Gene ID: 329 | BIRC2 Antibody Resource
BIRC2 Antibody Resource
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Summary: | The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
Function: | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. |
Subcellular location: | Cytoplasm. Nucleus. Note: Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells. |
PTM: | Ubl conjugation; |
Disease: | |
Biotechnological use: |
Antibodies
Type | Catalog | Name | Clonality | Species Reactivity | Application | Size | Price | More Info |
---|---|---|---|---|---|---|---|---|
DNA/cDNA/RNA | ANA10478 | BIRC2 (Human) cDNA (1ug) | 1ug | $189 | Details | |||
Protein Lysate | APL10478 | BIRC2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) | 200ug | $219 | Details | |||
Polyclonal Antibody | ARP30483_P050 | BIRC2 Antibody (ARP30483_P050) | Polyclonal | Bovine, Dog, Horse, Human | Not tested | 50 ug | $125 | Details |
Polyclonal Antibody | OAAB10716 | BIRC2 antibody - center region (OAAB10716) | Human | WB, IHC | 400ul | $289 | Details |
Product Images
BIRC2 Protocols
Species
Catalog | Predicted Species & Target | Target Reference | Predicted Homology |
---|---|---|---|
ARP30483 | Bovine BIRC2 antibody; Bos taurus BIRC2 antibody | G3MXL2 | 86.0% |
ARP30483 | Bovine BIRC2 antibody; Bos taurus BIRC2 antibody | G3X822 | 86.0% |
ARP30483 | Cat BIRC2 antibody; Felis catus BIRC2 antibody | M3WWK6 | 85.0% |
ARP30483 | Chimpanzee BIRC2 antibody; Pan troglodytes BIRC2 antibody | H2Q4M6 | 100.0% |
ARP30483 | Chimpanzee BIRC2 antibody; Pan troglodytes BIRC2 antibody | K7DRD3 | 100.0% |
ARP30483 | Dog BIRC2 antibody; Canis familiaris BIRC2 antibody | F1PT73 | 85.0% |
ARP30483 | Dog BIRC2 antibody; Canis familiaris BIRC2 antibody | Q38JA8 | 85.0% |
ARP30483 | Giant panda BIRC2 antibody; Ailuropoda melanoleuca BIRC2 antibody | G1LU18 | 92.0% |
ARP30483 | Horse BIRC2 antibody; Equus caballus BIRC2 antibody | F7DN02 | 93.0% |
ARP30483 | Human BIRC2 antibody; Homo sapiens BIRC2 antibody | E9PMH5 | 100.0% |
ARP30483 | Human BIRC2 antibody; Homo sapiens BIRC2 antibody | E9PNM6 | 100.0% |
ARP30483 | Human BIRC2 antibody; Homo sapiens BIRC2 antibody | H0YDY3 | 100.0% |
ARP30483 | Human BIRC2 antibody; Homo sapiens BIRC2 antibody | Q13490-2 | 100.0% |
ARP30483 | Human BIRC2 antibody; Homo sapiens BIRC2 antibody | Q13490 | 100.0% |
ARP30483 | Rhesus macaque BIRC2 antibody; Macaca mulatta BIRC2 antibody | F7FEH5 | 100.0% |
ARP30483 | Sumatran orangutan BIRC2 antibody; Pongo abelii BIRC2 antibody | H2NF28 | 100.0% |
ARP30483 | Thirteen-lined ground squirrel BIRC2 antibody; Spermophilus tridecemlineatus BIRC2 antibody | I3M6M0 | 92.0% |
Tissue & Cell Line Gene Expression Data
Data Source | Probeset | Sample | Avg | Mean | More Info |
---|---|---|---|---|---|
BioGPS Gene Atlas | 202076_at | 721_B_lymphoblasts | 271.750 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Adipocyte | 66.050 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | AdrenalCortex | 66.350 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Adrenalgland | 32.250 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Amygdala | 136.250 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Appendix | 48.950 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | AtrioventricularNode | 19.850 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | BDCA4+_DentriticCells | 511.650 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Bonemarrow | 13.900 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | BronchialEpithelialCells | 148.800 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CD105+_Endothelial | 291.050 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CD14+_Monocytes | 494.650 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CD19+_BCells(neg._sel.) | 560.000 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CD33+_Myeloid | 699.350 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CD34+ | 442.000 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CD4+_Tcells | 579.950 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CD56+_NKCells | 793.300 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CD71+_EarlyErythroid | 556.900 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CD8+_Tcells | 558.300 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CardiacMyocytes | 72.900 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Caudatenucleus | 46.150 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Cerebellum | 13.850 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CerebellumPeduncles | 17.900 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CiliaryGanglion | 27.850 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | CingulateCortex | 51.650 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Colorectaladenocarcinoma | 128.950 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | DorsalRootGanglion | 20.800 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | FetalThyroid | 117.900 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Fetalbrain | 321.600 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Fetalliver | 91.050 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Fetallung | 248.750 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | GlobusPallidus | 9.450 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Heart | 16.700 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Hypothalamus | 151.550 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Kidney | 11.300 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Leukemia_chronicMyelogenousK-562 | 93.050 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Leukemia_promyelocytic-HL-60 | 134.050 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Leukemialymphoblastic(MOLT-4) | 91.150 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Liver | 14.000 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Lung | 34.800 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Lymphnode | 148.900 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Lymphoma_burkitts(Daudi) | 69.350 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Lymphoma_burkitts(Raji) | 113.550 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | MedullaOblongata | 36.750 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | OccipitalLobe | 58.150 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | OlfactoryBulb | 143.400 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Ovary | 29.500 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Pancreas | 77.100 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | PancreaticIslet | 131.500 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | ParietalLobe | 49.650 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Pituitary | 138.950 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Placenta | 30.450 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Pons | 21.500 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | PrefrontalCortex | 121.300 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Prostate | 117.000 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Salivarygland | 94.600 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | SkeletalMuscle | 16.000 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Skin | 37.100 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | SmoothMuscle | 136.950 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Spinalcord | 115.350 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | SubthalamicNucleus | 18.450 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | SuperiorCervicalGanglion | 22.250 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | TemporalLobe | 15.050 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Testis | 21.050 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | TestisGermCell | 181.800 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | TestisIntersitial | 59.850 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | TestisLeydigCell | 73.950 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | TestisSeminiferousTubule | 83.650 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Thalamus | 72.950 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Thymus | 68.500 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Thyroid | 181.300 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Tongue | 27.850 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Tonsil | 79.600 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Trachea | 91.250 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | TrigeminalGanglion | 24.800 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Uterus | 209.150 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | UterusCorpus | 14.550 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | WholeBlood | 244.700 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | Wholebrain | 60.200 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | colon | 92.400 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | pineal_day | 202.620 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | pineal_night | 250.580 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | retina | 68.300 | 143.800 | Details |
BioGPS Gene Atlas | 202076_at | small_intestine | 47.400 | 143.800 | Details |
BioGPS NCI60 | 202076_at | 786 | 2895.614 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | A172 | 2246.542 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | A204 | 1746.736 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | A361 | 472.667 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | A498 | 1349.958 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | A549 | 1240.336 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | ACC3 | 1481.948 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | ACHN | 974.040 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | ALVA31 | 1160.844 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | CAKI1 | 997.469 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | CCRT CEM | 53.788 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | COLO205 | 992.935 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | DLD1 | 971.030 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | DU145 | 2871.945 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | EKVX | 8758.752 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | GM133 | 5331.666 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | GM1600 | 7842.416 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | GM2313 | 7818.816 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | GM2345 | 1534.549 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | GM2493 | 5826.188 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | GM97 | 2087.054 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HCC2998 | 2203.765 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HCT116 | 1196.931 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HCT15 | 1824.266 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HEK 293 T-rex | 661.734 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HEK 293T | 1515.419 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HEK293 | 1388.142 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HELA | 597.512 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HEPG2 | 1454.543 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HL60 | 822.613 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HOP62 | 722.292 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HOP92 | 1718.467 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HS578T | 1940.508 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HSG | 1926.007 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HT1080 | 1924.593 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | HT29 | 1374.310 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | IGROV1 | 1956.382 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | IOSE80 | 1341.505 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | JURKAT | 889.185 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | K562 | 608.170 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | KM12 | 1011.664 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | LN18 | 2959.661 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | LNCAP | 827.156 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | LOX IMVI | 2786.461 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | M14 | 1814.939 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | MALME 3M | 349.220 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | MCF7 | 547.646 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | MD MB231 | 3207.768 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | MDA MB435 | 323.304 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | MOLT4 | 1273.294 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | NCI 460 | 671.668 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | NCI H226 | 1568.226 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | NCI H23 | 2239.872 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | NCI H322M | 1725.083 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | NCVADR RES | 1453.767 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | OVCAR3 | 2705.975 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | OVCAR4 | 2088.057 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | OVCAR5 | 2335.326 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | OVCAR8 | 2425.512 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | PANC1 | 2821.370 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | RL7 | 853.140 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | RPMI 8226 | 931.891 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | RS11846 | 849.244 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | RXF393 | 1375.001 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SAOS2 | 1140.578 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SF268 | 25784.270 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SF295 | 9447.914 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SF539 | 1635.543 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SHSYSY+RA | 1106.593 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SHSYSY-RA | 1887.701 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SKMEL2 | 1286.582 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SKMEL28 | 657.664 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SKMEL5 | 772.581 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SKOV3 | 3429.858 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SN12C | 884.995 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SNB19 | 2713.454 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SNB75 | 2031.419 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SR | 1540.343 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | SW620 | 1578.148 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | T24 | 2335.692 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | T3M4 | 1318.597 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | TK10 | 2494.415 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | U118 | 2470.691 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | U138 | 2411.907 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | U20S | 1839.900 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | U251 | 1205.638 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | U87 | 1014.369 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | UACC257 | 938.786 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | UACC62 | 1085.048 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | UO31 | 2038.542 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | ZR75_1 | 1377.970 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | astrocytes | 4001.559 | 2150.130 | Details |
BioGPS NCI60 | 202076_at | huh-7 | 789.360 | 2150.130 | Details |