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Gene ID: 57492 | ARID1B Antibody Resource


ARID1B Antibody Resource
Gene Full Name: 
AT rich interactive domain 1B (SWI1-like)
Uniprot: 
Q8NFD5
Protein Name: 
AT-rich interactive domain-containing protein 1B
Nucleotide: 
XM_005267069
Alias: 
OSA2;6A3-5;DAN15;MRD12;P250R;BRIGHT;BAF250B;ELD/OSA1;
Ensembl: 
ENSG00000049618
Location: 
6q25.1
HPRD: 
10660
NCBI Gene: 
57492
MIM: 
614556

Summary: 
This locus encodes an AT-rich DNA interacting domain-containing protein. The encoded protein is a component of the SWI/SNF chromatin remodeling complex and may play a role in cell-cycle activation. The protein encoded by this locus is similar to AT-rich interactive domain-containing protein 1A. These two proteins function as alternative, mutually exclusive ARID-subunits of the SWI/SNF complex. The associated complexes play opposing roles. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2012]
Function: 
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth . Binds DNA non-specifically.
Subcellular location: 
Nucleus .
PTM: 
Acetylation;
Disease: 
Mental retardation, autosomal dominant 12 (MRD12) [MIM:614562]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD12 patients present with moderate to severe psychomotor retardation, and most show evidence of muscular hypotonia. In many patients, expressive speech is more severely affected than receptive function. Additional common findings include short stature, abnormal head shape and low-set, posteriorly rotated, and abnormally shaped ears, downslanting palpebral fissures, a bulbous nasal tip, a thin upper lip, minor teeth anomalies, and brachydactyly or single palmar creases. Autistic features are uncommon. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP34456_P050 ARID1B Antibody (ARP34456_P050) Polyclonal Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody ARP34457_P050 ARID1B Antibody (ARP34457_P050) Polyclonal Bovine, Dog, Human, Mouse, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody ARP34746_P050 ARID1B Antibody (ARP34746_P050) Polyclonal Dog, Guinea pig, Human, Pig, Yeast Not tested 50 ug $125 Details
Polyclonal Antibody ARP39282_P050 ARID1B Antibody (ARP39282_P050) Polyclonal Dog, Human, Mouse Not tested 50 ug $125 Details
Polyclonal Antibody ARP39283_P050 ARID1B Antibody (ARP39283_P050) Polyclonal Bovine, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody OAAF02555 ARID1B Antibody (OAAF02555) Polyclonal Human, Rat WB, IF, ELISA 100 ug $229 Details

Show all ARID1B antibodies


Product Images
ARID1B Antibody (OAAF02555) in HUVEC cells using Immunofluorescence

Sample Type: HUVEC

ARID1B Antibody (OAAF02555) in LOVO cells using Western Blot

Sample Type: LOVO


ARID1B Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP34456 Cat ARID1B antibody; Felis catus ARID1B antibody M3W5L6 93.0%
ARP34456 Chimpanzee ARID1B antibody; Pan troglodytes ARID1B antibody H2QTY4 100.0%
ARP34457 Chimpanzee ARID1B antibody; Pan troglodytes ARID1B antibody H2QTY4 100.0%
ARP34457 Collared flycatcher ARID1B antibody; Ficedula albicollis ARID1B antibody U3KDG9 100.0%
ARP34456 Collared flycatcher ARID1B antibody; Ficedula albicollis ARID1B antibody U3KDG9 93.0%
ARP39282 Dog ARID1B antibody; Canis familiaris ARID1B antibody F1PBJ5 93.0%
ARP34456 Dog ARID1B antibody; Canis familiaris ARID1B antibody F1PBJ5 86.0%
ARP34456 Domestic duck ARID1B antibody; Anas platyrhynchos ARID1B antibody U3IJ13 86.0%
ARP34457 Duckbill platypus ARID1B antibody; Ornithorhynchus anatinus ARID1B antibody F6WZ81 100.0%
ARP34456 Duckbill platypus ARID1B antibody; Ornithorhynchus anatinus ARID1B antibody F6WZ81 93.0%
ARP31102 Duckbill platypus ARID1B antibody; Ornithorhynchus anatinus ARID1B antibody F6WZ81 85.0%
ARP34456 European domestic ferret ARID1B antibody; Mustela putorius furo ARID1B antibody M3Y207 100.0%
ARP34457 European domestic ferret ARID1B antibody; Mustela putorius furo ARID1B antibody M3Y207 100.0%
ARP34456 Giant panda ARID1B antibody; Ailuropoda melanoleuca ARID1B antibody G1LT42 100.0%
ARP34457 Giant panda ARID1B antibody; Ailuropoda melanoleuca ARID1B antibody G1LT42 100.0%
ARP34456 Giant panda ARID1B antibody; Ailuropoda melanoleuca ARID1B antibody G1LT38 93.0%
ARP34457 Gray short-tailed opossum ARID1B antibody; Monodelphis domestica ARID1B antibody F6YJT2 100.0%
ARP34456 Gray short-tailed opossum ARID1B antibody; Monodelphis domestica ARID1B antibody F6YJT2 93.0%
ARP34457 Green anole ARID1B antibody; Anolis carolinensis ARID1B antibody G1KDQ1 93.0%
ARP34456 Green anole ARID1B antibody; Anolis carolinensis ARID1B antibody G1KDQ1 86.0%
ARP34456 Horse ARID1B antibody; Equus caballus ARID1B antibody F7DSY4 86.0%
ARP34746 Human ARID1B antibody; Homo sapiens ARID1B antibody G3XAA0 100.0%
ARP39282 Human ARID1B antibody; Homo sapiens ARID1B antibody G3XAA0 100.0%
ARP34456 Human ARID1B antibody; Homo sapiens ARID1B antibody H0Y2R3 100.0%
ARP34457 Human ARID1B antibody; Homo sapiens ARID1B antibody H0Y2R3 100.0%
ARP34456 Human ARID1B antibody; Homo sapiens ARID1B antibody H0Y7H8 100.0%
ARP34457 Human ARID1B antibody; Homo sapiens ARID1B antibody H0Y7H8 100.0%
ARP34746 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5-2 100.0%
ARP39282 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5-2 100.0%
ARP34456 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5-3 100.0%
ARP34457 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5-3 100.0%
ARP34746 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5-3 100.0%
ARP39282 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5-3 100.0%
ARP34746 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5 100.0%
ARP39282 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5 100.0%
ARP34456 Human ARID1B antibody; Homo sapiens ARID1B antibody G3XAA0 100.0%
ARP34457 Human ARID1B antibody; Homo sapiens ARID1B antibody G3XAA0 100.0%
ARP34456 Human ARID1B antibody; Homo sapiens ARID1B antibody H0Y3S9 93.0%
ARP34456 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5-2 93.0%
ARP34456 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5-4 93.0%
ARP34456 Human ARID1B antibody; Homo sapiens ARID1B antibody Q8NFD5 93.0%
ARP34457 Mouse ARID1B antibody; Mus musculus ARID1B antibody E9Q4N6 100.0%
ARP34457 Mouse ARID1B antibody; Mus musculus ARID1B antibody E9Q4N7 100.0%
ARP39282 Mouse ARID1B antibody; Mus musculus ARID1B antibody E9Q4N7 93.0%
ARP39282 Mouse ARID1B antibody; Mus musculus ARID1B antibody E9Q6R4 93.0%
ARP34456 Mouse ARID1B antibody; Mus musculus ARID1B antibody E9Q4N6 86.0%
ARP34456 Mouse ARID1B antibody; Mus musculus ARID1B antibody E9Q4N7 86.0%
ARP34456 Mouse ARID1B antibody; Mus musculus ARID1B antibody E9Q6R4 79.0%
ARP34456 Northern white-cheeked gibbon ARID1B antibody; Nomascus leucogenys ARID1B antibody G1S0H4 100.0%
ARP34457 Northern white-cheeked gibbon ARID1B antibody; Nomascus leucogenys ARID1B antibody G1S0H4 100.0%
ARP34456 Pig ARID1B antibody; Sus scrofa ARID1B antibody F1SB28 79.0%
ARP34457 Rabbit ARID1B antibody; Oryctolagus cuniculus ARID1B antibody G1SW33 100.0%
ARP34456 Rabbit ARID1B antibody; Oryctolagus cuniculus ARID1B antibody G1SW33 79.0%
ARP34457 Rat ARID1B antibody; Rattus norvegicus ARID1B antibody Q8CHN9 100.0%
ARP34456 Rat ARID1B antibody; Rattus norvegicus ARID1B antibody Q8CHN9 93.0%
ARP34456 Rhesus macaque ARID1B antibody; Macaca mulatta ARID1B antibody H9F685 93.0%
ARP34456 Small-eared galago ARID1B antibody; Otolemur garnettii ARID1B antibody H0X174 93.0%
ARP34456 Sumatran orangutan ARID1B antibody; Pongo abelii ARID1B antibody H2PKP8 100.0%
ARP34457 Sumatran orangutan ARID1B antibody; Pongo abelii ARID1B antibody H2PKP8 100.0%
ARP34457 Tasmanian devil ARID1B antibody; Sarcophilus harrisii ARID1B antibody G3X045 100.0%
ARP34456 Tasmanian devil ARID1B antibody; Sarcophilus harrisii ARID1B antibody G3X045 93.0%
ARP34456 Tasmanian devil ARID1B antibody; Sarcophilus harrisii ARID1B antibody G3X046 86.0%
ARP34457 Western clawed frog ARID1B antibody; Xenopus tropicalis ARID1B antibody F6TG36 100.0%
ARP34456 White-tufted-ear marmoset ARID1B antibody; Callithrix jacchus ARID1B antibody F7IS43 100.0%
ARP34457 White-tufted-ear marmoset ARID1B antibody; Callithrix jacchus ARID1B antibody F7IS43 100.0%
ARP34456 White-tufted-ear marmoset ARID1B antibody; Callithrix jacchus ARID1B antibody F7IME4 93.0%
ARP34456 Zebra finch ARID1B antibody; Taeniopygia guttata ARID1B antibody H0ZLJ0 86.0%

Tissue & Cell Line Gene Expression Data