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Gene ID: 84971 | ATG4D Antibody Resource


ATG4D Antibody Resource
Gene Full Name: 
autophagy related 4D, cysteine peptidase
Uniprot: 
Q86TL0
Protein Name: 
cysteine protease ATG4D
Nucleotide: 
NM_001281504
Alias: 
APG4D;AUTL4;APG4-D;
Ensembl: 
ENSG00000130734
Location: 
19p13.2
HPRD: 
07005
NCBI Gene: 
84971
MIM: 
611340

Summary: 
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Function: 
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
Subcellular location: 
Cysteine protease ATG4D: Cytoplasm. Cysteine protease ATG4D, mitochondrial: Cytoplasm. Mitochondrion matrix. Note: Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death.
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP58865_P050 ATG4D antibody - middle region (ARP58865_P050) Polyclonal Bovine, Dog, Guinea pig, Human, Pig, Rabbit WB 50ug $289 Details
Polyclonal Antibody OAEB00476 ATG4D Antibody (OAEB00476) Dog, Guinea pig, Horse, Human, Mouse, Pig, Rat ELISA 0.1mg $229 Details
Polyclonal Antibody OAAB01780 ATG4D Antibody (OAAB01780) Human DB, ELISA 400ul $289 Details
Polyclonal Antibody OAAB01781 ATG4D Antibody (OAAB01781) Human DB, ELISA 400ul $289 Details
Polyclonal Antibody OAAB01782 ATG4D Antibody (OAAB01782) Human DB, ELISA 400ul $289 Details
Polyclonal Antibody ARP58864_P050 ATG4D Antibody (ARP58864_P050) Polyclonal Bovine, Dog, Guinea pig, Human, Mouse, Pig, Rat Not tested 50 ug $125 Details
Monoclonal Antibody OAAB06789 ATG4D antibody (Ascites) (OAAB06789) Human WB 0.1 ml $289 Details
Monoclonal Antibody OAAB06790 ATG4D antibody (OAAB06790) Human WB, IF 400ul $289 Details
Polyclonal Antibody OAAB07692 ATG4D antibody - N - terminal region (OAAB07692) Mouse WB, IHC 400ul $289 Details
Polyclonal Antibody OAAB12466 APG4D antibody (center region S341) (OAAB12466) Human WB 400ul $289 Details
Polyclonal Antibody OAAB13591 ATG4D antibody - N - terminal region (OAAB13591) Human; Mouse WB, IHC 400ul $289 Details
Polyclonal Antibody OAAB13592 ATG4D antibody - center region (OAAB13592) Human; Mouse WB, IHC 400ul $289 Details
Polyclonal Antibody OAAB13593 ATG4D antibody - C - terminal region (OAAB13593) Human IF, WB, IHC 400ul $289 Details
Polyclonal Antibody OAAB13594 ATG4D antibody - C - terminal region (OAAB13594) Human WB, IHC 400ul $289 Details
Polyclonal Antibody OAAB13595 ATG4D antibody - center region (OAAB13595) Human WB 400ul $289 Details
Polyclonal Antibody OAAB13596 ATG4D antibody (OAAB13596) Human WB, IHC, FC 400ul $289 Details
Polyclonal Antibody OAEC02512 ATG4D Antibody (OAEC02512) Human WB, ELISA 100ug $229 Details
Polyclonal Antibody OAAF03547 ATG4D Antibody (OAAF03547) Polyclonal Human WB, ELISA 100 ug $229 Details

Show all ATG4D antibodies


Product Images
ATG4D antibody - middle region (ARP58865_P050) in 143B cells using Western Blot

Sample Type: 143B

ATG4D antibody - middle region (ARP58865_P050) in Human HCT15 cells using Western Blot

Sample Type: Human HCT15

ATG4D antibody (Ascites) (OAAB06789) in HL-60 cells using Western Blot

Sample Type: HL-60

ATG4D antibody (OAAB06790) in Hela cells using Immunofluorescence

Sample Type: Hela

ATG4D antibody (OAAB06790) in HL-60 cells using Western Blot

Sample Type: HL-60

ATG4D antibody - N - terminal region (OAAB07692) in Human skeletal muscle cells using Immunohistochemistry

Sample Type: Human skeletal muscle

ATG4D antibody - N - terminal region (OAAB07692) in Mouse liver cells using Western Blot

Sample Type: Mouse liver

APG4D antibody (center region (OAAB12466) in WiDr cells using Western Blot

Sample Type: WiDr

ATG4D antibody - center region (OAAB13592) in 293 cells using Western Blot

Sample Type: 293

ATG4D antibody - center region (OAAB13592) in HL-60 cells using Western Blot

Sample Type: HL-60

ATG4D antibody - center region (OAAB13592) in Human cancer, breast carcinoma, hepatocarcinoma cells using Immunohistochemistry

Sample Type: Human cancer, breast carcinoma, hepatocarcinoma

ATG4D antibody - center region (OAAB13592) in Mouse Kidney cells using Western Blot

Sample Type: Mouse Kidney

ATG4D Antibody (OAAF03547) in K562 cells using Western Blot

Sample Type: K562

ATG4D Antibody (OAEC02512) in K562 cells using Western Blot

Sample Type: K562


ATG4D Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP58865 Bovine ATG4D antibody; Bos taurus ATG4D antibody A5PK87 100.0%
ARP58865 Bovine ATG4D antibody; Bos taurus ATG4D antibody F1N5L1 100.0%
ARP58864 Bovine ATG4D antibody; Bos taurus ATG4D antibody A5PK87 86.0%
ARP58864 Bovine ATG4D antibody; Bos taurus ATG4D antibody A6QQI5 86.0%
ARP58864 Bovine ATG4D antibody; Bos taurus ATG4D antibody F1N5L1 86.0%
ARP58865 Cat ATG4D antibody; Felis catus ATG4D antibody M3W311 93.0%
ARP58865 Chimpanzee ATG4D antibody; Pan troglodytes ATG4D antibody H2QFC0 100.0%
ARP58864 Chimpanzee ATG4D antibody; Pan troglodytes ATG4D antibody K7C081 100.0%
ARP58865 Chimpanzee ATG4D antibody; Pan troglodytes ATG4D antibody K7C081 100.0%
ARP58865 Dog ATG4D antibody; Canis familiaris ATG4D antibody E2RDP2 93.0%
ARP58864 Dog ATG4D antibody; Canis familiaris ATG4D antibody E2RDP2 79.0%
ARP58865 European domestic ferret ATG4D antibody; Mustela putorius furo ATG4D antibody M3Y597 93.0%
ARP58864 European domestic ferret ATG4D antibody; Mustela putorius furo ATG4D antibody M3Y597 79.0%
ARP58865 Giant panda ATG4D antibody; Ailuropoda melanoleuca ATG4D antibody G1LY72 93.0%
ARP58864 Giant panda ATG4D antibody; Ailuropoda melanoleuca ATG4D antibody G1LY72 79.0%
ARP58865 Human ATG4D antibody; Homo sapiens ATG4D antibody K7ERK1 100.0%
ARP58865 Human ATG4D antibody; Homo sapiens ATG4D antibody K7ESM7 100.0%
ARP58864 Human ATG4D antibody; Homo sapiens ATG4D antibody Q86TL0 100.0%
ARP58865 Human ATG4D antibody; Homo sapiens ATG4D antibody Q86TL0 100.0%
ARP58864 Human ATG4D antibody; Homo sapiens ATG4D antibody K7EKP6 100.0%
ARP58865 Human ATG4D antibody; Homo sapiens ATG4D antibody K7EP43 100.0%
ARP58864 Human ATG4D antibody; Homo sapiens ATG4D antibody K7EPJ0 100.0%
ARP58864 Human ATG4D antibody; Homo sapiens ATG4D antibody K7EQN3 100.0%
ARP58864 Human ATG4D antibody; Homo sapiens ATG4D antibody K7ERK1 100.0%
ARP58865 Pig ATG4D antibody; Sus scrofa ATG4D antibody F1S3M2 100.0%
ARP58865 Pig ATG4D antibody; Sus scrofa ATG4D antibody Q684M2 100.0%
ARP58864 Pig ATG4D antibody; Sus scrofa ATG4D antibody F1S3M2 86.0%
ARP58864 Pig ATG4D antibody; Sus scrofa ATG4D antibody Q684M2 86.0%
ARP58865 Rabbit ATG4D antibody; Oryctolagus cuniculus ATG4D antibody G1T6V0 100.0%
ARP58865 Rhesus macaque ATG4D antibody; Macaca mulatta ATG4D antibody F7HIJ4 100.0%
ARP58865 Rhesus macaque ATG4D antibody; Macaca mulatta ATG4D antibody H9F680 100.0%
ARP58864 Rhesus macaque ATG4D antibody; Macaca mulatta ATG4D antibody F6X2V4 93.0%
ARP58864 Rhesus macaque ATG4D antibody; Macaca mulatta ATG4D antibody F7HIJ4 93.0%
ARP58864 Rhesus macaque ATG4D antibody; Macaca mulatta ATG4D antibody H9F680 93.0%
ARP58864 Small-eared galago ATG4D antibody; Otolemur garnettii ATG4D antibody H0X7A0 79.0%
ARP58865 Small-eared galago ATG4D antibody; Otolemur garnettii ATG4D antibody H0X7A0 79.0%
ARP58864 Tasmanian devil ATG4D antibody; Sarcophilus harrisii ATG4D antibody G3VT36 87.0%
ARP58865 Thirteen-lined ground squirrel ATG4D antibody; Spermophilus tridecemlineatus ATG4D antibody I3MW53 93.0%
ARP58864 Thirteen-lined ground squirrel ATG4D antibody; Spermophilus tridecemlineatus ATG4D antibody I3MW53 86.0%
ARP58864 White-tufted-ear marmoset ATG4D antibody; Callithrix jacchus ATG4D antibody F7D851 100.0%
ARP58865 White-tufted-ear marmoset ATG4D antibody; Callithrix jacchus ATG4D antibody F7D851 100.0%
ARP58864 White-tufted-ear marmoset ATG4D antibody; Callithrix jacchus ATG4D antibody F7D8C5 100.0%
ARP58865 White-tufted-ear marmoset ATG4D antibody; Callithrix jacchus ATG4D antibody F7D8C5 100.0%
ARP58864 White-tufted-ear marmoset ATG4D antibody; Callithrix jacchus ATG4D antibody U3FET9 100.0%
ARP58865 White-tufted-ear marmoset ATG4D antibody; Callithrix jacchus ATG4D antibody U3FET9 100.0%

Tissue & Cell Line Gene Expression Data