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Gene ID: 583 | BBS2 Antibody Resource


BBS2 Antibody Resource
Gene Full Name: 
Bardet-Biedl syndrome 2
Uniprot: 
Q9BXC9
Protein Name: 
Bardet-Biedl syndrome 2 protein
Nucleotide: 
XM_005256080
Alias: 
BBS;
Ensembl: 
ENSG00000125124
Location: 
16q21
HPRD: 
05855
NCBI Gene: 
583
MIM: 
606151

Summary: 
This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with six other BBS proteins.[provided by RefSeq, Jan 2009]
Function: 
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.
Subcellular location: 
Cell projection › cilium membrane. Cytoplasm. Cytoplasm › cytoskeleton › microtubule organizing center › centrosome › centriolar satellite .
PTM: 
Disease: 
Bardet-Biedl syndrome 2 (BBS2) [MIM:209900]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP59752_P050 BBS2 antibody - N-terminal region (ARP59752_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rat, Zebrafish WB 50ug $289 Details
Polyclonal Antibody ARP59751_P050 BBS2 antibody - middle region (ARP59751_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rat, Zebrafish WB 50ug $289 Details

Show all BBS2 antibodies


Product Images
BBS2 antibody - middle region (ARP59751_P050) in Human COLO205 cells using Western Blot

Sample Type: Human COLO205

BBS2 antibody - N-terminal region (ARP59752_P050) in Human MCF-7 cells using Western Blot

Sample Type: Human MCF-7


BBS2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP59752 African elephant BBS2 antibody; Loxodonta africana BBS2 antibody G3TIP0 93.0%
ARP59751 African elephant BBS2 antibody; Loxodonta africana BBS2 antibody G3TIP0 92.0%
ARP59751 Atlantic salmon BBS2 antibody; Salmo salar BBS2 antibody Q0H927 100.0%
ARP59752 Atlantic salmon BBS2 antibody; Salmo salar BBS2 antibody Q0H927 86.0%
ARP59751 Bovine BBS2 antibody; Bos taurus BBS2 antibody F1MU26 100.0%
ARP59752 Bovine BBS2 antibody; Bos taurus BBS2 antibody F1MU26 100.0%
ARP59751 Bovine BBS2 antibody; Bos taurus BBS2 antibody Q32L13 100.0%
ARP59752 Bovine BBS2 antibody; Bos taurus BBS2 antibody Q32L13 100.0%
ARP59751 Cat BBS2 antibody; Felis catus BBS2 antibody M3WA02 100.0%
ARP59752 Cat BBS2 antibody; Felis catus BBS2 antibody M3WA02 100.0%
ARP59751 Chicken BBS2 antibody; Gallus gallus BBS2 antibody F1NC06 100.0%
ARP59752 Chicken BBS2 antibody; Gallus gallus BBS2 antibody F1NC06 93.0%
ARP59752 Chimpanzee BBS2 antibody; Pan troglodytes BBS2 antibody H2QB48 100.0%
ARP59752 Chimpanzee BBS2 antibody; Pan troglodytes BBS2 antibody K7CYC5 100.0%
ARP59751 Chimpanzee BBS2 antibody; Pan troglodytes BBS2 antibody H2QB48 93.0%
ARP59751 Chimpanzee BBS2 antibody; Pan troglodytes BBS2 antibody K7CYC5 93.0%
ARP59752 Chinese softshell turtle BBS2 antibody; Pelodiscus sinensis BBS2 antibody K7FYE3 100.0%
ARP59751 Chinese softshell turtle BBS2 antibody; Pelodiscus sinensis BBS2 antibody K7FYE3 86.0%
ARP59751 Collared flycatcher BBS2 antibody; Ficedula albicollis BBS2 antibody U3JYK5 92.0%
ARP59752 Collared flycatcher BBS2 antibody; Ficedula albicollis BBS2 antibody U3JYK5 86.0%
ARP59751 Dog BBS2 antibody; Canis familiaris BBS2 antibody E2RRL8 100.0%
ARP59752 Dog BBS2 antibody; Canis familiaris BBS2 antibody E2RRL8 100.0%
ARP59751 Dog BBS2 antibody; Canis familiaris BBS2 antibody J9P3V7 100.0%
ARP59752 Dog BBS2 antibody; Canis familiaris BBS2 antibody J9P3V7 100.0%
ARP59751 Domestic duck BBS2 antibody; Anas platyrhynchos BBS2 antibody U3IYU1 100.0%
ARP59752 Domestic duck BBS2 antibody; Anas platyrhynchos BBS2 antibody U3IYU1 93.0%
ARP59751 European domestic ferret BBS2 antibody; Mustela putorius furo BBS2 antibody M3XWM7 100.0%
ARP59752 European domestic ferret BBS2 antibody; Mustela putorius furo BBS2 antibody M3XWM7 100.0%
ARP59751 Giant panda BBS2 antibody; Ailuropoda melanoleuca BBS2 antibody G1ME56 100.0%
ARP59752 Giant panda BBS2 antibody; Ailuropoda melanoleuca BBS2 antibody G1ME56 100.0%
ARP59752 Gray short-tailed opossum BBS2 antibody; Monodelphis domestica BBS2 antibody F7D8D3 100.0%
ARP59751 Gray short-tailed opossum BBS2 antibody; Monodelphis domestica BBS2 antibody F7D8D3 86.0%
ARP59751 Horse BBS2 antibody; Equus caballus BBS2 antibody F6PM46 100.0%
ARP59752 Horse BBS2 antibody; Equus caballus BBS2 antibody F6PM46 100.0%
ARP59751 Human BBS2 antibody; Homo sapiens BBS2 antibody H3BRL0 100.0%
ARP59752 Human BBS2 antibody; Homo sapiens BBS2 antibody H3BRL0 100.0%
ARP59751 Human BBS2 antibody; Homo sapiens BBS2 antibody Q9BXC9 100.0%
ARP59752 Human BBS2 antibody; Homo sapiens BBS2 antibody Q9BXC9 100.0%
ARP59752 Hydra BBS2 antibody; Hydra vulgaris BBS2 antibody T2M6C8 79.0%
ARP59752 Mouse BBS2 antibody; Mus musculus BBS2 antibody Q9CWF6 93.0%
ARP59751 Mouse BBS2 antibody; Mus musculus BBS2 antibody Q9CWF6 86.0%
ARP59751 Northern white-cheeked gibbon BBS2 antibody; Nomascus leucogenys BBS2 antibody G1QNZ0 100.0%
ARP59752 Northern white-cheeked gibbon BBS2 antibody; Nomascus leucogenys BBS2 antibody G1QNZ0 100.0%
ARP59751 Pig BBS2 antibody; Sus scrofa BBS2 antibody I3LT30 93.0%
ARP59752 Pig BBS2 antibody; Sus scrofa BBS2 antibody I3LT30 93.0%
ARP59751 Rabbit BBS2 antibody; Oryctolagus cuniculus BBS2 antibody G1TDC1 100.0%
ARP59752 Rabbit BBS2 antibody; Oryctolagus cuniculus BBS2 antibody G1TDC1 100.0%
ARP59751 Rat BBS2 antibody; Rattus norvegicus BBS2 antibody Q99MH9 93.0%
ARP59752 Rat BBS2 antibody; Rattus norvegicus BBS2 antibody Q99MH9 93.0%
ARP59751 Rhesus macaque BBS2 antibody; Macaca mulatta BBS2 antibody F6ZBL6 100.0%
ARP59752 Rhesus macaque BBS2 antibody; Macaca mulatta BBS2 antibody F6ZBL6 100.0%
ARP59751 Rhesus macaque BBS2 antibody; Macaca mulatta BBS2 antibody G7NPC3 100.0%
ARP59752 Rhesus macaque BBS2 antibody; Macaca mulatta BBS2 antibody G7NPC3 100.0%
ARP59751 Rhesus macaque BBS2 antibody; Macaca mulatta BBS2 antibody H9EVX2 100.0%
ARP59752 Rhesus macaque BBS2 antibody; Macaca mulatta BBS2 antibody H9EVX2 100.0%
ARP59752 Small-eared galago BBS2 antibody; Otolemur garnettii BBS2 antibody H0XC64 100.0%
ARP59751 Small-eared galago BBS2 antibody; Otolemur garnettii BBS2 antibody H0XC64 85.0%
ARP59751 Spotted green pufferfish BBS2 antibody; Tetraodon nigroviridis BBS2 antibody H3DMY8 91.0%
ARP59752 Spotted green pufferfish BBS2 antibody; Tetraodon nigroviridis BBS2 antibody H3DMY8 86.0%
ARP59751 Sumatran orangutan BBS2 antibody; Pongo abelii BBS2 antibody H2NQY4 100.0%
ARP59752 Tasmanian devil BBS2 antibody; Sarcophilus harrisii BBS2 antibody G3W852 100.0%
ARP59751 Tasmanian devil BBS2 antibody; Sarcophilus harrisii BBS2 antibody G3W852 92.0%
ARP59751 Thirteen-lined ground squirrel BBS2 antibody; Spermophilus tridecemlineatus BBS2 antibody I3M6W3 100.0%
ARP59752 Thirteen-lined ground squirrel BBS2 antibody; Spermophilus tridecemlineatus BBS2 antibody I3M6W3 100.0%
ARP59752 West Indian ocean coelacanth BBS2 antibody; Latimeria chalumnae BBS2 antibody H3B555 93.0%
ARP59751 West Indian ocean coelacanth BBS2 antibody; Latimeria chalumnae BBS2 antibody H3B555 91.0%
ARP59752 Western clawed frog BBS2 antibody; Xenopus tropicalis BBS2 antibody F7C228 93.0%
ARP59752 White-tufted-ear marmoset BBS2 antibody; Callithrix jacchus BBS2 antibody F7IFY6 100.0%
ARP59751 White-tufted-ear marmoset BBS2 antibody; Callithrix jacchus BBS2 antibody F7IFY6 93.0%
ARP59751 Zebra finch BBS2 antibody; Taeniopygia guttata BBS2 antibody H0Z855 86.0%
ARP59752 Zebra finch BBS2 antibody; Taeniopygia guttata BBS2 antibody H0Z855 86.0%
ARP59751 Zebrafish BBS2 antibody; Danio rerio BBS2 antibody Q6DI45 100.0%
ARP59751 Zebrafish BBS2 antibody; Danio rerio BBS2 antibody Q6PCA0 100.0%
ARP59751 Zebrafish BBS2 antibody; Danio rerio BBS2 antibody Q98SP7 100.0%
ARP59752 Zebrafish BBS2 antibody; Danio rerio BBS2 antibody Q6DI45 79.0%
ARP59752 Zebrafish BBS2 antibody; Danio rerio BBS2 antibody Q6PCA0 79.0%
ARP59752 Zebrafish BBS2 antibody; Danio rerio BBS2 antibody Q98SP7 79.0%

Tissue & Cell Line Gene Expression Data