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Gene ID: 329 | BIRC2 Antibody Resource


BIRC2 Antibody Resource
Gene Full Name: 
baculoviral IAP repeat containing 2
Uniprot: 
Q13490
Protein Name: 
baculoviral IAP repeat-containing protein 2
Nucleotide: 
NM_001166
Alias: 
API1;MIHB;HIAP2;RNF48;cIAP1;Hiap-2;c-IAP1;
Ensembl: 
ENSG00000110330
Location: 
11q22
HPRD: 
03419
NCBI Gene: 
329
MIM: 
601712

Summary: 
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Function: 
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
Subcellular location: 
Cytoplasm. Nucleus. Note: Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
PTM: 
Ubl conjugation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
DNA/cDNA/RNA ANA10478 BIRC2 (Human) cDNA (1ug) 1ug $189 Details
Protein Lysate APL10478 BIRC2 Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
Polyclonal Antibody ARP30483_P050 BIRC2 Antibody (ARP30483_P050) Polyclonal Bovine, Dog, Horse, Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAB10716 BIRC2 antibody - center region (OAAB10716) Human WB, IHC 400ul $289 Details

Show all BIRC2 antibodies


Product Images
BIRC2 antibody - center region (OAAB10716) in Human Kidney cells using Immunohistochemistry

Sample Type: Human Kidney

BIRC2 antibody - center region (OAAB10716) in MDA-MB231 cells using Western Blot

Sample Type: MDA-MB231


BIRC2 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP30483 Bovine BIRC2 antibody; Bos taurus BIRC2 antibody G3MXL2 86.0%
ARP30483 Bovine BIRC2 antibody; Bos taurus BIRC2 antibody G3X822 86.0%
ARP30483 Cat BIRC2 antibody; Felis catus BIRC2 antibody M3WWK6 85.0%
ARP30483 Chimpanzee BIRC2 antibody; Pan troglodytes BIRC2 antibody H2Q4M6 100.0%
ARP30483 Chimpanzee BIRC2 antibody; Pan troglodytes BIRC2 antibody K7DRD3 100.0%
ARP30483 Dog BIRC2 antibody; Canis familiaris BIRC2 antibody F1PT73 85.0%
ARP30483 Dog BIRC2 antibody; Canis familiaris BIRC2 antibody Q38JA8 85.0%
ARP30483 Giant panda BIRC2 antibody; Ailuropoda melanoleuca BIRC2 antibody G1LU18 92.0%
ARP30483 Horse BIRC2 antibody; Equus caballus BIRC2 antibody F7DN02 93.0%
ARP30483 Human BIRC2 antibody; Homo sapiens BIRC2 antibody E9PMH5 100.0%
ARP30483 Human BIRC2 antibody; Homo sapiens BIRC2 antibody E9PNM6 100.0%
ARP30483 Human BIRC2 antibody; Homo sapiens BIRC2 antibody H0YDY3 100.0%
ARP30483 Human BIRC2 antibody; Homo sapiens BIRC2 antibody Q13490-2 100.0%
ARP30483 Human BIRC2 antibody; Homo sapiens BIRC2 antibody Q13490 100.0%
ARP30483 Rhesus macaque BIRC2 antibody; Macaca mulatta BIRC2 antibody F7FEH5 100.0%
ARP30483 Sumatran orangutan BIRC2 antibody; Pongo abelii BIRC2 antibody H2NF28 100.0%
ARP30483 Thirteen-lined ground squirrel BIRC2 antibody; Spermophilus tridecemlineatus BIRC2 antibody I3M6M0 92.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas202076_at721_B_lymphoblasts271.750143.800Details
BioGPS Gene Atlas202076_atAdipocyte66.050143.800Details
BioGPS Gene Atlas202076_atAdrenalCortex66.350143.800Details
BioGPS Gene Atlas202076_atAdrenalgland32.250143.800Details
BioGPS Gene Atlas202076_atAmygdala136.250143.800Details
BioGPS Gene Atlas202076_atAppendix48.950143.800Details
BioGPS Gene Atlas202076_atAtrioventricularNode19.850143.800Details
BioGPS Gene Atlas202076_atBDCA4+_DentriticCells511.650143.800Details
BioGPS Gene Atlas202076_atBonemarrow13.900143.800Details
BioGPS Gene Atlas202076_atBronchialEpithelialCells148.800143.800Details
BioGPS Gene Atlas202076_atCD105+_Endothelial291.050143.800Details
BioGPS Gene Atlas202076_atCD14+_Monocytes494.650143.800Details
BioGPS Gene Atlas202076_atCD19+_BCells(neg._sel.)560.000143.800Details
BioGPS Gene Atlas202076_atCD33+_Myeloid699.350143.800Details
BioGPS Gene Atlas202076_atCD34+442.000143.800Details
BioGPS Gene Atlas202076_atCD4+_Tcells579.950143.800Details
BioGPS Gene Atlas202076_atCD56+_NKCells793.300143.800Details
BioGPS Gene Atlas202076_atCD71+_EarlyErythroid556.900143.800Details
BioGPS Gene Atlas202076_atCD8+_Tcells558.300143.800Details
BioGPS Gene Atlas202076_atCardiacMyocytes72.900143.800Details
BioGPS Gene Atlas202076_atCaudatenucleus46.150143.800Details
BioGPS Gene Atlas202076_atCerebellum13.850143.800Details
BioGPS Gene Atlas202076_atCerebellumPeduncles17.900143.800Details
BioGPS Gene Atlas202076_atCiliaryGanglion27.850143.800Details
BioGPS Gene Atlas202076_atCingulateCortex51.650143.800Details
BioGPS Gene Atlas202076_atColorectaladenocarcinoma128.950143.800Details
BioGPS Gene Atlas202076_atDorsalRootGanglion20.800143.800Details
BioGPS Gene Atlas202076_atFetalThyroid117.900143.800Details
BioGPS Gene Atlas202076_atFetalbrain321.600143.800Details
BioGPS Gene Atlas202076_atFetalliver91.050143.800Details
BioGPS Gene Atlas202076_atFetallung248.750143.800Details
BioGPS Gene Atlas202076_atGlobusPallidus9.450143.800Details
BioGPS Gene Atlas202076_atHeart16.700143.800Details
BioGPS Gene Atlas202076_atHypothalamus151.550143.800Details
BioGPS Gene Atlas202076_atKidney11.300143.800Details
BioGPS Gene Atlas202076_atLeukemia_chronicMyelogenousK-56293.050143.800Details
BioGPS Gene Atlas202076_atLeukemia_promyelocytic-HL-60134.050143.800Details
BioGPS Gene Atlas202076_atLeukemialymphoblastic(MOLT-4)91.150143.800Details
BioGPS Gene Atlas202076_atLiver14.000143.800Details
BioGPS Gene Atlas202076_atLung34.800143.800Details
BioGPS Gene Atlas202076_atLymphnode148.900143.800Details
BioGPS Gene Atlas202076_atLymphoma_burkitts(Daudi)69.350143.800Details
BioGPS Gene Atlas202076_atLymphoma_burkitts(Raji)113.550143.800Details
BioGPS Gene Atlas202076_atMedullaOblongata36.750143.800Details
BioGPS Gene Atlas202076_atOccipitalLobe58.150143.800Details
BioGPS Gene Atlas202076_atOlfactoryBulb143.400143.800Details
BioGPS Gene Atlas202076_atOvary29.500143.800Details
BioGPS Gene Atlas202076_atPancreas77.100143.800Details
BioGPS Gene Atlas202076_atPancreaticIslet131.500143.800Details
BioGPS Gene Atlas202076_atParietalLobe49.650143.800Details
BioGPS Gene Atlas202076_atPituitary138.950143.800Details
BioGPS Gene Atlas202076_atPlacenta30.450143.800Details
BioGPS Gene Atlas202076_atPons21.500143.800Details
BioGPS Gene Atlas202076_atPrefrontalCortex121.300143.800Details
BioGPS Gene Atlas202076_atProstate117.000143.800Details
BioGPS Gene Atlas202076_atSalivarygland94.600143.800Details
BioGPS Gene Atlas202076_atSkeletalMuscle16.000143.800Details
BioGPS Gene Atlas202076_atSkin37.100143.800Details
BioGPS Gene Atlas202076_atSmoothMuscle136.950143.800Details
BioGPS Gene Atlas202076_atSpinalcord115.350143.800Details
BioGPS Gene Atlas202076_atSubthalamicNucleus18.450143.800Details
BioGPS Gene Atlas202076_atSuperiorCervicalGanglion22.250143.800Details
BioGPS Gene Atlas202076_atTemporalLobe15.050143.800Details
BioGPS Gene Atlas202076_atTestis21.050143.800Details
BioGPS Gene Atlas202076_atTestisGermCell181.800143.800Details
BioGPS Gene Atlas202076_atTestisIntersitial59.850143.800Details
BioGPS Gene Atlas202076_atTestisLeydigCell73.950143.800Details
BioGPS Gene Atlas202076_atTestisSeminiferousTubule83.650143.800Details
BioGPS Gene Atlas202076_atThalamus72.950143.800Details
BioGPS Gene Atlas202076_atThymus68.500143.800Details
BioGPS Gene Atlas202076_atThyroid181.300143.800Details
BioGPS Gene Atlas202076_atTongue27.850143.800Details
BioGPS Gene Atlas202076_atTonsil79.600143.800Details
BioGPS Gene Atlas202076_atTrachea91.250143.800Details
BioGPS Gene Atlas202076_atTrigeminalGanglion24.800143.800Details
BioGPS Gene Atlas202076_atUterus209.150143.800Details
BioGPS Gene Atlas202076_atUterusCorpus14.550143.800Details
BioGPS Gene Atlas202076_atWholeBlood244.700143.800Details
BioGPS Gene Atlas202076_atWholebrain60.200143.800Details
BioGPS Gene Atlas202076_atcolon92.400143.800Details
BioGPS Gene Atlas202076_atpineal_day202.620143.800Details
BioGPS Gene Atlas202076_atpineal_night250.580143.800Details
BioGPS Gene Atlas202076_atretina68.300143.800Details
BioGPS Gene Atlas202076_atsmall_intestine47.400143.800Details
BioGPS NCI60202076_at7862895.6142150.130Details
BioGPS NCI60202076_atA1722246.5422150.130Details
BioGPS NCI60202076_atA2041746.7362150.130Details
BioGPS NCI60202076_atA361472.6672150.130Details
BioGPS NCI60202076_atA4981349.9582150.130Details
BioGPS NCI60202076_atA5491240.3362150.130Details
BioGPS NCI60202076_atACC31481.9482150.130Details
BioGPS NCI60202076_atACHN974.0402150.130Details
BioGPS NCI60202076_atALVA311160.8442150.130Details
BioGPS NCI60202076_atCAKI1997.4692150.130Details
BioGPS NCI60202076_atCCRT CEM53.7882150.130Details
BioGPS NCI60202076_atCOLO205992.9352150.130Details
BioGPS NCI60202076_atDLD1971.0302150.130Details
BioGPS NCI60202076_atDU1452871.9452150.130Details
BioGPS NCI60202076_atEKVX8758.7522150.130Details
BioGPS NCI60202076_atGM1335331.6662150.130Details
BioGPS NCI60202076_atGM16007842.4162150.130Details
BioGPS NCI60202076_atGM23137818.8162150.130Details
BioGPS NCI60202076_atGM23451534.5492150.130Details
BioGPS NCI60202076_atGM24935826.1882150.130Details
BioGPS NCI60202076_atGM972087.0542150.130Details
BioGPS NCI60202076_atHCC29982203.7652150.130Details
BioGPS NCI60202076_atHCT1161196.9312150.130Details
BioGPS NCI60202076_atHCT151824.2662150.130Details
BioGPS NCI60202076_atHEK 293 T-rex661.7342150.130Details
BioGPS NCI60202076_atHEK 293T1515.4192150.130Details
BioGPS NCI60202076_atHEK2931388.1422150.130Details
BioGPS NCI60202076_atHELA597.5122150.130Details
BioGPS NCI60202076_atHEPG21454.5432150.130Details
BioGPS NCI60202076_atHL60822.6132150.130Details
BioGPS NCI60202076_atHOP62722.2922150.130Details
BioGPS NCI60202076_atHOP921718.4672150.130Details
BioGPS NCI60202076_atHS578T1940.5082150.130Details
BioGPS NCI60202076_atHSG1926.0072150.130Details
BioGPS NCI60202076_atHT10801924.5932150.130Details
BioGPS NCI60202076_atHT291374.3102150.130Details
BioGPS NCI60202076_atIGROV11956.3822150.130Details
BioGPS NCI60202076_atIOSE801341.5052150.130Details
BioGPS NCI60202076_atJURKAT889.1852150.130Details
BioGPS NCI60202076_atK562608.1702150.130Details
BioGPS NCI60202076_atKM121011.6642150.130Details
BioGPS NCI60202076_atLN182959.6612150.130Details
BioGPS NCI60202076_atLNCAP827.1562150.130Details
BioGPS NCI60202076_atLOX IMVI2786.4612150.130Details
BioGPS NCI60202076_atM141814.9392150.130Details
BioGPS NCI60202076_atMALME 3M349.2202150.130Details
BioGPS NCI60202076_atMCF7547.6462150.130Details
BioGPS NCI60202076_atMD MB2313207.7682150.130Details
BioGPS NCI60202076_atMDA MB435323.3042150.130Details
BioGPS NCI60202076_atMOLT41273.2942150.130Details
BioGPS NCI60202076_atNCI 460671.6682150.130Details
BioGPS NCI60202076_atNCI H2261568.2262150.130Details
BioGPS NCI60202076_atNCI H232239.8722150.130Details
BioGPS NCI60202076_atNCI H322M1725.0832150.130Details
BioGPS NCI60202076_atNCVADR RES1453.7672150.130Details
BioGPS NCI60202076_atOVCAR32705.9752150.130Details
BioGPS NCI60202076_atOVCAR42088.0572150.130Details
BioGPS NCI60202076_atOVCAR52335.3262150.130Details
BioGPS NCI60202076_atOVCAR82425.5122150.130Details
BioGPS NCI60202076_atPANC12821.3702150.130Details
BioGPS NCI60202076_atRL7853.1402150.130Details
BioGPS NCI60202076_atRPMI 8226931.8912150.130Details
BioGPS NCI60202076_atRS11846849.2442150.130Details
BioGPS NCI60202076_atRXF3931375.0012150.130Details
BioGPS NCI60202076_atSAOS21140.5782150.130Details
BioGPS NCI60202076_atSF26825784.2702150.130Details
BioGPS NCI60202076_atSF2959447.9142150.130Details
BioGPS NCI60202076_atSF5391635.5432150.130Details
BioGPS NCI60202076_atSHSYSY+RA1106.5932150.130Details
BioGPS NCI60202076_atSHSYSY-RA1887.7012150.130Details
BioGPS NCI60202076_atSKMEL21286.5822150.130Details
BioGPS NCI60202076_atSKMEL28657.6642150.130Details
BioGPS NCI60202076_atSKMEL5772.5812150.130Details
BioGPS NCI60202076_atSKOV33429.8582150.130Details
BioGPS NCI60202076_atSN12C884.9952150.130Details
BioGPS NCI60202076_atSNB192713.4542150.130Details
BioGPS NCI60202076_atSNB752031.4192150.130Details
BioGPS NCI60202076_atSR1540.3432150.130Details
BioGPS NCI60202076_atSW6201578.1482150.130Details
BioGPS NCI60202076_atT242335.6922150.130Details
BioGPS NCI60202076_atT3M41318.5972150.130Details
BioGPS NCI60202076_atTK102494.4152150.130Details
BioGPS NCI60202076_atU1182470.6912150.130Details
BioGPS NCI60202076_atU1382411.9072150.130Details
BioGPS NCI60202076_atU20S1839.9002150.130Details
BioGPS NCI60202076_atU2511205.6382150.130Details
BioGPS NCI60202076_atU871014.3692150.130Details
BioGPS NCI60202076_atUACC257938.7862150.130Details
BioGPS NCI60202076_atUACC621085.0482150.130Details
BioGPS NCI60202076_atUO312038.5422150.130Details
BioGPS NCI60202076_atZR75_11377.9702150.130Details
BioGPS NCI60202076_atastrocytes4001.5592150.130Details
BioGPS NCI60202076_athuh-7789.3602150.130Details