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Gene ID: 330 | BIRC3 Antibody Resource


BIRC3 Antibody Resource
Gene Full Name: 
baculoviral IAP repeat containing 3
Uniprot: 
Q13489
Protein Name: 
baculoviral IAP repeat-containing protein 3
Nucleotide: 
NM_001165
Alias: 
AIP1;API2;MIHC;CIAP2;HAIP1;HIAP1;MALT2;RNF49;c-IAP2;
Ensembl: 
ENSG00000023445
Location: 
11q22
HPRD: 
03426
NCBI Gene: 
330
MIM: 
601721

Summary: 
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Function: 
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Subcellular location: 
Cytoplasm. Nucleus .
PTM: 
Ubl conjugation;
Disease: 
A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OASA05874 BIRC3 antibody - C-terminal region (OASA05874) WB 0.1mg $505 Details
Polyclonal Antibody OAEB00981 BIRC3 Antibody (OAEB00981) Human WB 0.1mg $289 Details
Polyclonal Antibody OAEB01023 BIRC3 Antibody (OAEB01023) Human WB 0.1mg $289 Details
Blocking Peptide OESA09506 BIRC3 CONTROL PEPTIDE (0.1mg) 0.1mg $640 Details
Polyclonal Antibody OAAB10318 BIRC3 antibody - N - terminal region (OAAB10318) Human WB, IF, IHC 400ul $289 Details
Polyclonal Antibody OAAB16482 cIAP2 (BIRC3) antibody - N - terminal region (OAAB16482) Human WB, IHC 400ul $289 Details

Show all BIRC3 antibodies


Product Images
BIRC3 antibody - N - terminal region (OAAB10318) in 293 cells using Western Blot

Sample Type: 293

BIRC3 antibody - N - terminal region (OAAB10318) in Human Tonsil cells using Immunohistochemistry

Sample Type: Human Tonsil

BIRC3 antibody - N - terminal region (OAAB10318) in MDA-MB435 cells using Immunofluorescence

Sample Type: MDA-MB435

BIRC3 antibody - N - terminal region (OAAB10318) in MDA-MB435 cells using Western Blot

Sample Type: MDA-MB435

cIAP2 (BIRC3) antibody - N - terminal region (OAAB16482) in A549 cells using Western Blot

Sample Type: A549

cIAP2 (BIRC3) antibody - N - terminal region (OAAB16482) in Human Brain cells using Immunohistochemistry

Sample Type: Human Brain

BIRC3 Antibody (OAEB00981) in Rat Testis cells using Western Blot

Sample Type: Rat Testis

BIRC3 Antibody (OAEB01023) in Hela cells using Western Blot

Sample Type: Hela


BIRC3 Protocols

Publications

Related Gene Trend Categories

Species
Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas210538_s_at721_B_lymphoblasts513.80039.410Details
BioGPS Gene Atlas210538_s_atAdipocyte8.05039.410Details
BioGPS Gene Atlas210538_s_atAdrenalCortex12.50039.410Details
BioGPS Gene Atlas210538_s_atAdrenalgland7.60039.410Details
BioGPS Gene Atlas210538_s_atAmygdala8.20039.410Details
BioGPS Gene Atlas210538_s_atAppendix11.50039.410Details
BioGPS Gene Atlas210538_s_atAtrioventricularNode7.65039.410Details
BioGPS Gene Atlas210538_s_atBDCA4+_DentriticCells9.45039.410Details
BioGPS Gene Atlas210538_s_atBonemarrow9.90039.410Details
BioGPS Gene Atlas210538_s_atBronchialEpithelialCells7.90039.410Details
BioGPS Gene Atlas210538_s_atCD105+_Endothelial8.50039.410Details
BioGPS Gene Atlas210538_s_atCD14+_Monocytes9.30039.410Details
BioGPS Gene Atlas210538_s_atCD19+_BCells(neg._sel.)1161.15039.410Details
BioGPS Gene Atlas210538_s_atCD33+_Myeloid11.00039.410Details
BioGPS Gene Atlas210538_s_atCD34+10.45039.410Details
BioGPS Gene Atlas210538_s_atCD4+_Tcells59.30039.410Details
BioGPS Gene Atlas210538_s_atCD56+_NKCells12.05039.410Details
BioGPS Gene Atlas210538_s_atCD71+_EarlyErythroid8.00039.410Details
BioGPS Gene Atlas210538_s_atCD8+_Tcells21.60039.410Details
BioGPS Gene Atlas210538_s_atCardiacMyocytes14.45039.410Details
BioGPS Gene Atlas210538_s_atCaudatenucleus7.80039.410Details
BioGPS Gene Atlas210538_s_atCerebellum6.80039.410Details
BioGPS Gene Atlas210538_s_atCerebellumPeduncles11.00039.410Details
BioGPS Gene Atlas210538_s_atCiliaryGanglion8.00039.410Details
BioGPS Gene Atlas210538_s_atCingulateCortex8.95039.410Details
BioGPS Gene Atlas210538_s_atColorectaladenocarcinoma8.45039.410Details
BioGPS Gene Atlas210538_s_atDorsalRootGanglion9.15039.410Details
BioGPS Gene Atlas210538_s_atFetalThyroid8.50039.410Details
BioGPS Gene Atlas210538_s_atFetalbrain8.30039.410Details
BioGPS Gene Atlas210538_s_atFetalliver7.50039.410Details
BioGPS Gene Atlas210538_s_atFetallung12.50039.410Details
BioGPS Gene Atlas210538_s_atGlobusPallidus6.70039.410Details
BioGPS Gene Atlas210538_s_atHeart12.20039.410Details
BioGPS Gene Atlas210538_s_atHypothalamus8.55039.410Details
BioGPS Gene Atlas210538_s_atKidney7.45039.410Details
BioGPS Gene Atlas210538_s_atLeukemia_chronicMyelogenousK-5627.40039.410Details
BioGPS Gene Atlas210538_s_atLeukemia_promyelocytic-HL-60278.65039.410Details
BioGPS Gene Atlas210538_s_atLeukemialymphoblastic(MOLT-4)6.75039.410Details
BioGPS Gene Atlas210538_s_atLiver14.10039.410Details
BioGPS Gene Atlas210538_s_atLung8.65039.410Details
BioGPS Gene Atlas210538_s_atLymphnode183.20039.410Details
BioGPS Gene Atlas210538_s_atLymphoma_burkitts(Daudi)69.35039.410Details
BioGPS Gene Atlas210538_s_atLymphoma_burkitts(Raji)363.60039.410Details
BioGPS Gene Atlas210538_s_atMedullaOblongata7.30039.410Details
BioGPS Gene Atlas210538_s_atOccipitalLobe7.20039.410Details
BioGPS Gene Atlas210538_s_atOlfactoryBulb6.90039.410Details
BioGPS Gene Atlas210538_s_atOvary6.30039.410Details
BioGPS Gene Atlas210538_s_atPancreas8.95039.410Details
BioGPS Gene Atlas210538_s_atPancreaticIslet32.65039.410Details
BioGPS Gene Atlas210538_s_atParietalLobe9.65039.410Details
BioGPS Gene Atlas210538_s_atPituitary9.75039.410Details
BioGPS Gene Atlas210538_s_atPlacenta8.10039.410Details
BioGPS Gene Atlas210538_s_atPons8.40039.410Details
BioGPS Gene Atlas210538_s_atPrefrontalCortex9.85039.410Details
BioGPS Gene Atlas210538_s_atProstate9.55039.410Details
BioGPS Gene Atlas210538_s_atSalivarygland9.75039.410Details
BioGPS Gene Atlas210538_s_atSkeletalMuscle15.35039.410Details
BioGPS Gene Atlas210538_s_atSkin12.85039.410Details
BioGPS Gene Atlas210538_s_atSmoothMuscle9.60039.410Details
BioGPS Gene Atlas210538_s_atSpinalcord8.95039.410Details
BioGPS Gene Atlas210538_s_atSubthalamicNucleus8.35039.410Details
BioGPS Gene Atlas210538_s_atSuperiorCervicalGanglion15.55039.410Details
BioGPS Gene Atlas210538_s_atTemporalLobe8.10039.410Details
BioGPS Gene Atlas210538_s_atTestis7.05039.410Details
BioGPS Gene Atlas210538_s_atTestisGermCell7.15039.410Details
BioGPS Gene Atlas210538_s_atTestisIntersitial7.65039.410Details
BioGPS Gene Atlas210538_s_atTestisLeydigCell9.25039.410Details
BioGPS Gene Atlas210538_s_atTestisSeminiferousTubule7.35039.410Details
BioGPS Gene Atlas210538_s_atThalamus8.75039.410Details
BioGPS Gene Atlas210538_s_atThymus7.15039.410Details
BioGPS Gene Atlas210538_s_atThyroid9.95039.410Details
BioGPS Gene Atlas210538_s_atTongue10.10039.410Details
BioGPS Gene Atlas210538_s_atTonsil49.65039.410Details
BioGPS Gene Atlas210538_s_atTrachea6.95039.410Details
BioGPS Gene Atlas210538_s_atTrigeminalGanglion12.45039.410Details
BioGPS Gene Atlas210538_s_atUterus7.50039.410Details
BioGPS Gene Atlas210538_s_atUterusCorpus9.65039.410Details
BioGPS Gene Atlas210538_s_atWholeBlood23.10039.410Details
BioGPS Gene Atlas210538_s_atWholebrain6.40039.410Details
BioGPS Gene Atlas210538_s_atcolon8.70039.410Details
BioGPS Gene Atlas210538_s_atpineal_day10.44039.410Details
BioGPS Gene Atlas210538_s_atpineal_night10.26039.410Details
BioGPS Gene Atlas210538_s_atretina10.05039.410Details
BioGPS Gene Atlas210538_s_atsmall_intestine8.30039.410Details
BioGPS NCI60210538_s_at786283.43463.830Details
BioGPS NCI60210538_s_atA17210.95363.830Details
BioGPS NCI60210538_s_atA20413.16363.830Details
BioGPS NCI60210538_s_atA36113.71963.830Details
BioGPS NCI60210538_s_atA49823.93563.830Details
BioGPS NCI60210538_s_atA54916.54463.830Details
BioGPS NCI60210538_s_atACC319.55763.830Details
BioGPS NCI60210538_s_atACHN88.09363.830Details
BioGPS NCI60210538_s_atALVA3116.86863.830Details
BioGPS NCI60210538_s_atCAKI179.21163.830Details
BioGPS NCI60210538_s_atCCRT CEM38.59863.830Details
BioGPS NCI60210538_s_atCOLO20514.53263.830Details
BioGPS NCI60210538_s_atDLD113.22263.830Details
BioGPS NCI60210538_s_atDU145100.67863.830Details
BioGPS NCI60210538_s_atEKVX416.28663.830Details
BioGPS NCI60210538_s_atGM13336.39463.830Details
BioGPS NCI60210538_s_atGM160017.99263.830Details
BioGPS NCI60210538_s_atGM231355.35263.830Details
BioGPS NCI60210538_s_atGM234513.35163.830Details
BioGPS NCI60210538_s_atGM249315.75363.830Details
BioGPS NCI60210538_s_atGM9721.41663.830Details
BioGPS NCI60210538_s_atHCC299899.54463.830Details
BioGPS NCI60210538_s_atHCT11612.65663.830Details
BioGPS NCI60210538_s_atHCT1512.88463.830Details
BioGPS NCI60210538_s_atHEK 293 T-rex13.98263.830Details
BioGPS NCI60210538_s_atHEK 293T13.10163.830Details
BioGPS NCI60210538_s_atHEK29312.66163.830Details
BioGPS NCI60210538_s_atHELA12.85563.830Details
BioGPS NCI60210538_s_atHEPG213.51963.830Details
BioGPS NCI60210538_s_atHL60284.32063.830Details
BioGPS NCI60210538_s_atHOP6225.45263.830Details
BioGPS NCI60210538_s_atHOP9229.34163.830Details
BioGPS NCI60210538_s_atHS578T13.22763.830Details
BioGPS NCI60210538_s_atHSG13.47963.830Details
BioGPS NCI60210538_s_atHT108014.01463.830Details
BioGPS NCI60210538_s_atHT2917.01263.830Details
BioGPS NCI60210538_s_atIGROV133.48663.830Details
BioGPS NCI60210538_s_atIOSE8013.31563.830Details
BioGPS NCI60210538_s_atJURKAT14.32963.830Details
BioGPS NCI60210538_s_atK56220.37563.830Details
BioGPS NCI60210538_s_atKM1217.35563.830Details
BioGPS NCI60210538_s_atLN188.43563.830Details
BioGPS NCI60210538_s_atLNCAP13.27563.830Details
BioGPS NCI60210538_s_atLOX IMVI87.87863.830Details
BioGPS NCI60210538_s_atM1412.97863.830Details
BioGPS NCI60210538_s_atMALME 3M15.87163.830Details
BioGPS NCI60210538_s_atMCF710.59263.830Details
BioGPS NCI60210538_s_atMD MB23126.47463.830Details
BioGPS NCI60210538_s_atMDA MB43516.21563.830Details
BioGPS NCI60210538_s_atMOLT421.34863.830Details
BioGPS NCI60210538_s_atNCI 46013.85363.830Details
BioGPS NCI60210538_s_atNCI H22615.73663.830Details
BioGPS NCI60210538_s_atNCI H23162.14363.830Details
BioGPS NCI60210538_s_atNCI H322M278.44663.830Details
BioGPS NCI60210538_s_atNCVADR RES13.13963.830Details
BioGPS NCI60210538_s_atOVCAR314.32663.830Details
BioGPS NCI60210538_s_atOVCAR422.05163.830Details
BioGPS NCI60210538_s_atOVCAR5351.25063.830Details
BioGPS NCI60210538_s_atOVCAR812.91963.830Details
BioGPS NCI60210538_s_atPANC1131.45363.830Details
BioGPS NCI60210538_s_atRL7475.27663.830Details
BioGPS NCI60210538_s_atRPMI 822615.87763.830Details
BioGPS NCI60210538_s_atRS1184628.81863.830Details
BioGPS NCI60210538_s_atRXF39330.47563.830Details
BioGPS NCI60210538_s_atSAOS213.42763.830Details
BioGPS NCI60210538_s_atSF2681278.33163.830Details
BioGPS NCI60210538_s_atSF295412.94563.830Details
BioGPS NCI60210538_s_atSF53916.59563.830Details
BioGPS NCI60210538_s_atSHSYSY+RA12.66563.830Details
BioGPS NCI60210538_s_atSHSYSY-RA13.30963.830Details
BioGPS NCI60210538_s_atSKMEL214.33663.830Details
BioGPS NCI60210538_s_atSKMEL2813.32363.830Details
BioGPS NCI60210538_s_atSKMEL511.04763.830Details
BioGPS NCI60210538_s_atSKOV316.77163.830Details
BioGPS NCI60210538_s_atSN12C13.33263.830Details
BioGPS NCI60210538_s_atSNB1912.74263.830Details
BioGPS NCI60210538_s_atSNB7514.12563.830Details
BioGPS NCI60210538_s_atSR92.10463.830Details
BioGPS NCI60210538_s_atSW62013.78663.830Details
BioGPS NCI60210538_s_atT2415.23863.830Details
BioGPS NCI60210538_s_atT3M417.41663.830Details
BioGPS NCI60210538_s_atTK10237.85463.830Details
BioGPS NCI60210538_s_atU11813.19163.830Details
BioGPS NCI60210538_s_atU13811.65563.830Details
BioGPS NCI60210538_s_atU20S13.11263.830Details
BioGPS NCI60210538_s_atU25113.20763.830Details
BioGPS NCI60210538_s_atU8711.17063.830Details
BioGPS NCI60210538_s_atUACC25712.95863.830Details
BioGPS NCI60210538_s_atUACC6213.42963.830Details
BioGPS NCI60210538_s_atUO31159.59663.830Details
BioGPS NCI60210538_s_atZR75_114.00363.830Details
BioGPS NCI60210538_s_atastrocytes12.56763.830Details
BioGPS NCI60210538_s_athuh-714.73063.830Details