-AFF, ELISA, FC, WB 0.1mg $670 Details
Polyclonal Antibody OASA06063 C3 Antibody (OASA06063) Human TB 1ml $115 Details
Polyclonal Antibody OASA09139 C3 Antibody (OASA09139) Human IHC-AFF, ELISA 1ml $230 Details
Polyclonal Antibody OASA09140 C3 Antibody (OASA09140) Human ELISA, IF 1mg $430 Details
Polyclonal Antibody OASA09141 C3 Antibody (OASA09141) Human IHC-AFF 1ml $415 Details
Polyclonal Antibody OASA09142 C3 Antibody (OASA09142) Human ELISA, WB 1ml $330 Details
Polyclonal Antibody OASA09143 C3 Antibody (OASA09143) Human ELISA, RID 1ml $585 Details
Polyclonal Antibody OAMA03022 Chicken anti Human C3 Antibody (1mg) ELISA, WB 1mg $150 Details
Polyclonal Antibody OAMA03458 Sheep anti Complement C3c Antibody (1ml) 1ml $160 Details
Polyclonal Antibody OAMA03459 Sheep anti Complement C3c Antibody (1ml) WB, IHC-PLP 1ml $305 Details
Polyclonal Antibody OAMA03578 Goat anti Human C3 Antibody (10ml) TB 10ml $105 Details
Polyclonal Antibody OAMA03807 Goat anti Guinea Pig C3 Antibody (1ml) 1ml $265 Details
Others OOSA09710 NATIVE HUMAN C3 Antigen (1mg) 1mg $360 Details
Others OOSA09711 NATIVE HUMAN C3b Antigen (0.1mg) Human 0.1mg $715 Details
Polyclonal Antibody ARP60072_P050 C3 Antibody (ARP60072_P050) Polyclonal Horse, Human, Rabbit, Rat Not tested 50 ug $125 Details
Monoclonal Antibody OAAB07081 C3 antibody - C - terminal region (OAAB07081) Human WB 400ul $289 Details
Monoclonal Antibody OAAB07082 C3 antibody - C - terminal region (OAAB07082) Human WB 400ul $289 Details
Polyclonal Antibody OAAB09991 C3 antibody - C - terminal region (OAAB09991) Human WB, IF 400ul $289 Details
Polyclonal Antibody OAGA00087 C3 antibody (OAGA00087) Polyclonal Human, Mouse ICC/IF, IHC (Formalin-fixed paraffin-embedded sections), WB 100 ul $340 Details

Show all C3 antibodies


Product Images
C3 Antibody (OASA09139) in Native Human C3c cells using ELISA

Sample Type: Native Human C3c

C3 Antibody (OASA09140) in Native Human C3c cells using ELISA

Sample Type: Native Human C3c

C3 Antibody (OASA09142) in Native Human C3c cells using ELISA

Sample Type: Native Human C3c


C3 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60071 Bovine C3 antibody; Bos taurus C3 antibody G3X7A5 86.0%
ARP60071 Bovine C3 antibody; Bos taurus C3 antibody Q2UVX4 86.0%
ARP60071 Bovine C3 antibody; Bos taurus C3 antibody Q6KDN5 86.0%
ARP60072 Bovine C3 antibody; Bos taurus C3 antibody G3X7A5 83.0%
ARP60072 Bovine C3 antibody; Bos taurus C3 antibody Q2UVX4 83.0%
ARP60072 Chimpanzee C3 antibody; Pan troglodytes C3 antibody K7CUE1 100.0%
ARP60071 Chimpanzee C3 antibody; Pan troglodytes C3 antibody K7CUE1 93.0%
ARP60071 Dog C3 antibody; Canis familiaris C3 antibody F1PIX8 85.0%
ARP60071 European domestic ferret C3 antibody; Mustela putorius furo C3 antibody M3Y6H7 79.0%
ARP60071 Giant panda C3 antibody; Ailuropoda melanoleuca C3 antibody G1LL53 79.0%
ARP49831 Gray short-tailed opossum C3 antibody; Monodelphis domestica C3 antibody F6YF42 82.0%
ARP49831 Gray short-tailed opossum C3 antibody; Monodelphis domestica C3 antibody F6ZDV8 82.0%
ARP60071 Guinea pig C3 antibody; Cavia porcellus C3 antibody H0V2L4 79.0%
ARP60071 Guinea pig C3 antibody; Cavia porcellus C3 antibody H0VG32 79.0%
ARP60071 Guinea pig C3 antibody; Cavia porcellus C3 antibody H0W536 79.0%
ARP60071 Guinea pig C3 antibody; Cavia porcellus C3 antibody P12387 79.0%
ARP60071 Human C3 antibody; Homo sapiens C3 antibody P01024 100.0%
ARP60072 Human C3 antibody; Homo sapiens C3 antibody P01024 100.0%
ARP60071 Indian cobra C3 antibody; Naja naja C3 antibody Q01833 90.0%
ARP60071 Pig C3 antibody; Sus scrofa C3 antibody P01025 79.0%
ARP60071 Rabbit C3 antibody; Oryctolagus cuniculus C3 antibody P12247 79.0%
ARP60072 Rabbit C3 antibody; Oryctolagus cuniculus C3 antibody P12247 79.0%
ARP60072 Rat C3 antibody; Rattus norvegicus C3 antibody M0RBF1 83.0%
ARP60072 Rat C3 antibody; Rattus norvegicus C3 antibody M0RBJ7 83.0%
ARP60072 Rat C3 antibody; Rattus norvegicus C3 antibody P01026 83.0%
ARP60071 Rhesus macaque C3 antibody; Macaca mulatta C3 antibody F7EV32 100.0%
ARP60072 Rhesus macaque C3 antibody; Macaca mulatta C3 antibody F7EV32 100.0%
ARP60071 Rhesus macaque C3 antibody; Macaca mulatta C3 antibody H9EXI6 100.0%
ARP60072 Rhesus macaque C3 antibody; Macaca mulatta C3 antibody H9EXI6 100.0%
ARP60071 Rhesus macaque C3 antibody; Macaca mulatta C3 antibody I2CT48 100.0%
ARP60072 Rhesus macaque C3 antibody; Macaca mulatta C3 antibody I2CT48 100.0%
ARP60072 Small-eared galago C3 antibody; Otolemur garnettii C3 antibody H0WJW4 86.0%
ARP60071 Small-eared galago C3 antibody; Otolemur garnettii C3 antibody H0WJW4 79.0%
ARP60071 Sumatran orangutan C3 antibody; Pongo abelii C3 antibody H2NX88 100.0%
ARP60072 Sumatran orangutan C3 antibody; Pongo abelii C3 antibody H2NX88 100.0%
ARP60071 Thirteen-lined ground squirrel C3 antibody; Spermophilus tridecemlineatus C3 antibody I3M2C6 86.0%
ARP60072 Thirteen-lined ground squirrel C3 antibody; Spermophilus tridecemlineatus C3 antibody I3M2C6 83.0%
ARP60071 White-tufted-ear marmoset C3 antibody; Callithrix jacchus C3 antibody F6ZAR9 100.0%
ARP60071 White-tufted-ear marmoset C3 antibody; Callithrix jacchus C3 antibody U3DGG8 100.0%
ARP60072 White-tufted-ear marmoset C3 antibody; Callithrix jacchus C3 antibody U3DGG8 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas217767_at721_B_lymphoblasts13.200661.620Details
BioGPS Gene Atlas217767_atAdipocyte1216.650661.620Details
BioGPS Gene Atlas217767_atAdrenalCortex923.150661.620Details
BioGPS Gene Atlas217767_atAdrenalgland1012.500661.620Details
BioGPS Gene Atlas217767_atAmygdala146.200661.620Details
BioGPS Gene Atlas217767_atAppendix1397.100661.620Details
BioGPS Gene Atlas217767_atAtrioventricularNode152.600661.620Details
BioGPS Gene Atlas217767_atBDCA4+_DentriticCells7.500661.620Details
BioGPS Gene Atlas217767_atBonemarrow15.600661.620Details
BioGPS Gene Atlas217767_atBronchialEpithelialCells18.050661.620Details
BioGPS Gene Atlas217767_atCD105+_Endothelial7.150661.620Details
BioGPS Gene Atlas217767_atCD14+_Monocytes13.150661.620Details
BioGPS Gene Atlas217767_atCD19+_BCells(neg._sel.)7.100661.620Details
BioGPS Gene Atlas217767_atCD33+_Myeloid11.300661.620Details
BioGPS Gene Atlas217767_atCD34+8.500661.620Details
BioGPS Gene Atlas217767_atCD4+_Tcells7.300661.620Details
BioGPS Gene Atlas217767_atCD56+_NKCells12.500661.620Details
BioGPS Gene Atlas217767_atCD71+_EarlyErythroid12.250661.620Details
BioGPS Gene Atlas217767_atCD8+_Tcells6.650661.620Details
BioGPS Gene Atlas217767_atCardiacMyocytes55.950661.620Details
BioGPS Gene Atlas217767_atCaudatenucleus166.800661.620Details
BioGPS Gene Atlas217767_atCerebellum18.800661.620Details
BioGPS Gene Atlas217767_atCerebellumPeduncles32.100661.620Details
BioGPS Gene Atlas217767_atCiliaryGanglion70.800661.620Details
BioGPS Gene Atlas217767_atCingulateCortex16.850661.620Details
BioGPS Gene Atlas217767_atColorectaladenocarcinoma7.000661.620Details
BioGPS Gene Atlas217767_atDorsalRootGanglion97.150661.620Details
BioGPS Gene Atlas217767_atFetalThyroid427.150661.620Details
BioGPS Gene Atlas217767_atFetalbrain14.250661.620Details
BioGPS Gene Atlas217767_atFetalliver2641.150661.620Details
BioGPS Gene Atlas217767_atFetallung4925.600661.620Details
BioGPS Gene Atlas217767_atGlobusPallidus20.650661.620Details
BioGPS Gene Atlas217767_atHeart258.800661.620Details
BioGPS Gene Atlas217767_atHypothalamus592.900661.620Details
BioGPS Gene Atlas217767_atKidney13.000661.620Details
BioGPS Gene Atlas217767_atLeukemia_chronicMyelogenousK-56213.750661.620Details
BioGPS Gene Atlas217767_atLeukemia_promyelocytic-HL-606.000661.620Details
BioGPS Gene Atlas217767_atLeukemialymphoblastic(MOLT-4)6.650661.620Details
BioGPS Gene Atlas217767_atLiver21751.551661.620Details
BioGPS Gene Atlas217767_atLung2131.200661.620Details
BioGPS Gene Atlas217767_atLymphnode658.200661.620Details
BioGPS Gene Atlas217767_atLymphoma_burkitts(Daudi)8.550661.620Details
BioGPS Gene Atlas217767_atLymphoma_burkitts(Raji)11.750661.620Details
BioGPS Gene Atlas217767_atMedullaOblongata15.600661.620Details
BioGPS Gene Atlas217767_atOccipitalLobe120.750661.620Details
BioGPS Gene Atlas217767_atOlfactoryBulb477.050661.620Details
BioGPS Gene Atlas217767_atOvary4990.150661.620Details
BioGPS Gene Atlas217767_atPancreas793.350661.620Details
BioGPS Gene Atlas217767_atPancreaticIslet3485.550661.620Details
BioGPS Gene Atlas217767_atParietalLobe49.800661.620Details
BioGPS Gene Atlas217767_atPituitary108.800661.620Details
BioGPS Gene Atlas217767_atPlacenta67.050661.620Details
BioGPS Gene Atlas217767_atPons14.900661.620Details
BioGPS Gene Atlas217767_atPrefrontalCortex92.750661.620Details
BioGPS Gene Atlas217767_atProstate64.150661.620Details
BioGPS Gene Atlas217767_atSalivarygland475.200661.620Details
BioGPS Gene Atlas217767_atSkeletalMuscle52.000661.620Details
BioGPS Gene Atlas217767_atSkin181.500661.620Details
BioGPS Gene Atlas217767_atSmoothMuscle3133.550661.620Details
BioGPS Gene Atlas217767_atSpinalcord837.900661.620Details
BioGPS Gene Atlas217767_atSubthalamicNucleus17.300661.620Details
BioGPS Gene Atlas217767_atSuperiorCervicalGanglion12.000661.620Details
BioGPS Gene Atlas217767_atTemporalLobe19.550661.620Details
BioGPS Gene Atlas217767_atTestis18.500661.620Details
BioGPS Gene Atlas217767_atTestisGermCell60.600661.620Details
BioGPS Gene Atlas217767_atTestisIntersitial23.500661.620Details
BioGPS Gene Atlas217767_atTestisLeydigCell32.350661.620Details
BioGPS Gene Atlas217767_atTestisSeminiferousTubule90.700661.620Details
BioGPS Gene Atlas217767_atThalamus279.850661.620Details
BioGPS Gene Atlas217767_atThymus532.600661.620Details
BioGPS Gene Atlas217767_atThyroid102.800661.620Details
BioGPS Gene Atlas217767_atTongue49.400661.620Details
BioGPS Gene Atlas217767_atTonsil909.950661.620Details
BioGPS Gene Atlas217767_atTrachea354.550661.620Details
BioGPS Gene Atlas217767_atTrigeminalGanglion18.150661.620Details
BioGPS Gene Atlas217767_atUterus115.550661.620Details
BioGPS Gene Atlas217767_atUterusCorpus14.550661.620Details
BioGPS Gene Atlas217767_atWholeBlood16.550661.620Details
BioGPS Gene Atlas217767_atWholebrain104.300661.620Details
BioGPS Gene Atlas217767_atcolon98.900661.620Details
BioGPS Gene Atlas217767_atpineal_day130.120661.620Details
BioGPS Gene Atlas217767_atpineal_night57.000661.620Details
BioGPS Gene Atlas217767_atretina434.975661.620Details
BioGPS Gene Atlas217767_atsmall_intestine118.100661.620Details
BioGPS NCI60217767_at7864.804266.860Details
BioGPS NCI60217767_atA1724.509266.860Details
BioGPS NCI60217767_atA2044.649266.860Details
BioGPS NCI60217767_atA3614.722266.860Details
BioGPS NCI60217767_atA49816.988266.860Details
BioGPS NCI60217767_atA54911.937266.860Details
BioGPS NCI60217767_atACC36822.096266.860Details
BioGPS NCI60217767_atACHN24.695266.860Details
BioGPS NCI60217767_atALVA314.821266.860Details
BioGPS NCI60217767_atCAKI1249.530266.860Details
BioGPS NCI60217767_atCCRT CEM5.262266.860Details
BioGPS NCI60217767_atCOLO2054.680266.860Details
BioGPS NCI60217767_atDLD14.551266.860Details
BioGPS NCI60217767_atDU1454.501266.860Details
BioGPS NCI60217767_atEKVX7724.445266.860Details
BioGPS NCI60217767_atGM133377.408266.860Details
BioGPS NCI60217767_atGM16004.948266.860Details
BioGPS NCI60217767_atGM23135.252266.860Details
BioGPS NCI60217767_atGM23454.710266.860Details
BioGPS NCI60217767_atGM24934.885266.860Details
BioGPS NCI60217767_atGM975.269266.860Details
BioGPS NCI60217767_atHCC29984.156266.860Details
BioGPS NCI60217767_atHCT1164.673266.860Details
BioGPS NCI60217767_atHCT154.326266.860Details
BioGPS NCI60217767_atHEK 293 T-rex4.812266.860Details
BioGPS NCI60217767_atHEK 293T4.657266.860Details
BioGPS NCI60217767_atHEK2934.681266.860Details
BioGPS NCI60217767_atHELA557.158266.860Details
BioGPS NCI60217767_atHEPG25506.111266.860Details
BioGPS NCI60217767_atHL604.883266.860Details
BioGPS NCI60217767_atHOP6231.794266.860Details
BioGPS NCI60217767_atHOP921042.161266.860Details
BioGPS NCI60217767_atHS578T4.643266.860Details
BioGPS NCI60217767_atHSG2287.053266.860Details
BioGPS NCI60217767_atHT108014.298266.860Details
BioGPS NCI60217767_atHT294.939266.860Details
BioGPS NCI60217767_atIGROV14.653266.860Details
BioGPS NCI60217767_atIOSE804.802266.860Details
BioGPS NCI60217767_atJURKAT4.668266.860Details
BioGPS NCI60217767_atK5625.051266.860Details
BioGPS NCI60217767_atKM124.825266.860Details
BioGPS NCI60217767_atLN184.460266.860Details
BioGPS NCI60217767_atLNCAP4.726266.860Details
BioGPS NCI60217767_atLOX IMVI94.941266.860Details
BioGPS NCI60217767_atM144.615266.860Details
BioGPS NCI60217767_atMALME 3M4.910266.860Details
BioGPS NCI60217767_atMCF74.602266.860Details
BioGPS NCI60217767_atMD MB2314.717266.860Details
BioGPS NCI60217767_atMDA MB4355.051266.860Details
BioGPS NCI60217767_atMOLT44.791266.860Details
BioGPS NCI60217767_atNCI 4604.849266.860Details
BioGPS NCI60217767_atNCI H226141.451266.860Details
BioGPS NCI60217767_atNCI H234.686266.860Details
BioGPS NCI60217767_atNCI H322M4.779266.860Details
BioGPS NCI60217767_atNCVADR RES10.681266.860Details
BioGPS NCI60217767_atOVCAR34.856266.860Details
BioGPS NCI60217767_atOVCAR4353.979266.860Details
BioGPS NCI60217767_atOVCAR5120.073266.860Details
BioGPS NCI60217767_atOVCAR84.551266.860Details
BioGPS NCI60217767_atPANC14.744266.860Details
BioGPS NCI60217767_atRL74.743266.860Details
BioGPS NCI60217767_atRPMI 82264.806266.860Details
BioGPS NCI60217767_atRS118464.974266.860Details
BioGPS NCI60217767_atRXF39331.629266.860Details
BioGPS NCI60217767_atSAOS24.731266.860Details
BioGPS NCI60217767_atSF2688.889266.860Details
BioGPS NCI60217767_atSF295206.001266.860Details
BioGPS NCI60217767_atSF5397.983266.860Details
BioGPS NCI60217767_atSHSYSY+RA4.499266.860Details
BioGPS NCI60217767_atSHSYSY-RA4.612266.860Details
BioGPS NCI60217767_atSKMEL24.656266.860Details
BioGPS NCI60217767_atSKMEL284.694266.860Details
BioGPS NCI60217767_atSKMEL54.402266.860Details
BioGPS NCI60217767_atSKOV36.177266.860Details
BioGPS NCI60217767_atSN12C4.633266.860Details
BioGPS NCI60217767_atSNB194.498266.860Details
BioGPS NCI60217767_atSNB7522.623266.860Details
BioGPS NCI60217767_atSR4.844266.860Details
BioGPS NCI60217767_atSW6204.724266.860Details
BioGPS NCI60217767_atT244.771266.860Details
BioGPS NCI60217767_atT3M4170.950266.860Details
BioGPS NCI60217767_atTK10414.547266.860Details
BioGPS NCI60217767_atU1184.673266.860Details
BioGPS NCI60217767_atU1384.452266.860Details
BioGPS NCI60217767_atU20S4.572266.860Details
BioGPS NCI60217767_atU2514.616266.860Details
BioGPS NCI60217767_atU879.840266.860Details
BioGPS NCI60217767_atUACC2574.595266.860Details
BioGPS NCI60217767_atUACC624.777266.860Details
BioGPS NCI60217767_atUO31547.706266.860Details
BioGPS NCI60217767_atZR75_116.383266.860Details
BioGPS NCI60217767_atastrocytes4.716266.860Details
BioGPS NCI60217767_athuh-7743.079266.860Details