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Gene ID: 29760 | BLNK Antibody Resource


BLNK Antibody Resource
Gene Full Name: 
B-cell linker
Uniprot: 
Q8WV28
Protein Name: 
B-cell linker protein
Nucleotide: 
NM_001114094
Alias: 
bca;AGM4;BASH;LY57;SLP65;BLNK-S;SLP-65;
Ensembl: 
ENSG00000095585
Location: 
10q23.2-q23.33
HPRD: 
05153
NCBI Gene: 
29760
MIM: 
604515

Summary: 
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Function: 
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Subcellular location: 
Cytoplasm. Cell membrane. Note: BCR activation results in the translocation to membrane fraction.
PTM: 
Phosphoprotein;
Disease: 
Agammaglobulinemia 4, autosomal recessive (AGM4) [MIM:613502]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP46185_P050 BLNK antibody - middle region (ARP46185_P050) Polyclonal Bovine, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody OASA06058 BLNK antibody - C-terminal region (OASA06058) Human WB 0.1mg $365 Details
Polyclonal Antibody OASA08369 Blnk Antibody (OASA08369) Mouse WB 0.1mg $410 Details
Polyclonal Antibody OAEB01814 Goat Anti-BLNK / SLP-65 Antibody (OAEB01814) Bovine, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat WB 0.1mg $289 Details
Polyclonal Antibody OAAB03485 BLNK antibody - center region (OAAB03485) Human WB, FC, IHC, ELISA 400ul $289 Details
Others OPPA00063 BLNK Human - Recombinant Human B-Cell Linker (5ug) 5ug $100 Details
Monoclonal Antibody OAAB07059 BLNK antibody (Ascites) (OAAB07059) Human WB 0.1 ml $289 Details
Polyclonal Antibody OAAB09727 BLNK antibody - N - terminal region (OAAB09727) Human WB 400ul $289 Details
Polyclonal Antibody OAEC03981 BLNK (Phospho-Tyr84) Antibody (OAEC03981) Human; Mouse; Rat WB, IHC, ELISA 100ug $229 Details
Polyclonal Antibody OAGA00321 BLNK antibody (OAGA00321) Polyclonal Human ICC/IF, WB 100 ul $340 Details
Polyclonal Antibody OAAF00491 BLNK (Phospho-Tyr84) Antibody (OAAF00491) Polyclonal Human, Mouse, Rat WB, IHC, ELISA 100 ug $229 Details
Polyclonal Antibody OAAF00868 BLNK Antibody (OAAF00868) Polyclonal Human, Mouse WB, IHC, ELISA 100 ug $229 Details

Show all BLNK antibodies


Product Images
BLNK antibody - middle region (ARP46185_P050) in Human NCI-H226 cells using Western Blot

Sample Type: Human NCI-H226

 BLNK antibody - center region (OAAB03485) in human hepatocarcinoma cells using Immunohistochemistry

Sample Type: human hepatocarcinoma

 BLNK antibody - center region (OAAB03485) in NCI-H460 cells using Western Blot

Sample Type: NCI-H460

 BLNK antibody - center region (OAAB03485) in NCI-H460 cells using Flow Cytometry

Sample Type: NCI-H460

 BLNK antibody (Ascites) (OAAB07059) in CEM cells using Western Blot

Sample Type: CEM

 BLNK antibody - N - terminal region (OAAB09727) in 293 cells using Western Blot

Sample Type: 293

 BLNK (Phospho-Tyr84) Antibody (OAAF00491) in Human brain cells using Immunohistochemistry

Sample Type: Human brain

 BLNK (Phospho-Tyr84) Antibody (OAAF00491) in K562 cells using Western Blot

Sample Type: K562

 BLNK Antibody (OAAF00868) in 293 cells using Western Blot

Sample Type: 293

 BLNK Antibody (OAAF00868) in Human tonsil cells using Immunohistochemistry

Sample Type: Human tonsil

 Goat Anti-BLNK / SLP-65 Antibody (OAEB01814) in BLNK (RC202488) cells using Western Blot

Sample Type: BLNK (RC202488)

 Goat Anti-BLNK / SLP-65 Antibody (OAEB01814) in Daudi cells using Western Blot

Sample Type: Daudi

 BLNK (Phospho-Tyr84) Antibody (OAEC03981) in Human brain cells using Immunohistochemistry

Sample Type: Human brain

 BLNK (Phospho-Tyr84) Antibody (OAEC03981) in K562 cells using Western Blot

Sample Type: K562

BLNK Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP46185 African clawed frog BLNK antibody; Xenopus laevis BLNK antibody Q5U4V8 92.0%
ARP46185 Atlantic salmon BLNK antibody; Salmo salar BLNK antibody C0H8Z7 83.0%
ARP46185 Bovine BLNK antibody; Bos taurus BLNK antibody F1MDI4 100.0%
ARP46185 Bovine BLNK antibody; Bos taurus BLNK antibody Q2KJG7 100.0%
ARP46185 Cat BLNK antibody; Felis catus BLNK antibody M3W765 86.0%
ARP46185 Chicken BLNK antibody; Gallus gallus BLNK antibody Q9YGC1-2 93.0%
ARP46185 Chicken BLNK antibody; Gallus gallus BLNK antibody Q9YGC1 93.0%
ARP46185 Chicken BLNK antibody; Gallus gallus BLNK antibody F1NFD7 93.0%
ARP46185 Chimpanzee BLNK antibody; Pan troglodytes BLNK antibody H2Q2B8 100.0%
ARP46185 Chinese softshell turtle BLNK antibody; Pelodiscus sinensis BLNK antibody K7FK74 92.0%
ARP46185 Collared flycatcher BLNK antibody; Ficedula albicollis BLNK antibody U3JZV7 92.0%
ARP46185 Dog BLNK antibody; Canis familiaris BLNK antibody F1P8D0 100.0%
ARP46185 Domestic duck BLNK antibody; Anas platyrhynchos BLNK antibody U3IG24 93.0%
ARP56889 Duckbill platypus BLNK antibody; Ornithorhynchus anatinus BLNK antibody F6VL77 82.0%
ARP46185 European domestic ferret BLNK antibody; Mustela putorius furo BLNK antibody M3Z069 93.0%
ARP46185 Green anole BLNK antibody; Anolis carolinensis BLNK antibody H9GB09 92.0%
ARP46185 Human BLNK antibody; Homo sapiens BLNK antibody Q8WV28-2 100.0%
ARP46185 Human BLNK antibody; Homo sapiens BLNK antibody Q8WV28-3 100.0%
ARP46185 Human BLNK antibody; Homo sapiens BLNK antibody Q8WV28 100.0%
ARP46185 Human BLNK antibody; Homo sapiens BLNK antibody F5GXS1 100.0%
ARP46185 Mouse BLNK antibody; Mus musculus BLNK antibody Q9QUN3 100.0%
ARP46185 Mouse BLNK antibody; Mus musculus BLNK antibody D3YWR2 100.0%
ARP46185 Pig BLNK antibody; Sus scrofa BLNK antibody F1SBG3 100.0%
ARP46185 Rabbit BLNK antibody; Oryctolagus cuniculus BLNK antibody G1SIH8 100.0%
ARP46185 Rat BLNK antibody; Rattus norvegicus BLNK antibody Q4KM52 100.0%
ARP46185 Rhesus macaque BLNK antibody; Macaca mulatta BLNK antibody F7EYN2 100.0%
ARP46185 Rhesus macaque BLNK antibody; Macaca mulatta BLNK antibody H9F623 100.0%
ARP46185 Sumatran orangutan BLNK antibody; Pongo abelii BLNK antibody H2NB51 100.0%
ARP46185 Tasmanian devil BLNK antibody; Sarcophilus harrisii BLNK antibody G3VUL5 100.0%
ARP46185 Thirteen-lined ground squirrel BLNK antibody; Spermophilus tridecemlineatus BLNK antibody I3MJP2 100.0%
ARP46185 Western clawed frog BLNK antibody; Xenopus tropicalis BLNK antibody Q5HZD8 92.0%
ARP46185 Western clawed frog BLNK antibody; Xenopus tropicalis BLNK antibody B1WAX1 92.0%
ARP46185 Western clawed frog BLNK antibody; Xenopus tropicalis BLNK antibody F6T909 92.0%
ARP46185 Western clawed frog BLNK antibody; Xenopus tropicalis BLNK antibody F7B1G6 92.0%
ARP46185 Western clawed frog BLNK antibody; Xenopus tropicalis BLNK antibody Q08D21 92.0%
ARP46185 White-tufted-ear marmoset BLNK antibody; Callithrix jacchus BLNK antibody U3CRA7 100.0%
ARP46185 Zebra finch BLNK antibody; Taeniopygia guttata BLNK antibody H0ZFH2 86.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas207655_s_at721_B_lymphoblasts1092.50056.480Details
BioGPS Gene Atlas207655_s_atAdipocyte7.30056.480Details
BioGPS Gene Atlas207655_s_atAdrenalCortex8.50056.480Details
BioGPS Gene Atlas207655_s_atAdrenalgland6.40056.480Details
BioGPS Gene Atlas207655_s_atAmygdala7.85056.480Details
BioGPS Gene Atlas207655_s_atAppendix9.90056.480Details
BioGPS Gene Atlas207655_s_atAtrioventricularNode6.20056.480Details
BioGPS Gene Atlas207655_s_atBDCA4+_DentriticCells1381.30056.480Details
BioGPS Gene Atlas207655_s_atBonemarrow8.40056.480Details
BioGPS Gene Atlas207655_s_atBronchialEpithelialCells7.55056.480Details
BioGPS Gene Atlas207655_s_atCD105+_Endothelial8.35056.480Details
BioGPS Gene Atlas207655_s_atCD14+_Monocytes9.05056.480Details
BioGPS Gene Atlas207655_s_atCD19+_BCells(neg._sel.)830.50056.480Details
BioGPS Gene Atlas207655_s_atCD33+_Myeloid10.05056.480Details
BioGPS Gene Atlas207655_s_atCD34+226.70056.480Details
BioGPS Gene Atlas207655_s_atCD4+_Tcells7.35056.480Details
BioGPS Gene Atlas207655_s_atCD56+_NKCells9.35056.480Details
BioGPS Gene Atlas207655_s_atCD71+_EarlyErythroid7.05056.480Details
BioGPS Gene Atlas207655_s_atCD8+_Tcells6.45056.480Details
BioGPS Gene Atlas207655_s_atCardiacMyocytes10.75056.480Details
BioGPS Gene Atlas207655_s_atCaudatenucleus6.75056.480Details
BioGPS Gene Atlas207655_s_atCerebellum6.20056.480Details
BioGPS Gene Atlas207655_s_atCerebellumPeduncles8.80056.480Details
BioGPS Gene Atlas207655_s_atCiliaryGanglion5.75056.480Details
BioGPS Gene Atlas207655_s_atCingulateCortex7.70056.480Details
BioGPS Gene Atlas207655_s_atColorectaladenocarcinoma7.40056.480Details
BioGPS Gene Atlas207655_s_atDorsalRootGanglion6.25056.480Details
BioGPS Gene Atlas207655_s_atFetalThyroid8.10056.480Details
BioGPS Gene Atlas207655_s_atFetalbrain7.30056.480Details
BioGPS Gene Atlas207655_s_atFetalliver6.55056.480Details
BioGPS Gene Atlas207655_s_atFetallung6.30056.480Details
BioGPS Gene Atlas207655_s_atGlobusPallidus5.65056.480Details
BioGPS Gene Atlas207655_s_atHeart10.70056.480Details
BioGPS Gene Atlas207655_s_atHypothalamus8.55056.480Details
BioGPS Gene Atlas207655_s_atKidney8.40056.480Details
BioGPS Gene Atlas207655_s_atLeukemia_chronicMyelogenousK-5626.75056.480Details
BioGPS Gene Atlas207655_s_atLeukemia_promyelocytic-HL-6043.05056.480Details
BioGPS Gene Atlas207655_s_atLeukemialymphoblastic(MOLT-4)5.90056.480Details
BioGPS Gene Atlas207655_s_atLiver12.65056.480Details
BioGPS Gene Atlas207655_s_atLung8.30056.480Details
BioGPS Gene Atlas207655_s_atLymphnode171.35056.480Details
BioGPS Gene Atlas207655_s_atLymphoma_burkitts(Daudi)232.10056.480Details
BioGPS Gene Atlas207655_s_atLymphoma_burkitts(Raji)13.50056.480Details
BioGPS Gene Atlas207655_s_atMedullaOblongata6.85056.480Details
BioGPS Gene Atlas207655_s_atOccipitalLobe6.60056.480Details
BioGPS Gene Atlas207655_s_atOlfactoryBulb6.05056.480Details
BioGPS Gene Atlas207655_s_atOvary5.55056.480Details
BioGPS Gene Atlas207655_s_atPancreas6.50056.480Details
BioGPS Gene Atlas207655_s_atPancreaticIslet10.50056.480Details
BioGPS Gene Atlas207655_s_atParietalLobe8.00056.480Details
BioGPS Gene Atlas207655_s_atPituitary8.95056.480Details
BioGPS Gene Atlas207655_s_atPlacenta7.75056.480Details
BioGPS Gene Atlas207655_s_atPons7.30056.480Details
BioGPS Gene Atlas207655_s_atPrefrontalCortex9.10056.480Details
BioGPS Gene Atlas207655_s_atProstate9.00056.480Details
BioGPS Gene Atlas207655_s_atSalivarygland31.30056.480Details
BioGPS Gene Atlas207655_s_atSkeletalMuscle9.20056.480Details
BioGPS Gene Atlas207655_s_atSkin6.20056.480Details
BioGPS Gene Atlas207655_s_atSmoothMuscle8.55056.480Details
BioGPS Gene Atlas207655_s_atSpinalcord12.10056.480Details
BioGPS Gene Atlas207655_s_atSubthalamicNucleus6.90056.480Details
BioGPS Gene Atlas207655_s_atSuperiorCervicalGanglion13.35056.480Details
BioGPS Gene Atlas207655_s_atTemporalLobe6.95056.480Details
BioGPS Gene Atlas207655_s_atTestis6.50056.480Details
BioGPS Gene Atlas207655_s_atTestisGermCell6.45056.480Details
BioGPS Gene Atlas207655_s_atTestisIntersitial6.25056.480Details
BioGPS Gene Atlas207655_s_atTestisLeydigCell7.60056.480Details
BioGPS Gene Atlas207655_s_atTestisSeminiferousTubule6.40056.480Details
BioGPS Gene Atlas207655_s_atThalamus7.70056.480Details
BioGPS Gene Atlas207655_s_atThymus11.00056.480Details
BioGPS Gene Atlas207655_s_atThyroid15.15056.480Details
BioGPS Gene Atlas207655_s_atTongue9.35056.480Details
BioGPS Gene Atlas207655_s_atTonsil209.55056.480Details
BioGPS Gene Atlas207655_s_atTrachea6.50056.480Details
BioGPS Gene Atlas207655_s_atTrigeminalGanglion8.40056.480Details
BioGPS Gene Atlas207655_s_atUterus6.15056.480Details
BioGPS Gene Atlas207655_s_atUterusCorpus7.05056.480Details
BioGPS Gene Atlas207655_s_atWholeBlood9.00056.480Details
BioGPS Gene Atlas207655_s_atWholebrain6.40056.480Details
BioGPS Gene Atlas207655_s_atcolon30.40056.480Details
BioGPS Gene Atlas207655_s_atpineal_day9.46056.480Details
BioGPS Gene Atlas207655_s_atpineal_night8.86056.480Details
BioGPS Gene Atlas207655_s_atretina9.25056.480Details
BioGPS Gene Atlas207655_s_atsmall_intestine94.30056.480Details
BioGPS NCI60207655_s_at7865.44636.720Details
BioGPS NCI60207655_s_atA1724.86436.720Details
BioGPS NCI60207655_s_atA2045.14236.720Details
BioGPS NCI60207655_s_atA3615.27736.720Details
BioGPS NCI60207655_s_atA4985.16336.720Details
BioGPS NCI60207655_s_atA5495.36136.720Details
BioGPS NCI60207655_s_atACC35.74436.720Details
BioGPS NCI60207655_s_atACHN4.61236.720Details
BioGPS NCI60207655_s_atALVA315.78036.720Details
BioGPS NCI60207655_s_atCAKI15.61036.720Details
BioGPS NCI60207655_s_atCCRT CEM6.68736.720Details
BioGPS NCI60207655_s_atCOLO2055.19836.720Details
BioGPS NCI60207655_s_atDLD15.05336.720Details
BioGPS NCI60207655_s_atDU1454.83336.720Details
BioGPS NCI60207655_s_atEKVX28.79536.720Details
BioGPS NCI60207655_s_atGM1335.41136.720Details
BioGPS NCI60207655_s_atGM16005.61136.720Details
BioGPS NCI60207655_s_atGM23135.42136.720Details
BioGPS NCI60207655_s_atGM23455.20036.720Details
BioGPS NCI60207655_s_atGM24935.76836.720Details
BioGPS NCI60207655_s_atGM976.57536.720Details
BioGPS NCI60207655_s_atHCC29984.51936.720Details
BioGPS NCI60207655_s_atHCT1165.20036.720Details
BioGPS NCI60207655_s_atHCT154.79136.720Details
BioGPS NCI60207655_s_atHEK 293 T-rex5.74536.720Details
BioGPS NCI60207655_s_atHEK 293T5.21936.720Details
BioGPS NCI60207655_s_atHEK2935.25736.720Details
BioGPS NCI60207655_s_atHELA4.70436.720Details
BioGPS NCI60207655_s_atHEPG25.21436.720Details
BioGPS NCI60207655_s_atHL60130.43736.720Details
BioGPS NCI60207655_s_atHOP625.19936.720Details
BioGPS NCI60207655_s_atHOP925.07936.720Details
BioGPS NCI60207655_s_atHS578T5.12336.720Details
BioGPS NCI60207655_s_atHSG4.88736.720Details
BioGPS NCI60207655_s_atHT10805.06236.720Details
BioGPS NCI60207655_s_atHT295.86936.720Details
BioGPS NCI60207655_s_atIGROV15.08236.720Details
BioGPS NCI60207655_s_atIOSE805.15136.720Details
BioGPS NCI60207655_s_atJURKAT5.17336.720Details
BioGPS NCI60207655_s_atK5625.94036.720Details
BioGPS NCI60207655_s_atKM125.56436.720Details
BioGPS NCI60207655_s_atLN184.70536.720Details
BioGPS NCI60207655_s_atLNCAP31.93236.720Details
BioGPS NCI60207655_s_atLOX IMVI5.17136.720Details
BioGPS NCI60207655_s_atM145.16336.720Details
BioGPS NCI60207655_s_atMALME 3M5.72236.720Details
BioGPS NCI60207655_s_atMCF75.04836.720Details
BioGPS NCI60207655_s_atMD MB2315.51536.720Details
BioGPS NCI60207655_s_atMDA MB4355.83636.720Details
BioGPS NCI60207655_s_atMOLT45.52636.720Details
BioGPS NCI60207655_s_atNCI 4605.39036.720Details
BioGPS NCI60207655_s_atNCI H2265.41236.720Details
BioGPS NCI60207655_s_atNCI H235.14936.720Details
BioGPS NCI60207655_s_atNCI H322M5.18936.720Details
BioGPS NCI60207655_s_atNCVADR RES4.76836.720Details
BioGPS NCI60207655_s_atOVCAR35.66736.720Details
BioGPS NCI60207655_s_atOVCAR45.41636.720Details
BioGPS NCI60207655_s_atOVCAR55.05036.720Details
BioGPS NCI60207655_s_atOVCAR84.70036.720Details
BioGPS NCI60207655_s_atPANC15.28036.720Details
BioGPS NCI60207655_s_atRL7717.83936.720Details
BioGPS NCI60207655_s_atRPMI 8226803.72036.720Details
BioGPS NCI60207655_s_atRS118461594.04336.720Details
BioGPS NCI60207655_s_atRXF3935.17136.720Details
BioGPS NCI60207655_s_atSAOS25.25136.720Details
BioGPS NCI60207655_s_atSF2685.18136.720Details
BioGPS NCI60207655_s_atSF2954.92236.720Details
BioGPS NCI60207655_s_atSF5394.70336.720Details
BioGPS NCI60207655_s_atSHSYSY+RA4.90936.720Details
BioGPS NCI60207655_s_atSHSYSY-RA5.06536.720Details
BioGPS NCI60207655_s_atSKMEL25.17536.720Details
BioGPS NCI60207655_s_atSKMEL285.19536.720Details
BioGPS NCI60207655_s_atSKMEL54.81136.720Details
BioGPS NCI60207655_s_atSKOV35.56936.720Details
BioGPS NCI60207655_s_atSN12C5.13336.720Details
BioGPS NCI60207655_s_atSNB194.72536.720Details
BioGPS NCI60207655_s_atSNB755.08736.720Details
BioGPS NCI60207655_s_atSR5.43236.720Details
BioGPS NCI60207655_s_atSW6205.33936.720Details
BioGPS NCI60207655_s_atT245.38836.720Details
BioGPS NCI60207655_s_atT3M45.53536.720Details
BioGPS NCI60207655_s_atTK105.12636.720Details
BioGPS NCI60207655_s_atU1185.04336.720Details
BioGPS NCI60207655_s_atU1384.73436.720Details
BioGPS NCI60207655_s_atU20S5.03536.720Details
BioGPS NCI60207655_s_atU2515.06336.720Details
BioGPS NCI60207655_s_atU874.95936.720Details
BioGPS NCI60207655_s_atUACC2575.01136.720Details
BioGPS NCI60207655_s_atUACC625.31536.720Details
BioGPS NCI60207655_s_atUO314.96636.720Details
BioGPS NCI60207655_s_atZR75_15.47236.720Details
BioGPS NCI60207655_s_atastrocytes5.24336.720Details
BioGPS NCI60207655_s_athuh-75.58236.720Details

 

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