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Gene ID: 140564 | APOBEC3D Antibody Resource


APOBEC3D Antibody Resource
Gene Full Name: 
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
Uniprot: 
Q96AK3
Protein Name: 
DNA dC->dU-editing enzyme APOBEC-3D
Nucleotide: 
NM_152426
Alias: 
A3D;ARP6;APOBEC3E;APOBEC3DE;
Ensembl: 
ENSG00000243811
Location: 
22q13.1
HPRD: 
16501
NCBI Gene: 
140564
MIM: 
609900

Summary: 
This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]
Function: 
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.
Subcellular location: 
Cytoplasm. Cytoplasm › P-body .
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP41147_P050 APOBEC3D antibody - N-terminal region (ARP41147_P050) Polyclonal Human IHC, WB 50ug $289 Details
Polyclonal Antibody ARP41148_P050 APOBEC3D Antibody (ARP41148_P050) Polyclonal Not tested 50 ug $125 Details
Polyclonal Antibody OAAB14301 APOBEC3D antibody - N - terminal region (OAAB14301) Human WB 400ul $289 Details

Show all APOBEC3D antibodies


Product Images
APOBEC3D antibody - N-terminal region (ARP41147_P050) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2

APOBEC3D antibody - N-terminal region (ARP41147_P050) in Human kidney cells using Immunohistochemistry

Sample Type: Human kidney

APOBEC3D antibody - N - terminal region (OAAB14301) in Human placenta cells using Western Blot

Sample Type: Human placenta


APOBEC3D Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP41147 Chimpanzee APOBEC3D antibody; Pan troglodytes APOBEC3D antibody K7D903 93.0%
ARP34347 Chimpanzee APOBEC3D antibody; Pan troglodytes APOBEC3D antibody K7D903 92.0%
ARP46114 Chimpanzee APOBEC3D antibody; Pan troglodytes APOBEC3D antibody K7D903 91.0%
ARP34347 Human APOBEC3D antibody; Homo sapiens APOBEC3D antibody Q96AK3 100.0%
ARP41147 Human APOBEC3D antibody; Homo sapiens APOBEC3D antibody Q96AK3 100.0%
ARP46114 Human APOBEC3D antibody; Homo sapiens APOBEC3D antibody Q96AK3 91.0%
ARP46114 Rhesus macaque APOBEC3D antibody; Macaca mulatta APOBEC3D antibody F6XHA6 92.0%
ARP34347 Rhesus macaque APOBEC3D antibody; Macaca mulatta APOBEC3D antibody F6XHA6 85.0%

Tissue & Cell Line Gene Expression Data