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Gene ID: 27113 | BBC3 Antibody Resource


BBC3 Antibody Resource
Gene Full Name: 
BCL2 binding component 3
Uniprot: 
Q96PG8
Protein Name: 
bcl-2-binding component 3
Nucleotide: 
NM_001127242
Alias: 
JFY1;PUMA;JFY-1;
Ensembl: 
ENSG00000105327
Location: 
19q13.3-q13.4
HPRD: 
16165
NCBI Gene: 
27113
MIM: 
605854

Summary: 
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Function: 
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Isoform 3 fails to show any growth-inhibitory or apoptotic activity.
Subcellular location: 
Mitochondrion. Note: Localized to the mitochondria in order to induce cytochrome c release. Isoform 3 is not found in mitochondria.
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP58945_P050 BBC3 antibody - N-terminal region (ARP58945_P050) Polyclonal Human WB 50ug $289 Details
Polyclonal Antibody OASA06049 GOAT ANTI HUMAN BCL-2 BINDING COMPONENT 3 Antibody WB 0.1mg $500 Details
Polyclonal Antibody OASA07026 BBC3 Antibody (OASA07026) Human IHC-FFPE, WB 0.1mg $355 Details
Polyclonal Antibody OASA07027 BBC3 Antibody (OASA07027) Human IHC-FFPE, WB 50ug $220 Details
Polyclonal Antibody OAEB00959 BBC3 Antibody (OAEB00959) Human WB 0.1mg $289 Details
Polyclonal Antibody OARA02812 BBC3 Antibody (OARA02812) ELISA, WB 100ug $450 Details
Polyclonal Antibody ARP58946_P050 BBC3 Antibody (ARP58946_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAB09482 Puma BH3 Domain antibody (OAAB09482) Human WB, IHC, IF, FC 400ul $289 Details
Polyclonal Antibody OAAB10400 BBC3 antibody - center region (OAAB10400) Human WB, IHC 400ul $289 Details

Show all BBC3 antibodies


Product Images
BBC3 antibody - N-terminal region (ARP58945_P050) in Human Hep3B, HepG2 cells using Western Blot

Sample Type: Human Hep3B, HepG2

BBC3 antibody - N-terminal region (ARP58945_P050) in Human Placenta cells using Western Blot

Sample Type: Human Placenta

Puma BH3 Domain antibody (OAAB09482) in Hela cells using Flow Cytometry

Sample Type: Hela

Puma BH3 Domain antibody (OAAB09482) in Hela cells using Immunofluorescence

Sample Type: Hela

Puma BH3 Domain antibody (OAAB09482) in HL-60 cells using Western Blot

Sample Type: HL-60

Puma BH3 Domain antibody (OAAB09482) in Human Breast cells using Immunohistochemistry

Sample Type: Human Breast

BBC3 antibody - center region (OAAB10400) in A549 cells using Western Blot

Sample Type: A549

BBC3 antibody - center region (OAAB10400) in Human cervix cells using Immunohistochemistry

Sample Type: Human cervix

BBC3 Antibody (OAEB00959) in Peripheral Blood Lymphocytes cells using Western Blot

Sample Type: Peripheral Blood Lymphocytes

BBC3 Antibody (OASA07026) in human breast carcinoma cells using Immunohistochemistry

Sample Type: human breast carcinoma

BBC3 Antibody (OASA07027) in human breast carcinoma cells using Immunohistochemistry

Sample Type: human breast carcinoma


BBC3 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP58945 Chimpanzee BBC3 antibody; Pan troglodytes BBC3 antibody H2QGP2 100.0%
ARP58946 Chimpanzee BBC3 antibody; Pan troglodytes BBC3 antibody H2QGP2 100.0%
ARP58945 Human BBC3 antibody; Homo sapiens BBC3 antibody Q96PG8 100.0%
ARP58946 Human BBC3 antibody; Homo sapiens BBC3 antibody Q96PG8 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas211692_s_at721_B_lymphoblasts30.50024.910Details
BioGPS Gene Atlas211692_s_atAdipocyte24.65024.910Details
BioGPS Gene Atlas211692_s_atAdrenalCortex32.70024.910Details
BioGPS Gene Atlas211692_s_atAdrenalgland21.80024.910Details
BioGPS Gene Atlas211692_s_atAmygdala20.25024.910Details
BioGPS Gene Atlas211692_s_atAppendix24.50024.910Details
BioGPS Gene Atlas211692_s_atAtrioventricularNode31.50024.910Details
BioGPS Gene Atlas211692_s_atBDCA4+_DentriticCells22.35024.910Details
BioGPS Gene Atlas211692_s_atBonemarrow23.40024.910Details
BioGPS Gene Atlas211692_s_atBronchialEpithelialCells17.80024.910Details
BioGPS Gene Atlas211692_s_atCD105+_Endothelial24.25024.910Details
BioGPS Gene Atlas211692_s_atCD14+_Monocytes24.50024.910Details
BioGPS Gene Atlas211692_s_atCD19+_BCells(neg._sel.)25.00024.910Details
BioGPS Gene Atlas211692_s_atCD33+_Myeloid30.35024.910Details
BioGPS Gene Atlas211692_s_atCD34+30.15024.910Details
BioGPS Gene Atlas211692_s_atCD4+_Tcells26.50024.910Details
BioGPS Gene Atlas211692_s_atCD56+_NKCells30.00024.910Details
BioGPS Gene Atlas211692_s_atCD71+_EarlyErythroid23.35024.910Details
BioGPS Gene Atlas211692_s_atCD8+_Tcells21.15024.910Details
BioGPS Gene Atlas211692_s_atCardiacMyocytes25.10024.910Details
BioGPS Gene Atlas211692_s_atCaudatenucleus21.65024.910Details
BioGPS Gene Atlas211692_s_atCerebellum19.45024.910Details
BioGPS Gene Atlas211692_s_atCerebellumPeduncles41.50024.910Details
BioGPS Gene Atlas211692_s_atCiliaryGanglion21.20024.910Details
BioGPS Gene Atlas211692_s_atCingulateCortex30.45024.910Details
BioGPS Gene Atlas211692_s_atColorectaladenocarcinoma24.25024.910Details
BioGPS Gene Atlas211692_s_atDorsalRootGanglion31.20024.910Details
BioGPS Gene Atlas211692_s_atFetalThyroid23.90024.910Details
BioGPS Gene Atlas211692_s_atFetalbrain24.15024.910Details
BioGPS Gene Atlas211692_s_atFetalliver20.80024.910Details
BioGPS Gene Atlas211692_s_atFetallung19.70024.910Details
BioGPS Gene Atlas211692_s_atGlobusPallidus20.00024.910Details
BioGPS Gene Atlas211692_s_atHeart29.40024.910Details
BioGPS Gene Atlas211692_s_atHypothalamus24.60024.910Details
BioGPS Gene Atlas211692_s_atKidney19.65024.910Details
BioGPS Gene Atlas211692_s_atLeukemia_chronicMyelogenousK-56228.40024.910Details
BioGPS Gene Atlas211692_s_atLeukemia_promyelocytic-HL-6024.15024.910Details
BioGPS Gene Atlas211692_s_atLeukemialymphoblastic(MOLT-4)18.85024.910Details
BioGPS Gene Atlas211692_s_atLiver29.30024.910Details
BioGPS Gene Atlas211692_s_atLung26.60024.910Details
BioGPS Gene Atlas211692_s_atLymphnode20.50024.910Details
BioGPS Gene Atlas211692_s_atLymphoma_burkitts(Daudi)31.95024.910Details
BioGPS Gene Atlas211692_s_atLymphoma_burkitts(Raji)29.75024.910Details
BioGPS Gene Atlas211692_s_atMedullaOblongata26.20024.910Details
BioGPS Gene Atlas211692_s_atOccipitalLobe24.80024.910Details
BioGPS Gene Atlas211692_s_atOlfactoryBulb19.65024.910Details
BioGPS Gene Atlas211692_s_atOvary19.80024.910Details
BioGPS Gene Atlas211692_s_atPancreas25.05024.910Details
BioGPS Gene Atlas211692_s_atPancreaticIslet26.90024.910Details
BioGPS Gene Atlas211692_s_atParietalLobe26.65024.910Details
BioGPS Gene Atlas211692_s_atPituitary31.00024.910Details
BioGPS Gene Atlas211692_s_atPlacenta25.15024.910Details
BioGPS Gene Atlas211692_s_atPons30.60024.910Details
BioGPS Gene Atlas211692_s_atPrefrontalCortex28.55024.910Details
BioGPS Gene Atlas211692_s_atProstate24.40024.910Details
BioGPS Gene Atlas211692_s_atSalivarygland19.35024.910Details
BioGPS Gene Atlas211692_s_atSkeletalMuscle28.75024.910Details
BioGPS Gene Atlas211692_s_atSkin20.40024.910Details
BioGPS Gene Atlas211692_s_atSmoothMuscle27.25024.910Details
BioGPS Gene Atlas211692_s_atSpinalcord25.90024.910Details
BioGPS Gene Atlas211692_s_atSubthalamicNucleus23.20024.910Details
BioGPS Gene Atlas211692_s_atSuperiorCervicalGanglion28.85024.910Details
BioGPS Gene Atlas211692_s_atTemporalLobe28.70024.910Details
BioGPS Gene Atlas211692_s_atTestis20.50024.910Details
BioGPS Gene Atlas211692_s_atTestisGermCell18.90024.910Details
BioGPS Gene Atlas211692_s_atTestisIntersitial24.20024.910Details
BioGPS Gene Atlas211692_s_atTestisLeydigCell23.95024.910Details
BioGPS Gene Atlas211692_s_atTestisSeminiferousTubule31.15024.910Details
BioGPS Gene Atlas211692_s_atThalamus25.00024.910Details
BioGPS Gene Atlas211692_s_atThymus17.45024.910Details
BioGPS Gene Atlas211692_s_atThyroid22.15024.910Details
BioGPS Gene Atlas211692_s_atTongue23.85024.910Details
BioGPS Gene Atlas211692_s_atTonsil24.50024.910Details
BioGPS Gene Atlas211692_s_atTrachea19.30024.910Details
BioGPS Gene Atlas211692_s_atTrigeminalGanglion43.50024.910Details
BioGPS Gene Atlas211692_s_atUterus16.55024.910Details
BioGPS Gene Atlas211692_s_atUterusCorpus24.75024.910Details
BioGPS Gene Atlas211692_s_atWholeBlood26.55024.910Details
BioGPS Gene Atlas211692_s_atWholebrain16.85024.910Details
BioGPS Gene Atlas211692_s_atcolon21.65024.910Details
BioGPS Gene Atlas211692_s_atpineal_day23.68024.910Details
BioGPS Gene Atlas211692_s_atpineal_night23.68024.910Details
BioGPS Gene Atlas211692_s_atretina26.45024.910Details
BioGPS Gene Atlas211692_s_atsmall_intestine17.30024.910Details
BioGPS NCI60211692_s_at78650.46079.420Details
BioGPS NCI60211692_s_atA17267.98979.420Details
BioGPS NCI60211692_s_atA20493.95879.420Details
BioGPS NCI60211692_s_atA36197.34979.420Details
BioGPS NCI60211692_s_atA49870.52279.420Details
BioGPS NCI60211692_s_atA54971.59879.420Details
BioGPS NCI60211692_s_atACC378.99079.420Details
BioGPS NCI60211692_s_atACHN74.12579.420Details
BioGPS NCI60211692_s_atALVA3173.49779.420Details
BioGPS NCI60211692_s_atCAKI172.18279.420Details
BioGPS NCI60211692_s_atCCRT CEM76.05279.420Details
BioGPS NCI60211692_s_atCOLO20570.50779.420Details
BioGPS NCI60211692_s_atDLD179.25279.420Details
BioGPS NCI60211692_s_atDU14564.88779.420Details
BioGPS NCI60211692_s_atEKVX61.07379.420Details
BioGPS NCI60211692_s_atGM13372.18879.420Details
BioGPS NCI60211692_s_atGM160073.07579.420Details
BioGPS NCI60211692_s_atGM231361.36879.420Details
BioGPS NCI60211692_s_atGM234564.37779.420Details
BioGPS NCI60211692_s_atGM249377.45079.420Details
BioGPS NCI60211692_s_atGM9776.56379.420Details
BioGPS NCI60211692_s_atHCC299869.85079.420Details
BioGPS NCI60211692_s_atHCT11684.28279.420Details
BioGPS NCI60211692_s_atHCT1567.51379.420Details
BioGPS NCI60211692_s_atHEK 293 T-rex68.51979.420Details
BioGPS NCI60211692_s_atHEK 293T71.00579.420Details
BioGPS NCI60211692_s_atHEK29370.44179.420Details
BioGPS NCI60211692_s_atHELA67.93679.420Details
BioGPS NCI60211692_s_atHEPG284.58179.420Details
BioGPS NCI60211692_s_atHL60292.83179.420Details
BioGPS NCI60211692_s_atHOP6277.55979.420Details
BioGPS NCI60211692_s_atHOP9264.35479.420Details
BioGPS NCI60211692_s_atHS578T63.74679.420Details
BioGPS NCI60211692_s_atHSG61.27879.420Details
BioGPS NCI60211692_s_atHT1080117.69279.420Details
BioGPS NCI60211692_s_atHT2954.76379.420Details
BioGPS NCI60211692_s_atIGROV1139.73679.420Details
BioGPS NCI60211692_s_atIOSE8069.65479.420Details
BioGPS NCI60211692_s_atJURKAT69.90479.420Details
BioGPS NCI60211692_s_atK56277.27279.420Details
BioGPS NCI60211692_s_atKM1275.17879.420Details
BioGPS NCI60211692_s_atLN1864.95379.420Details
BioGPS NCI60211692_s_atLNCAP70.37279.420Details
BioGPS NCI60211692_s_atLOX IMVI70.33679.420Details
BioGPS NCI60211692_s_atM1461.02079.420Details
BioGPS NCI60211692_s_atMALME 3M79.85179.420Details
BioGPS NCI60211692_s_atMCF774.79279.420Details
BioGPS NCI60211692_s_atMD MB23170.83079.420Details
BioGPS NCI60211692_s_atMDA MB43573.67479.420Details
BioGPS NCI60211692_s_atMOLT493.64579.420Details
BioGPS NCI60211692_s_atNCI 46071.95279.420Details
BioGPS NCI60211692_s_atNCI H22671.66179.420Details
BioGPS NCI60211692_s_atNCI H2395.40779.420Details
BioGPS NCI60211692_s_atNCI H322M70.11979.420Details
BioGPS NCI60211692_s_atNCVADR RES68.22579.420Details
BioGPS NCI60211692_s_atOVCAR372.74479.420Details
BioGPS NCI60211692_s_atOVCAR469.57879.420Details
BioGPS NCI60211692_s_atOVCAR562.68679.420Details
BioGPS NCI60211692_s_atOVCAR844.21679.420Details
BioGPS NCI60211692_s_atPANC1135.56379.420Details
BioGPS NCI60211692_s_atRL7149.18479.420Details
BioGPS NCI60211692_s_atRPMI 822673.79179.420Details
BioGPS NCI60211692_s_atRS11846103.15379.420Details
BioGPS NCI60211692_s_atRXF39370.02479.420Details
BioGPS NCI60211692_s_atSAOS264.81479.420Details
BioGPS NCI60211692_s_atSF26870.47479.420Details
BioGPS NCI60211692_s_atSF29569.60779.420Details
BioGPS NCI60211692_s_atSF53961.37579.420Details
BioGPS NCI60211692_s_atSHSYSY+RA90.13579.420Details
BioGPS NCI60211692_s_atSHSYSY-RA108.01979.420Details
BioGPS NCI60211692_s_atSKMEL259.60179.420Details
BioGPS NCI60211692_s_atSKMEL28108.32679.420Details
BioGPS NCI60211692_s_atSKMEL5150.14779.420Details
BioGPS NCI60211692_s_atSKOV358.89079.420Details
BioGPS NCI60211692_s_atSN12C63.22679.420Details
BioGPS NCI60211692_s_atSNB1948.57179.420Details
BioGPS NCI60211692_s_atSNB7563.44879.420Details
BioGPS NCI60211692_s_atSR71.22179.420Details
BioGPS NCI60211692_s_atSW62070.50079.420Details
BioGPS NCI60211692_s_atT2453.31879.420Details
BioGPS NCI60211692_s_atT3M4128.35579.420Details
BioGPS NCI60211692_s_atTK1070.33579.420Details
BioGPS NCI60211692_s_atU11864.09079.420Details
BioGPS NCI60211692_s_atU13857.74279.420Details
BioGPS NCI60211692_s_atU20S67.62479.420Details
BioGPS NCI60211692_s_atU25169.85279.420Details
BioGPS NCI60211692_s_atU8766.03379.420Details
BioGPS NCI60211692_s_atUACC25776.10379.420Details
BioGPS NCI60211692_s_atUACC62113.81279.420Details
BioGPS NCI60211692_s_atUO3169.05879.420Details
BioGPS NCI60211692_s_atZR75_171.95579.420Details
BioGPS NCI60211692_s_atastrocytes71.50879.420Details
BioGPS NCI60211692_s_athuh-766.13579.420Details