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Gene ID: 701 | BUB1B Antibody Resource


BUB1B Antibody Resource
Gene Full Name: 
BUB1 mitotic checkpoint serine/threonine kinase B
Uniprot: 
O60566
Protein Name: 
mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Nucleotide: 
NM_001211
Alias: 
MVA1;SSK1;BUBR1;Bub1A;MAD3L;hBUBR1;BUB1beta;
Ensembl: 
ENSG00000156970
Location: 
15q15
HPRD: 
04176
NCBI Gene: 
701
MIM: 
602860

Summary: 
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]
Function: 
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
Subcellular location: 
Cytoplasm. Nucleus. Chromosome › centromere › kinetochore. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Note: Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5.
PTM: 
Acetylation;
Disease: 
Defects in BUB1B are associated with tumor formation.Premature chromatid separation trait (PCS) [MIM:176430]: Consists of separate and splayed chromatids with discernible centromeres and involves all or most chromosomes of a metaphase. It is found in up to 2% of metaphases in cultured lymphocytes from approximately 40% of normal individuals. When PCS is present in 5% or more of cells, it is known as the heterozygous PCS trait and has no obvious phenotypic effect, although some have reported decreased fertility. Inheritance is autosomal dominant. Note: The disease is caused by mutations affecting the gene represented in this entry. Mosaic variegated aneuploidy syndrome 1 (MVA1) [MIM:257300]: A severe developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in several cases. Note: The disease is caused by mutations affecting the gene represented in this entry. MVA1 is caused by biallelic mutations in the BUB1B gene.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB05065 BUB1B antibody - center region (OAAB05065) Human WB, ELISA 400ul $289 Details
Polyclonal Antibody OAAB05066 BUB1B antibody - N-terminal region (OAAB05066) Human WB, ELISA 400ul $289 Details
Polyclonal Antibody ARP46050_P050 BUB1B Antibody (ARP46050_P050) Polyclonal Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody ARP46051_P050 BUB1B Antibody (ARP46051_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Rabbit Not tested 50 ug $125 Details
Polyclonal Antibody OAAB17416 BUBR1 (BUB1B) antibody - N - terminal region (OAAB17416) Human WB 400ul $289 Details
Polyclonal Antibody OAEC02100 BUB1B Antibody (OAEC02100) Human; Mouse WB, ELISA 100ug $229 Details
Polyclonal Antibody OAAF02041 BUB1B Antibody (OAAF02041) Polyclonal Human, Mouse WB, ELISA 100 ug $229 Details

Show all BUB1B antibodies


Product Images
BUBR1 (BUB1B) antibody - N - terminal region (OAAB17416) in 293, BUB1B cells using Western Blot

Sample Type: 293, BUB1B

BUB1B Antibody (OAAF02041) in HeLa, HepG2 all cells using Western Blot

Sample Type: HeLa, HepG2 all

BUB1B Antibody (OAEC02100) in Human Hela cells using Western Blot

Sample Type: Human Hela


BUB1B Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP46051 African elephant BUB1B antibody; Loxodonta africana BUB1B antibody G3T802 87.0%
ARP46050 African elephant BUB1B antibody; Loxodonta africana BUB1B antibody G3T802 79.0%
ARP46051 Cat BUB1B antibody; Felis catus BUB1B antibody M3WI56 86.0%
ARP46050 Cat BUB1B antibody; Felis catus BUB1B antibody M3WI56 79.0%
ARP46050 Chimpanzee BUB1B antibody; Pan troglodytes BUB1B antibody H2Q958 100.0%
ARP46051 Chimpanzee BUB1B antibody; Pan troglodytes BUB1B antibody H2Q958 100.0%
ARP46050 Chimpanzee BUB1B antibody; Pan troglodytes BUB1B antibody K7C836 100.0%
ARP46051 Chimpanzee BUB1B antibody; Pan troglodytes BUB1B antibody K7C836 100.0%
ARP46050 Dog BUB1B antibody; Canis familiaris BUB1B antibody F1PLV9 86.0%
ARP46051 Dog BUB1B antibody; Canis familiaris BUB1B antibody F1PLV9 86.0%
ARP46050 European domestic ferret BUB1B antibody; Mustela putorius furo BUB1B antibody M3YAG0 86.0%
ARP46051 European domestic ferret BUB1B antibody; Mustela putorius furo BUB1B antibody M3YAG0 79.0%
ARP46050 Giant panda BUB1B antibody; Ailuropoda melanoleuca BUB1B antibody G1MFQ8 86.0%
ARP46051 Giant panda BUB1B antibody; Ailuropoda melanoleuca BUB1B antibody G1MFQ8 86.0%
ARP46050 Giant panda BUB1B antibody; Ailuropoda melanoleuca BUB1B antibody G1MFR2 86.0%
ARP46051 Giant panda BUB1B antibody; Ailuropoda melanoleuca BUB1B antibody G1MFR2 86.0%
ARP46050 Gray short-tailed opossum BUB1B antibody; Monodelphis domestica BUB1B antibody F6X4B4 86.0%
ARP46051 Horse BUB1B antibody; Equus caballus BUB1B antibody F6X411 100.0%
ARP46050 Horse BUB1B antibody; Equus caballus BUB1B antibody F6X411 93.0%
ARP46050 Human BUB1B antibody; Homo sapiens BUB1B antibody O60566-2 100.0%
ARP46051 Human BUB1B antibody; Homo sapiens BUB1B antibody O60566-2 100.0%
ARP46050 Human BUB1B antibody; Homo sapiens BUB1B antibody O60566-3 100.0%
ARP46051 Human BUB1B antibody; Homo sapiens BUB1B antibody O60566-3 100.0%
ARP46050 Human BUB1B antibody; Homo sapiens BUB1B antibody O60566 100.0%
ARP46051 Human BUB1B antibody; Homo sapiens BUB1B antibody O60566 100.0%
ARP46050 Mouse BUB1B antibody; Mus musculus BUB1B antibody Q3UZD6 86.0%
ARP46050 Mouse BUB1B antibody; Mus musculus BUB1B antibody Q8K2E5 86.0%
ARP46050 Mouse BUB1B antibody; Mus musculus BUB1B antibody Q9Z1S0 86.0%
ARP46050 Northern white-cheeked gibbon BUB1B antibody; Nomascus leucogenys BUB1B antibody G1QQS2 100.0%
ARP46051 Northern white-cheeked gibbon BUB1B antibody; Nomascus leucogenys BUB1B antibody G1QQS2 100.0%
ARP46050 Rat BUB1B antibody; Rattus norvegicus BUB1B antibody F1LMI1 86.0%
ARP46050 Rhesus macaque BUB1B antibody; Macaca mulatta BUB1B antibody H9ZCX5 100.0%
ARP46051 Rhesus macaque BUB1B antibody; Macaca mulatta BUB1B antibody H9ZCX5 100.0%
ARP46050 Small-eared galago BUB1B antibody; Otolemur garnettii BUB1B antibody H0WYI1 100.0%
ARP46051 Small-eared galago BUB1B antibody; Otolemur garnettii BUB1B antibody H0WYI1 93.0%
ARP46050 Sumatran orangutan BUB1B antibody; Pongo abelii BUB1B antibody H2NMT8 100.0%
ARP46051 Sumatran orangutan BUB1B antibody; Pongo abelii BUB1B antibody H2NMT8 100.0%
ARP46050 Tasmanian devil BUB1B antibody; Sarcophilus harrisii BUB1B antibody G3WG59 79.0%
ARP46050 Tasmanian devil BUB1B antibody; Sarcophilus harrisii BUB1B antibody G3WG60 79.0%
ARP46050 Thirteen-lined ground squirrel BUB1B antibody; Spermophilus tridecemlineatus BUB1B antibody I3MDU5 93.0%
ARP46051 Thirteen-lined ground squirrel BUB1B antibody; Spermophilus tridecemlineatus BUB1B antibody I3MDU5 93.0%
ARP46050 White-tufted-ear marmoset BUB1B antibody; Callithrix jacchus BUB1B antibody F7HZM1 100.0%
ARP46051 White-tufted-ear marmoset BUB1B antibody; Callithrix jacchus BUB1B antibody F7HZM1 100.0%
ARP46050 White-tufted-ear marmoset BUB1B antibody; Callithrix jacchus BUB1B antibody F7HZN2 100.0%
ARP46051 White-tufted-ear marmoset BUB1B antibody; Callithrix jacchus BUB1B antibody F7HZN2 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas203755_at721_B_lymphoblasts661.60030.210Details
BioGPS Gene Atlas203755_atAdipocyte5.00030.210Details
BioGPS Gene Atlas203755_atAdrenalCortex5.65030.210Details
BioGPS Gene Atlas203755_atAdrenalgland4.40030.210Details
BioGPS Gene Atlas203755_atAmygdala5.10030.210Details
BioGPS Gene Atlas203755_atAppendix5.55030.210Details
BioGPS Gene Atlas203755_atAtrioventricularNode4.20030.210Details
BioGPS Gene Atlas203755_atBDCA4+_DentriticCells13.50030.210Details
BioGPS Gene Atlas203755_atBonemarrow5.70030.210Details
BioGPS Gene Atlas203755_atBronchialEpithelialCells5.40030.210Details
BioGPS Gene Atlas203755_atCD105+_Endothelial265.90030.210Details
BioGPS Gene Atlas203755_atCD14+_Monocytes5.70030.210Details
BioGPS Gene Atlas203755_atCD19+_BCells(neg._sel.)5.55030.210Details
BioGPS Gene Atlas203755_atCD33+_Myeloid12.80030.210Details
BioGPS Gene Atlas203755_atCD34+230.45030.210Details
BioGPS Gene Atlas203755_atCD4+_Tcells5.35030.210Details
BioGPS Gene Atlas203755_atCD56+_NKCells6.20030.210Details
BioGPS Gene Atlas203755_atCD71+_EarlyErythroid117.95030.210Details
BioGPS Gene Atlas203755_atCD8+_Tcells5.05030.210Details
BioGPS Gene Atlas203755_atCardiacMyocytes57.15030.210Details
BioGPS Gene Atlas203755_atCaudatenucleus4.65030.210Details
BioGPS Gene Atlas203755_atCerebellum4.20030.210Details
BioGPS Gene Atlas203755_atCerebellumPeduncles6.00030.210Details
BioGPS Gene Atlas203755_atCiliaryGanglion4.50030.210Details
BioGPS Gene Atlas203755_atCingulateCortex5.35030.210Details
BioGPS Gene Atlas203755_atColorectaladenocarcinoma47.10030.210Details
BioGPS Gene Atlas203755_atDorsalRootGanglion4.15030.210Details
BioGPS Gene Atlas203755_atFetalThyroid5.10030.210Details
BioGPS Gene Atlas203755_atFetalbrain5.00030.210Details
BioGPS Gene Atlas203755_atFetalliver12.00030.210Details
BioGPS Gene Atlas203755_atFetallung4.45030.210Details
BioGPS Gene Atlas203755_atGlobusPallidus3.85030.210Details
BioGPS Gene Atlas203755_atHeart7.05030.210Details
BioGPS Gene Atlas203755_atHypothalamus5.60030.210Details
BioGPS Gene Atlas203755_atKidney4.30030.210Details
BioGPS Gene Atlas203755_atLeukemia_chronicMyelogenousK-56259.75030.210Details
BioGPS Gene Atlas203755_atLeukemia_promyelocytic-HL-60207.65030.210Details
BioGPS Gene Atlas203755_atLeukemialymphoblastic(MOLT-4)215.10030.210Details
BioGPS Gene Atlas203755_atLiver7.00030.210Details
BioGPS Gene Atlas203755_atLung5.60030.210Details
BioGPS Gene Atlas203755_atLymphnode4.45030.210Details
BioGPS Gene Atlas203755_atLymphoma_burkitts(Daudi)95.85030.210Details
BioGPS Gene Atlas203755_atLymphoma_burkitts(Raji)77.50030.210Details
BioGPS Gene Atlas203755_atMedullaOblongata4.60030.210Details
BioGPS Gene Atlas203755_atOccipitalLobe4.50030.210Details
BioGPS Gene Atlas203755_atOlfactoryBulb3.90030.210Details
BioGPS Gene Atlas203755_atOvary4.15030.210Details
BioGPS Gene Atlas203755_atPancreas4.30030.210Details
BioGPS Gene Atlas203755_atPancreaticIslet5.45030.210Details
BioGPS Gene Atlas203755_atParietalLobe5.50030.210Details
BioGPS Gene Atlas203755_atPituitary5.90030.210Details
BioGPS Gene Atlas203755_atPlacenta5.20030.210Details
BioGPS Gene Atlas203755_atPons5.25030.210Details
BioGPS Gene Atlas203755_atPrefrontalCortex6.15030.210Details
BioGPS Gene Atlas203755_atProstate5.95030.210Details
BioGPS Gene Atlas203755_atSalivarygland4.15030.210Details
BioGPS Gene Atlas203755_atSkeletalMuscle6.35030.210Details
BioGPS Gene Atlas203755_atSkin4.15030.210Details
BioGPS Gene Atlas203755_atSmoothMuscle6.00030.210Details
BioGPS Gene Atlas203755_atSpinalcord5.35030.210Details
BioGPS Gene Atlas203755_atSubthalamicNucleus4.75030.210Details
BioGPS Gene Atlas203755_atSuperiorCervicalGanglion6.15030.210Details
BioGPS Gene Atlas203755_atTemporalLobe4.80030.210Details
BioGPS Gene Atlas203755_atTestis20.70030.210Details
BioGPS Gene Atlas203755_atTestisGermCell56.40030.210Details
BioGPS Gene Atlas203755_atTestisIntersitial31.40030.210Details
BioGPS Gene Atlas203755_atTestisLeydigCell36.70030.210Details
BioGPS Gene Atlas203755_atTestisSeminiferousTubule26.30030.210Details
BioGPS Gene Atlas203755_atThalamus5.30030.210Details
BioGPS Gene Atlas203755_atThymus37.10030.210Details
BioGPS Gene Atlas203755_atThyroid6.30030.210Details
BioGPS Gene Atlas203755_atTongue5.35030.210Details
BioGPS Gene Atlas203755_atTonsil20.35030.210Details
BioGPS Gene Atlas203755_atTrachea4.15030.210Details
BioGPS Gene Atlas203755_atTrigeminalGanglion5.75030.210Details
BioGPS Gene Atlas203755_atUterus3.95030.210Details
BioGPS Gene Atlas203755_atUterusCorpus4.80030.210Details
BioGPS Gene Atlas203755_atWholeBlood5.55030.210Details
BioGPS Gene Atlas203755_atWholebrain4.05030.210Details
BioGPS Gene Atlas203755_atcolon5.20030.210Details
BioGPS Gene Atlas203755_atpineal_day6.42030.210Details
BioGPS Gene Atlas203755_atpineal_night6.32030.210Details
BioGPS Gene Atlas203755_atretina6.22530.210Details
BioGPS Gene Atlas203755_atsmall_intestine7.65030.210Details
BioGPS NCI60203755_at7862198.5981144.760Details
BioGPS NCI60203755_atA172505.9391144.760Details
BioGPS NCI60203755_atA2041439.9841144.760Details
BioGPS NCI60203755_atA361875.7211144.760Details
BioGPS NCI60203755_atA4981872.1871144.760Details
BioGPS NCI60203755_atA549926.5131144.760Details
BioGPS NCI60203755_atACC31027.4321144.760Details
BioGPS NCI60203755_atACHN312.3971144.760Details
BioGPS NCI60203755_atALVA311252.6041144.760Details
BioGPS NCI60203755_atCAKI1309.8841144.760Details
BioGPS NCI60203755_atCCRT CEM241.5531144.760Details
BioGPS NCI60203755_atCOLO2051068.7951144.760Details
BioGPS NCI60203755_atDLD11630.5811144.760Details
BioGPS NCI60203755_atDU1452710.2761144.760Details
BioGPS NCI60203755_atEKVX3125.2561144.760Details
BioGPS NCI60203755_atGM133718.8991144.760Details
BioGPS NCI60203755_atGM1600655.7481144.760Details
BioGPS NCI60203755_atGM23131020.6001144.760Details
BioGPS NCI60203755_atGM23451624.5801144.760Details
BioGPS NCI60203755_atGM2493656.2981144.760Details
BioGPS NCI60203755_atGM97667.1061144.760Details
BioGPS NCI60203755_atHCC29981143.9501144.760Details
BioGPS NCI60203755_atHCT1162065.2741144.760Details
BioGPS NCI60203755_atHCT151778.8801144.760Details
BioGPS NCI60203755_atHEK 293 T-rex1617.3611144.760Details
BioGPS NCI60203755_atHEK 293T1102.4151144.760Details
BioGPS NCI60203755_atHEK2931836.7831144.760Details
BioGPS NCI60203755_atHELA3503.1231144.760Details
BioGPS NCI60203755_atHEPG21537.2181144.760Details
BioGPS NCI60203755_atHL60902.4701144.760Details
BioGPS NCI60203755_atHOP62898.4021144.760Details
BioGPS NCI60203755_atHOP92110.3751144.760Details
BioGPS NCI60203755_atHS578T877.4071144.760Details
BioGPS NCI60203755_atHSG1347.4511144.760Details
BioGPS NCI60203755_atHT1080255.1051144.760Details
BioGPS NCI60203755_atHT291556.6031144.760Details
BioGPS NCI60203755_atIGROV1861.8371144.760Details
BioGPS NCI60203755_atIOSE801436.2931144.760Details
BioGPS NCI60203755_atJURKAT3163.7741144.760Details
BioGPS NCI60203755_atK5621439.8911144.760Details
BioGPS NCI60203755_atKM121415.8551144.760Details
BioGPS NCI60203755_atLN18209.1431144.760Details
BioGPS NCI60203755_atLNCAP500.6221144.760Details
BioGPS NCI60203755_atLOX IMVI528.5011144.760Details
BioGPS NCI60203755_atM141597.4781144.760Details
BioGPS NCI60203755_atMALME 3M578.8841144.760Details
BioGPS NCI60203755_atMCF7618.0521144.760Details
BioGPS NCI60203755_atMD MB2311355.5031144.760Details
BioGPS NCI60203755_atMDA MB435253.7151144.760Details
BioGPS NCI60203755_atMOLT41522.6951144.760Details
BioGPS NCI60203755_atNCI 4601198.6861144.760Details
BioGPS NCI60203755_atNCI H226944.8501144.760Details
BioGPS NCI60203755_atNCI H23857.2071144.760Details
BioGPS NCI60203755_atNCI H322M2209.9431144.760Details
BioGPS NCI60203755_atNCVADR RES883.7971144.760Details
BioGPS NCI60203755_atOVCAR32101.2071144.760Details
BioGPS NCI60203755_atOVCAR41262.8571144.760Details
BioGPS NCI60203755_atOVCAR51473.2101144.760Details
BioGPS NCI60203755_atOVCAR81958.5411144.760Details
BioGPS NCI60203755_atPANC1323.3611144.760Details
BioGPS NCI60203755_atRL72982.0951144.760Details
BioGPS NCI60203755_atRPMI 8226855.4281144.760Details
BioGPS NCI60203755_atRS118461322.4561144.760Details
BioGPS NCI60203755_atRXF3931173.2831144.760Details
BioGPS NCI60203755_atSAOS21957.8001144.760Details
BioGPS NCI60203755_atSF2681422.2401144.760Details
BioGPS NCI60203755_atSF295636.9261144.760Details
BioGPS NCI60203755_atSF5391678.5441144.760Details
BioGPS NCI60203755_atSHSYSY+RA1850.9961144.760Details
BioGPS NCI60203755_atSHSYSY-RA644.5101144.760Details
BioGPS NCI60203755_atSKMEL2876.4421144.760Details
BioGPS NCI60203755_atSKMEL2832.2111144.760Details
BioGPS NCI60203755_atSKMEL552.7111144.760Details
BioGPS NCI60203755_atSKOV32636.5731144.760Details
BioGPS NCI60203755_atSN12C596.4921144.760Details
BioGPS NCI60203755_atSNB19943.5031144.760Details
BioGPS NCI60203755_atSNB75363.5581144.760Details
BioGPS NCI60203755_atSR988.9921144.760Details
BioGPS NCI60203755_atSW6201745.5711144.760Details
BioGPS NCI60203755_atT242119.4761144.760Details
BioGPS NCI60203755_atT3M41121.3501144.760Details
BioGPS NCI60203755_atTK101586.1051144.760Details
BioGPS NCI60203755_atU118669.5051144.760Details
BioGPS NCI60203755_atU138783.6661144.760Details
BioGPS NCI60203755_atU20S896.5271144.760Details
BioGPS NCI60203755_atU251950.2361144.760Details
BioGPS NCI60203755_atU87458.2601144.760Details
BioGPS NCI60203755_atUACC257536.2471144.760Details
BioGPS NCI60203755_atUACC629.9361144.760Details
BioGPS NCI60203755_atUO31722.2861144.760Details
BioGPS NCI60203755_atZR75_11112.0701144.760Details
BioGPS NCI60203755_atastrocytes99.2121144.760Details
BioGPS NCI60203755_athuh-71395.5151144.760Details