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Gene ID: 8313 | AXIN2 Antibody Resource


AXIN2 Antibody Resource
Gene Full Name: 
axin 2
Uniprot: 
Q9Y2T1
Protein Name: 
axin-2
Nucleotide: 
XM_005257719
Alias: 
AXIL;ODCRCS;
Ensembl: 
ENSG00000168646
Location: 
17q23-q24
HPRD: 
04935
NCBI Gene: 
8313
MIM: 
604025

Summary: 
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Function: 
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B .
Subcellular location: 
Cytoplasm.
PTM: 
ADP-ribosylation;
Disease: 
Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note: The gene represented in this entry is involved in disease pathogenesis.Oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]: Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB02831 AXIN2 antibody - C-terminal region (OAAB02831) Human WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody OAPB01241 AXIN2 Antibody (OAPB01241) Polyclonal Human; Mouse; Rat ELISA, WB 0.1 mg $355 Details
Polyclonal Antibody ARP32098_P050 AXIN2 Antibody (ARP32098_P050) Polyclonal Bovine, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Not tested 50 ug $50 Details
Polyclonal Antibody ARP32099_P050 AXIN2 Antibody (ARP32099_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rabbit Not tested 50 ug $50 Details

Show all AXIN2 antibodies


Product Images
AXIN2 antibody - C-terminal region (OAAB02831) in human brain cells using Immunohistochemistry

Sample Type: human brain

AXIN2 antibody - C-terminal region (OAAB02831) in Jurkat cells using Western Blot

Sample Type: Jurkat


AXIN2 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP32099 Bovine AXIN2 antibody; Bos taurus AXIN2 antibody G3X7P3 100.0%
ARP32098 Bovine AXIN2 antibody; Bos taurus AXIN2 antibody G3X7P3 93.0%
ARP32098 Cat AXIN2 antibody; Felis catus AXIN2 antibody M3XAL0 100.0%
ARP32099 Cat AXIN2 antibody; Felis catus AXIN2 antibody M3XAL0 100.0%
ARP32098 Chicken AXIN2 antibody; Gallus gallus AXIN2 antibody Q6TLV9 93.0%
ARP32098 Chicken AXIN2 antibody; Gallus gallus AXIN2 antibody F1P136 93.0%
ARP32099 Chicken AXIN2 antibody; Gallus gallus AXIN2 antibody Q6TLV9 79.0%
ARP32099 Chicken AXIN2 antibody; Gallus gallus AXIN2 antibody F1P136 79.0%
ARP32098 Chimpanzee AXIN2 antibody; Pan troglodytes AXIN2 antibody H2QDP9 100.0%
ARP32099 Chimpanzee AXIN2 antibody; Pan troglodytes AXIN2 antibody H2QDP9 100.0%
ARP32098 Chimpanzee AXIN2 antibody; Pan troglodytes AXIN2 antibody K7CHS6 100.0%
ARP32099 Chimpanzee AXIN2 antibody; Pan troglodytes AXIN2 antibody K7CHS6 100.0%
ARP32098 Chinese softshell turtle AXIN2 antibody; Pelodiscus sinensis AXIN2 antibody K7G9P5 100.0%
ARP32099 Chinese softshell turtle AXIN2 antibody; Pelodiscus sinensis AXIN2 antibody K7G9P5 79.0%
ARP32098 Collared flycatcher AXIN2 antibody; Ficedula albicollis AXIN2 antibody U3JIC1 100.0%
ARP32098 Dog AXIN2 antibody; Canis familiaris AXIN2 antibody E2R9F8 100.0%
ARP32099 Dog AXIN2 antibody; Canis familiaris AXIN2 antibody E2R9F8 93.0%
ARP32098 Domestic duck AXIN2 antibody; Anas platyrhynchos AXIN2 antibody U3IUE4 100.0%
ARP32099 Domestic duck AXIN2 antibody; Anas platyrhynchos AXIN2 antibody U3IUE4 79.0%
ARP32098 Duckbill platypus AXIN2 antibody; Ornithorhynchus anatinus AXIN2 antibody F7CUP5 100.0%
ARP32099 Duckbill platypus AXIN2 antibody; Ornithorhynchus anatinus AXIN2 antibody F7CUP5 86.0%
ARP32098 European domestic ferret AXIN2 antibody; Mustela putorius furo AXIN2 antibody M3YT87 100.0%
ARP32099 European domestic ferret AXIN2 antibody; Mustela putorius furo AXIN2 antibody M3YT87 86.0%
ARP32098 Gray short-tailed opossum AXIN2 antibody; Monodelphis domestica AXIN2 antibody D7PLZ2 100.0%
ARP32098 Gray short-tailed opossum AXIN2 antibody; Monodelphis domestica AXIN2 antibody F6TVK6 100.0%
ARP32098 Green anole AXIN2 antibody; Anolis carolinensis AXIN2 antibody H9G5B4 100.0%
ARP32099 Green anole AXIN2 antibody; Anolis carolinensis AXIN2 antibody H9G5B4 86.0%
ARP32099 Horse AXIN2 antibody; Equus caballus AXIN2 antibody F6SK96 93.0%
ARP32098 Human AXIN2 antibody; Homo sapiens AXIN2 antibody B7ZKL5 100.0%
ARP32098 Human AXIN2 antibody; Homo sapiens AXIN2 antibody Q9Y2T1 100.0%
ARP32099 Human AXIN2 antibody; Homo sapiens AXIN2 antibody Q9Y2T1 100.0%
ARP32098 Human AXIN2 antibody; Homo sapiens AXIN2 antibody E7ES00 100.0%
ARP32098 Human AXIN2 antibody; Homo sapiens AXIN2 antibody F5GX43 100.0%
ARP32098 Human AXIN2 antibody; Homo sapiens AXIN2 antibody J3QQJ3 100.0%
ARP32098 Human AXIN2 antibody; Homo sapiens AXIN2 antibody J3QRK4 100.0%
ARP32098 Mouse AXIN2 antibody; Mus musculus AXIN2 antibody A2ABR0 100.0%
ARP32098 Mouse AXIN2 antibody; Mus musculus AXIN2 antibody O88566 100.0%
ARP32098 Mouse AXIN2 antibody; Mus musculus AXIN2 antibody Q3UQK5 100.0%
ARP32099 Mouse AXIN2 antibody; Mus musculus AXIN2 antibody Q3UQK5 79.0%
ARP32099 Mouse AXIN2 antibody; Mus musculus AXIN2 antibody O88566 79.0%
ARP32098 Pig AXIN2 antibody; Sus scrofa AXIN2 antibody F1RV18 93.0%
ARP32098 Rabbit AXIN2 antibody; Oryctolagus cuniculus AXIN2 antibody G1T2M6 100.0%
ARP32099 Rabbit AXIN2 antibody; Oryctolagus cuniculus AXIN2 antibody G1T2M6 100.0%
ARP32098 Rat AXIN2 antibody; Rattus norvegicus AXIN2 antibody O70240 100.0%
ARP32099 Rhesus macaque AXIN2 antibody; Macaca mulatta AXIN2 antibody H9F796 100.0%
ARP32099 Rhesus macaque AXIN2 antibody; Macaca mulatta AXIN2 antibody H9ZE47 100.0%
ARP32098 Rhesus macaque AXIN2 antibody; Macaca mulatta AXIN2 antibody H9FJA9 93.0%
ARP32098 Rhesus macaque AXIN2 antibody; Macaca mulatta AXIN2 antibody H9ZE47 93.0%
ARP32098 Small-eared galago AXIN2 antibody; Otolemur garnettii AXIN2 antibody H0WYQ7 100.0%
ARP32099 Small-eared galago AXIN2 antibody; Otolemur garnettii AXIN2 antibody H0WYQ7 100.0%
ARP32098 Sumatran orangutan AXIN2 antibody; Pongo abelii AXIN2 antibody H2NUH3 100.0%
ARP32099 Sumatran orangutan AXIN2 antibody; Pongo abelii AXIN2 antibody H2NUH3 100.0%
ARP32098 Tasmanian devil AXIN2 antibody; Sarcophilus harrisii AXIN2 antibody G3VT89 100.0%
ARP32098 Tasmanian devil AXIN2 antibody; Sarcophilus harrisii AXIN2 antibody G3VT90 100.0%
ARP32099 Tasmanian devil AXIN2 antibody; Sarcophilus harrisii AXIN2 antibody G3VT89 79.0%
ARP32099 Tasmanian devil AXIN2 antibody; Sarcophilus harrisii AXIN2 antibody G3VT90 79.0%
ARP32098 Thirteen-lined ground squirrel AXIN2 antibody; Spermophilus tridecemlineatus AXIN2 antibody I3N719 100.0%
ARP32099 Thirteen-lined ground squirrel AXIN2 antibody; Spermophilus tridecemlineatus AXIN2 antibody I3N719 100.0%
ARP32098 Western clawed frog AXIN2 antibody; Xenopus tropicalis AXIN2 antibody F6UXQ9 92.0%
ARP32098 White-tufted-ear marmoset AXIN2 antibody; Callithrix jacchus AXIN2 antibody U3CHU2 100.0%
ARP32099 White-tufted-ear marmoset AXIN2 antibody; Callithrix jacchus AXIN2 antibody U3CHU2 100.0%
ARP32098 White-tufted-ear marmoset AXIN2 antibody; Callithrix jacchus AXIN2 antibody H9KXB6 100.0%
ARP32099 White-tufted-ear marmoset AXIN2 antibody; Callithrix jacchus AXIN2 antibody H9KXB6 100.0%
ARP32098 White-tufted-ear marmoset AXIN2 antibody; Callithrix jacchus AXIN2 antibody H9KXB8 100.0%
ARP32099 White-tufted-ear marmoset AXIN2 antibody; Callithrix jacchus AXIN2 antibody H9KXB8 100.0%
ARP32098 White-tufted-ear marmoset AXIN2 antibody; Callithrix jacchus AXIN2 antibody H9KY85 100.0%
ARP32098 Zebra finch AXIN2 antibody; Taeniopygia guttata AXIN2 antibody H0Z192 93.0%
ARP32098 zebra mbuna AXIN2 antibody; Maylandia zebra AXIN2 antibody R9WTP2 86.0%
ARP32098 Zebrafish AXIN2 antibody; Danio rerio AXIN2 antibody Q502Q2 93.0%
ARP32098 Zebrafish AXIN2 antibody; Danio rerio AXIN2 antibody B3DKI7 93.0%
ARP32098 Zebrafish AXIN2 antibody; Danio rerio AXIN2 antibody Q7ZW51 93.0%
ARP32098 Zebrafish AXIN2 antibody; Danio rerio AXIN2 antibody F1QKQ5 93.0%
ARP32098 Zebrafish AXIN2 antibody; Danio rerio AXIN2 antibody P57095 93.0%

Tissue & Cell Line Gene Expression Data