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Gene ID: 170302 | ARX Antibody Resource


ARX Antibody Resource
Gene Full Name: 
aristaless related homeobox
Uniprot: 
Q96QS3
Protein Name: 
homeobox protein ARX
Nucleotide: 
NM_139058
Alias: 
ISSX;PRTS;CT121;EIEE1;MRX29;MRX32;MRX33;MRX36;MRX38;MRX43;MRX54;MRX76;MRX87;MRXS1;
Ensembl: 
ENSG00000004848
Location: 
Xp21.3
HPRD: 
02307
NCBI Gene: 
170302
MIM: 
300382

Summary: 
This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is thought to be involved in CNS development. Mutations in this gene cause X-linked mental retardation and epilepsy. [provided by RefSeq, Jul 2008]
Function: 
Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate.
Subcellular location: 
Nucleus.
PTM: 
Disease: 
Lissencephaly, X-linked 2 (LISX2) [MIM:300215]: A classic type lissencephaly associated with abnormal genitalia. Patients have severe congenital or postnatal microcephaly, lissencephaly, agenesis of the corpus callosum, neonatal-onset intractable epilepsy, poor temperature regulation, chronic diarrhea, and ambiguous or underdeveloped genitalia. Note: The disease is caused by mutations affecting the gene represented in this entry. Epileptic encephalopathy, early infantile, 1 (EIEE1) [MIM:308350]: A severe form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. Note: The disease is caused by mutations affecting the gene represented in this entry. Partington syndrome (PRTS) [MIM:309510]: Characterized by mental retardation, episodic dystonic hand movements, and dysarthria. Note: The disease is caused by mutations affecting the gene represented in this entry. Mental retardation, X-linked, ARX-related (MRXARX) [MIM:300419]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. Note: The disease is caused by mutations affecting the gene represented in this entry. Agenesis of the corpus callosum, with abnormal genitalia (ACCAG) [MIM:300004]: A X-linked syndrome with variable expression in females. It is characterized by agenesis of corpus callosum, mental retardation and seizures. Manifestations in surviving males include severe acquired micrencephaly, mental retardation, limb contractures, scoliosis, tapered fingers with hyperconvex nails, a characteristic face with large eyes, prominent supraorbital ridges, synophrys, optic atrophy, broad alveolar ridges, and seizures. Urologic anomalies include renal dysplasia, cryptorchidism, and hypospadias. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP36825_T100 ARX antibody - middle region (ARP36825_T100) Polyclonal Dog, Guinea pig, Human, Mouse, Rat WB 100ug $229 Details
Polyclonal Antibody ARP36824_T100 ARX antibody - middle region (ARP36824_T100) Polyclonal Dog, Guinea pig, Horse, Human, Mouse, Rabbit, Rat WB 100ug $229 Details
Polyclonal Antibody ARP31598_P050 ARX antibody - middle region (ARP31598_P050) Polyclonal Dog, Human, Mouse, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody OAAB01361 Arx antibody - N-terminal region (OAAB01361) Human; Mouse WB, ELISA 400ul $289 Details
Polyclonal Antibody ARP32206_P050 ARX Antibody (ARP32206_P050) Polyclonal Dog, Human, Pig, Rabbit Not tested 50 ug $50 Details
Polyclonal Antibody OAAB12139 ARX antibody - N - terminal region (OAAB12139) Human WB 400ul $289 Details
Polyclonal Antibody OAEC03260 ARX Antibody (OAEC03260) Human; Mouse; Rat WB, ELISA 100ug $229 Details
Polyclonal Antibody OAAF04528 ARX Antibody (OAAF04528) Polyclonal Human, Mouse, Rat WB, ELISA 100 ug $289 Details

Show all ARX antibodies


Product Images
ARX antibody - middle region (ARP31598_P050) in Human HeLa cells using Western Blot

Sample Type: Human HeLa

ARX antibody - middle region (ARP36824_T100) in Mouse NIH-3T3 cells using Western Blot

Sample Type: Mouse NIH-3T3

ARX antibody - middle region (ARP36825_T100) in Mouse NIH-3T3 cells using Western Blot

Sample Type: Mouse NIH-3T3

Arx antibody - N-terminal region (OAAB01361) in Arx cells using Western Blot

Sample Type: Arx

ARX antibody - N - terminal region (OAAB12139) in Arx, NCI-H292 cells using Western Blot

Sample Type: Arx, NCI-H292

ARX Antibody (OAAF04528) in 293 cells using Western Blot

Sample Type: 293

ARX Antibody (OAEC03260) in 293 cells using Western Blot

Sample Type: 293


ARX Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP31598 Synthetic construct ARX antibody B6IDD4 100.0%
ARP32206 Synthetic construct ARX antibody B6IDD4 100.0%
ARP36824 Synthetic construct ARX antibody B6IDD4 93.0%
ARP36825 Synthetic construct ARX antibody B6IDD4 93.0%
ARP41105 African clawed frog ARX antibody; Xenopus laevis ARX antibody Q699W9 79.0%
ARP32206 Cat ARX antibody; Felis catus ARX antibody M3X0C3 85.0%
ARP36825 Dog ARX antibody; Canis familiaris ARX antibody E2QVR4 100.0%
ARP36825 Dog ARX antibody; Canis familiaris ARX antibody F6XTT5 100.0%
ARP36825 Dog ARX antibody; Canis familiaris ARX antibody J9NW39 100.0%
ARP36824 Dog ARX antibody; Canis familiaris ARX antibody E2QVR4 93.0%
ARP36824 Dog ARX antibody; Canis familiaris ARX antibody F6XTT5 93.0%
ARP36824 Dog ARX antibody; Canis familiaris ARX antibody J9NW39 93.0%
ARP31598 Dog ARX antibody; Canis familiaris ARX antibody E2QVR4 92.0%
ARP31598 Dog ARX antibody; Canis familiaris ARX antibody F6XTT5 92.0%
ARP31598 Dog ARX antibody; Canis familiaris ARX antibody J9NW39 92.0%
ARP32206 Dog ARX antibody; Canis familiaris ARX antibody E2QVR4 85.0%
ARP32206 Dog ARX antibody; Canis familiaris ARX antibody F6XTT5 85.0%
ARP32206 Dog ARX antibody; Canis familiaris ARX antibody J9NW39 85.0%
ARP32206 European domestic ferret ARX antibody; Mustela putorius furo ARX antibody M3XLY8 85.0%
ARP31598 Gray short-tailed opossum ARX antibody; Monodelphis domestica ARX antibody F7EY18 100.0%
ARP36824 Gray short-tailed opossum ARX antibody; Monodelphis domestica ARX antibody F7EY18 79.0%
ARP36824 Horse ARX antibody; Equus caballus ARX antibody F6YKC8 79.0%
ARP31598 Human ARX antibody; Homo sapiens ARX antibody Q96QS3 100.0%
ARP32206 Human ARX antibody; Homo sapiens ARX antibody Q96QS3 100.0%
ARP36824 Human ARX antibody; Homo sapiens ARX antibody Q96QS3 93.0%
ARP36825 Human ARX antibody; Homo sapiens ARX antibody Q96QS3 93.0%
ARP32206 Little brown bat ARX antibody; Myotis lucifugus ARX antibody G1Q0P6 83.0%
ARP36824 Mouse ARX antibody; Mus musculus ARX antibody O35085 100.0%
ARP36825 Mouse ARX antibody; Mus musculus ARX antibody O35085 100.0%
ARP31598 Mouse ARX antibody; Mus musculus ARX antibody O35085 92.0%
ARP32206 Mouse ARX antibody; Mus musculus ARX antibody O35085 83.0%
ARP32206 Pig ARX antibody; Sus scrofa ARX antibody I3LRI8 85.0%
ARP31598 Rabbit ARX antibody; Oryctolagus cuniculus ARX antibody G1U424 100.0%
ARP36824 Rabbit ARX antibody; Oryctolagus cuniculus ARX antibody G1U424 93.0%
ARP32206 Rabbit ARX antibody; Oryctolagus cuniculus ARX antibody G1U424 85.0%
ARP36824 Rat ARX antibody; Rattus norvegicus ARX antibody A6YP92 93.0%
ARP36824 Rat ARX antibody; Rattus norvegicus ARX antibody F1LQW2 93.0%
ARP31598 Rat ARX antibody; Rattus norvegicus ARX antibody A6YP92 92.0%
ARP31598 Rat ARX antibody; Rattus norvegicus ARX antibody F1LQW2 92.0%
ARP36825 Rat ARX antibody; Rattus norvegicus ARX antibody A6YP92 86.0%
ARP36825 Rat ARX antibody; Rattus norvegicus ARX antibody F1LQW2 86.0%
ARP31598 Rhesus macaque ARX antibody; Macaca mulatta ARX antibody F7HF24 100.0%
ARP32206 Rhesus macaque ARX antibody; Macaca mulatta ARX antibody F7HF24 100.0%
ARP32206 Rhesus macaque ARX antibody; Macaca mulatta ARX antibody H9F135 100.0%
ARP36825 Rhesus macaque ARX antibody; Macaca mulatta ARX antibody F7HF24 93.0%
ARP36824 Rhesus macaque ARX antibody; Macaca mulatta ARX antibody F7HF24 86.0%
ARP36825 Small-eared galago ARX antibody; Otolemur garnettii ARX antibody H0XRJ8 100.0%
ARP31598 Small-eared galago ARX antibody; Otolemur garnettii ARX antibody H0XRJ8 92.0%
ARP32206 Small-eared galago ARX antibody; Otolemur garnettii ARX antibody H0XRJ8 85.0%
ARP36824 Small-eared galago ARX antibody; Otolemur garnettii ARX antibody H0XRJ8 79.0%
ARP32206 Sumatran orangutan ARX antibody; Pongo abelii ARX antibody H2PV60 100.0%
ARP31598 Tammar wallaby ARX antibody; Macropus eugenii ARX antibody F8QQG6 91.0%
ARP36824 Tammar wallaby ARX antibody; Macropus eugenii ARX antibody F8QQG6 79.0%
ARP36824 Thirteen-lined ground squirrel ARX antibody; Spermophilus tridecemlineatus ARX antibody I3NDF3 93.0%
ARP36825 Thirteen-lined ground squirrel ARX antibody; Spermophilus tridecemlineatus ARX antibody I3NDF3 93.0%
ARP31598 Thirteen-lined ground squirrel ARX antibody; Spermophilus tridecemlineatus ARX antibody I3NDF3 85.0%
ARP32206 Thirteen-lined ground squirrel ARX antibody; Spermophilus tridecemlineatus ARX antibody I3NDF3 85.0%

Tissue & Cell Line Gene Expression Data