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Gene ID: 717 | C2 Antibody Resource


C2 Antibody Resource
Gene Full Name: 
complement component 2
Uniprot: 
P06681
Protein Name: 
complement C2
Nucleotide: 
NR_073063
Alias: 
CO2;ARMD14;
Ensembl: 
ENSG00000166278
Location: 
6p21.3
HPRD: 
08939
NCBI Gene: 
717
MIM: 
613927

Summary: 
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
Function: 
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
Subcellular location: 
Secreted.
PTM: 
Disulfide bond;
Disease: 
Complement component 2 deficiency (C2D) [MIM:217000]: A rare defect of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent invasive infections. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP41669_T100 C2 antibody - middle region (ARP41669_T100) Polyclonal Bovine, Dog, Horse, Human, Mouse, Pig, Rat, Sheep WB 100ug $229 Details
Polyclonal Antibody ARP41668_P050 C2 antibody - N-terminal region (ARP41668_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat WB 50ug $289 Details
Protein Lysate APL10421 C2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
DNA/cDNA/RNA ANA10421 C2 (Human) cDNA (1ug) 1ug $189 Details
DNA/cDNA/RNA ANA10752 C2 (Human) cDNA (1ug) 1ug $189 Details
DNA/cDNA/RNA ANA10656 C2 (Human) cDNA (1ug) 1ug $189 Details
DNA/cDNA/RNA ANA10753 C2 (Human) cDNA (1ug) 1ug $189 Details
Protein Lysate APL10752 C2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
Protein Lysate APL10656 C2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
Protein Lysate APL10753 C2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
Polyclonal Antibody OAAB00679 C2 antibody - N-terminal region (OAAB00679) Human; Hamster WB, ELISA 400ul $289 Details
Polyclonal Antibody OAGA00397 C2 antibody (OAGA00397) Polyclonal Human ICC/IF, WB 100 ul $340 Details

Show all C2 antibodies


Product Images
C2 antibody - N-terminal region (ARP41668_P050) in Human Heart cells using Western Blot

Sample Type: Human Heart

C2 antibody - middle region (ARP41669_T100) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

C2 antibody - N-terminal region (OAAB00679) in CHO cells using Western Blot

Sample Type: CHO


C2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP41669 Bornean orangutan C2 antibody; Pongo pygmaeus C2 antibody Q8SQ75 100.0%
ARP41669 Bovine C2 antibody; Bos taurus C2 antibody Q0V7N2 93.0%
ARP41669 Bovine C2 antibody; Bos taurus C2 antibody Q3SYW2 93.0%
ARP41669 Chimpanzee C2 antibody; Pan troglodytes C2 antibody H2QSP9 100.0%
ARP41669 Chimpanzee C2 antibody; Pan troglodytes C2 antibody Q8SQ74 100.0%
ARP41669 Duckbill platypus C2 antibody; Ornithorhynchus anatinus C2 antibody F7DRC0 86.0%
ARP41669 Duckbill platypus C2 antibody; Ornithorhynchus anatinus C2 antibody F7DRC5 86.0%
ARP41669 Horse C2 antibody; Equus caballus C2 antibody F6PPQ0 100.0%
ARP41669 Human C2 antibody; Homo sapiens C2 antibody B3KTX9 100.0%
ARP41669 Human C2 antibody; Homo sapiens C2 antibody B4DQI1 100.0%
ARP41669 Human C2 antibody; Homo sapiens C2 antibody E9PDZ0 100.0%
ARP41669 Human C2 antibody; Homo sapiens C2 antibody H0Y3H6 100.0%
ARP41669 Human C2 antibody; Homo sapiens C2 antibody P06681-2 100.0%
ARP41669 Human C2 antibody; Homo sapiens C2 antibody P06681-3 100.0%
ARP41669 Human C2 antibody; Homo sapiens C2 antibody P06681 100.0%
ARP41669 Human C2 antibody; Homo sapiens C2 antibody Q5JP69 100.0%
ARP41669 Human C2 antibody; Homo sapiens C2 antibody Q95IG1 100.0%
ARP41669 Lowland gorilla C2 antibody; Gorilla gorilla gorilla C2 antibody Q863A0 100.0%
ARP41669 Mouse C2 antibody; Mus musculus C2 antibody B8JJM9 100.0%
ARP41669 Mouse C2 antibody; Mus musculus C2 antibody B8JJN2 100.0%
ARP41669 Mouse C2 antibody; Mus musculus C2 antibody P21180-2 100.0%
ARP41669 Mouse C2 antibody; Mus musculus C2 antibody P21180 100.0%
ARP41669 Mouse C2 antibody; Mus musculus C2 antibody Q792Q3 100.0%
ARP41669 Pig C2 antibody; Sus scrofa C2 antibody A5PF02 100.0%
ARP41669 Pig C2 antibody; Sus scrofa C2 antibody F1RQW7 100.0%
ARP41669 Rabbit C2 antibody; Oryctolagus cuniculus C2 antibody G1SS66 93.0%
ARP56331 Rat C2 antibody; Rattus norvegicus C2 antibody G3V615 100.0%
ARP41669 Rat C2 antibody; Rattus norvegicus C2 antibody Q6MG73 100.0%
ARP41669 Rat C2 antibody; Rattus norvegicus C2 antibody Q8CIP8 100.0%
ARP41669 Rhesus macaque C2 antibody; Macaca mulatta C2 antibody H9F7N7 100.0%
ARP41669 Sheep C2 antibody; Ovis aries C2 antibody A5YBU8 93.0%
ARP41669 Sumatran orangutan C2 antibody; Pongo abelii C2 antibody H2PIL3 100.0%
ARP41669 White-tufted-ear marmoset C2 antibody; Callithrix jacchus C2 antibody U3DWS1 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas203052_at721_B_lymphoblasts4.85013.880Details
BioGPS Gene Atlas203052_atAdipocyte5.40013.880Details
BioGPS Gene Atlas203052_atAdrenalCortex4.80013.880Details
BioGPS Gene Atlas203052_atAdrenalgland3.90013.880Details
BioGPS Gene Atlas203052_atAmygdala4.15013.880Details
BioGPS Gene Atlas203052_atAppendix4.60013.880Details
BioGPS Gene Atlas203052_atAtrioventricularNode4.50013.880Details
BioGPS Gene Atlas203052_atBDCA4+_DentriticCells4.30013.880Details
BioGPS Gene Atlas203052_atBonemarrow3.95013.880Details
BioGPS Gene Atlas203052_atBronchialEpithelialCells3.85013.880Details
BioGPS Gene Atlas203052_atCD105+_Endothelial6.55013.880Details
BioGPS Gene Atlas203052_atCD14+_Monocytes4.20013.880Details
BioGPS Gene Atlas203052_atCD19+_BCells(neg._sel.)4.15013.880Details
BioGPS Gene Atlas203052_atCD33+_Myeloid5.45013.880Details
BioGPS Gene Atlas203052_atCD34+5.00013.880Details
BioGPS Gene Atlas203052_atCD4+_Tcells4.20013.880Details
BioGPS Gene Atlas203052_atCD56+_NKCells4.70013.880Details
BioGPS Gene Atlas203052_atCD71+_EarlyErythroid3.85013.880Details
BioGPS Gene Atlas203052_atCD8+_Tcells3.75013.880Details
BioGPS Gene Atlas203052_atCardiacMyocytes5.15013.880Details
BioGPS Gene Atlas203052_atCaudatenucleus3.55013.880Details
BioGPS Gene Atlas203052_atCerebellum3.20013.880Details
BioGPS Gene Atlas203052_atCerebellumPeduncles4.55013.880Details
BioGPS Gene Atlas203052_atCiliaryGanglion3.25013.880Details
BioGPS Gene Atlas203052_atCingulateCortex4.10013.880Details
BioGPS Gene Atlas203052_atColorectaladenocarcinoma3.90013.880Details
BioGPS Gene Atlas203052_atDorsalRootGanglion3.20013.880Details
BioGPS Gene Atlas203052_atFetalThyroid3.80013.880Details
BioGPS Gene Atlas203052_atFetalbrain3.95013.880Details
BioGPS Gene Atlas203052_atFetalliver45.70013.880Details
BioGPS Gene Atlas203052_atFetallung6.20013.880Details
BioGPS Gene Atlas203052_atGlobusPallidus2.95013.880Details
BioGPS Gene Atlas203052_atHeart5.20013.880Details
BioGPS Gene Atlas203052_atHypothalamus4.30013.880Details
BioGPS Gene Atlas203052_atKidney3.30013.880Details
BioGPS Gene Atlas203052_atLeukemia_chronicMyelogenousK-5623.55013.880Details
BioGPS Gene Atlas203052_atLeukemia_promyelocytic-HL-603.50013.880Details
BioGPS Gene Atlas203052_atLeukemialymphoblastic(MOLT-4)3.20013.880Details
BioGPS Gene Atlas203052_atLiver746.95013.880Details
BioGPS Gene Atlas203052_atLung68.85013.880Details
BioGPS Gene Atlas203052_atLymphnode4.60013.880Details
BioGPS Gene Atlas203052_atLymphoma_burkitts(Daudi)5.00013.880Details
BioGPS Gene Atlas203052_atLymphoma_burkitts(Raji)5.50013.880Details
BioGPS Gene Atlas203052_atMedullaOblongata3.55013.880Details
BioGPS Gene Atlas203052_atOccipitalLobe3.55013.880Details
BioGPS Gene Atlas203052_atOlfactoryBulb3.10013.880Details
BioGPS Gene Atlas203052_atOvary3.15013.880Details
BioGPS Gene Atlas203052_atPancreas4.35013.880Details
BioGPS Gene Atlas203052_atPancreaticIslet4.25013.880Details
BioGPS Gene Atlas203052_atParietalLobe4.25013.880Details
BioGPS Gene Atlas203052_atPituitary4.65013.880Details
BioGPS Gene Atlas203052_atPlacenta5.60013.880Details
BioGPS Gene Atlas203052_atPons4.65013.880Details
BioGPS Gene Atlas203052_atPrefrontalCortex4.85013.880Details
BioGPS Gene Atlas203052_atProstate4.60013.880Details
BioGPS Gene Atlas203052_atSalivarygland3.20013.880Details
BioGPS Gene Atlas203052_atSkeletalMuscle5.00013.880Details
BioGPS Gene Atlas203052_atSkin3.20013.880Details
BioGPS Gene Atlas203052_atSmoothMuscle4.45013.880Details
BioGPS Gene Atlas203052_atSpinalcord4.35013.880Details
BioGPS Gene Atlas203052_atSubthalamicNucleus3.60013.880Details
BioGPS Gene Atlas203052_atSuperiorCervicalGanglion6.10013.880Details
BioGPS Gene Atlas203052_atTemporalLobe5.60013.880Details
BioGPS Gene Atlas203052_atTestis3.35013.880Details
BioGPS Gene Atlas203052_atTestisGermCell3.30013.880Details
BioGPS Gene Atlas203052_atTestisIntersitial3.30013.880Details
BioGPS Gene Atlas203052_atTestisLeydigCell4.45013.880Details
BioGPS Gene Atlas203052_atTestisSeminiferousTubule3.40013.880Details
BioGPS Gene Atlas203052_atThalamus4.00013.880Details
BioGPS Gene Atlas203052_atThymus3.10013.880Details
BioGPS Gene Atlas203052_atThyroid4.95013.880Details
BioGPS Gene Atlas203052_atTongue4.00013.880Details
BioGPS Gene Atlas203052_atTonsil4.45013.880Details
BioGPS Gene Atlas203052_atTrachea3.30013.880Details
BioGPS Gene Atlas203052_atTrigeminalGanglion4.25013.880Details
BioGPS Gene Atlas203052_atUterus3.15013.880Details
BioGPS Gene Atlas203052_atUterusCorpus3.70013.880Details
BioGPS Gene Atlas203052_atWholeBlood4.30013.880Details
BioGPS Gene Atlas203052_atWholebrain3.35013.880Details
BioGPS Gene Atlas203052_atcolon3.95013.880Details
BioGPS Gene Atlas203052_atpineal_day4.88013.880Details
BioGPS Gene Atlas203052_atpineal_night4.78013.880Details
BioGPS Gene Atlas203052_atretina4.77513.880Details
BioGPS Gene Atlas203052_atsmall_intestine3.80013.880Details
BioGPS NCI60203052_at7864.1219.770Details
BioGPS NCI60203052_atA1723.8339.770Details
BioGPS NCI60203052_atA2044.0089.770Details
BioGPS NCI60203052_atA3614.0539.770Details
BioGPS NCI60203052_atA4983.9959.770Details
BioGPS NCI60203052_atA5494.0819.770Details
BioGPS NCI60203052_atACC34.1939.770Details
BioGPS NCI60203052_atACHN3.7919.770Details
BioGPS NCI60203052_atALVA314.2619.770Details
BioGPS NCI60203052_atCAKI14.1609.770Details
BioGPS NCI60203052_atCCRT CEM4.4349.770Details
BioGPS NCI60203052_atCOLO2054.0489.770Details
BioGPS NCI60203052_atDLD13.9589.770Details
BioGPS NCI60203052_atDU1453.8559.770Details
BioGPS NCI60203052_atEKVX3.8719.770Details
BioGPS NCI60203052_atGM1334.1029.770Details
BioGPS NCI60203052_atGM16004.1979.770Details
BioGPS NCI60203052_atGM23134.0809.770Details
BioGPS NCI60203052_atGM23454.0379.770Details
BioGPS NCI60203052_atGM24934.2219.770Details
BioGPS NCI60203052_atGM974.4509.770Details
BioGPS NCI60203052_atHCC29983.8249.770Details
BioGPS NCI60203052_atHCT1164.0089.770Details
BioGPS NCI60203052_atHCT153.9029.770Details
BioGPS NCI60203052_atHEK 293 T-rex4.0939.770Details
BioGPS NCI60203052_atHEK 293T3.9919.770Details
BioGPS NCI60203052_atHEK2933.9879.770Details
BioGPS NCI60203052_atHELA3.8069.770Details
BioGPS NCI60203052_atHEPG2621.0849.770Details
BioGPS NCI60203052_atHL604.1179.770Details
BioGPS NCI60203052_atHOP624.0199.770Details
BioGPS NCI60203052_atHOP923.9019.770Details
BioGPS NCI60203052_atHS578T3.9459.770Details
BioGPS NCI60203052_atHSG5.4399.770Details
BioGPS NCI60203052_atHT10803.9619.770Details
BioGPS NCI60203052_atHT294.2739.770Details
BioGPS NCI60203052_atIGROV13.9769.770Details
BioGPS NCI60203052_atIOSE803.9839.770Details
BioGPS NCI60203052_atJURKAT4.0089.770Details
BioGPS NCI60203052_atK5624.2859.770Details
BioGPS NCI60203052_atKM124.1709.770Details
BioGPS NCI60203052_atLN183.8049.770Details
BioGPS NCI60203052_atLNCAP4.0159.770Details
BioGPS NCI60203052_atLOX IMVI4.0089.770Details
BioGPS NCI60203052_atM143.9579.770Details
BioGPS NCI60203052_atMALME 3M4.2499.770Details
BioGPS NCI60203052_atMCF73.8859.770Details
BioGPS NCI60203052_atMD MB2314.0489.770Details
BioGPS NCI60203052_atMDA MB4354.2629.770Details
BioGPS NCI60203052_atMOLT44.1409.770Details
BioGPS NCI60203052_atNCI 4604.1159.770Details
BioGPS NCI60203052_atNCI H2264.1079.770Details
BioGPS NCI60203052_atNCI H234.0009.770Details
BioGPS NCI60203052_atNCI H322M4.0119.770Details
BioGPS NCI60203052_atNCVADR RES3.8019.770Details
BioGPS NCI60203052_atOVCAR34.2609.770Details
BioGPS NCI60203052_atOVCAR43.9959.770Details
BioGPS NCI60203052_atOVCAR53.9469.770Details
BioGPS NCI60203052_atOVCAR83.7809.770Details
BioGPS NCI60203052_atPANC14.0779.770Details
BioGPS NCI60203052_atRL74.0809.770Details
BioGPS NCI60203052_atRPMI 82264.0679.770Details
BioGPS NCI60203052_atRS118464.1979.770Details
BioGPS NCI60203052_atRXF3935.8329.770Details
BioGPS NCI60203052_atSAOS24.0579.770Details
BioGPS NCI60203052_atSF2683.9989.770Details
BioGPS NCI60203052_atSF2953.9509.770Details
BioGPS NCI60203052_atSF5393.8919.770Details
BioGPS NCI60203052_atSHSYSY+RA3.9019.770Details
BioGPS NCI60203052_atSHSYSY-RA3.9629.770Details
BioGPS NCI60203052_atSKMEL23.9859.770Details
BioGPS NCI60203052_atSKMEL284.0249.770Details
BioGPS NCI60203052_atSKMEL54.8099.770Details
BioGPS NCI60203052_atSKOV34.1619.770Details
BioGPS NCI60203052_atSN12C3.9709.770Details
BioGPS NCI60203052_atSNB193.8099.770Details
BioGPS NCI60203052_atSNB754.0129.770Details
BioGPS NCI60203052_atSR4.2379.770Details
BioGPS NCI60203052_atSW6204.0759.770Details
BioGPS NCI60203052_atT244.1109.770Details
BioGPS NCI60203052_atT3M44.1689.770Details
BioGPS NCI60203052_atTK103.9959.770Details
BioGPS NCI60203052_atU1183.9139.770Details
BioGPS NCI60203052_atU1383.8019.770Details
BioGPS NCI60203052_atU20S3.8859.770Details
BioGPS NCI60203052_atU2513.9509.770Details
BioGPS NCI60203052_atU873.9089.770Details
BioGPS NCI60203052_atUACC2573.9349.770Details
BioGPS NCI60203052_atUACC624.0609.770Details
BioGPS NCI60203052_atUO313.8819.770Details
BioGPS NCI60203052_atZR75_14.1219.770Details
BioGPS NCI60203052_atastrocytes4.0059.770Details
BioGPS NCI60203052_athuh-74.1369.770Details