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Gene ID: 56624 | ASAH2 Antibody Resource


ASAH2 Antibody Resource
Gene Full Name: 
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
Uniprot: 
Q9NR71
Protein Name: 
neutral ceramidase
Nucleotide: 
NM_001143974
Alias: 
HNAC1;BCDase;LCDase;NCDase;N-CDase;
Ensembl: 
ENSG00000188611
Location: 
10q11.21
HPRD: 
NCBI Gene: 
56624
MIM: 
611202

Summary: 
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008]
Function: 
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.
Subcellular location: 
Cell membrane; Single-pass type II membrane protein. Note: The neutral ceramidase soluble form is a secreted protein. According to , it is mitochondrial. However, they used a shorter form in its N-terminus, which may explain this localization which probably does not exist in vivo.
PTM: 
Glycoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAPB00727 ASAH2 Antibody (OAPB00727) Polyclonal Human; Mouse; Rat ELISA, WB 0.1 mg $355 Details
Polyclonal Antibody ARP60810_P050 ASAH2 Antibody (ARP60810_P050) Polyclonal Not tested 50 ug $125 Details
Polyclonal Antibody ARP60811_P050 ASAH2 Antibody (ARP60811_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAB13095 ASAH2 antibody - C - terminal region (OAAB13095) Human; Mouse WB 400ul $289 Details

Show all ASAH2 antibodies


Product Images
ASAH2 antibody - C - terminal region (OAAB13095) in Mouse bladder cells using Western Blot

Sample Type: Mouse bladder

ASAH2 Antibody (OAPB00727) in 293 cells using Western Blot

Sample Type: 293


ASAH2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60810 Bovine ASAH2 antibody; Bos taurus ASAH2 antibody E1BJU5 100.0%
ARP70006 Bovine ASAH2 antibody; Bos taurus ASAH2 antibody E1BJU5 100.0%
ARP70007 Bovine ASAH2 antibody; Bos taurus ASAH2 antibody E1BJU5 100.0%
ARP70005 Bovine ASAH2 antibody; Bos taurus ASAH2 antibody E1BJU5 79.0%
ARP60810 Cat ASAH2 antibody; Felis catus ASAH2 antibody M3XC00 100.0%
ARP70006 Cat ASAH2 antibody; Felis catus ASAH2 antibody M3XC00 100.0%
ARP70007 Cat ASAH2 antibody; Felis catus ASAH2 antibody M3XC00 92.0%
ARP70005 Cat ASAH2 antibody; Felis catus ASAH2 antibody M3XC00 86.0%
ARP70008 Cat ASAH2 antibody; Felis catus ASAH2 antibody M3XC00 79.0%
ARP60810 Chicken ASAH2 antibody; Gallus gallus ASAH2 antibody F1NN67 85.0%
ARP70007 Chicken ASAH2 antibody; Gallus gallus ASAH2 antibody F1NN67 79.0%
ARP60811 Chimpanzee ASAH2 antibody; Pan troglodytes ASAH2 antibody H2Q1W7 100.0%
ARP70005 Chimpanzee ASAH2 antibody; Pan troglodytes ASAH2 antibody H2Q1W7 100.0%
ARP70006 Chimpanzee ASAH2 antibody; Pan troglodytes ASAH2 antibody H2Q1W7 100.0%
ARP70007 Chimpanzee ASAH2 antibody; Pan troglodytes ASAH2 antibody H2Q1W7 100.0%
ARP60810 Chimpanzee ASAH2 antibody; Pan troglodytes ASAH2 antibody H2Q1W7 100.0%
ARP70008 Chimpanzee ASAH2 antibody; Pan troglodytes ASAH2 antibody H2Q1W7 93.0%
ARP70006 Dog ASAH2 antibody; Canis familiaris ASAH2 antibody E2QVL9 100.0%
ARP70006 Dog ASAH2 antibody; Canis familiaris ASAH2 antibody F6XSK9 100.0%
ARP60810 Dog ASAH2 antibody; Canis familiaris ASAH2 antibody E2QVL9 93.0%
ARP70007 Dog ASAH2 antibody; Canis familiaris ASAH2 antibody E2QVL9 93.0%
ARP60810 Duckbill platypus ASAH2 antibody; Ornithorhynchus anatinus ASAH2 antibody F7G0L3 79.0%
ARP70005 Duckbill platypus ASAH2 antibody; Ornithorhynchus anatinus ASAH2 antibody F7G0L3 79.0%
ARP70007 Duckbill platypus ASAH2 antibody; Ornithorhynchus anatinus ASAH2 antibody F7G0L3 79.0%
ARP60810 European domestic ferret ASAH2 antibody; Mustela putorius furo ASAH2 antibody M3YZV8 93.0%
ARP70007 European domestic ferret ASAH2 antibody; Mustela putorius furo ASAH2 antibody M3YZV8 93.0%
ARP70005 European domestic ferret ASAH2 antibody; Mustela putorius furo ASAH2 antibody M3YZV8 86.0%
ARP70006 European domestic ferret ASAH2 antibody; Mustela putorius furo ASAH2 antibody M3YZV8 86.0%
ARP70008 European domestic ferret ASAH2 antibody; Mustela putorius furo ASAH2 antibody M3YZV8 79.0%
ARP60810 Giant panda ASAH2 antibody; Ailuropoda melanoleuca ASAH2 antibody G1L140 93.0%
ARP70007 Giant panda ASAH2 antibody; Ailuropoda melanoleuca ASAH2 antibody G1L140 93.0%
ARP60810 Giant panda ASAH2 antibody; Ailuropoda melanoleuca ASAH2 antibody G1L145 93.0%
ARP70007 Giant panda ASAH2 antibody; Ailuropoda melanoleuca ASAH2 antibody G1L145 93.0%
ARP70006 Giant panda ASAH2 antibody; Ailuropoda melanoleuca ASAH2 antibody G1L140 92.0%
ARP70005 Giant panda ASAH2 antibody; Ailuropoda melanoleuca ASAH2 antibody G1L140 86.0%
ARP70008 Giant panda ASAH2 antibody; Ailuropoda melanoleuca ASAH2 antibody G1L140 79.0%
ARP70006 Green anole ASAH2 antibody; Anolis carolinensis ASAH2 antibody H9GEG4 83.0%
ARP60810 Green anole ASAH2 antibody; Anolis carolinensis ASAH2 antibody H9GEG4 79.0%
ARP60810 Horse ASAH2 antibody; Equus caballus ASAH2 antibody F6ZD40 100.0%
ARP70006 Horse ASAH2 antibody; Equus caballus ASAH2 antibody F6ZD40 100.0%
ARP70007 Horse ASAH2 antibody; Equus caballus ASAH2 antibody F6ZD40 100.0%
ARP60810 Horse ASAH2 antibody; Equus caballus ASAH2 antibody F7BLY2 100.0%
ARP70006 Horse ASAH2 antibody; Equus caballus ASAH2 antibody F7BLY2 100.0%
ARP70007 Horse ASAH2 antibody; Equus caballus ASAH2 antibody F7BLY2 100.0%
ARP60810 Human ASAH2 antibody; Homo sapiens ASAH2 antibody E9PBM9 100.0%
ARP70005 Human ASAH2 antibody; Homo sapiens ASAH2 antibody E9PBM9 100.0%
ARP70006 Human ASAH2 antibody; Homo sapiens ASAH2 antibody E9PBM9 100.0%
ARP70007 Human ASAH2 antibody; Homo sapiens ASAH2 antibody E9PBM9 100.0%
ARP60810 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71-2 100.0%
ARP60811 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71-2 100.0%
ARP70005 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71-2 100.0%
ARP70006 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71-2 100.0%
ARP70007 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71-2 100.0%
ARP60810 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71 100.0%
ARP60811 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71 100.0%
ARP70005 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71 100.0%
ARP70006 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71 100.0%
ARP70007 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71 100.0%
ARP70008 Human ASAH2 antibody; Homo sapiens ASAH2 antibody E9PBM9 93.0%
ARP70008 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71-2 93.0%
ARP70008 Human ASAH2 antibody; Homo sapiens ASAH2 antibody Q9NR71 93.0%
ARP60810 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B7ZN55 100.0%
ARP70006 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B7ZN55 100.0%
ARP70007 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B7ZN55 100.0%
ARP60810 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B9EHG7 100.0%
ARP70006 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B9EHG7 100.0%
ARP70007 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B9EHG7 100.0%
ARP60810 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody Q9JHE3 100.0%
ARP70006 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody Q9JHE3 100.0%
ARP70007 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody Q9JHE3 100.0%
ARP70005 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B7ZN55 86.0%
ARP70005 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B9EHG7 86.0%
ARP70005 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody Q9JHE3 86.0%
ARP70008 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B7ZN55 79.0%
ARP70008 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody B9EHG7 79.0%
ARP70008 Mouse ASAH2 antibody; Mus musculus ASAH2 antibody Q9JHE3 79.0%
ARP60810 Northern white-cheeked gibbon ASAH2 antibody; Nomascus leucogenys ASAH2 antibody G1RN48 100.0%
ARP70005 Northern white-cheeked gibbon ASAH2 antibody; Nomascus leucogenys ASAH2 antibody G1RN48 100.0%
ARP70006 Northern white-cheeked gibbon ASAH2 antibody; Nomascus leucogenys ASAH2 antibody G1RN48 100.0%
ARP70007 Northern white-cheeked gibbon ASAH2 antibody; Nomascus leucogenys ASAH2 antibody G1RN48 100.0%
ARP60811 Northern white-cheeked gibbon ASAH2 antibody; Nomascus leucogenys ASAH2 antibody G1RN48 93.0%
ARP70008 Northern white-cheeked gibbon ASAH2 antibody; Nomascus leucogenys ASAH2 antibody G1RN48 93.0%
ARP70006 Pig ASAH2 antibody; Sus scrofa ASAH2 antibody F1SCZ9 100.0%
ARP60810 Rabbit ASAH2 antibody; Oryctolagus cuniculus ASAH2 antibody G1TD55 100.0%
ARP70007 Rabbit ASAH2 antibody; Oryctolagus cuniculus ASAH2 antibody G1TD55 100.0%
ARP70005 Rabbit ASAH2 antibody; Oryctolagus cuniculus ASAH2 antibody G1TD55 79.0%
ARP70006 Rabbit ASAH2 antibody; Oryctolagus cuniculus ASAH2 antibody G1TD55 79.0%
ARP70006 Rat ASAH2 antibody; Rattus norvegicus ASAH2 antibody Q91XT9 100.0%
ARP60810 Rat ASAH2 antibody; Rattus norvegicus ASAH2 antibody Q91XT9 92.0%
ARP70005 Rat ASAH2 antibody; Rattus norvegicus ASAH2 antibody Q91XT9 86.0%
ARP70007 Rat ASAH2 antibody; Rattus norvegicus ASAH2 antibody Q91XT9 86.0%
ARP70008 Rat ASAH2 antibody; Rattus norvegicus ASAH2 antibody Q91XT9 79.0%
ARP60810 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7EC16 100.0%
ARP60811 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7EC16 100.0%
ARP70006 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7EC16 100.0%
ARP70007 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7EC16 100.0%
ARP60810 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7EC19 100.0%
ARP70007 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7EC19 100.0%
ARP60810 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7ESF6 100.0%
ARP60811 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7ESF6 100.0%
ARP70006 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7ESF6 100.0%
ARP70007 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7ESF6 100.0%
ARP60811 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7EC19 92.0%
ARP70005 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7EC16 86.0%
ARP70005 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7ESF6 86.0%
ARP70008 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7EC16 79.0%
ARP70008 Rhesus macaque ASAH2 antibody; Macaca mulatta ASAH2 antibody F7ESF6 79.0%
ARP70007 Western clawed frog ASAH2 antibody; Xenopus tropicalis ASAH2 antibody B3DM04 79.0%
ARP70007 Western clawed frog ASAH2 antibody; Xenopus tropicalis ASAH2 antibody F6XXS6 79.0%
ARP60810 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7I129 100.0%
ARP70007 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7I129 100.0%
ARP60810 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7EVB3 100.0%
ARP70007 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7EVB3 100.0%
ARP60810 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7F890 100.0%
ARP70007 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7F890 100.0%
ARP70005 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7I129 93.0%
ARP70006 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7I129 93.0%
ARP70005 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7EVB3 93.0%
ARP70006 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7EVB3 93.0%
ARP70005 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7F890 93.0%
ARP70006 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7F890 93.0%
ARP60811 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7I129 92.0%
ARP60811 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7EVB3 92.0%
ARP60811 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7F890 92.0%
ARP70008 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7F890 86.0%
ARP70008 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7I129 86.0%
ARP70008 White-tufted-ear marmoset ASAH2 antibody; Callithrix jacchus ASAH2 antibody F7EVB3 86.0%

Tissue & Cell Line Gene Expression Data