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Gene ID: 84100 | ARL6 Antibody Resource


ARL6 Antibody Resource
Gene Full Name: 
ADP-ribosylation factor-like 6
Uniprot: 
Q9H0F7
Protein Name: 
ADP-ribosylation factor-like protein 6
Nucleotide: 
NR_103511
Alias: 
BBS3;RP55;
Ensembl: 
ENSG00000113966
Location: 
3q11.2
HPRD: 
10588
NCBI Gene: 
84100
MIM: 
608845

Summary: 
The protein encoded by this gene belongs to the ARF-like (ADP ribosylation factor-like) sub-family of the ARF family of GTP-binding proteins which are involved in regulation of intracellular traffic. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS). Alternative splicing results in multiple transcript variants of this gene. A vision-specific transcript encoding a different protein has been described (PMID: 20333246). [provided by RefSeq, May 2013]
Function: 
Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.
Subcellular location: 
Cell projection › cilium membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm › cytoskeleton › cilium axoneme. Cytoplasm › cytoskeleton › cilium basal body. Note: Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane.
PTM: 
Lipoprotein;
Disease: 
Bardet-Biedl syndrome 3 (BBS3) [MIM:209900]: A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease. Note: The disease is caused by mutations affecting the gene represented in this entry. Retinitis pigmentosa 55 (RP55) [MIM:613575]: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Others OPPA00127 ARL6 Human - Recombinant Human ADP-Ribosylation Factor-Like 6 (2ug) 2ug $100 Details
Polyclonal Antibody ARP65153_P050 ARL6 Antibody (ARP65153_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Yeast, Zebrafish Not tested 50 ug $125 Details
Polyclonal Antibody ARP65154_P050 ARL6 Antibody (ARP65154_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Not tested 50 ug $125 Details
Polyclonal Antibody OAAB15845 ARL6 antibody - N - terminal region (OAAB15845) Human WB, IHC 400ul $289 Details

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Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP65153 African clawed frog ARL6 antibody; Xenopus laevis ARL6 antibody Q2ABY0 100.0%
ARP65153 African clawed frog ARL6 antibody; Xenopus laevis ARL6 antibody Q68EX8 100.0%
ARP65153 American bullfrog ARL6 antibody; Lithobates catesbeiana ARL6 antibody C1C3L9 93.0%
ARP65153 Bovine ARL6 antibody; Bos taurus ARL6 antibody Q0IIM2 100.0%
ARP65154 Bovine ARL6 antibody; Bos taurus ARL6 antibody Q0IIM2 92.0%
ARP65153 Cat ARL6 antibody; Felis catus ARL6 antibody M3WWM1 100.0%
ARP65153 Cat ARL6 antibody; Felis catus ARL6 antibody M3XE96 100.0%
ARP65154 Cat ARL6 antibody; Felis catus ARL6 antibody M3WWM1 92.0%
ARP65154 Cat ARL6 antibody; Felis catus ARL6 antibody M3XE96 92.0%
ARP65153 Chimpanzee ARL6 antibody; Pan troglodytes ARL6 antibody H2QMZ4 100.0%
ARP65154 Chimpanzee ARL6 antibody; Pan troglodytes ARL6 antibody H2QMZ4 100.0%
ARP65153 Chinese softshell turtle ARL6 antibody; Pelodiscus sinensis ARL6 antibody K7FLU5 100.0%
ARP65154 Chinese softshell turtle ARL6 antibody; Pelodiscus sinensis ARL6 antibody K7FLU5 85.0%
ARP65153 Collared flycatcher ARL6 antibody; Ficedula albicollis ARL6 antibody U3JG05 100.0%
ARP65154 Collared flycatcher ARL6 antibody; Ficedula albicollis ARL6 antibody U3JG05 85.0%
ARP65153 Dog ARL6 antibody; Canis familiaris ARL6 antibody E2RRS0 100.0%
ARP65154 Dog ARL6 antibody; Canis familiaris ARL6 antibody E2RRS0 92.0%
ARP65153 Domestic duck ARL6 antibody; Anas platyrhynchos ARL6 antibody U3I8L4 100.0%
ARP65154 Domestic duck ARL6 antibody; Anas platyrhynchos ARL6 antibody U3I8L4 85.0%
ARP65153 Duckbill platypus ARL6 antibody; Ornithorhynchus anatinus ARL6 antibody F6TJD2 100.0%
ARP65153 European domestic ferret ARL6 antibody; Mustela putorius furo ARL6 antibody M3XU97 100.0%
ARP65154 European domestic ferret ARL6 antibody; Mustela putorius furo ARL6 antibody M3XU97 92.0%
ARP65153 Giant panda ARL6 antibody; Ailuropoda melanoleuca ARL6 antibody G1M4X8 100.0%
ARP65154 Giant panda ARL6 antibody; Ailuropoda melanoleuca ARL6 antibody G1M4X8 92.0%
ARP65153 Gray short-tailed opossum ARL6 antibody; Monodelphis domestica ARL6 antibody F6QF28 100.0%
ARP65154 Gray short-tailed opossum ARL6 antibody; Monodelphis domestica ARL6 antibody F6QF28 85.0%
ARP65153 Green anole ARL6 antibody; Anolis carolinensis ARL6 antibody G1KIJ0 100.0%
ARP65154 Green anole ARL6 antibody; Anolis carolinensis ARL6 antibody G1KIJ0 85.0%
ARP65153 Horse ARL6 antibody; Equus caballus ARL6 antibody F6V1R0 100.0%
ARP65154 Horse ARL6 antibody; Equus caballus ARL6 antibody F6V1R0 92.0%
ARP65153 Human ARL6 antibody; Homo sapiens ARL6 antibody Q9H0F7-2 100.0%
ARP65154 Human ARL6 antibody; Homo sapiens ARL6 antibody Q9H0F7-2 100.0%
ARP65153 Human ARL6 antibody; Homo sapiens ARL6 antibody Q9H0F7 100.0%
ARP65154 Human ARL6 antibody; Homo sapiens ARL6 antibody Q9H0F7 100.0%
ARP65153 Human ARL6 antibody; Homo sapiens ARL6 antibody C9IZ13 100.0%
ARP65154 Human ARL6 antibody; Homo sapiens ARL6 antibody C9IZ13 100.0%
ARP65153 Hydra ARL6 antibody; Hydra vulgaris ARL6 antibody T2M5Q0 92.0%
ARP65153 Mouse ARL6 antibody; Mus musculus ARL6 antibody D3Z067 100.0%
ARP65153 Mouse ARL6 antibody; Mus musculus ARL6 antibody O88848-2 100.0%
ARP65153 Mouse ARL6 antibody; Mus musculus ARL6 antibody O88848 100.0%
ARP65153 Mouse ARL6 antibody; Mus musculus ARL6 antibody Q3TUM2 100.0%
ARP65153 Mouse ARL6 antibody; Mus musculus ARL6 antibody Q3U6U3 100.0%
ARP65153 Mouse ARL6 antibody; Mus musculus ARL6 antibody Q8VCV3 100.0%
ARP65154 Mouse ARL6 antibody; Mus musculus ARL6 antibody D3Z067 92.0%
ARP65154 Mouse ARL6 antibody; Mus musculus ARL6 antibody O88848-2 92.0%
ARP65154 Mouse ARL6 antibody; Mus musculus ARL6 antibody O88848 92.0%
ARP65154 Mouse ARL6 antibody; Mus musculus ARL6 antibody Q3TUM2 92.0%
ARP65154 Mouse ARL6 antibody; Mus musculus ARL6 antibody Q3U6U3 92.0%
ARP65154 Mouse ARL6 antibody; Mus musculus ARL6 antibody Q8VCV3 92.0%
ARP65153 Pig ARL6 antibody; Sus scrofa ARL6 antibody I3LJG1 100.0%
ARP65154 Pig ARL6 antibody; Sus scrofa ARL6 antibody I3LJG1 92.0%
ARP65153 Rabbit ARL6 antibody; Oryctolagus cuniculus ARL6 antibody G1TLB3 100.0%
ARP65154 Rabbit ARL6 antibody; Oryctolagus cuniculus ARL6 antibody G1TLB3 92.0%
ARP65153 Rainbow smelt ARL6 antibody; Osmerus mordax ARL6 antibody C1BJB5 100.0%
ARP65153 Rainbow smelt ARL6 antibody; Osmerus mordax ARL6 antibody C1BM01 100.0%
ARP65153 Rainbow smelt ARL6 antibody; Osmerus mordax ARL6 antibody C1BM81 100.0%
ARP65153 Rat ARL6 antibody; Rattus norvegicus ARL6 antibody B1WC73 100.0%
ARP65153 Rat ARL6 antibody; Rattus norvegicus ARL6 antibody F7F983 100.0%
ARP65154 Rat ARL6 antibody; Rattus norvegicus ARL6 antibody B1WC73 85.0%
ARP65154 Rat ARL6 antibody; Rattus norvegicus ARL6 antibody F7F983 85.0%
ARP65153 Rhesus macaque ARL6 antibody; Macaca mulatta ARL6 antibody F7EGS4 100.0%
ARP65154 Rhesus macaque ARL6 antibody; Macaca mulatta ARL6 antibody F7EGS4 100.0%
ARP65153 Small-eared galago ARL6 antibody; Otolemur garnettii ARL6 antibody H0WGM3 93.0%
ARP65154 Small-eared galago ARL6 antibody; Otolemur garnettii ARL6 antibody H0WGM3 92.0%
ARP65153 Sumatran orangutan ARL6 antibody; Pongo abelii ARL6 antibody H2P9Y8 100.0%
ARP65153 Sumatran orangutan ARL6 antibody; Pongo abelii ARL6 antibody Q5R4G5 100.0%
ARP65154 Sumatran orangutan ARL6 antibody; Pongo abelii ARL6 antibody Q5R4G5 100.0%
ARP65153 Tasmanian devil ARL6 antibody; Sarcophilus harrisii ARL6 antibody G3VZE0 100.0%
ARP65154 Tasmanian devil ARL6 antibody; Sarcophilus harrisii ARL6 antibody G3VZE0 85.0%
ARP65153 Thirteen-lined ground squirrel ARL6 antibody; Spermophilus tridecemlineatus ARL6 antibody I3NC55 100.0%
ARP65154 Thirteen-lined ground squirrel ARL6 antibody; Spermophilus tridecemlineatus ARL6 antibody I3NC55 92.0%
ARP65153 White-tufted-ear marmoset ARL6 antibody; Callithrix jacchus ARL6 antibody U3EQH7 100.0%
ARP65153 White-tufted-ear marmoset ARL6 antibody; Callithrix jacchus ARL6 antibody F6VLT6 100.0%
ARP65154 White-tufted-ear marmoset ARL6 antibody; Callithrix jacchus ARL6 antibody U3EQH7 92.0%
ARP65154 White-tufted-ear marmoset ARL6 antibody; Callithrix jacchus ARL6 antibody F6VLT6 92.0%
ARP65153 Zebra finch ARL6 antibody; Taeniopygia guttata ARL6 antibody H0ZTF1 100.0%
ARP65154 Zebra finch ARL6 antibody; Taeniopygia guttata ARL6 antibody H0ZTF1 85.0%
ARP65153 Zebrafish ARL6 antibody; Danio rerio ARL6 antibody Q5M9P8-2 100.0%
ARP65153 Zebrafish ARL6 antibody; Danio rerio ARL6 antibody Q5M9P8 100.0%

Tissue & Cell Line Gene Expression Data