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Gene ID: 8915 | BCL10 Antibody Resource


BCL10 Antibody Resource
Gene Full Name: 
B-cell CLL/lymphoma 10
Uniprot: 
O95999
Protein Name: 
B-cell lymphoma/leukemia 10
Nucleotide: 
XM_005271311
Alias: 
CLAP;mE10;CIPER;c-E10;CARMEN;
Ensembl: 
ENSG00000142867
Location: 
1p22
HPRD: 
04625
NCBI Gene: 
8915
MIM: 
603517

Summary: 
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
Function: 
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
Subcellular location: 
Cytoplasm › perinuclear region. Membrane raft. Note: Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
PTM: 
Acetylation;
Disease: 
A chromosomal aberration involving BCL10 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(1;14)(p22;q32). Although the BCL10/IgH translocation leaves the coding region of BCL10 intact, frequent BCL10 mutations could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.Defects in BCL10 are involved in various types of cancer.Mesothelioma, malignant (MESOM) [MIM:156240]: An aggressive neoplasm of the serosal lining of the chest. It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. Note: The gene represented in this entry may be involved in disease pathogenesis.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Monoclonal Antibody OASA00965 BCL10 Antibody (OASA00965) Human ELISA, FC, IP, IHC-FFPE, WB 0.2mg $455 Details
Monoclonal Antibody OASA00966 BCL10 Antibody (OASA00966) Human ELISA, FC, IP, IHC-FFPE, WB 0.1mg $235 Details
Monoclonal Antibody OASA00967 BCL10 Antibody (OASA00967) Human FC 100 Tests $500 Details
Polyclonal Antibody OASA07454 BCL10 Antibody (OASA07454) Human WB 0.1mg $310 Details
Polyclonal Antibody OASA07455 BCL10 Antibody (OASA07455) Human WB 50ug $220 Details
Polyclonal Antibody OAAB00715 BCL10 antibody - N-terminal region (OAAB00715) Human; Mouse WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody OAAF03002 BCL10 Antibody (OAAF03002) Polyclonal Human, Mouse, Rat WB, IHC, ELISA 100 ug $229 Details

Show all BCL10 antibodies


Product Images
BCL10 antibody - N-terminal region (OAAB00715) in Human Tonsil cells using Immunohistochemistry

Sample Type: Human Tonsil

BCL10 antibody - N-terminal region (OAAB00715) in Mouse Kidney cells using Western Blot

Sample Type: Mouse Kidney

BCL10 Antibody (OAAF03002) in Human colon carcinoma cells using Immunohistochemistry

Sample Type: Human colon carcinoma

BCL10 Antibody (OAAF03002) in K562 cells using Western Blot

Sample Type: K562

BCL10 Antibody (OASA00965) in Human tonsil cells using Immunohistochemistry

Sample Type: Human tonsil

BCL10 Antibody (OASA00966) in Human tonsil cells using Immunohistochemistry

Sample Type: Human tonsil

BCL10 Antibody (OASA00967) in human tonsil cells using Flow Cytometry

Sample Type: human tonsil

BCL10 Antibody (OASA07454) in Raji cells using Western Blot

Sample Type: Raji

BCL10 Antibody (OASA07455) in Raji cells using Western Blot

Sample Type: Raji


BCL10 Protocols

Publications
Related Gene Trend Categories
Species
Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas205263_at721_B_lymphoblasts38.70020.940Details
BioGPS Gene Atlas205263_atAdipocyte11.00020.940Details
BioGPS Gene Atlas205263_atAdrenalCortex12.40020.940Details
BioGPS Gene Atlas205263_atAdrenalgland11.75020.940Details
BioGPS Gene Atlas205263_atAmygdala10.90020.940Details
BioGPS Gene Atlas205263_atAppendix16.25020.940Details
BioGPS Gene Atlas205263_atAtrioventricularNode9.85020.940Details
BioGPS Gene Atlas205263_atBDCA4+_DentriticCells12.25020.940Details
BioGPS Gene Atlas205263_atBonemarrow13.45020.940Details
BioGPS Gene Atlas205263_atBronchialEpithelialCells152.05020.940Details
BioGPS Gene Atlas205263_atCD105+_Endothelial13.80020.940Details
BioGPS Gene Atlas205263_atCD14+_Monocytes18.40020.940Details
BioGPS Gene Atlas205263_atCD19+_BCells(neg._sel.)26.35020.940Details
BioGPS Gene Atlas205263_atCD33+_Myeloid43.75020.940Details
BioGPS Gene Atlas205263_atCD34+16.80020.940Details
BioGPS Gene Atlas205263_atCD4+_Tcells11.10020.940Details
BioGPS Gene Atlas205263_atCD56+_NKCells20.60020.940Details
BioGPS Gene Atlas205263_atCD71+_EarlyErythroid9.05020.940Details
BioGPS Gene Atlas205263_atCD8+_Tcells10.35020.940Details
BioGPS Gene Atlas205263_atCardiacMyocytes16.10020.940Details
BioGPS Gene Atlas205263_atCaudatenucleus9.80020.940Details
BioGPS Gene Atlas205263_atCerebellum9.55020.940Details
BioGPS Gene Atlas205263_atCerebellumPeduncles14.00020.940Details
BioGPS Gene Atlas205263_atCiliaryGanglion8.20020.940Details
BioGPS Gene Atlas205263_atCingulateCortex11.70020.940Details
BioGPS Gene Atlas205263_atColorectaladenocarcinoma10.65020.940Details
BioGPS Gene Atlas205263_atDorsalRootGanglion8.25020.940Details
BioGPS Gene Atlas205263_atFetalThyroid13.45020.940Details
BioGPS Gene Atlas205263_atFetalbrain10.85020.940Details
BioGPS Gene Atlas205263_atFetalliver10.55020.940Details
BioGPS Gene Atlas205263_atFetallung24.05020.940Details
BioGPS Gene Atlas205263_atGlobusPallidus7.40020.940Details
BioGPS Gene Atlas205263_atHeart13.75020.940Details
BioGPS Gene Atlas205263_atHypothalamus9.95020.940Details
BioGPS Gene Atlas205263_atKidney11.35020.940Details
BioGPS Gene Atlas205263_atLeukemia_chronicMyelogenousK-56210.35020.940Details
BioGPS Gene Atlas205263_atLeukemia_promyelocytic-HL-6015.25020.940Details
BioGPS Gene Atlas205263_atLeukemialymphoblastic(MOLT-4)9.95020.940Details
BioGPS Gene Atlas205263_atLiver15.60020.940Details
BioGPS Gene Atlas205263_atLung17.20020.940Details
BioGPS Gene Atlas205263_atLymphnode10.00020.940Details
BioGPS Gene Atlas205263_atLymphoma_burkitts(Daudi)15.65020.940Details
BioGPS Gene Atlas205263_atLymphoma_burkitts(Raji)15.50020.940Details
BioGPS Gene Atlas205263_atMedullaOblongata9.75020.940Details
BioGPS Gene Atlas205263_atOccipitalLobe9.65020.940Details
BioGPS Gene Atlas205263_atOlfactoryBulb8.10020.940Details
BioGPS Gene Atlas205263_atOvary7.80020.940Details
BioGPS Gene Atlas205263_atPancreas14.75020.940Details
BioGPS Gene Atlas205263_atPancreaticIslet12.70020.940Details
BioGPS Gene Atlas205263_atParietalLobe12.25020.940Details
BioGPS Gene Atlas205263_atPituitary13.30020.940Details
BioGPS Gene Atlas205263_atPlacenta32.05020.940Details
BioGPS Gene Atlas205263_atPons11.10020.940Details
BioGPS Gene Atlas205263_atPrefrontalCortex14.55020.940Details
BioGPS Gene Atlas205263_atProstate23.35020.940Details
BioGPS Gene Atlas205263_atSalivarygland9.20020.940Details
BioGPS Gene Atlas205263_atSkeletalMuscle13.60020.940Details
BioGPS Gene Atlas205263_atSkin9.50020.940Details
BioGPS Gene Atlas205263_atSmoothMuscle16.55020.940Details
BioGPS Gene Atlas205263_atSpinalcord11.85020.940Details
BioGPS Gene Atlas205263_atSubthalamicNucleus9.30020.940Details
BioGPS Gene Atlas205263_atSuperiorCervicalGanglion16.55020.940Details
BioGPS Gene Atlas205263_atTemporalLobe10.70020.940Details
BioGPS Gene Atlas205263_atTestis9.55020.940Details
BioGPS Gene Atlas205263_atTestisGermCell10.30020.940Details
BioGPS Gene Atlas205263_atTestisIntersitial8.85020.940Details
BioGPS Gene Atlas205263_atTestisLeydigCell11.20020.940Details
BioGPS Gene Atlas205263_atTestisSeminiferousTubule9.50020.940Details
BioGPS Gene Atlas205263_atThalamus11.05020.940Details
BioGPS Gene Atlas205263_atThymus12.85020.940Details
BioGPS Gene Atlas205263_atThyroid13.60020.940Details
BioGPS Gene Atlas205263_atTongue11.55020.940Details
BioGPS Gene Atlas205263_atTonsil14.15020.940Details
BioGPS Gene Atlas205263_atTrachea15.25020.940Details
BioGPS Gene Atlas205263_atTrigeminalGanglion12.65020.940Details
BioGPS Gene Atlas205263_atUterus20.50020.940Details
BioGPS Gene Atlas205263_atUterusCorpus12.70020.940Details
BioGPS Gene Atlas205263_atWholeBlood213.95020.940Details
BioGPS Gene Atlas205263_atWholebrain11.20020.940Details
BioGPS Gene Atlas205263_atcolon225.00020.940Details
BioGPS Gene Atlas205263_atpineal_day13.02020.940Details
BioGPS Gene Atlas205263_atpineal_night14.06020.940Details
BioGPS Gene Atlas205263_atretina16.85020.940Details
BioGPS Gene Atlas205263_atsmall_intestine92.85020.940Details
BioGPS NCI60205263_at786654.069403.150Details
BioGPS NCI60205263_atA172467.058403.150Details
BioGPS NCI60205263_atA204338.978403.150Details
BioGPS NCI60205263_atA36197.025403.150Details
BioGPS NCI60205263_atA498265.009403.150Details
BioGPS NCI60205263_atA54991.968403.150Details
BioGPS NCI60205263_atACC3186.657403.150Details
BioGPS NCI60205263_atACHN849.409403.150Details
BioGPS NCI60205263_atALVA31856.699403.150Details
BioGPS NCI60205263_atCAKI1268.176403.150Details
BioGPS NCI60205263_atCCRT CEM40.810403.150Details
BioGPS NCI60205263_atCOLO205210.468403.150Details
BioGPS NCI60205263_atDLD1465.555403.150Details
BioGPS NCI60205263_atDU145250.853403.150Details
BioGPS NCI60205263_atEKVX161.500403.150Details
BioGPS NCI60205263_atGM1331128.074403.150Details
BioGPS NCI60205263_atGM1600699.362403.150Details
BioGPS NCI60205263_atGM2313901.291403.150Details
BioGPS NCI60205263_atGM23451014.560403.150Details
BioGPS NCI60205263_atGM2493928.330403.150Details
BioGPS NCI60205263_atGM971138.140403.150Details
BioGPS NCI60205263_atHCC2998522.450403.150Details
BioGPS NCI60205263_atHCT116342.959403.150Details
BioGPS NCI60205263_atHCT15600.924403.150Details
BioGPS NCI60205263_atHEK 293 T-rex158.470403.150Details
BioGPS NCI60205263_atHEK 293T316.257403.150Details
BioGPS NCI60205263_atHEK293492.550403.150Details
BioGPS NCI60205263_atHELA119.964403.150Details
BioGPS NCI60205263_atHEPG2143.164403.150Details
BioGPS NCI60205263_atHL6080.273403.150Details
BioGPS NCI60205263_atHOP62515.609403.150Details
BioGPS NCI60205263_atHOP9296.495403.150Details
BioGPS NCI60205263_atHS578T341.846403.150Details
BioGPS NCI60205263_atHSG77.082403.150Details
BioGPS NCI60205263_atHT1080314.293403.150Details
BioGPS NCI60205263_atHT29598.697403.150Details
BioGPS NCI60205263_atIGROV1518.858403.150Details
BioGPS NCI60205263_atIOSE80341.941403.150Details
BioGPS NCI60205263_atJURKAT237.492403.150Details
BioGPS NCI60205263_atK562131.470403.150Details
BioGPS NCI60205263_atKM12469.188403.150Details
BioGPS NCI60205263_atLN18582.559403.150Details
BioGPS NCI60205263_atLNCAP313.684403.150Details
BioGPS NCI60205263_atLOX IMVI786.203403.150Details
BioGPS NCI60205263_atM14291.019403.150Details
BioGPS NCI60205263_atMALME 3M63.228403.150Details
BioGPS NCI60205263_atMCF7266.371403.150Details
BioGPS NCI60205263_atMD MB231451.010403.150Details
BioGPS NCI60205263_atMDA MB43552.740403.150Details
BioGPS NCI60205263_atMOLT4206.999403.150Details
BioGPS NCI60205263_atNCI 460159.448403.150Details
BioGPS NCI60205263_atNCI H2261012.540403.150Details
BioGPS NCI60205263_atNCI H23368.838403.150Details
BioGPS NCI60205263_atNCI H322M379.615403.150Details
BioGPS NCI60205263_atNCVADR RES327.177403.150Details
BioGPS NCI60205263_atOVCAR3142.506403.150Details
BioGPS NCI60205263_atOVCAR4342.763403.150Details
BioGPS NCI60205263_atOVCAR5313.275403.150Details
BioGPS NCI60205263_atOVCAR8739.169403.150Details
BioGPS NCI60205263_atPANC11532.758403.150Details
BioGPS NCI60205263_atRL7209.949403.150Details
BioGPS NCI60205263_atRPMI 822688.502403.150Details
BioGPS NCI60205263_atRS11846131.087403.150Details
BioGPS NCI60205263_atRXF393834.151403.150Details
BioGPS NCI60205263_atSAOS2918.047403.150Details
BioGPS NCI60205263_atSF268426.306403.150Details
BioGPS NCI60205263_atSF295373.694403.150Details
BioGPS NCI60205263_atSF539257.810403.150Details
BioGPS NCI60205263_atSHSYSY+RA215.357403.150Details
BioGPS NCI60205263_atSHSYSY-RA186.967403.150Details
BioGPS NCI60205263_atSKMEL2272.035403.150Details
BioGPS NCI60205263_atSKMEL28277.872403.150Details
BioGPS NCI60205263_atSKMEL586.385403.150Details
BioGPS NCI60205263_atSKOV3152.049403.150Details
BioGPS NCI60205263_atSN12C257.840403.150Details
BioGPS NCI60205263_atSNB19323.748403.150Details
BioGPS NCI60205263_atSNB75312.432403.150Details
BioGPS NCI60205263_atSR143.440403.150Details
BioGPS NCI60205263_atSW620136.417403.150Details
BioGPS NCI60205263_atT241140.953403.150Details
BioGPS NCI60205263_atT3M41079.022403.150Details
BioGPS NCI60205263_atTK10306.289403.150Details
BioGPS NCI60205263_atU118352.165403.150Details
BioGPS NCI60205263_atU138479.990403.150Details
BioGPS NCI60205263_atU20S323.704403.150Details
BioGPS NCI60205263_atU251680.215403.150Details
BioGPS NCI60205263_atU87278.478403.150Details
BioGPS NCI60205263_atUACC257156.567403.150Details
BioGPS NCI60205263_atUACC6275.189403.150Details
BioGPS NCI60205263_atUO31656.531403.150Details
BioGPS NCI60205263_atZR75_1158.562403.150Details
BioGPS NCI60205263_atastrocytes395.956403.150Details
BioGPS NCI60205263_athuh-7217.594403.150Details