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Gene ID: 84446 | Brsk1 Antibody Resource


Brsk1 Antibody Resource
Gene Full Name: 
BR serine/threonine kinase 1
Uniprot: 
Q8TDC3
Protein Name: 
serine/threonine-protein kinase BRSK1
Nucleotide: 
XM_005259326
Alias: 
hSAD1;
Ensembl: 
ENSG00000160469
Location: 
19q13.4
HPRD: 
12533
NCBI Gene: 
84446
MIM: 
609235

Summary: 
Function: 
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.
Subcellular location: 
Cytoplasm. Nucleus. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Cell junction › synapse. Note: Localizes to synaptic vesicles in neurons . Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.
PTM: 
Phosphoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OASA07093 BRSK1 Antibody (OASA07093) Human IHC-FFPE, WB 0.1mg $355 Details
Polyclonal Antibody OASA07094 BRSK1 Antibody (OASA07094) Human IHC-FFPE, WB 50ug $190 Details
Polyclonal Antibody OASA07095 BRSK1 antibody - C-terminal region (OASA07095) Human IHC-FFPE, WB 0.1mg $355 Details
Polyclonal Antibody OASA07096 BRSK1 antibody - C-terminal region (OASA07096) Human IHC-FFPE, WB 50ug $190 Details
Polyclonal Antibody ARP59832_P050 Brsk1 antibody - C-terminal region (ARP59832_P050) Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat WB 50ug $289 Details
Polyclonal Antibody OAPB00508 BRSK1 Antibody (OAPB00508) Polyclonal Human; Mouse; Rat ELISA, WB, IHC 0.1 mg $355 Details
Polyclonal Antibody OAPB00509 BRSK1 Antibody (OAPB00509) Polyclonal Human; Mouse; Rat ELISA, WB, IHC 0.1 mg $355 Details
Polyclonal Antibody ARP59833_P050 BRSK1 Antibody (ARP59833_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody OAAB15258 BRSK1antibody - center region (OAAB15258) Mouse WB 400ul $289 Details
Polyclonal Antibody OAAB17557 SAD1 (BRSK1) antibody - N - terminal region (OAAB17557) Human WB 400ul $289 Details
Polyclonal Antibody OAAB17558 BRSK1 antibody - C - terminal region (OAAB17558) Human WB, IHC 400ul $289 Details
Polyclonal Antibody OAAF02566 BRSK1 Antibody (OAAF02566) Polyclonal Human, Mouse WB, ELISA 100 ug $229 Details

Show all Brsk1 antibodies


Product Images
Brsk1 antibody - C-terminal region (ARP59832_P050) in Mouse Heart cells using Western Blot

Sample Type: Mouse Heart

BRSK1antibody - center region (OAAB15258) in Mouse Brain cells using Western Blot

Sample Type: Mouse Brain

SAD1 (BRSK1) antibody - N - terminal region (OAAB17557) in Mouse Liver cells using Western Blot

Sample Type: Mouse Liver

BRSK1 antibody - C - terminal region (OAAB17558) in Human Testis cells using Immunohistochemistry

Sample Type: Human Testis

BRSK1 antibody - C - terminal region (OAAB17558) in Mouse Liver cells using Western Blot

Sample Type: Mouse Liver

BRSK1 Antibody (OAAF02566) in 293 cells using Western Blot

Sample Type: 293

BRSK1 Antibody (OAPB00508) in Human brain cells using Western Blot

Sample Type: Human brain

BRSK1 Antibody (OAPB00508) in Human brain cells using Immunohistochemistry

Sample Type: Human brain

BRSK1 Antibody (OAPB00509) in Human brain cells using Western Blot

Sample Type: Human brain

BRSK1 Antibody (OAPB00509) in Human brain cells using Immunohistochemistry

Sample Type: Human brain


Brsk1 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP59833 African elephant Brsk1 antibody; Loxodonta africana Brsk1 antibody G3T0J4 100.0%
ARP59833 African elephant Brsk1 antibody; Loxodonta africana Brsk1 antibody G3U4Z1 100.0%
ARP59832 African elephant Brsk1 antibody; Loxodonta africana Brsk1 antibody G3T0J4 93.0%
ARP59832 African elephant Brsk1 antibody; Loxodonta africana Brsk1 antibody G3U4Z1 93.0%
ARP59832 Bovine Brsk1 antibody; Bos taurus Brsk1 antibody F1MXK4 100.0%
ARP59833 Bovine Brsk1 antibody; Bos taurus Brsk1 antibody F1MXK4 93.0%
ARP59833 Cat Brsk1 antibody; Felis catus Brsk1 antibody M3W4F3 100.0%
ARP59832 Cat Brsk1 antibody; Felis catus Brsk1 antibody M3W4F3 86.0%
ARP59832 Chimpanzee Brsk1 antibody; Pan troglodytes Brsk1 antibody H2QH58 100.0%
ARP59833 Chimpanzee Brsk1 antibody; Pan troglodytes Brsk1 antibody H2QH58 100.0%
ARP59833 Dog Brsk1 antibody; Canis familiaris Brsk1 antibody F1PPP8 100.0%
ARP59832 Dog Brsk1 antibody; Canis familiaris Brsk1 antibody F1PPP8 92.0%
ARP59833 European domestic ferret Brsk1 antibody; Mustela putorius furo Brsk1 antibody M3Y8B5 100.0%
ARP59832 European domestic ferret Brsk1 antibody; Mustela putorius furo Brsk1 antibody M3Y8B5 92.0%
ARP59833 Giant panda Brsk1 antibody; Ailuropoda melanoleuca Brsk1 antibody G1LA61 100.0%
ARP59833 Giant panda Brsk1 antibody; Ailuropoda melanoleuca Brsk1 antibody G1LA73 100.0%
ARP59832 Giant panda Brsk1 antibody; Ailuropoda melanoleuca Brsk1 antibody G1LA61 92.0%
ARP59832 Giant panda Brsk1 antibody; Ailuropoda melanoleuca Brsk1 antibody G1LA73 92.0%
ARP59833 Guinea pig Brsk1 antibody; Cavia porcellus Brsk1 antibody H0VDT9 100.0%
ARP59832 Guinea pig Brsk1 antibody; Cavia porcellus Brsk1 antibody H0VDT9 93.0%
ARP59833 Horse Brsk1 antibody; Equus caballus Brsk1 antibody F6XVE0 100.0%
ARP59832 Horse Brsk1 antibody; Equus caballus Brsk1 antibody F6XVE0 92.0%
ARP59832 Human Brsk1 antibody; Homo sapiens Brsk1 antibody J3KNK0 100.0%
ARP59833 Human Brsk1 antibody; Homo sapiens Brsk1 antibody J3KNK0 100.0%
ARP59832 Human Brsk1 antibody; Homo sapiens Brsk1 antibody Q8TDC3-2 100.0%
ARP59833 Human Brsk1 antibody; Homo sapiens Brsk1 antibody Q8TDC3-2 100.0%
ARP59832 Human Brsk1 antibody; Homo sapiens Brsk1 antibody Q8TDC3 100.0%
ARP59833 Human Brsk1 antibody; Homo sapiens Brsk1 antibody Q8TDC3 100.0%
ARP59832 Mouse Brsk1 antibody; Mus musculus Brsk1 antibody D3Z5P0 100.0%
ARP59833 Mouse Brsk1 antibody; Mus musculus Brsk1 antibody D3Z5P0 100.0%
ARP59832 Mouse Brsk1 antibody; Mus musculus Brsk1 antibody Q5RJI5 100.0%
ARP59833 Mouse Brsk1 antibody; Mus musculus Brsk1 antibody Q5RJI5 100.0%
ARP59833 Rat Brsk1 antibody; Rattus norvegicus Brsk1 antibody B2DD29 100.0%
ARP59832 Rat Brsk1 antibody; Rattus norvegicus Brsk1 antibody B2DD29 93.0%
ARP59832 Rhesus macaque Brsk1 antibody; Macaca mulatta Brsk1 antibody H9EMW8 100.0%
ARP59833 Rhesus macaque Brsk1 antibody; Macaca mulatta Brsk1 antibody H9EMW8 100.0%
ARP59833 Small-eared galago Brsk1 antibody; Otolemur garnettii Brsk1 antibody H0WNR1 100.0%
ARP59832 Small-eared galago Brsk1 antibody; Otolemur garnettii Brsk1 antibody H0WNR1 93.0%
ARP59833 Sumatran orangutan Brsk1 antibody; Pongo abelii Brsk1 antibody H2P072 100.0%
ARP59833 Thirteen-lined ground squirrel Brsk1 antibody; Spermophilus tridecemlineatus Brsk1 antibody I3M6P1 100.0%
ARP59832 Thirteen-lined ground squirrel Brsk1 antibody; Spermophilus tridecemlineatus Brsk1 antibody I3M6P1 93.0%
ARP59832 White-tufted-ear marmoset Brsk1 antibody; Callithrix jacchus Brsk1 antibody F6X7E2 100.0%
ARP59833 White-tufted-ear marmoset Brsk1 antibody; Callithrix jacchus Brsk1 antibody F6X7E2 100.0%
ARP59832 White-tufted-ear marmoset Brsk1 antibody; Callithrix jacchus Brsk1 antibody U3CA35 100.0%
ARP59833 White-tufted-ear marmoset Brsk1 antibody; Callithrix jacchus Brsk1 antibody U3CA35 100.0%

Tissue & Cell Line Gene Expression Data