Gene ID: 378708 | APITD1 Antibody Resource
APITD1 Antibody Resource
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Tissue & Cell Line Gene Expression Data
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Summary: | This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010] |
Function: | DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. |
Subcellular location: | Nucleus. Chromosome › centromere. Chromosome › centromere › kinetochore. Note: Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. |
PTM: | Acetylation; |
Disease: | |
Biotechnological use: |
Antibodies
Type | Catalog | Name | Clonality | Species Reactivity | Application | Size | Price | More Info |
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Polyclonal Antibody | OAAB02336 | APITD1 antibody - center region (OAAB02336) | Human; Mouse | WB, IHC | 400ul | $289 | Details |
Product Images
APITD1 Protocols
Publications
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Related Gene Trend Categories
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Species
Catalog | Predicted Species & Target | Target Reference | Predicted Homology |
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ARP59540 | Human APITD1 antibody; Homo sapiens APITD1 antibody | Q8N2Z9-2 | 100.0% |
ARP66717 | Human APITD1 antibody; Homo sapiens APITD1 antibody | Q8N2Z9-2 | 100.0% |
ARP52466 | Three-spined stickleback APITD1 antibody; Gasterosteus aculeatus APITD1 antibody | G3PEW1 | 79.0% |
ARP63707 | Three-spined stickleback APITD1 antibody; Gasterosteus aculeatus APITD1 antibody | G3PEW1 | 79.0% |
Tissue & Cell Line Gene Expression Data
Data Source | Probeset | Sample | Avg | Mean | More Info |
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BioGPS Gene Atlas | 213454_at | 721_B_lymphoblasts | 46.550 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Adipocyte | 7.200 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | AdrenalCortex | 8.400 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Adrenalgland | 6.800 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Amygdala | 9.300 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Appendix | 14.700 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | AtrioventricularNode | 6.050 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | BDCA4+_DentriticCells | 6.750 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Bonemarrow | 7.050 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | BronchialEpithelialCells | 19.150 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CD105+_Endothelial | 78.400 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CD14+_Monocytes | 6.200 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CD19+_BCells(neg._sel.) | 7.400 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CD33+_Myeloid | 8.700 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CD34+ | 16.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CD4+_Tcells | 6.800 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CD56+_NKCells | 7.100 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CD71+_EarlyErythroid | 17.350 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CD8+_Tcells | 5.900 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CardiacMyocytes | 9.750 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Caudatenucleus | 8.300 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Cerebellum | 6.750 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CerebellumPeduncles | 7.700 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CiliaryGanglion | 6.250 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | CingulateCortex | 7.850 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Colorectaladenocarcinoma | 11.850 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | DorsalRootGanglion | 6.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | FetalThyroid | 6.950 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Fetalbrain | 6.900 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Fetalliver | 8.800 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Fetallung | 5.800 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | GlobusPallidus | 5.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Heart | 12.050 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Hypothalamus | 8.550 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Kidney | 14.100 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Leukemia_chronicMyelogenousK-562 | 6.150 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Leukemia_promyelocytic-HL-60 | 36.600 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Leukemialymphoblastic(MOLT-4) | 7.150 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Liver | 11.600 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Lung | 7.950 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Lymphnode | 5.900 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Lymphoma_burkitts(Daudi) | 23.850 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Lymphoma_burkitts(Raji) | 29.500 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | MedullaOblongata | 6.500 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | OccipitalLobe | 6.500 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | OlfactoryBulb | 5.700 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Ovary | 4.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Pancreas | 5.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | PancreaticIslet | 15.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | ParietalLobe | 7.300 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Pituitary | 21.050 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Placenta | 6.900 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Pons | 7.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | PrefrontalCortex | 8.100 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Prostate | 13.000 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Salivarygland | 5.950 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | SkeletalMuscle | 9.850 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Skin | 5.550 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | SmoothMuscle | 8.250 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Spinalcord | 7.600 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | SubthalamicNucleus | 6.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | SuperiorCervicalGanglion | 12.000 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | TemporalLobe | 6.850 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Testis | 116.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | TestisGermCell | 99.200 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | TestisIntersitial | 137.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | TestisLeydigCell | 39.050 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | TestisSeminiferousTubule | 57.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Thalamus | 7.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Thymus | 6.300 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Thyroid | 26.200 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Tongue | 7.000 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Tonsil | 7.150 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Trachea | 6.150 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | TrigeminalGanglion | 7.900 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Uterus | 5.650 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | UterusCorpus | 9.750 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | WholeBlood | 7.150 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | Wholebrain | 10.800 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | colon | 8.650 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | pineal_day | 10.380 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | pineal_night | 8.840 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | retina | 9.450 | 15.390 | Details |
BioGPS Gene Atlas | 213454_at | small_intestine | 8.700 | 15.390 | Details |
BioGPS NCI60 | 213454_at | 786 | 196.099 | 231.280 | Details |
BioGPS NCI60 | 213454_at | A172 | 49.114 | 231.280 | Details |
BioGPS NCI60 | 213454_at | A204 | 97.035 | 231.280 | Details |
BioGPS NCI60 | 213454_at | A361 | 227.945 | 231.280 | Details |
BioGPS NCI60 | 213454_at | A498 | 68.087 | 231.280 | Details |
BioGPS NCI60 | 213454_at | A549 | 102.204 | 231.280 | Details |
BioGPS NCI60 | 213454_at | ACC3 | 116.557 | 231.280 | Details |
BioGPS NCI60 | 213454_at | ACHN | 142.890 | 231.280 | Details |
BioGPS NCI60 | 213454_at | ALVA31 | 467.746 | 231.280 | Details |
BioGPS NCI60 | 213454_at | CAKI1 | 108.295 | 231.280 | Details |
BioGPS NCI60 | 213454_at | CCRT CEM | 57.318 | 231.280 | Details |
BioGPS NCI60 | 213454_at | COLO205 | 495.634 | 231.280 | Details |
BioGPS NCI60 | 213454_at | DLD1 | 403.803 | 231.280 | Details |
BioGPS NCI60 | 213454_at | DU145 | 200.490 | 231.280 | Details |
BioGPS NCI60 | 213454_at | EKVX | 165.163 | 231.280 | Details |
BioGPS NCI60 | 213454_at | GM133 | 424.955 | 231.280 | Details |
BioGPS NCI60 | 213454_at | GM1600 | 78.230 | 231.280 | Details |
BioGPS NCI60 | 213454_at | GM2313 | 147.088 | 231.280 | Details |
BioGPS NCI60 | 213454_at | GM2345 | 179.933 | 231.280 | Details |
BioGPS NCI60 | 213454_at | GM2493 | 125.460 | 231.280 | Details |
BioGPS NCI60 | 213454_at | GM97 | 30.414 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HCC2998 | 97.145 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HCT116 | 301.052 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HCT15 | 129.969 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HEK 293 T-rex | 222.250 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HEK 293T | 526.226 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HEK293 | 229.668 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HELA | 437.096 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HEPG2 | 101.136 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HL60 | 275.393 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HOP62 | 210.112 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HOP92 | 167.387 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HS578T | 228.886 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HSG | 89.420 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HT1080 | 76.381 | 231.280 | Details |
BioGPS NCI60 | 213454_at | HT29 | 356.876 | 231.280 | Details |
BioGPS NCI60 | 213454_at | IGROV1 | 77.120 | 231.280 | Details |
BioGPS NCI60 | 213454_at | IOSE80 | 325.641 | 231.280 | Details |
BioGPS NCI60 | 213454_at | JURKAT | 456.692 | 231.280 | Details |
BioGPS NCI60 | 213454_at | K562 | 124.860 | 231.280 | Details |
BioGPS NCI60 | 213454_at | KM12 | 236.009 | 231.280 | Details |
BioGPS NCI60 | 213454_at | LN18 | 440.940 | 231.280 | Details |
BioGPS NCI60 | 213454_at | LNCAP | 208.196 | 231.280 | Details |
BioGPS NCI60 | 213454_at | LOX IMVI | 62.479 | 231.280 | Details |
BioGPS NCI60 | 213454_at | M14 | 380.960 | 231.280 | Details |
BioGPS NCI60 | 213454_at | MALME 3M | 67.626 | 231.280 | Details |
BioGPS NCI60 | 213454_at | MCF7 | 354.022 | 231.280 | Details |
BioGPS NCI60 | 213454_at | MD MB231 | 102.269 | 231.280 | Details |
BioGPS NCI60 | 213454_at | MDA MB435 | 115.606 | 231.280 | Details |
BioGPS NCI60 | 213454_at | MOLT4 | 112.348 | 231.280 | Details |
BioGPS NCI60 | 213454_at | NCI 460 | 294.150 | 231.280 | Details |
BioGPS NCI60 | 213454_at | NCI H226 | 127.924 | 231.280 | Details |
BioGPS NCI60 | 213454_at | NCI H23 | 232.531 | 231.280 | Details |
BioGPS NCI60 | 213454_at | NCI H322M | 255.351 | 231.280 | Details |
BioGPS NCI60 | 213454_at | NCVADR RES | 88.884 | 231.280 | Details |
BioGPS NCI60 | 213454_at | OVCAR3 | 240.477 | 231.280 | Details |
BioGPS NCI60 | 213454_at | OVCAR4 | 78.231 | 231.280 | Details |
BioGPS NCI60 | 213454_at | OVCAR5 | 93.550 | 231.280 | Details |
BioGPS NCI60 | 213454_at | OVCAR8 | 267.286 | 231.280 | Details |
BioGPS NCI60 | 213454_at | PANC1 | 100.966 | 231.280 | Details |
BioGPS NCI60 | 213454_at | RL7 | 94.589 | 231.280 | Details |
BioGPS NCI60 | 213454_at | RPMI 8226 | 161.720 | 231.280 | Details |
BioGPS NCI60 | 213454_at | RS11846 | 94.745 | 231.280 | Details |
BioGPS NCI60 | 213454_at | RXF393 | 127.434 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SAOS2 | 88.807 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SF268 | 100.892 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SF295 | 271.929 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SF539 | 261.407 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SHSYSY+RA | 75.676 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SHSYSY-RA | 94.495 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SKMEL2 | 314.344 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SKMEL28 | 117.166 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SKMEL5 | 69.868 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SKOV3 | 395.091 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SN12C | 117.995 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SNB19 | 218.219 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SNB75 | 71.757 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SR | 90.510 | 231.280 | Details |
BioGPS NCI60 | 213454_at | SW620 | 470.833 | 231.280 | Details |
BioGPS NCI60 | 213454_at | T24 | 364.082 | 231.280 | Details |
BioGPS NCI60 | 213454_at | T3M4 | 86.997 | 231.280 | Details |
BioGPS NCI60 | 213454_at | TK10 | 252.330 | 231.280 | Details |
BioGPS NCI60 | 213454_at | U118 | 492.904 | 231.280 | Details |
BioGPS NCI60 | 213454_at | U138 | 680.472 | 231.280 | Details |
BioGPS NCI60 | 213454_at | U20S | 832.895 | 231.280 | Details |
BioGPS NCI60 | 213454_at | U251 | 323.686 | 231.280 | Details |
BioGPS NCI60 | 213454_at | U87 | 432.001 | 231.280 | Details |
BioGPS NCI60 | 213454_at | UACC257 | 91.167 | 231.280 | Details |
BioGPS NCI60 | 213454_at | UACC62 | 127.223 | 231.280 | Details |
BioGPS NCI60 | 213454_at | UO31 | 247.637 | 231.280 | Details |
BioGPS NCI60 | 213454_at | ZR75_1 | 194.015 | 231.280 | Details |
BioGPS NCI60 | 213454_at | astrocytes | 50.072 | 231.280 | Details |
BioGPS NCI60 | 213454_at | huh-7 | 247.054 | 231.280 | Details |