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Gene ID: 164668 | APOBEC3H Antibody Resource


APOBEC3H Antibody Resource
Gene Full Name: 
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
Uniprot: 
Q6NTF7
Protein Name: 
DNA dC->dU-editing enzyme APOBEC-3H
Nucleotide: 
NM_001166003
Alias: 
A3H;ARP10;
Ensembl: 
ENSG00000100298
Location: 
22q13.1
HPRD: 
16508
NCBI Gene: 
164668
MIM: 
610976

Summary: 
This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Function: 
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Subcellular location: 
Nucleus. Cytoplasm. Cytoplasm › P-body. Note: Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP65003_P050 APOBEC3H Antibody - C-terminal region (ARP65003_P050) Human WB 50ug $289 Details
Polyclonal Antibody ARP65004_P050 APOBEC3H Antibody (ARP65004_P050) Polyclonal Human Not tested 50 ug $125 Details

Show all APOBEC3H antibodies


Product Images
APOBEC3H Antibody - C-terminal region (ARP65003_P050) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat


APOBEC3H Protocols
Publications

Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP65003 Angolan talapoin APOBEC3H antibody; Miopithecus talapoin APOBEC3H antibody Q1WBT1 100.0%
ARP65004 Angolan talapoin APOBEC3H antibody; Miopithecus talapoin APOBEC3H antibody Q1WBT1 100.0%
ARP65003 Bornean orangutan APOBEC3H antibody; Pongo pygmaeus APOBEC3H antibody B7T0U8 100.0%
ARP65004 Bornean orangutan APOBEC3H antibody; Pongo pygmaeus APOBEC3H antibody B7T0U8 100.0%
ARP65003 Bornean orangutan APOBEC3H antibody; Pongo pygmaeus APOBEC3H antibody Q1WBT4 100.0%
ARP65004 Bornean orangutan APOBEC3H antibody; Pongo pygmaeus APOBEC3H antibody Q1WBT4 100.0%
ARP65004 Brown woolly monkey APOBEC3H antibody; Lagothrix lagotricha APOBEC3H antibody Q1WBS9 93.0%
ARP65003 Chimpanzee APOBEC3H antibody; Pan troglodytes APOBEC3H antibody B7T0U6 100.0%
ARP65004 Chimpanzee APOBEC3H antibody; Pan troglodytes APOBEC3H antibody B7T0U6 100.0%
ARP65003 Chimpanzee APOBEC3H antibody; Pan troglodytes APOBEC3H antibody Q1WBT7 100.0%
ARP65004 Chimpanzee APOBEC3H antibody; Pan troglodytes APOBEC3H antibody Q1WBT7 100.0%
ARP65003 Chimpanzee APOBEC3H antibody; Pan troglodytes APOBEC3H antibody H2QLQ0 100.0%
ARP65004 Chimpanzee APOBEC3H antibody; Pan troglodytes APOBEC3H antibody H2QLQ0 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7T0V0 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7T0V0 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM3 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM3 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM4 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM4 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM6 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM6 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM7 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM7 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody Q6NTF7-2 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM8 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM8 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody Q6NTF7-2 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody B7TQM9 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody Q6NTF7-3 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody Q6NTF7-3 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody Q6NTF7-4 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody Q6NTF7 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody Q6NTF7 100.0%
ARP65003 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody M4W6S4 100.0%
ARP65004 Human APOBEC3H antibody; Homo sapiens APOBEC3H antibody M4W6S4 100.0%
ARP65003 Northern white-cheeked gibbon APOBEC3H antibody; Nomascus leucogenys APOBEC3H antibody M3ZCD3 100.0%
ARP65004 Northern white-cheeked gibbon APOBEC3H antibody; Nomascus leucogenys APOBEC3H antibody M3ZCD3 100.0%
ARP65003 Olive baboon APOBEC3H antibody; Papio anubis APOBEC3H antibody Q1WBT9 100.0%
ARP65004 Olive baboon APOBEC3H antibody; Papio anubis APOBEC3H antibody Q1WBT9 100.0%
ARP65003 Pygmy chimpanzee APOBEC3H antibody; Pan paniscus APOBEC3H antibody Q1WBT8 100.0%
ARP65004 Pygmy chimpanzee APOBEC3H antibody; Pan paniscus APOBEC3H antibody Q1WBT8 100.0%
ARP65004 Red-chested mustached tamarin APOBEC3H antibody; Saguinus labiatus APOBEC3H antibody Q1WBT0 92.0%
ARP65004 Rhesus macaque APOBEC3H antibody; Macaca mulatta APOBEC3H antibody F6SJ45 100.0%
ARP65004 Rhesus macaque APOBEC3H antibody; Macaca mulatta APOBEC3H antibody Q19Q52 100.0%
ARP65003 Rhesus macaque APOBEC3H antibody; Macaca mulatta APOBEC3H antibody Q19Q52 93.0%
ARP65003 Rhesus macaque APOBEC3H antibody; Macaca mulatta APOBEC3H antibody F6SJ45 92.0%
ARP65003 Siamang APOBEC3H antibody; Hylobates syndactylus APOBEC3H antibody B7T0U9 100.0%
ARP65004 Siamang APOBEC3H antibody; Hylobates syndactylus APOBEC3H antibody B7T0U9 100.0%
ARP65003 Siamang APOBEC3H antibody; Hylobates syndactylus APOBEC3H antibody Q1WBT6 100.0%
ARP65004 Siamang APOBEC3H antibody; Hylobates syndactylus APOBEC3H antibody Q1WBT6 100.0%
ARP65003 Sooty mangabey APOBEC3H antibody; Cercocebus atys APOBEC3H antibody Q1WBT3 100.0%
ARP65004 Sooty mangabey APOBEC3H antibody; Cercocebus atys APOBEC3H antibody Q1WBT3 100.0%
ARP65003 Sumatran orangutan APOBEC3H antibody; Pongo abelii APOBEC3H antibody H2P4F3 100.0%
ARP65004 Sumatran orangutan APOBEC3H antibody; Pongo abelii APOBEC3H antibody H2P4F3 100.0%
ARP65003 western gorilla APOBEC3H antibody; Gorilla gorilla APOBEC3H antibody Q1WBT5 100.0%
ARP65003 western gorilla APOBEC3H antibody; Gorilla gorilla APOBEC3H antibody B7T0U7 93.0%
ARP65004 western gorilla APOBEC3H antibody; Gorilla gorilla APOBEC3H antibody B7T0U7 92.0%
ARP65004 western gorilla APOBEC3H antibody; Gorilla gorilla APOBEC3H antibody Q1WBT5 92.0%
ARP65004 White-bellied spider monkey APOBEC3H antibody; Ateles belzebuth APOBEC3H antibody Q1WBT2 100.0%

Tissue & Cell Line Gene Expression Data