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Gene ID: 79444 | BIRC7 Antibody Resource


BIRC7 Antibody Resource
Gene Full Name: 
baculoviral IAP repeat containing 7
Uniprot: 
Q96CA5
Protein Name: 
baculoviral IAP repeat-containing protein 7
Nucleotide: 
NM_139317
Alias: 
KIAP;LIVIN;MLIAP;RNF50;ML-IAP;
Ensembl: 
ENSG00000101197
Location: 
20q13.3
HPRD: 
05761
NCBI Gene: 
79444
MIM: 
605737

Summary: 
This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jul 2013]
Function: 
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
Subcellular location: 
Nucleus. Cytoplasm. Golgi apparatus. Note: Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
PTM: 
Ubl conjugation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody AVARP02033_P050 BIRC7 antibody - middle region (AVARP02033_P050) Polyclonal Bovine, Dog, Human, Rabbit WB 50ug $289 Details
Polyclonal Antibody OASA06333 BIRC7 antibody - C-terminal region (OASA06333) Human ELISA, WB 0.1mg $545 Details
Polyclonal Antibody OASA07943 BIRC7 Antibody (OASA07943) Human WB 0.1mg $355 Details
Polyclonal Antibody OASA07944 BIRC7 Antibody (OASA07944) Human WB 50ug $190 Details
Protein OPPA01727 BIRC7 Human - Recombinant Human Baculoviral IAP Repeat-Containing 7 (5ug) 5ug $100 Details
Polyclonal Antibody OAEB01995 Goat Anti-LIVIN / BIRC7 Antibody (OAEB01995) Human WB 0.1mg $289 Details
Polyclonal Antibody OAAB16485 BIRC7 antibody - C - terminal region (OAAB16485) Human WB, IHC 400ul $289 Details
Polyclonal Antibody OAGA01063 BIRC7 antibody (OAGA01063) Polyclonal Human ICC/IF, IHC (Formalin-fixed paraffin-embedded sections) 100 ul $340 Details
Polyclonal Antibody OAGA01065 BIRC7 antibody (OAGA01065) Polyclonal Human ICC/IF, IHC (Formalin-fixed paraffin-embedded sections), WB 100 ul $340 Details

Show all BIRC7 antibodies


Product Images
BIRC7 antibody - middle region (AVARP02033_P050) in Human THP-1 cells using Western Blot

Sample Type: Human THP-1

BIRC7 antibody - C - terminal region (OAAB16485) in 293 cells using Western Blot

Sample Type: 293

BIRC7 antibody - C - terminal region (OAAB16485) in Human cancer, breast carcinoma, hepatocarcinoma cells using Immunohistochemistry

Sample Type: Human cancer, breast carcinoma, hepatocarcinoma

Goat Anti-LIVIN / BIRC7 Antibody (OAEB01995) in MOLT-4 cells using Western Blot

Sample Type: MOLT-4


BIRC7 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP30562 Bovine BIRC7 antibody; Bos taurus BIRC7 antibody E1BB31 86.0%
ARP30562 Bovine BIRC7 antibody; Bos taurus BIRC7 antibody G3N2J3 86.0%
ARP30562 Cat BIRC7 antibody; Felis catus BIRC7 antibody M3WAG6 85.0%
ARP30562 Chimpanzee BIRC7 antibody; Pan troglodytes BIRC7 antibody H2QKS0 93.0%
ARP30481 Chinese softshell turtle BIRC7 antibody; Pelodiscus sinensis BIRC7 antibody K7G2E2 82.0%
ARP30562 Dog BIRC7 antibody; Canis familiaris BIRC7 antibody E2RHC5 85.0%
ARP30562 European domestic ferret BIRC7 antibody; Mustela putorius furo BIRC7 antibody M3Y9Q6 86.0%
ARP30562 Horse BIRC7 antibody; Equus caballus BIRC7 antibody F7DCT8 79.0%
ARP30562 Human BIRC7 antibody; Homo sapiens BIRC7 antibody A8MTF4 100.0%
ARP30562 Human BIRC7 antibody; Homo sapiens BIRC7 antibody Q96CA5-2 100.0%
ARP30562 Human BIRC7 antibody; Homo sapiens BIRC7 antibody Q96CA5 100.0%
ARP30562 Rabbit BIRC7 antibody; Oryctolagus cuniculus BIRC7 antibody G1SJF7 93.0%
ARP30562 Rhesus macaque BIRC7 antibody; Macaca mulatta BIRC7 antibody F7HHH8 100.0%
ARP30562 Rhesus macaque BIRC7 antibody; Macaca mulatta BIRC7 antibody H9F2D6 100.0%
ARP30562 Small-eared galago BIRC7 antibody; Otolemur garnettii BIRC7 antibody H0XW62 86.0%
ARP30562 Sumatran orangutan BIRC7 antibody; Pongo abelii BIRC7 antibody H2P2K9 100.0%
ARP30562 White-tufted-ear marmoset BIRC7 antibody; Callithrix jacchus BIRC7 antibody F7ERH0 86.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas220451_s_at721_B_lymphoblasts29.05035.760Details
BioGPS Gene Atlas220451_s_atAdipocyte21.40035.760Details
BioGPS Gene Atlas220451_s_atAdrenalCortex30.55035.760Details
BioGPS Gene Atlas220451_s_atAdrenalgland20.75035.760Details
BioGPS Gene Atlas220451_s_atAmygdala24.00035.760Details
BioGPS Gene Atlas220451_s_atAppendix24.15035.760Details
BioGPS Gene Atlas220451_s_atAtrioventricularNode37.25035.760Details
BioGPS Gene Atlas220451_s_atBDCA4+_DentriticCells22.60035.760Details
BioGPS Gene Atlas220451_s_atBonemarrow24.80035.760Details
BioGPS Gene Atlas220451_s_atBronchialEpithelialCells20.10035.760Details
BioGPS Gene Atlas220451_s_atCD105+_Endothelial54.90035.760Details
BioGPS Gene Atlas220451_s_atCD14+_Monocytes26.30035.760Details
BioGPS Gene Atlas220451_s_atCD19+_BCells(neg._sel.)25.50035.760Details
BioGPS Gene Atlas220451_s_atCD33+_Myeloid29.00035.760Details
BioGPS Gene Atlas220451_s_atCD34+30.45035.760Details
BioGPS Gene Atlas220451_s_atCD4+_Tcells32.40035.760Details
BioGPS Gene Atlas220451_s_atCD56+_NKCells30.25035.760Details
BioGPS Gene Atlas220451_s_atCD71+_EarlyErythroid27.65035.760Details
BioGPS Gene Atlas220451_s_atCD8+_Tcells35.70035.760Details
BioGPS Gene Atlas220451_s_atCardiacMyocytes242.15035.760Details
BioGPS Gene Atlas220451_s_atCaudatenucleus21.75035.760Details
BioGPS Gene Atlas220451_s_atCerebellum19.55035.760Details
BioGPS Gene Atlas220451_s_atCerebellumPeduncles30.30035.760Details
BioGPS Gene Atlas220451_s_atCiliaryGanglion21.65035.760Details
BioGPS Gene Atlas220451_s_atCingulateCortex28.25035.760Details
BioGPS Gene Atlas220451_s_atColorectaladenocarcinoma131.60035.760Details
BioGPS Gene Atlas220451_s_atDorsalRootGanglion49.20035.760Details
BioGPS Gene Atlas220451_s_atFetalThyroid26.60035.760Details
BioGPS Gene Atlas220451_s_atFetalbrain22.45035.760Details
BioGPS Gene Atlas220451_s_atFetalliver31.55035.760Details
BioGPS Gene Atlas220451_s_atFetallung17.50035.760Details
BioGPS Gene Atlas220451_s_atGlobusPallidus18.90035.760Details
BioGPS Gene Atlas220451_s_atHeart32.85035.760Details
BioGPS Gene Atlas220451_s_atHypothalamus23.65035.760Details
BioGPS Gene Atlas220451_s_atKidney19.95035.760Details
BioGPS Gene Atlas220451_s_atLeukemia_chronicMyelogenousK-56220.35035.760Details
BioGPS Gene Atlas220451_s_atLeukemia_promyelocytic-HL-6020.10035.760Details
BioGPS Gene Atlas220451_s_atLeukemialymphoblastic(MOLT-4)20.05035.760Details
BioGPS Gene Atlas220451_s_atLiver35.05035.760Details
BioGPS Gene Atlas220451_s_atLung24.05035.760Details
BioGPS Gene Atlas220451_s_atLymphnode21.60035.760Details
BioGPS Gene Atlas220451_s_atLymphoma_burkitts(Daudi)34.30035.760Details
BioGPS Gene Atlas220451_s_atLymphoma_burkitts(Raji)218.95035.760Details
BioGPS Gene Atlas220451_s_atMedullaOblongata14.90035.760Details
BioGPS Gene Atlas220451_s_atOccipitalLobe21.50035.760Details
BioGPS Gene Atlas220451_s_atOlfactoryBulb47.75035.760Details
BioGPS Gene Atlas220451_s_atOvary22.00035.760Details
BioGPS Gene Atlas220451_s_atPancreas21.00035.760Details
BioGPS Gene Atlas220451_s_atPancreaticIslet24.65035.760Details
BioGPS Gene Atlas220451_s_atParietalLobe25.85035.760Details
BioGPS Gene Atlas220451_s_atPituitary27.00035.760Details
BioGPS Gene Atlas220451_s_atPlacenta28.80035.760Details
BioGPS Gene Atlas220451_s_atPons22.55035.760Details
BioGPS Gene Atlas220451_s_atPrefrontalCortex34.00035.760Details
BioGPS Gene Atlas220451_s_atProstate29.55035.760Details
BioGPS Gene Atlas220451_s_atSalivarygland35.60035.760Details
BioGPS Gene Atlas220451_s_atSkeletalMuscle29.80035.760Details
BioGPS Gene Atlas220451_s_atSkin28.95035.760Details
BioGPS Gene Atlas220451_s_atSmoothMuscle27.25035.760Details
BioGPS Gene Atlas220451_s_atSpinalcord31.25035.760Details
BioGPS Gene Atlas220451_s_atSubthalamicNucleus31.25035.760Details
BioGPS Gene Atlas220451_s_atSuperiorCervicalGanglion41.65035.760Details
BioGPS Gene Atlas220451_s_atTemporalLobe24.20035.760Details
BioGPS Gene Atlas220451_s_atTestis20.05035.760Details
BioGPS Gene Atlas220451_s_atTestisGermCell17.95035.760Details
BioGPS Gene Atlas220451_s_atTestisIntersitial20.20035.760Details
BioGPS Gene Atlas220451_s_atTestisLeydigCell23.95035.760Details
BioGPS Gene Atlas220451_s_atTestisSeminiferousTubule31.65035.760Details
BioGPS Gene Atlas220451_s_atThalamus27.60035.760Details
BioGPS Gene Atlas220451_s_atThymus17.45035.760Details
BioGPS Gene Atlas220451_s_atThyroid31.60035.760Details
BioGPS Gene Atlas220451_s_atTongue27.50035.760Details
BioGPS Gene Atlas220451_s_atTonsil23.50035.760Details
BioGPS Gene Atlas220451_s_atTrachea23.30035.760Details
BioGPS Gene Atlas220451_s_atTrigeminalGanglion62.80035.760Details
BioGPS Gene Atlas220451_s_atUterus20.65035.760Details
BioGPS Gene Atlas220451_s_atUterusCorpus23.45035.760Details
BioGPS Gene Atlas220451_s_atWholeBlood20.10035.760Details
BioGPS Gene Atlas220451_s_atWholebrain13.90035.760Details
BioGPS Gene Atlas220451_s_atcolon27.95035.760Details
BioGPS Gene Atlas220451_s_atpineal_day38.68035.760Details
BioGPS Gene Atlas220451_s_atpineal_night45.28035.760Details
BioGPS Gene Atlas220451_s_atretina113.05035.760Details
BioGPS Gene Atlas220451_s_atsmall_intestine28.85035.760Details
BioGPS NCI60220451_s_at786101.091147.770Details
BioGPS NCI60220451_s_atA17227.067147.770Details
BioGPS NCI60220451_s_atA204199.795147.770Details
BioGPS NCI60220451_s_atA361232.189147.770Details
BioGPS NCI60220451_s_atA498119.437147.770Details
BioGPS NCI60220451_s_atA549128.158147.770Details
BioGPS NCI60220451_s_atACC3228.452147.770Details
BioGPS NCI60220451_s_atACHN57.190147.770Details
BioGPS NCI60220451_s_atALVA31108.744147.770Details
BioGPS NCI60220451_s_atCAKI1103.598147.770Details
BioGPS NCI60220451_s_atCCRT CEM410.118147.770Details
BioGPS NCI60220451_s_atCOLO205157.602147.770Details
BioGPS NCI60220451_s_atDLD170.026147.770Details
BioGPS NCI60220451_s_atDU14590.952147.770Details
BioGPS NCI60220451_s_atEKVX90.569147.770Details
BioGPS NCI60220451_s_atGM13378.443147.770Details
BioGPS NCI60220451_s_atGM1600100.259147.770Details
BioGPS NCI60220451_s_atGM231398.812147.770Details
BioGPS NCI60220451_s_atGM234587.194147.770Details
BioGPS NCI60220451_s_atGM2493104.405147.770Details
BioGPS NCI60220451_s_atGM97120.302147.770Details
BioGPS NCI60220451_s_atHCC299829.036147.770Details
BioGPS NCI60220451_s_atHCT11662.215147.770Details
BioGPS NCI60220451_s_atHCT1519.118147.770Details
BioGPS NCI60220451_s_atHEK 293 T-rex227.587147.770Details
BioGPS NCI60220451_s_atHEK 293T48.312147.770Details
BioGPS NCI60220451_s_atHEK29351.025147.770Details
BioGPS NCI60220451_s_atHELA25.076147.770Details
BioGPS NCI60220451_s_atHEPG266.804147.770Details
BioGPS NCI60220451_s_atHL6047.117147.770Details
BioGPS NCI60220451_s_atHOP6296.078147.770Details
BioGPS NCI60220451_s_atHOP9220.507147.770Details
BioGPS NCI60220451_s_atHS578T93.043147.770Details
BioGPS NCI60220451_s_atHSG89.747147.770Details
BioGPS NCI60220451_s_atHT108070.703147.770Details
BioGPS NCI60220451_s_atHT29182.101147.770Details
BioGPS NCI60220451_s_atIGROV193.653147.770Details
BioGPS NCI60220451_s_atIOSE8072.821147.770Details
BioGPS NCI60220451_s_atJURKAT96.034147.770Details
BioGPS NCI60220451_s_atK562346.338147.770Details
BioGPS NCI60220451_s_atKM12218.905147.770Details
BioGPS NCI60220451_s_atLN1843.218147.770Details
BioGPS NCI60220451_s_atLNCAP166.688147.770Details
BioGPS NCI60220451_s_atLOX IMVI232.483147.770Details
BioGPS NCI60220451_s_atM1470.395147.770Details
BioGPS NCI60220451_s_atMALME 3M718.810147.770Details
BioGPS NCI60220451_s_atMCF727.657147.770Details
BioGPS NCI60220451_s_atMD MB231211.671147.770Details
BioGPS NCI60220451_s_atMDA MB435146.605147.770Details
BioGPS NCI60220451_s_atMOLT4121.280147.770Details
BioGPS NCI60220451_s_atNCI 460222.953147.770Details
BioGPS NCI60220451_s_atNCI H226125.791147.770Details
BioGPS NCI60220451_s_atNCI H23103.070147.770Details
BioGPS NCI60220451_s_atNCI H322M133.488147.770Details
BioGPS NCI60220451_s_atNCVADR RES43.870147.770Details
BioGPS NCI60220451_s_atOVCAR3194.530147.770Details
BioGPS NCI60220451_s_atOVCAR4140.491147.770Details
BioGPS NCI60220451_s_atOVCAR5106.255147.770Details
BioGPS NCI60220451_s_atOVCAR839.957147.770Details
BioGPS NCI60220451_s_atPANC1173.396147.770Details
BioGPS NCI60220451_s_atRL799.949147.770Details
BioGPS NCI60220451_s_atRPMI 8226137.849147.770Details
BioGPS NCI60220451_s_atRS11846186.889147.770Details
BioGPS NCI60220451_s_atRXF39370.064147.770Details
BioGPS NCI60220451_s_atSAOS297.316147.770Details
BioGPS NCI60220451_s_atSF268110.060147.770Details
BioGPS NCI60220451_s_atSF29591.093147.770Details
BioGPS NCI60220451_s_atSF539100.002147.770Details
BioGPS NCI60220451_s_atSHSYSY+RA90.032147.770Details
BioGPS NCI60220451_s_atSHSYSY-RA106.979147.770Details
BioGPS NCI60220451_s_atSKMEL298.429147.770Details
BioGPS NCI60220451_s_atSKMEL282202.384147.770Details
BioGPS NCI60220451_s_atSKMEL5121.952147.770Details
BioGPS NCI60220451_s_atSKOV3226.339147.770Details
BioGPS NCI60220451_s_atSN12C65.428147.770Details
BioGPS NCI60220451_s_atSNB1981.163147.770Details
BioGPS NCI60220451_s_atSNB75160.053147.770Details
BioGPS NCI60220451_s_atSR104.604147.770Details
BioGPS NCI60220451_s_atSW620194.560147.770Details
BioGPS NCI60220451_s_atT24188.074147.770Details
BioGPS NCI60220451_s_atT3M4102.895147.770Details
BioGPS NCI60220451_s_atTK10170.457147.770Details
BioGPS NCI60220451_s_atU11851.300147.770Details
BioGPS NCI60220451_s_atU13831.877147.770Details
BioGPS NCI60220451_s_atU20S17.794147.770Details
BioGPS NCI60220451_s_atU251171.057147.770Details
BioGPS NCI60220451_s_atU8743.462147.770Details
BioGPS NCI60220451_s_atUACC2571687.886147.770Details
BioGPS NCI60220451_s_atUACC6293.343147.770Details
BioGPS NCI60220451_s_atUO3157.454147.770Details
BioGPS NCI60220451_s_atZR75_1112.263147.770Details
BioGPS NCI60220451_s_atastrocytes18.604147.770Details
BioGPS NCI60220451_s_athuh-7137.834147.770Details