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Gene ID: 51062 | ATL1 Antibody Resource


ATL1 Antibody Resource
Gene Full Name: 
atlastin GTPase 1
Uniprot: 
Q8WXF7
Protein Name: 
atlastin-1
Nucleotide: 
NM_001127713
Alias: 
FSP1;GBP3;SPG3;HSN1D;SPG3A;AD-FSP;atlastin1;
Ensembl: 
ENSG00000198513
Location: 
14q22.1
HPRD: 
05918
NCBI Gene: 
51062
MIM: 
606439

Summary: 
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function: 
GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development.
Subcellular location: 
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection › axon .
PTM: 
Phosphoprotein;
Disease: 
Spastic paraplegia 3, autosomal dominant (SPG3) [MIM:182600]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note: The disease is caused by mutations affecting the gene represented in this entry. Hereditary sensory neuropathy 1D (HSN1D) [MIM:613708]: A disease characterized by adult-onset distal axonal sensory neuropathy leading to mutilating ulcerations as well as hyporeflexia. Some patients may show features suggesting upper neuron involvement. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB12214 ATL1 antibody - C - terminal region (OAAB12214) Human WB 400ul $289 Details

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Product Images
ATL1 antibody - C - terminal region (OAAB12214) in NCI-H292 cells using Western Blot

Sample Type: NCI-H292


ATL1 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP64901 African elephant ATL1 antibody; Loxodonta africana ATL1 antibody G3TC17 100.0%
ARP64901 African elephant ATL1 antibody; Loxodonta africana ATL1 antibody G3TXP2 100.0%
ARP64900 African elephant ATL1 antibody; Loxodonta africana ATL1 antibody G3TC17 92.0%
ARP64900 African elephant ATL1 antibody; Loxodonta africana ATL1 antibody G3TXP2 92.0%
ARP64900 Bovine ATL1 antibody; Bos taurus ATL1 antibody Q58D72 100.0%
ARP64901 Bovine ATL1 antibody; Bos taurus ATL1 antibody Q58D72 100.0%
ARP64900 Cat ATL1 antibody; Felis catus ATL1 antibody M3WXA3 100.0%
ARP64901 Cat ATL1 antibody; Felis catus ATL1 antibody M3WXA3 100.0%
ARP64901 Chicken ATL1 antibody; Gallus gallus ATL1 antibody F1NAM6 100.0%
ARP64901 Chimpanzee ATL1 antibody; Pan troglodytes ATL1 antibody H2QZF3 100.0%
ARP64901 Chimpanzee ATL1 antibody; Pan troglodytes ATL1 antibody H2R0R0 100.0%
ARP64901 Chimpanzee ATL1 antibody; Pan troglodytes ATL1 antibody H2R3T9 100.0%
ARP64900 Chimpanzee ATL1 antibody; Pan troglodytes ATL1 antibody H2QZF3 93.0%
ARP64900 Chimpanzee ATL1 antibody; Pan troglodytes ATL1 antibody H2R0R0 93.0%
ARP64900 Chimpanzee ATL1 antibody; Pan troglodytes ATL1 antibody H2R3T9 93.0%
ARP64901 Chinese softshell turtle ATL1 antibody; Pelodiscus sinensis ATL1 antibody K7FBX0 100.0%
ARP64901 Collared flycatcher ATL1 antibody; Ficedula albicollis ATL1 antibody U3JGM6 100.0%
ARP64900 Crab-eating macaque ATL1 antibody; Macaca fascicularis ATL1 antibody Q60HD2 100.0%
ARP64901 Crab-eating macaque ATL1 antibody; Macaca fascicularis ATL1 antibody Q60HD2 100.0%
ARP64900 Dog ATL1 antibody; Canis familiaris ATL1 antibody F1Q4H4 100.0%
ARP64901 Dog ATL1 antibody; Canis familiaris ATL1 antibody F1Q4H4 100.0%
ARP64900 Dog ATL1 antibody; Canis familiaris ATL1 antibody F6X7C0 100.0%
ARP64901 Dog ATL1 antibody; Canis familiaris ATL1 antibody F6X7C0 100.0%
ARP64901 Domestic duck ATL1 antibody; Anas platyrhynchos ATL1 antibody U3I6I6 100.0%
ARP64901 Duckbill platypus ATL1 antibody; Ornithorhynchus anatinus ATL1 antibody F6VNS3 100.0%
ARP64900 Duckbill platypus ATL1 antibody; Ornithorhynchus anatinus ATL1 antibody F6VNS3 92.0%
ARP64900 European domestic ferret ATL1 antibody; Mustela putorius furo ATL1 antibody M3Y168 100.0%
ARP64901 European domestic ferret ATL1 antibody; Mustela putorius furo ATL1 antibody M3Y168 100.0%
ARP64900 Giant panda ATL1 antibody; Ailuropoda melanoleuca ATL1 antibody G1LTT3 100.0%
ARP64901 Giant panda ATL1 antibody; Ailuropoda melanoleuca ATL1 antibody G1LTT3 100.0%
ARP64900 Giant panda ATL1 antibody; Ailuropoda melanoleuca ATL1 antibody G1LTT9 100.0%
ARP64901 Giant panda ATL1 antibody; Ailuropoda melanoleuca ATL1 antibody G1LTT9 100.0%
ARP64901 Gray short-tailed opossum ATL1 antibody; Monodelphis domestica ATL1 antibody F7EX94 100.0%
ARP64900 Horse ATL1 antibody; Equus caballus ATL1 antibody F6RNF6 100.0%
ARP64901 Horse ATL1 antibody; Equus caballus ATL1 antibody F6RNF6 100.0%
ARP64901 Human ATL1 antibody; Homo sapiens ATL1 antibody G3V334 100.0%
ARP64900 Human ATL1 antibody; Homo sapiens ATL1 antibody F8WD04 100.0%
ARP33293 Human ATL1 antibody; Homo sapiens ATL1 antibody L8B8F6 100.0%
ARP64901 Human ATL1 antibody; Homo sapiens ATL1 antibody F8WD04 100.0%
ARP64900 Human ATL1 antibody; Homo sapiens ATL1 antibody Q8WXF7-2 100.0%
ARP33294 Human ATL1 antibody; Homo sapiens ATL1 antibody L8B8F6 100.0%
ARP64901 Human ATL1 antibody; Homo sapiens ATL1 antibody Q8WXF7-2 100.0%
ARP39569 Human ATL1 antibody; Homo sapiens ATL1 antibody L8B8F6 100.0%
ARP64900 Human ATL1 antibody; Homo sapiens ATL1 antibody Q8WXF7 100.0%
ARP39819 Human ATL1 antibody; Homo sapiens ATL1 antibody L8B8F6 100.0%
ARP64901 Human ATL1 antibody; Homo sapiens ATL1 antibody Q8WXF7 100.0%
ARP39820 Human ATL1 antibody; Homo sapiens ATL1 antibody L8B8F6 100.0%
ARP30893 Human ATL1 antibody; Homo sapiens ATL1 antibody L8B8F6 92.0%
ARP33041 Human ATL1 antibody; Homo sapiens ATL1 antibody L8B8F6 86.0%
ARP33040 Human ATL1 antibody; Homo sapiens ATL1 antibody L8B8F6 83.0%
ARP64901 Mouse ATL1 antibody; Mus musculus ATL1 antibody Q8BH66 100.0%
ARP64900 Northern white-cheeked gibbon ATL1 antibody; Nomascus leucogenys ATL1 antibody G1RNM0 100.0%
ARP64901 Northern white-cheeked gibbon ATL1 antibody; Nomascus leucogenys ATL1 antibody G1RNM0 100.0%
ARP64900 Pig ATL1 antibody; Sus scrofa ATL1 antibody F1SHX5 100.0%
ARP64901 Pig ATL1 antibody; Sus scrofa ATL1 antibody F1SHX5 100.0%
ARP64901 Rabbit ATL1 antibody; Oryctolagus cuniculus ATL1 antibody G1TE90 100.0%
ARP64900 Rabbit ATL1 antibody; Oryctolagus cuniculus ATL1 antibody G1TE90 92.0%
ARP64901 Rat ATL1 antibody; Rattus norvegicus ATL1 antibody Q6PST4 100.0%
ARP64900 Rat ATL1 antibody; Rattus norvegicus ATL1 antibody Q6PST4 85.0%
ARP64901 Rhesus macaque ATL1 antibody; Macaca mulatta ATL1 antibody F6X4P5 100.0%
ARP64900 Rhesus macaque ATL1 antibody; Macaca mulatta ATL1 antibody F6X4Q4 100.0%
ARP64901 Rhesus macaque ATL1 antibody; Macaca mulatta ATL1 antibody F6X4Q4 100.0%
ARP64900 Rhesus macaque ATL1 antibody; Macaca mulatta ATL1 antibody H9FV60 100.0%
ARP64901 Rhesus macaque ATL1 antibody; Macaca mulatta ATL1 antibody H9FV60 100.0%
ARP64900 Rhesus macaque ATL1 antibody; Macaca mulatta ATL1 antibody H9FV61 100.0%
ARP64901 Rhesus macaque ATL1 antibody; Macaca mulatta ATL1 antibody H9FV61 100.0%
ARP64901 Small-eared galago ATL1 antibody; Otolemur garnettii ATL1 antibody H0XAY0 100.0%
ARP64900 Small-eared galago ATL1 antibody; Otolemur garnettii ATL1 antibody H0XAY0 93.0%
ARP64901 Spotted green pufferfish ATL1 antibody; Tetraodon nigroviridis ATL1 antibody H3DPT7 100.0%
ARP64900 Sumatran orangutan ATL1 antibody; Pongo abelii ATL1 antibody Q5R4P1 100.0%
ARP64901 Sumatran orangutan ATL1 antibody; Pongo abelii ATL1 antibody Q5R4P1 100.0%
ARP64901 Tasmanian devil ATL1 antibody; Sarcophilus harrisii ATL1 antibody G3VML7 100.0%
ARP64900 Thirteen-lined ground squirrel ATL1 antibody; Spermophilus tridecemlineatus ATL1 antibody I3MI80 100.0%
ARP64901 Western clawed frog ATL1 antibody; Xenopus tropicalis ATL1 antibody Q0VFK0 100.0%
ARP64901 Western clawed frog ATL1 antibody; Xenopus tropicalis ATL1 antibody F7DVU9 100.0%
ARP64901 Western clawed frog ATL1 antibody; Xenopus tropicalis ATL1 antibody F7DVW8 100.0%
ARP64900 White-tufted-ear marmoset ATL1 antibody; Callithrix jacchus ATL1 antibody F7E6J5 100.0%
ARP64901 White-tufted-ear marmoset ATL1 antibody; Callithrix jacchus ATL1 antibody F7E6J5 100.0%
ARP64900 White-tufted-ear marmoset ATL1 antibody; Callithrix jacchus ATL1 antibody F7EJ48 100.0%
ARP64901 White-tufted-ear marmoset ATL1 antibody; Callithrix jacchus ATL1 antibody F7EJ48 100.0%
ARP64901 Zebra finch ATL1 antibody; Taeniopygia guttata ATL1 antibody H0ZSG3 100.0%
ARP64901 Zebrafish ATL1 antibody; Danio rerio ATL1 antibody B8A6H1 100.0%
ARP64901 Zebrafish ATL1 antibody; Danio rerio ATL1 antibody E9QGX9 100.0%
ARP64901 Zebrafish ATL1 antibody; Danio rerio ATL1 antibody F1R155 100.0%

Tissue & Cell Line Gene Expression Data