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Gene ID: 570 | BAAT Antibody Resource


BAAT Antibody Resource
Gene Full Name: 
bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
Uniprot: 
Q14032
Protein Name: 
bile acid-CoA:amino acid N-acyltransferase
Nucleotide: 
NM_001701
Alias: 
BAT;BACAT;
Ensembl: 
ENSG00000136881
Location: 
9q22.3
HPRD: 
08376
NCBI Gene: 
570
MIM: 
602938

Summary: 
The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Function: 
Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs.
Subcellular location: 
Cytoplasm .
PTM: 
Disease: 
Familial hypercholanemia (FHCA) [MIM:607748]: A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Note: The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP45686_P050 BAAT antibody - N-terminal region (ARP45686_P050) Polyclonal Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody ARP45687_P050 BAAT Antibody (ARP45687_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody ARP45688_P050 BAAT Antibody (ARP45688_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Not tested 50 ug $125 Details

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Product Images
BAAT antibody - N-terminal region (ARP45686_P050) in Human Liver cells using Western Blot

Sample Type: Human Liver


BAAT Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP45686 Cat BAAT antibody; Felis catus BAAT antibody M3VWL0 92.0%
ARP45688 Cat BAAT antibody; Felis catus BAAT antibody M3VWL0 86.0%
ARP45688 Chicken BAAT antibody; Gallus gallus BAAT antibody F1NBC1 100.0%
ARP45686 Chimpanzee BAAT antibody; Pan troglodytes BAAT antibody H2R6I2 100.0%
ARP45688 Chimpanzee BAAT antibody; Pan troglodytes BAAT antibody H2R6I2 100.0%
ARP45687 Chimpanzee BAAT antibody; Pan troglodytes BAAT antibody H2R6I2 93.0%
ARP45688 Chinese softshell turtle BAAT antibody; Pelodiscus sinensis BAAT antibody K7FMS7 100.0%
ARP45688 Collared flycatcher BAAT antibody; Ficedula albicollis BAAT antibody U3KC86 100.0%
ARP45686 Dog BAAT antibody; Canis familiaris BAAT antibody E2QZH6 93.0%
ARP45688 Dog BAAT antibody; Canis familiaris BAAT antibody E2QZH6 86.0%
ARP45686 European domestic ferret BAAT antibody; Mustela putorius furo BAAT antibody M3Y677 100.0%
ARP45688 European domestic ferret BAAT antibody; Mustela putorius furo BAAT antibody M3Y677 86.0%
ARP45686 Giant panda BAAT antibody; Ailuropoda melanoleuca BAAT antibody D2HV26 93.0%
ARP45688 Giant panda BAAT antibody; Ailuropoda melanoleuca BAAT antibody D2HV26 93.0%
ARP45688 Green anole BAAT antibody; Anolis carolinensis BAAT antibody H9GPQ8 92.0%
ARP45686 Horse BAAT antibody; Equus caballus BAAT antibody F7CVD9 100.0%
ARP45688 Horse BAAT antibody; Equus caballus BAAT antibody F7CVD9 93.0%
ARP45686 Human BAAT antibody; Homo sapiens BAAT antibody Q14032 100.0%
ARP45687 Human BAAT antibody; Homo sapiens BAAT antibody Q14032 100.0%
ARP45688 Human BAAT antibody; Homo sapiens BAAT antibody Q14032 100.0%
ARP45688 Mouse BAAT antibody; Mus musculus BAAT antibody Q91X34 100.0%
ARP45686 Mouse BAAT antibody; Mus musculus BAAT antibody Q91X34 86.0%
ARP45686 Northern white-cheeked gibbon BAAT antibody; Nomascus leucogenys BAAT antibody G1S5I6 100.0%
ARP45688 Northern white-cheeked gibbon BAAT antibody; Nomascus leucogenys BAAT antibody G1S5I6 100.0%
ARP45687 Northern white-cheeked gibbon BAAT antibody; Nomascus leucogenys BAAT antibody G1S5I6 93.0%
ARP45688 Pig BAAT antibody; Sus scrofa BAAT antibody F1SSB1 100.0%
ARP45686 Pig BAAT antibody; Sus scrofa BAAT antibody F1SSB1 79.0%
ARP45686 Rabbit BAAT antibody; Oryctolagus cuniculus BAAT antibody G1SXS4 100.0%
ARP45688 Rabbit BAAT antibody; Oryctolagus cuniculus BAAT antibody G1SXS4 93.0%
ARP45688 Rat BAAT antibody; Rattus norvegicus BAAT antibody Q63276 100.0%
ARP45686 Rat BAAT antibody; Rattus norvegicus BAAT antibody Q63276 93.0%
ARP45688 Rhesus macaque BAAT antibody; Macaca mulatta BAAT antibody F7HT86 100.0%
ARP45686 Rhesus macaque BAAT antibody; Macaca mulatta BAAT antibody F7HT86 93.0%
ARP45687 Rhesus macaque BAAT antibody; Macaca mulatta BAAT antibody F7HT86 86.0%
ARP45686 Small-eared galago BAAT antibody; Otolemur garnettii BAAT antibody H0X2I3 100.0%
ARP45688 Small-eared galago BAAT antibody; Otolemur garnettii BAAT antibody H0X2I3 100.0%
ARP45686 Sumatran orangutan BAAT antibody; Pongo abelii BAAT antibody H2PSW9 100.0%
ARP45688 Sumatran orangutan BAAT antibody; Pongo abelii BAAT antibody H2PSW9 100.0%
ARP45687 Sumatran orangutan BAAT antibody; Pongo abelii BAAT antibody H2PSW9 93.0%
ARP45688 Tasmanian devil BAAT antibody; Sarcophilus harrisii BAAT antibody G3WGF7 100.0%
ARP45686 Tasmanian devil BAAT antibody; Sarcophilus harrisii BAAT antibody G3WGF7 86.0%
ARP45688 Thirteen-lined ground squirrel BAAT antibody; Spermophilus tridecemlineatus BAAT antibody I3N978 93.0%
ARP45686 Thirteen-lined ground squirrel BAAT antibody; Spermophilus tridecemlineatus BAAT antibody I3N978 86.0%
ARP45688 Western clawed frog BAAT antibody; Xenopus tropicalis BAAT antibody A4IIX4 83.0%
ARP45688 Western clawed frog BAAT antibody; Xenopus tropicalis BAAT antibody F6Y417 83.0%
ARP45686 White-tufted-ear marmoset BAAT antibody; Callithrix jacchus BAAT antibody F7I2J0 100.0%
ARP45688 White-tufted-ear marmoset BAAT antibody; Callithrix jacchus BAAT antibody F7I2J0 93.0%
ARP45687 White-tufted-ear marmoset BAAT antibody; Callithrix jacchus BAAT antibody F7I2J0 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas206913_at721_B_lymphoblasts7.1007.550Details
BioGPS Gene Atlas206913_atAdipocyte6.1007.550Details
BioGPS Gene Atlas206913_atAdrenalCortex6.9507.550Details
BioGPS Gene Atlas206913_atAdrenalgland6.2507.550Details
BioGPS Gene Atlas206913_atAmygdala6.4007.550Details
BioGPS Gene Atlas206913_atAppendix6.3507.550Details
BioGPS Gene Atlas206913_atAtrioventricularNode5.2507.550Details
BioGPS Gene Atlas206913_atBDCA4+_DentriticCells6.5507.550Details
BioGPS Gene Atlas206913_atBonemarrow6.3507.550Details
BioGPS Gene Atlas206913_atBronchialEpithelialCells6.2507.550Details
BioGPS Gene Atlas206913_atCD105+_Endothelial6.2007.550Details
BioGPS Gene Atlas206913_atCD14+_Monocytes6.5007.550Details
BioGPS Gene Atlas206913_atCD19+_BCells(neg._sel.)7.0507.550Details
BioGPS Gene Atlas206913_atCD33+_Myeloid7.9507.550Details
BioGPS Gene Atlas206913_atCD34+7.7507.550Details
BioGPS Gene Atlas206913_atCD4+_Tcells6.7007.550Details
BioGPS Gene Atlas206913_atCD56+_NKCells6.9507.550Details
BioGPS Gene Atlas206913_atCD71+_EarlyErythroid5.9007.550Details
BioGPS Gene Atlas206913_atCD8+_Tcells5.5007.550Details
BioGPS Gene Atlas206913_atCardiacMyocytes8.0007.550Details
BioGPS Gene Atlas206913_atCaudatenucleus9.3007.550Details
BioGPS Gene Atlas206913_atCerebellum5.3007.550Details
BioGPS Gene Atlas206913_atCerebellumPeduncles9.7007.550Details
BioGPS Gene Atlas206913_atCiliaryGanglion4.8007.550Details
BioGPS Gene Atlas206913_atCingulateCortex6.7007.550Details
BioGPS Gene Atlas206913_atColorectaladenocarcinoma6.3507.550Details
BioGPS Gene Atlas206913_atDorsalRootGanglion5.0507.550Details
BioGPS Gene Atlas206913_atFetalThyroid6.0507.550Details
BioGPS Gene Atlas206913_atFetalbrain6.2507.550Details
BioGPS Gene Atlas206913_atFetalliver6.7007.550Details
BioGPS Gene Atlas206913_atFetallung15.1507.550Details
BioGPS Gene Atlas206913_atGlobusPallidus4.7007.550Details
BioGPS Gene Atlas206913_atHeart8.3507.550Details
BioGPS Gene Atlas206913_atHypothalamus6.7007.550Details
BioGPS Gene Atlas206913_atKidney5.6507.550Details
BioGPS Gene Atlas206913_atLeukemia_chronicMyelogenousK-5625.7007.550Details
BioGPS Gene Atlas206913_atLeukemia_promyelocytic-HL-605.6007.550Details
BioGPS Gene Atlas206913_atLeukemialymphoblastic(MOLT-4)5.1007.550Details
BioGPS Gene Atlas206913_atLiver82.8507.550Details
BioGPS Gene Atlas206913_atLung6.6507.550Details
BioGPS Gene Atlas206913_atLymphnode5.5007.550Details
BioGPS Gene Atlas206913_atLymphoma_burkitts(Daudi)9.9007.550Details
BioGPS Gene Atlas206913_atLymphoma_burkitts(Raji)9.2507.550Details
BioGPS Gene Atlas206913_atMedullaOblongata7.4007.550Details
BioGPS Gene Atlas206913_atOccipitalLobe5.9007.550Details
BioGPS Gene Atlas206913_atOlfactoryBulb5.0007.550Details
BioGPS Gene Atlas206913_atOvary4.3007.550Details
BioGPS Gene Atlas206913_atPancreas8.1007.550Details
BioGPS Gene Atlas206913_atPancreaticIslet6.7507.550Details
BioGPS Gene Atlas206913_atParietalLobe7.8507.550Details
BioGPS Gene Atlas206913_atPituitary7.4507.550Details
BioGPS Gene Atlas206913_atPlacenta6.3507.550Details
BioGPS Gene Atlas206913_atPons7.6007.550Details
BioGPS Gene Atlas206913_atPrefrontalCortex7.3007.550Details
BioGPS Gene Atlas206913_atProstate7.2507.550Details
BioGPS Gene Atlas206913_atSalivarygland5.1007.550Details
BioGPS Gene Atlas206913_atSkeletalMuscle7.9507.550Details
BioGPS Gene Atlas206913_atSkin5.1507.550Details
BioGPS Gene Atlas206913_atSmoothMuscle6.9007.550Details
BioGPS Gene Atlas206913_atSpinalcord6.8007.550Details
BioGPS Gene Atlas206913_atSubthalamicNucleus5.7007.550Details
BioGPS Gene Atlas206913_atSuperiorCervicalGanglion7.3507.550Details
BioGPS Gene Atlas206913_atTemporalLobe5.7507.550Details
BioGPS Gene Atlas206913_atTestis5.5007.550Details
BioGPS Gene Atlas206913_atTestisGermCell5.7007.550Details
BioGPS Gene Atlas206913_atTestisIntersitial5.3507.550Details
BioGPS Gene Atlas206913_atTestisLeydigCell6.3007.550Details
BioGPS Gene Atlas206913_atTestisSeminiferousTubule5.4507.550Details
BioGPS Gene Atlas206913_atThalamus10.5507.550Details
BioGPS Gene Atlas206913_atThymus5.1007.550Details
BioGPS Gene Atlas206913_atThyroid7.8007.550Details
BioGPS Gene Atlas206913_atTongue6.5007.550Details
BioGPS Gene Atlas206913_atTonsil6.2007.550Details
BioGPS Gene Atlas206913_atTrachea5.3507.550Details
BioGPS Gene Atlas206913_atTrigeminalGanglion6.4007.550Details
BioGPS Gene Atlas206913_atUterus5.0507.550Details
BioGPS Gene Atlas206913_atUterusCorpus5.5507.550Details
BioGPS Gene Atlas206913_atWholeBlood6.3507.550Details
BioGPS Gene Atlas206913_atWholebrain5.3007.550Details
BioGPS Gene Atlas206913_atcolon6.3507.550Details
BioGPS Gene Atlas206913_atpineal_day7.4607.550Details
BioGPS Gene Atlas206913_atpineal_night7.3007.550Details
BioGPS Gene Atlas206913_atretina7.7007.550Details
BioGPS Gene Atlas206913_atsmall_intestine6.1007.550Details
BioGPS NCI60206913_at7865.2038.240Details
BioGPS NCI60206913_atA1724.6628.240Details
BioGPS NCI60206913_atA2045.0218.240Details
BioGPS NCI60206913_atA3615.0988.240Details
BioGPS NCI60206913_atA4985.0558.240Details
BioGPS NCI60206913_atA5495.6918.240Details
BioGPS NCI60206913_atACC35.3058.240Details
BioGPS NCI60206913_atACHN4.8618.240Details
BioGPS NCI60206913_atALVA315.6038.240Details
BioGPS NCI60206913_atCAKI15.4068.240Details
BioGPS NCI60206913_atCCRT CEM6.0098.240Details
BioGPS NCI60206913_atCOLO205331.5618.240Details
BioGPS NCI60206913_atDLD14.9198.240Details
BioGPS NCI60206913_atDU1454.9908.240Details
BioGPS NCI60206913_atEKVX4.8108.240Details
BioGPS NCI60206913_atGM1335.1638.240Details
BioGPS NCI60206913_atGM16005.2758.240Details
BioGPS NCI60206913_atGM23135.1488.240Details
BioGPS NCI60206913_atGM23455.0808.240Details
BioGPS NCI60206913_atGM24935.2378.240Details
BioGPS NCI60206913_atGM975.6858.240Details
BioGPS NCI60206913_atHCC29984.4358.240Details
BioGPS NCI60206913_atHCT1165.0488.240Details
BioGPS NCI60206913_atHCT154.7228.240Details
BioGPS NCI60206913_atHEK 293 T-rex5.3618.240Details
BioGPS NCI60206913_atHEK 293T4.9878.240Details
BioGPS NCI60206913_atHEK2934.9868.240Details
BioGPS NCI60206913_atHELA4.6588.240Details
BioGPS NCI60206913_atHEPG25.1178.240Details
BioGPS NCI60206913_atHL605.2328.240Details
BioGPS NCI60206913_atHOP625.0658.240Details
BioGPS NCI60206913_atHOP924.8318.240Details
BioGPS NCI60206913_atHS578T4.9578.240Details
BioGPS NCI60206913_atHSG4.8148.240Details
BioGPS NCI60206913_atHT10805.0248.240Details
BioGPS NCI60206913_atHT295.6128.240Details
BioGPS NCI60206913_atIGROV14.9428.240Details
BioGPS NCI60206913_atIOSE804.9628.240Details
BioGPS NCI60206913_atJURKAT5.0588.240Details
BioGPS NCI60206913_atK5625.7828.240Details
BioGPS NCI60206913_atKM127.2448.240Details
BioGPS NCI60206913_atLN184.6398.240Details
BioGPS NCI60206913_atLNCAP5.0698.240Details
BioGPS NCI60206913_atLOX IMVI5.0458.240Details
BioGPS NCI60206913_atM145.0228.240Details
BioGPS NCI60206913_atMALME 3M5.5598.240Details
BioGPS NCI60206913_atMCF74.8388.240Details
BioGPS NCI60206913_atMD MB2315.1018.240Details
BioGPS NCI60206913_atMDA MB4355.6658.240Details
BioGPS NCI60206913_atMOLT45.3738.240Details
BioGPS NCI60206913_atNCI 4605.2388.240Details
BioGPS NCI60206913_atNCI H2265.2688.240Details
BioGPS NCI60206913_atNCI H235.0438.240Details
BioGPS NCI60206913_atNCI H322M5.0418.240Details
BioGPS NCI60206913_atNCVADR RES4.6638.240Details
BioGPS NCI60206913_atOVCAR35.4368.240Details
BioGPS NCI60206913_atOVCAR45.0408.240Details
BioGPS NCI60206913_atOVCAR55.0048.240Details
BioGPS NCI60206913_atOVCAR84.6418.240Details
BioGPS NCI60206913_atPANC15.1638.240Details
BioGPS NCI60206913_atRL75.2828.240Details
BioGPS NCI60206913_atRPMI 82265.1618.240Details
BioGPS NCI60206913_atRS118467.3038.240Details
BioGPS NCI60206913_atRXF3935.0198.240Details
BioGPS NCI60206913_atSAOS25.0868.240Details
BioGPS NCI60206913_atSF2685.0528.240Details
BioGPS NCI60206913_atSF2955.0088.240Details
BioGPS NCI60206913_atSF5394.6558.240Details
BioGPS NCI60206913_atSHSYSY+RA4.9588.240Details
BioGPS NCI60206913_atSHSYSY-RA4.9418.240Details
BioGPS NCI60206913_atSKMEL25.0548.240Details
BioGPS NCI60206913_atSKMEL2816.6628.240Details
BioGPS NCI60206913_atSKMEL54.9758.240Details
BioGPS NCI60206913_atSKOV35.2968.240Details
BioGPS NCI60206913_atSN12C5.0478.240Details
BioGPS NCI60206913_atSNB194.6138.240Details
BioGPS NCI60206913_atSNB754.9958.240Details
BioGPS NCI60206913_atSR5.1368.240Details
BioGPS NCI60206913_atSW6205.1738.240Details
BioGPS NCI60206913_atT245.2418.240Details
BioGPS NCI60206913_atT3M45.3898.240Details
BioGPS NCI60206913_atTK105.0438.240Details
BioGPS NCI60206913_atU1184.8418.240Details
BioGPS NCI60206913_atU1384.6338.240Details
BioGPS NCI60206913_atU20S4.8768.240Details
BioGPS NCI60206913_atU2514.9318.240Details
BioGPS NCI60206913_atU874.8178.240Details
BioGPS NCI60206913_atUACC2574.9998.240Details
BioGPS NCI60206913_atUACC625.0998.240Details
BioGPS NCI60206913_atUO314.8178.240Details
BioGPS NCI60206913_atZR75_15.1508.240Details
BioGPS NCI60206913_atastrocytes5.0198.240Details
BioGPS NCI60206913_athuh-75.2658.240Details