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Gene ID: 54829 | ASPN Antibody Resource


ASPN Antibody Resource
Gene Full Name: 
asporin
Uniprot: 
Q9BXN1
Protein Name: 
asporin
Nucleotide: 
NM_001193335
Alias: 
OS3;PLAP1;PLAP-1;SLRR1C;
Ensembl: 
ENSG00000106819
Location: 
9q22
HPRD: 
16288
NCBI Gene: 
54829
MIM: 
608135

Summary: 
This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Function: 
Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins . Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
Subcellular location: 
Secreted › extracellular space › extracellular matrix .
PTM: 
Disulfide bond;
Disease: 
Osteoarthritis 3 (OS3) [MIM:607850]: A degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to osteoarthritis is conferred by a triplet repeat expansion polymorphism. ASPN allele having 14 aspartic acid repeats in the N-terminal region of the protein (D14), is overrepresented relative to the common allele having 13 aspartic acid repeats (D13). The frequency of the D14 allele increases with disease severity. The D14 allele is also overrepresented in individuals with hip osteoarthritis. Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to intervertebral disk disease, particularly lumbar disk degeneration, is conferred by a triplet repeat expansion polymorphism. ASPN allele having 14 aspartic acid repeats in the N-terminal region of the protein (D14), is associated with the disorder in some populations ().
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP42487_T100 ASPN antibody - middle region (ARP42487_T100) Polyclonal Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat IHC, WB 100ug $229 Details
Polyclonal Antibody OAEB02330 Goat Anti-Asporin / ASPN Antibody (OAEB02330) Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat WB, IF 0.1mg $289 Details
Polyclonal Antibody OAAB03627 ASPN antibody - center region (OAAB03627) Human WB, IHC, ELISA 400ul $289 Details

Show all ASPN antibodies


Product Images
ASPN antibody - middle region (ARP42487_T100) in HepG2 cells using Western Blot

Sample Type: HepG2

ASPN antibody - middle region (ARP42487_T100) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2

ASPN antibody - middle region (ARP42487_T100) in Human Muscle cells using Immunohistochemistry

Sample Type: Human Muscle

ASPN antibody - center region (OAAB03627) in HL60 cells using Western Blot

Sample Type: HL60

ASPN antibody - center region (OAAB03627) in human hepatocarcinoma cells using Immunohistochemistry

Sample Type: human hepatocarcinoma

Goat Anti-Asporin / ASPN Antibody (OAEB02330) in ATDC5 cells using Immunofluorescence

Sample Type: ATDC5


ASPN Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP42487 African clawed frog ASPN antibody; Xenopus laevis ASPN antibody Q5XHD6 79.0%
ARP42487 Bovine ASPN antibody; Bos taurus ASPN antibody Q3ZBN5 93.0%
ARP42487 Cat ASPN antibody; Felis catus ASPN antibody M3WWN6 93.0%
ARP42487 Chicken ASPN antibody; Gallus gallus ASPN antibody E1BT96 86.0%
ARP42487 Chimpanzee ASPN antibody; Pan troglodytes ASPN antibody H2QXG6 100.0%
ARP42487 Chimpanzee ASPN antibody; Pan troglodytes ASPN antibody K7BV89 100.0%
ARP42487 Chinese softshell turtle ASPN antibody; Pelodiscus sinensis ASPN antibody K7G7E1 86.0%
ARP42487 Collared flycatcher ASPN antibody; Ficedula albicollis ASPN antibody U3K345 79.0%
ARP42487 Dog ASPN antibody; Canis familiaris ASPN antibody E2RBW8 86.0%
ARP42487 Domestic duck ASPN antibody; Anas platyrhynchos ASPN antibody U3IBY3 86.0%
ARP42487 Duckbill platypus ASPN antibody; Ornithorhynchus anatinus ASPN antibody F7CWY5 86.0%
ARP56332 Duckbill platypus ASPN antibody; Ornithorhynchus anatinus ASPN antibody F7CWY5 83.0%
ARP42487 European domestic ferret ASPN antibody; Mustela putorius furo ASPN antibody M3Y037 93.0%
ARP42487 Giant panda ASPN antibody; Ailuropoda melanoleuca ASPN antibody G1M4I3 93.0%
ARP42487 Gray short-tailed opossum ASPN antibody; Monodelphis domestica ASPN antibody H9H6T2 86.0%
ARP42487 Horse ASPN antibody; Equus caballus ASPN antibody F7E284 93.0%
ARP42487 Human ASPN antibody; Homo sapiens ASPN antibody Q6P528 100.0%
ARP42487 Human ASPN antibody; Homo sapiens ASPN antibody Q9BXN1 100.0%
ARP42487 Mouse ASPN antibody; Mus musculus ASPN antibody A6H6K1 93.0%
ARP42487 Mouse ASPN antibody; Mus musculus ASPN antibody Q99MQ4 93.0%
ARP56332 Mouse ASPN antibody; Mus musculus ASPN antibody A6H6K1 83.0%
ARP56332 Mouse ASPN antibody; Mus musculus ASPN antibody Q99MQ4 83.0%
ARP42487 Northern white-cheeked gibbon ASPN antibody; Nomascus leucogenys ASPN antibody G1S364 100.0%
ARP42487 Pig ASPN antibody; Sus scrofa ASPN antibody F1SUE4 93.0%
ARP42487 Rabbit ASPN antibody; Oryctolagus cuniculus ASPN antibody G1U4P8 86.0%
ARP56332 Rabbit ASPN antibody; Oryctolagus cuniculus ASPN antibody G1U4P8 83.0%
ARP42487 Rat ASPN antibody; Rattus norvegicus ASPN antibody Q5XIH1 100.0%
ARP42487 Small-eared galago ASPN antibody; Otolemur garnettii ASPN antibody H0XCE6 93.0%
ARP42487 Sumatran orangutan ASPN antibody; Pongo abelii ASPN antibody H2PSP4 100.0%
ARP42487 Thirteen-lined ground squirrel ASPN antibody; Spermophilus tridecemlineatus ASPN antibody I3N5Y7 86.0%
ARP54695 Western clawed frog ASPN antibody; Xenopus tropicalis ASPN antibody F7AM25 82.0%
ARP42487 Western clawed frog ASPN antibody; Xenopus tropicalis ASPN antibody F7AM25 79.0%
ARP42487 White-tufted-ear marmoset ASPN antibody; Callithrix jacchus ASPN antibody F7ILC6 100.0%
ARP56613 Zebra finch ASPN antibody; Taeniopygia guttata ASPN antibody H0Z4N9 92.0%
ARP42487 Zebra finch ASPN antibody; Taeniopygia guttata ASPN antibody H0Z4N9 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas219087_at721_B_lymphoblasts6.60015.070Details
BioGPS Gene Atlas219087_atAdipocyte35.40015.070Details
BioGPS Gene Atlas219087_atAdrenalCortex7.50015.070Details
BioGPS Gene Atlas219087_atAdrenalgland5.40015.070Details
BioGPS Gene Atlas219087_atAmygdala6.05015.070Details
BioGPS Gene Atlas219087_atAppendix7.80015.070Details
BioGPS Gene Atlas219087_atAtrioventricularNode6.00015.070Details
BioGPS Gene Atlas219087_atBDCA4+_DentriticCells6.00015.070Details
BioGPS Gene Atlas219087_atBonemarrow6.35015.070Details
BioGPS Gene Atlas219087_atBronchialEpithelialCells5.70015.070Details
BioGPS Gene Atlas219087_atCD105+_Endothelial5.95015.070Details
BioGPS Gene Atlas219087_atCD14+_Monocytes6.30015.070Details
BioGPS Gene Atlas219087_atCD19+_BCells(neg._sel.)6.20015.070Details
BioGPS Gene Atlas219087_atCD33+_Myeloid7.40015.070Details
BioGPS Gene Atlas219087_atCD34+7.10015.070Details
BioGPS Gene Atlas219087_atCD4+_Tcells6.20015.070Details
BioGPS Gene Atlas219087_atCD56+_NKCells6.70015.070Details
BioGPS Gene Atlas219087_atCD71+_EarlyErythroid5.65015.070Details
BioGPS Gene Atlas219087_atCD8+_Tcells5.35015.070Details
BioGPS Gene Atlas219087_atCardiacMyocytes9.20015.070Details
BioGPS Gene Atlas219087_atCaudatenucleus5.55015.070Details
BioGPS Gene Atlas219087_atCerebellum5.10015.070Details
BioGPS Gene Atlas219087_atCerebellumPeduncles7.15015.070Details
BioGPS Gene Atlas219087_atCiliaryGanglion8.80015.070Details
BioGPS Gene Atlas219087_atCingulateCortex6.25015.070Details
BioGPS Gene Atlas219087_atColorectaladenocarcinoma6.05015.070Details
BioGPS Gene Atlas219087_atDorsalRootGanglion8.25015.070Details
BioGPS Gene Atlas219087_atFetalThyroid7.20015.070Details
BioGPS Gene Atlas219087_atFetalbrain5.95015.070Details
BioGPS Gene Atlas219087_atFetalliver35.95015.070Details
BioGPS Gene Atlas219087_atFetallung26.10015.070Details
BioGPS Gene Atlas219087_atGlobusPallidus4.60015.070Details
BioGPS Gene Atlas219087_atHeart8.90015.070Details
BioGPS Gene Atlas219087_atHypothalamus6.35015.070Details
BioGPS Gene Atlas219087_atKidney5.35015.070Details
BioGPS Gene Atlas219087_atLeukemia_chronicMyelogenousK-5625.50015.070Details
BioGPS Gene Atlas219087_atLeukemia_promyelocytic-HL-605.40015.070Details
BioGPS Gene Atlas219087_atLeukemialymphoblastic(MOLT-4)4.65015.070Details
BioGPS Gene Atlas219087_atLiver10.70015.070Details
BioGPS Gene Atlas219087_atLung6.55015.070Details
BioGPS Gene Atlas219087_atLymphnode5.25015.070Details
BioGPS Gene Atlas219087_atLymphoma_burkitts(Daudi)7.95015.070Details
BioGPS Gene Atlas219087_atLymphoma_burkitts(Raji)8.95015.070Details
BioGPS Gene Atlas219087_atMedullaOblongata5.40015.070Details
BioGPS Gene Atlas219087_atOccipitalLobe5.30015.070Details
BioGPS Gene Atlas219087_atOlfactoryBulb4.70015.070Details
BioGPS Gene Atlas219087_atOvary6.25015.070Details
BioGPS Gene Atlas219087_atPancreas5.40015.070Details
BioGPS Gene Atlas219087_atPancreaticIslet8.30015.070Details
BioGPS Gene Atlas219087_atParietalLobe6.55015.070Details
BioGPS Gene Atlas219087_atPituitary7.25015.070Details
BioGPS Gene Atlas219087_atPlacenta5.95015.070Details
BioGPS Gene Atlas219087_atPons5.85015.070Details
BioGPS Gene Atlas219087_atPrefrontalCortex7.45015.070Details
BioGPS Gene Atlas219087_atProstate7.20015.070Details
BioGPS Gene Atlas219087_atSalivarygland5.40015.070Details
BioGPS Gene Atlas219087_atSkeletalMuscle7.80015.070Details
BioGPS Gene Atlas219087_atSkin5.65015.070Details
BioGPS Gene Atlas219087_atSmoothMuscle6.80015.070Details
BioGPS Gene Atlas219087_atSpinalcord6.40015.070Details
BioGPS Gene Atlas219087_atSubthalamicNucleus5.60015.070Details
BioGPS Gene Atlas219087_atSuperiorCervicalGanglion19.05015.070Details
BioGPS Gene Atlas219087_atTemporalLobe5.60015.070Details
BioGPS Gene Atlas219087_atTestis5.10015.070Details
BioGPS Gene Atlas219087_atTestisGermCell9.05015.070Details
BioGPS Gene Atlas219087_atTestisIntersitial5.15015.070Details
BioGPS Gene Atlas219087_atTestisLeydigCell6.30015.070Details
BioGPS Gene Atlas219087_atTestisSeminiferousTubule5.20015.070Details
BioGPS Gene Atlas219087_atThalamus6.20015.070Details
BioGPS Gene Atlas219087_atThymus4.80015.070Details
BioGPS Gene Atlas219087_atThyroid25.80015.070Details
BioGPS Gene Atlas219087_atTongue7.55015.070Details
BioGPS Gene Atlas219087_atTonsil6.05015.070Details
BioGPS Gene Atlas219087_atTrachea22.85015.070Details
BioGPS Gene Atlas219087_atTrigeminalGanglion7.10015.070Details
BioGPS Gene Atlas219087_atUterus553.75015.070Details
BioGPS Gene Atlas219087_atUterusCorpus33.45015.070Details
BioGPS Gene Atlas219087_atWholeBlood6.50015.070Details
BioGPS Gene Atlas219087_atWholebrain4.95015.070Details
BioGPS Gene Atlas219087_atcolon21.05015.070Details
BioGPS Gene Atlas219087_atpineal_day7.32015.070Details
BioGPS Gene Atlas219087_atpineal_night7.50015.070Details
BioGPS Gene Atlas219087_atretina7.37515.070Details
BioGPS Gene Atlas219087_atsmall_intestine44.00015.070Details
BioGPS NCI60219087_at7866.2886.150Details
BioGPS NCI60219087_atA1725.5226.150Details
BioGPS NCI60219087_atA2045.9996.150Details
BioGPS NCI60219087_atA3616.1356.150Details
BioGPS NCI60219087_atA4986.0296.150Details
BioGPS NCI60219087_atA5496.2446.150Details
BioGPS NCI60219087_atACC36.5576.150Details
BioGPS NCI60219087_atACHN5.3766.150Details
BioGPS NCI60219087_atALVA317.0146.150Details
BioGPS NCI60219087_atCAKI16.6036.150Details
BioGPS NCI60219087_atCCRT CEM8.2036.150Details
BioGPS NCI60219087_atCOLO2056.1346.150Details
BioGPS NCI60219087_atDLD15.8776.150Details
BioGPS NCI60219087_atDU1455.6316.150Details
BioGPS NCI60219087_atEKVX5.6326.150Details
BioGPS NCI60219087_atGM1336.2466.150Details
BioGPS NCI60219087_atGM16006.4956.150Details
BioGPS NCI60219087_atGM23136.2256.150Details
BioGPS NCI60219087_atGM23456.1076.150Details
BioGPS NCI60219087_atGM24936.6806.150Details
BioGPS NCI60219087_atGM977.9916.150Details
BioGPS NCI60219087_atHCC29985.1696.150Details
BioGPS NCI60219087_atHCT1166.0516.150Details
BioGPS NCI60219087_atHCT155.5106.150Details
BioGPS NCI60219087_atHEK 293 T-rex6.5446.150Details
BioGPS NCI60219087_atHEK 293T6.0176.150Details
BioGPS NCI60219087_atHEK2936.0846.150Details
BioGPS NCI60219087_atHELA5.4646.150Details
BioGPS NCI60219087_atHEPG26.0756.150Details
BioGPS NCI60219087_atHL607.0276.150Details
BioGPS NCI60219087_atHOP626.0796.150Details
BioGPS NCI60219087_atHOP925.6716.150Details
BioGPS NCI60219087_atHS578T9.0396.150Details
BioGPS NCI60219087_atHSG5.7126.150Details
BioGPS NCI60219087_atHT10805.9156.150Details
BioGPS NCI60219087_atHT296.9166.150Details
BioGPS NCI60219087_atIGROV15.9296.150Details
BioGPS NCI60219087_atIOSE805.9686.150Details
BioGPS NCI60219087_atJURKAT6.0466.150Details
BioGPS NCI60219087_atK5627.0366.150Details
BioGPS NCI60219087_atKM126.5806.150Details
BioGPS NCI60219087_atLN185.4976.150Details
BioGPS NCI60219087_atLNCAP6.0796.150Details
BioGPS NCI60219087_atLOX IMVI6.0386.150Details
BioGPS NCI60219087_atM145.9896.150Details
BioGPS NCI60219087_atMALME 3M6.8706.150Details
BioGPS NCI60219087_atMCF75.7026.150Details
BioGPS NCI60219087_atMD MB2316.1666.150Details
BioGPS NCI60219087_atMDA MB4357.0376.150Details
BioGPS NCI60219087_atMOLT46.8366.150Details
BioGPS NCI60219087_atNCI 4606.4096.150Details
BioGPS NCI60219087_atNCI H2266.3816.150Details
BioGPS NCI60219087_atNCI H236.0336.150Details
BioGPS NCI60219087_atNCI H322M6.0446.150Details
BioGPS NCI60219087_atNCVADR RES5.4236.150Details
BioGPS NCI60219087_atOVCAR36.4886.150Details
BioGPS NCI60219087_atOVCAR46.0286.150Details
BioGPS NCI60219087_atOVCAR55.8906.150Details
BioGPS NCI60219087_atOVCAR85.4006.150Details
BioGPS NCI60219087_atPANC16.1586.150Details
BioGPS NCI60219087_atRL76.2816.150Details
BioGPS NCI60219087_atRPMI 82266.3656.150Details
BioGPS NCI60219087_atRS118466.9956.150Details
BioGPS NCI60219087_atRXF3935.9966.150Details
BioGPS NCI60219087_atSAOS26.1456.150Details
BioGPS NCI60219087_atSF2686.0286.150Details
BioGPS NCI60219087_atSF2955.7466.150Details
BioGPS NCI60219087_atSF5395.4356.150Details
BioGPS NCI60219087_atSHSYSY+RA5.7716.150Details
BioGPS NCI60219087_atSHSYSY-RA5.9116.150Details
BioGPS NCI60219087_atSKMEL26.0236.150Details
BioGPS NCI60219087_atSKMEL286.0766.150Details
BioGPS NCI60219087_atSKMEL55.6056.150Details
BioGPS NCI60219087_atSKOV36.4076.150Details
BioGPS NCI60219087_atSN12C5.9666.150Details
BioGPS NCI60219087_atSNB195.4986.150Details
BioGPS NCI60219087_atSNB756.6036.150Details
BioGPS NCI60219087_atSR6.3406.150Details
BioGPS NCI60219087_atSW6206.3006.150Details
BioGPS NCI60219087_atT246.3096.150Details
BioGPS NCI60219087_atT3M46.5576.150Details
BioGPS NCI60219087_atTK106.0216.150Details
BioGPS NCI60219087_atU1185.7856.150Details
BioGPS NCI60219087_atU1385.4956.150Details
BioGPS NCI60219087_atU20S5.8496.150Details
BioGPS NCI60219087_atU2515.8976.150Details
BioGPS NCI60219087_atU875.7256.150Details
BioGPS NCI60219087_atUACC2575.9446.150Details
BioGPS NCI60219087_atUACC626.1876.150Details
BioGPS NCI60219087_atUO315.6456.150Details
BioGPS NCI60219087_atZR75_16.5036.150Details
BioGPS NCI60219087_atastrocytes6.1036.150Details
BioGPS NCI60219087_athuh-76.3236.150Details