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Gene ID: 57448 | BIRC6 Antibody Resource


BIRC6 Antibody Resource
Gene Full Name: 
baculoviral IAP repeat containing 6
Uniprot: 
Q9NR09
Protein Name: 
baculoviral IAP repeat-containing protein 6
Nucleotide: 
XM_005264449
Alias: 
BRUCE;APOLLON;
Ensembl: 
ENSG00000115760
Location: 
2p22.3
HPRD: 
05731
NCBI Gene: 
57448
MIM: 
605638

Summary: 
This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Function: 
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification.
Subcellular location: 
Golgi apparatus › trans-Golgi network membrane. Midbody. Endosome. Cytoplasm › cytoskeleton › spindle pole. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.
PTM: 
Phosphoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAEB00236 Goat Anti-BIRC6 / Apollon Antibody (OAEB00236) Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat ELISA 0.1mg $229 Details
Polyclonal Antibody OAEB00815 Goat Anti-BIRC6 / Apollon (aa 4724 -4735) Antibody (OAEB00815) Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish ELISA 0.1mg $229 Details

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Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP69170 Western clawed frog BIRC6 antibody; Xenopus tropicalis BIRC6 antibody F7ALH1 83.0%

Tissue & Cell Line Gene Expression Data