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Gene ID: 378708 | APITD1 Antibody Resource


APITD1 Antibody Resource
Gene Full Name: 
apoptosis-inducing, TAF9-like domain 1
Uniprot: 
Q8N2Z9
Protein Name: 
centromere protein S
Nucleotide: 
XM_005263453
Alias: 
MHF1;CENPS;CENP-S;FAAP16;
Ensembl: 
Location: 
1p36.22
HPRD: 
NCBI Gene: 
378708
MIM: 
609130

Summary: 
This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]
Function: 
DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.
Subcellular location: 
Nucleus. Chromosome › centromere. Chromosome › centromere › kinetochore. Note: Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
PTM: 
Acetylation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB02336 APITD1 antibody - center region (OAAB02336) Human; Mouse WB, IHC 400ul $289 Details

Show all APITD1 antibodies


Product Images
APITD1 antibody - center region (OAAB02336) in brain cells using Immunohistochemistry

Sample Type: brain

 APITD1 antibody - center region (OAAB02336) in mouse NIH-3T3 cells using Western Blot

Sample Type: mouse NIH-3T3

APITD1 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP59540 Human APITD1 antibody; Homo sapiens APITD1 antibody Q8N2Z9-2 100.0%
ARP66717 Human APITD1 antibody; Homo sapiens APITD1 antibody Q8N2Z9-2 100.0%
ARP52466 Three-spined stickleback APITD1 antibody; Gasterosteus aculeatus APITD1 antibody G3PEW1 79.0%
ARP63707 Three-spined stickleback APITD1 antibody; Gasterosteus aculeatus APITD1 antibody G3PEW1 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas213454_at721_B_lymphoblasts46.55015.390Details
BioGPS Gene Atlas213454_atAdipocyte7.20015.390Details
BioGPS Gene Atlas213454_atAdrenalCortex8.40015.390Details
BioGPS Gene Atlas213454_atAdrenalgland6.80015.390Details
BioGPS Gene Atlas213454_atAmygdala9.30015.390Details
BioGPS Gene Atlas213454_atAppendix14.70015.390Details
BioGPS Gene Atlas213454_atAtrioventricularNode6.05015.390Details
BioGPS Gene Atlas213454_atBDCA4+_DentriticCells6.75015.390Details
BioGPS Gene Atlas213454_atBonemarrow7.05015.390Details
BioGPS Gene Atlas213454_atBronchialEpithelialCells19.15015.390Details
BioGPS Gene Atlas213454_atCD105+_Endothelial78.40015.390Details
BioGPS Gene Atlas213454_atCD14+_Monocytes6.20015.390Details
BioGPS Gene Atlas213454_atCD19+_BCells(neg._sel.)7.40015.390Details
BioGPS Gene Atlas213454_atCD33+_Myeloid8.70015.390Details
BioGPS Gene Atlas213454_atCD34+16.45015.390Details
BioGPS Gene Atlas213454_atCD4+_Tcells6.80015.390Details
BioGPS Gene Atlas213454_atCD56+_NKCells7.10015.390Details
BioGPS Gene Atlas213454_atCD71+_EarlyErythroid17.35015.390Details
BioGPS Gene Atlas213454_atCD8+_Tcells5.90015.390Details
BioGPS Gene Atlas213454_atCardiacMyocytes9.75015.390Details
BioGPS Gene Atlas213454_atCaudatenucleus8.30015.390Details
BioGPS Gene Atlas213454_atCerebellum6.75015.390Details
BioGPS Gene Atlas213454_atCerebellumPeduncles7.70015.390Details
BioGPS Gene Atlas213454_atCiliaryGanglion6.25015.390Details
BioGPS Gene Atlas213454_atCingulateCortex7.85015.390Details
BioGPS Gene Atlas213454_atColorectaladenocarcinoma11.85015.390Details
BioGPS Gene Atlas213454_atDorsalRootGanglion6.45015.390Details
BioGPS Gene Atlas213454_atFetalThyroid6.95015.390Details
BioGPS Gene Atlas213454_atFetalbrain6.90015.390Details
BioGPS Gene Atlas213454_atFetalliver8.80015.390Details
BioGPS Gene Atlas213454_atFetallung5.80015.390Details
BioGPS Gene Atlas213454_atGlobusPallidus5.45015.390Details
BioGPS Gene Atlas213454_atHeart12.05015.390Details
BioGPS Gene Atlas213454_atHypothalamus8.55015.390Details
BioGPS Gene Atlas213454_atKidney14.10015.390Details
BioGPS Gene Atlas213454_atLeukemia_chronicMyelogenousK-5626.15015.390Details
BioGPS Gene Atlas213454_atLeukemia_promyelocytic-HL-6036.60015.390Details
BioGPS Gene Atlas213454_atLeukemialymphoblastic(MOLT-4)7.15015.390Details
BioGPS Gene Atlas213454_atLiver11.60015.390Details
BioGPS Gene Atlas213454_atLung7.95015.390Details
BioGPS Gene Atlas213454_atLymphnode5.90015.390Details
BioGPS Gene Atlas213454_atLymphoma_burkitts(Daudi)23.85015.390Details
BioGPS Gene Atlas213454_atLymphoma_burkitts(Raji)29.50015.390Details
BioGPS Gene Atlas213454_atMedullaOblongata6.50015.390Details
BioGPS Gene Atlas213454_atOccipitalLobe6.50015.390Details
BioGPS Gene Atlas213454_atOlfactoryBulb5.70015.390Details
BioGPS Gene Atlas213454_atOvary4.45015.390Details
BioGPS Gene Atlas213454_atPancreas5.45015.390Details
BioGPS Gene Atlas213454_atPancreaticIslet15.45015.390Details
BioGPS Gene Atlas213454_atParietalLobe7.30015.390Details
BioGPS Gene Atlas213454_atPituitary21.05015.390Details
BioGPS Gene Atlas213454_atPlacenta6.90015.390Details
BioGPS Gene Atlas213454_atPons7.45015.390Details
BioGPS Gene Atlas213454_atPrefrontalCortex8.10015.390Details
BioGPS Gene Atlas213454_atProstate13.00015.390Details
BioGPS Gene Atlas213454_atSalivarygland5.95015.390Details
BioGPS Gene Atlas213454_atSkeletalMuscle9.85015.390Details
BioGPS Gene Atlas213454_atSkin5.55015.390Details
BioGPS Gene Atlas213454_atSmoothMuscle8.25015.390Details
BioGPS Gene Atlas213454_atSpinalcord7.60015.390Details
BioGPS Gene Atlas213454_atSubthalamicNucleus6.45015.390Details
BioGPS Gene Atlas213454_atSuperiorCervicalGanglion12.00015.390Details
BioGPS Gene Atlas213454_atTemporalLobe6.85015.390Details
BioGPS Gene Atlas213454_atTestis116.45015.390Details
BioGPS Gene Atlas213454_atTestisGermCell99.20015.390Details
BioGPS Gene Atlas213454_atTestisIntersitial137.45015.390Details
BioGPS Gene Atlas213454_atTestisLeydigCell39.05015.390Details
BioGPS Gene Atlas213454_atTestisSeminiferousTubule57.45015.390Details
BioGPS Gene Atlas213454_atThalamus7.45015.390Details
BioGPS Gene Atlas213454_atThymus6.30015.390Details
BioGPS Gene Atlas213454_atThyroid26.20015.390Details
BioGPS Gene Atlas213454_atTongue7.00015.390Details
BioGPS Gene Atlas213454_atTonsil7.15015.390Details
BioGPS Gene Atlas213454_atTrachea6.15015.390Details
BioGPS Gene Atlas213454_atTrigeminalGanglion7.90015.390Details
BioGPS Gene Atlas213454_atUterus5.65015.390Details
BioGPS Gene Atlas213454_atUterusCorpus9.75015.390Details
BioGPS Gene Atlas213454_atWholeBlood7.15015.390Details
BioGPS Gene Atlas213454_atWholebrain10.80015.390Details
BioGPS Gene Atlas213454_atcolon8.65015.390Details
BioGPS Gene Atlas213454_atpineal_day10.38015.390Details
BioGPS Gene Atlas213454_atpineal_night8.84015.390Details
BioGPS Gene Atlas213454_atretina9.45015.390Details
BioGPS Gene Atlas213454_atsmall_intestine8.70015.390Details
BioGPS NCI60213454_at786196.099231.280Details
BioGPS NCI60213454_atA17249.114231.280Details
BioGPS NCI60213454_atA20497.035231.280Details
BioGPS NCI60213454_atA361227.945231.280Details
BioGPS NCI60213454_atA49868.087231.280Details
BioGPS NCI60213454_atA549102.204231.280Details
BioGPS NCI60213454_atACC3116.557231.280Details
BioGPS NCI60213454_atACHN142.890231.280Details
BioGPS NCI60213454_atALVA31467.746231.280Details
BioGPS NCI60213454_atCAKI1108.295231.280Details
BioGPS NCI60213454_atCCRT CEM57.318231.280Details
BioGPS NCI60213454_atCOLO205495.634231.280Details
BioGPS NCI60213454_atDLD1403.803231.280Details
BioGPS NCI60213454_atDU145200.490231.280Details
BioGPS NCI60213454_atEKVX165.163231.280Details
BioGPS NCI60213454_atGM133424.955231.280Details
BioGPS NCI60213454_atGM160078.230231.280Details
BioGPS NCI60213454_atGM2313147.088231.280Details
BioGPS NCI60213454_atGM2345179.933231.280Details
BioGPS NCI60213454_atGM2493125.460231.280Details
BioGPS NCI60213454_atGM9730.414231.280Details
BioGPS NCI60213454_atHCC299897.145231.280Details
BioGPS NCI60213454_atHCT116301.052231.280Details
BioGPS NCI60213454_atHCT15129.969231.280Details
BioGPS NCI60213454_atHEK 293 T-rex222.250231.280Details
BioGPS NCI60213454_atHEK 293T526.226231.280Details
BioGPS NCI60213454_atHEK293229.668231.280Details
BioGPS NCI60213454_atHELA437.096231.280Details
BioGPS NCI60213454_atHEPG2101.136231.280Details
BioGPS NCI60213454_atHL60275.393231.280Details
BioGPS NCI60213454_atHOP62210.112231.280Details
BioGPS NCI60213454_atHOP92167.387231.280Details
BioGPS NCI60213454_atHS578T228.886231.280Details
BioGPS NCI60213454_atHSG89.420231.280Details
BioGPS NCI60213454_atHT108076.381231.280Details
BioGPS NCI60213454_atHT29356.876231.280Details
BioGPS NCI60213454_atIGROV177.120231.280Details
BioGPS NCI60213454_atIOSE80325.641231.280Details
BioGPS NCI60213454_atJURKAT456.692231.280Details
BioGPS NCI60213454_atK562124.860231.280Details
BioGPS NCI60213454_atKM12236.009231.280Details
BioGPS NCI60213454_atLN18440.940231.280Details
BioGPS NCI60213454_atLNCAP208.196231.280Details
BioGPS NCI60213454_atLOX IMVI62.479231.280Details
BioGPS NCI60213454_atM14380.960231.280Details
BioGPS NCI60213454_atMALME 3M67.626231.280Details
BioGPS NCI60213454_atMCF7354.022231.280Details
BioGPS NCI60213454_atMD MB231102.269231.280Details
BioGPS NCI60213454_atMDA MB435115.606231.280Details
BioGPS NCI60213454_atMOLT4112.348231.280Details
BioGPS NCI60213454_atNCI 460294.150231.280Details
BioGPS NCI60213454_atNCI H226127.924231.280Details
BioGPS NCI60213454_atNCI H23232.531231.280Details
BioGPS NCI60213454_atNCI H322M255.351231.280Details
BioGPS NCI60213454_atNCVADR RES88.884231.280Details
BioGPS NCI60213454_atOVCAR3240.477231.280Details
BioGPS NCI60213454_atOVCAR478.231231.280Details
BioGPS NCI60213454_atOVCAR593.550231.280Details
BioGPS NCI60213454_atOVCAR8267.286231.280Details
BioGPS NCI60213454_atPANC1100.966231.280Details
BioGPS NCI60213454_atRL794.589231.280Details
BioGPS NCI60213454_atRPMI 8226161.720231.280Details
BioGPS NCI60213454_atRS1184694.745231.280Details
BioGPS NCI60213454_atRXF393127.434231.280Details
BioGPS NCI60213454_atSAOS288.807231.280Details
BioGPS NCI60213454_atSF268100.892231.280Details
BioGPS NCI60213454_atSF295271.929231.280Details
BioGPS NCI60213454_atSF539261.407231.280Details
BioGPS NCI60213454_atSHSYSY+RA75.676231.280Details
BioGPS NCI60213454_atSHSYSY-RA94.495231.280Details
BioGPS NCI60213454_atSKMEL2314.344231.280Details
BioGPS NCI60213454_atSKMEL28117.166231.280Details
BioGPS NCI60213454_atSKMEL569.868231.280Details
BioGPS NCI60213454_atSKOV3395.091231.280Details
BioGPS NCI60213454_atSN12C117.995231.280Details
BioGPS NCI60213454_atSNB19218.219231.280Details
BioGPS NCI60213454_atSNB7571.757231.280Details
BioGPS NCI60213454_atSR90.510231.280Details
BioGPS NCI60213454_atSW620470.833231.280Details
BioGPS NCI60213454_atT24364.082231.280Details
BioGPS NCI60213454_atT3M486.997231.280Details
BioGPS NCI60213454_atTK10252.330231.280Details
BioGPS NCI60213454_atU118492.904231.280Details
BioGPS NCI60213454_atU138680.472231.280Details
BioGPS NCI60213454_atU20S832.895231.280Details
BioGPS NCI60213454_atU251323.686231.280Details
BioGPS NCI60213454_atU87432.001231.280Details
BioGPS NCI60213454_atUACC25791.167231.280Details
BioGPS NCI60213454_atUACC62127.223231.280Details
BioGPS NCI60213454_atUO31247.637231.280Details
BioGPS NCI60213454_atZR75_1194.015231.280Details
BioGPS NCI60213454_atastrocytes50.072231.280Details
BioGPS NCI60213454_athuh-7247.054231.280Details

 

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