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Gene ID: 221927 | BRAT1 Antibody Resource


BRAT1 Antibody Resource
Gene Full Name: 
BRCA1-associated ATM activator 1
Uniprot: 
Q6PJG6
Protein Name: 
BRCA1-associated ATM activator 1
Nucleotide: 
NM_152743
Alias: 
BAAT1;RMFSL;C7orf27;
Ensembl: 
ENSG00000106009
Location: 
7p22.3
HPRD: 
12914
NCBI Gene: 
221927
MIM: 
614506

Summary: 
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]
Function: 
Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of ATM.
Subcellular location: 
Nucleus. Note: Present at double strand breaks (DSBs) following ionizing radiation treatment.
PTM: 
Phosphoprotein;
Disease: 
Rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL) [MIM:614498]: A lethal, neonatal, neurologic disorder characterized by episodic jerking that is apparent in utero, lack of psychomotor development, axial and limb rigidity, frequent multifocal seizures, and dysautonomia. At birth, affected individuals have small heads, overlapping cranial sutures, small or absent fontanels, and depressed frontal bones. Infants show poorly responsive focal jerks of the tongue, face and arms in a nearly continuous sequence throughout life. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP62762_P050 BRAT1 Antibody - C-terminal region (ARP62762_P050) Human WB 50ug $289 Details
Polyclonal Antibody ARP62763_P050 BRAT1 Antibody (ARP62763_P050) Polyclonal Human Not tested 50 ug $125 Details

Show all BRAT1 antibodies


Product Images
BRAT1 Antibody - C-terminal region (ARP62762_P050) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2


BRAT1 Protocols
Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP62763 Chimpanzee BRAT1 antibody; Pan troglodytes BRAT1 antibody H2QU38 100.0%
ARP62763 Chimpanzee BRAT1 antibody; Pan troglodytes BRAT1 antibody K7BNY7 100.0%
ARP62763 Chimpanzee BRAT1 antibody; Pan troglodytes BRAT1 antibody K7CMM8 100.0%
ARP62762 Chimpanzee BRAT1 antibody; Pan troglodytes BRAT1 antibody H2QU38 93.0%
ARP62762 Chimpanzee BRAT1 antibody; Pan troglodytes BRAT1 antibody K7BNY7 93.0%
ARP62762 Chimpanzee BRAT1 antibody; Pan troglodytes BRAT1 antibody K7CMM8 93.0%
ARP62762 Human BRAT1 antibody; Homo sapiens BRAT1 antibody Q6PJG6-3 100.0%
ARP62763 Human BRAT1 antibody; Homo sapiens BRAT1 antibody Q6PJG6-3 100.0%
ARP62762 Human BRAT1 antibody; Homo sapiens BRAT1 antibody Q6PJG6 100.0%
ARP62763 Human BRAT1 antibody; Homo sapiens BRAT1 antibody Q6PJG6 100.0%
ARP62763 Northern white-cheeked gibbon BRAT1 antibody; Nomascus leucogenys BRAT1 antibody G1RIE4 100.0%
ARP62763 Rhesus macaque BRAT1 antibody; Macaca mulatta BRAT1 antibody H9YWL2 100.0%
ARP62763 Sumatran orangutan BRAT1 antibody; Pongo abelii BRAT1 antibody H2PLC5 100.0%
ARP62763 White-tufted-ear marmoset BRAT1 antibody; Callithrix jacchus BRAT1 antibody F6V8P8 93.0%
ARP62763 White-tufted-ear marmoset BRAT1 antibody; Callithrix jacchus BRAT1 antibody F7IPM9 93.0%
ARP62763 White-tufted-ear marmoset BRAT1 antibody; Callithrix jacchus BRAT1 antibody U3DSR1 93.0%
ARP62763 White-tufted-ear marmoset BRAT1 antibody; Callithrix jacchus BRAT1 antibody U3E2B5 93.0%

Tissue & Cell Line Gene Expression Data