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Gene ID: 200558 | APLF Antibody Resource


APLF Antibody Resource
Gene Full Name: 
aprataxin and PNKP like factor
Uniprot: 
Q8IW19
Protein Name: 
aprataxin and PNK-like factor
Nucleotide: 
XM_005264190
Alias: 
APFL;PALF;Xip1;C2orf13;
Ensembl: 
ENSG00000169621
Location: 
2p13.3
HPRD: 
09848
NCBI Gene: 
200558
MIM: 
611035

Summary: 
C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008]
Function: 
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.
Subcellular location: 
Nucleus. Cytoplasm › cytosol. Note: Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.
PTM: 
ADP-ribosylation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP65293_P050 APLF Antibody - C-terminal region (ARP65293_P050) Human WB 50ug $289 Details
Polyclonal Antibody ARP65294_P050 APLF Antibody (ARP65294_P050) Polyclonal Horse, Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAF01609 APLF Antibody (OAAF01609) Polyclonal Human, Mouse WB, IHC, ELISA 100 ug $229 Details

Show all APLF antibodies


Product Images
APLF Antibody - C-terminal region (ARP65293_P050) in Human PANC1 cells using Western Blot

Sample Type: Human PANC1

APLF Antibody (OAAF01609) in COS7 cells using Western Blot

Sample Type: COS7

APLF Antibody (OAAF01609) in HT-29 cells using Western Blot

Sample Type: HT-29

APLF Antibody (OAAF01609) in Human brain cells using Immunohistochemistry

Sample Type: Human brain


APLF Protocols

Publications

Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP65293 African elephant APLF antibody; Loxodonta africana APLF antibody G3T7Q4 86.0%
ARP65293 Bovine APLF antibody; Bos taurus APLF antibody A0JNH9 86.0%
ARP65293 Bovine APLF antibody; Bos taurus APLF antibody G3MZQ3 86.0%
ARP65293 European domestic ferret APLF antibody; Mustela putorius furo APLF antibody M3Y4I0 86.0%
ARP65293 Giant panda APLF antibody; Ailuropoda melanoleuca APLF antibody G1L0N0 86.0%
ARP65293 Horse APLF antibody; Equus caballus APLF antibody F6ZW04 86.0%
ARP65294 Horse APLF antibody; Equus caballus APLF antibody F6ZW04 83.0%
ARP65293 Human APLF antibody; Homo sapiens APLF antibody Q8IW19 100.0%
ARP65294 Human APLF antibody; Homo sapiens APLF antibody Q8IW19 100.0%
ARP65293 Mouse APLF antibody; Mus musculus APLF antibody Q9D842-2 79.0%
ARP65293 Mouse APLF antibody; Mus musculus APLF antibody Q9D842-3 79.0%
ARP65293 Mouse APLF antibody; Mus musculus APLF antibody Q9D842 79.0%
ARP65293 Northern white-cheeked gibbon APLF antibody; Nomascus leucogenys APLF antibody G1RG64 100.0%
ARP65294 Northern white-cheeked gibbon APLF antibody; Nomascus leucogenys APLF antibody G1RG64 100.0%
ARP65293 Pig APLF antibody; Sus scrofa APLF antibody F1SJ24 93.0%
ARP65293 Rabbit APLF antibody; Oryctolagus cuniculus APLF antibody G1SQD8 86.0%
ARP65293 Rabbit APLF antibody; Oryctolagus cuniculus APLF antibody U3KNX3 86.0%
ARP65293 Rat APLF antibody; Rattus norvegicus APLF antibody F6Q5G6 86.0%
ARP65293 Rat APLF antibody; Rattus norvegicus APLF antibody Q4KLI5 86.0%
ARP65293 Rhesus macaque APLF antibody; Macaca mulatta APLF antibody H9F4X7 100.0%
ARP65294 Rhesus macaque APLF antibody; Macaca mulatta APLF antibody H9F4X7 100.0%
ARP65294 Sumatran orangutan APLF antibody; Pongo abelii APLF antibody H2P5Z9 100.0%
ARP65293 Sumatran orangutan APLF antibody; Pongo abelii APLF antibody H2P5Z9 93.0%
ARP65293 Thirteen-lined ground squirrel APLF antibody; Spermophilus tridecemlineatus APLF antibody I3MND1 86.0%
ARP65293 Thirteen-lined ground squirrel APLF antibody; Spermophilus tridecemlineatus APLF antibody I3N0L5 86.0%
ARP65293 White-tufted-ear marmoset APLF antibody; Callithrix jacchus APLF antibody F7GLI9 93.0%

Tissue & Cell Line Gene Expression Data