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Gene ID: 83464 | APH1B Antibody Resource


APH1B Antibody Resource
Gene Full Name: 
APH1B gamma secretase subunit
Uniprot: 
Q8WW43
Protein Name: 
gamma-secretase subunit APH-1B
Nucleotide: 
NM_031301
Alias: 
PSFL;APH-1B;PRO1328;TAAV688;
Ensembl: 
ENSG00000138613
Location: 
15q22.2
HPRD: 
06361
NCBI Gene: 
83464
MIM: 
607630

Summary: 
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011]
Function: 
Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
Subcellular location: 
Membrane; Multi-pass membrane protein Potential.
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP53808_P050 APH1B antibody - C-terminal region (ARP53808_P050) Bovine, Dog, Horse, Human, Mouse, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody ARP53807_P050 APH1B Antibody - N-terminal region (ARP53807_P050) Polyclonal Human WB 50ug $289 Details

Show all APH1B antibodies


Product Images
APH1B Antibody - N-terminal region (ARP53807_P050) in Human Lung Tumor cells using Western Blot

Sample Type: Human Lung Tumor

APH1B antibody - C-terminal region (ARP53808_P050) in Human THP-1 cells using Western Blot

Sample Type: Human THP-1


APH1B Protocols
Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP53807 Bovine APH1B antibody; Bos taurus APH1B antibody E1BB58 92.0%
ARP45011 Cat APH1B antibody; Felis catus APH1B antibody M3W712 92.0%
ARP53808 Cat APH1B antibody; Felis catus APH1B antibody M3W712 85.0%
ARP53807 Cat APH1B antibody; Felis catus APH1B antibody M3W712 79.0%
ARP53807 Chimpanzee APH1B antibody; Pan troglodytes APH1B antibody H2Q9J9 100.0%
ARP53808 Chimpanzee APH1B antibody; Pan troglodytes APH1B antibody H2Q9J9 100.0%
ARP45011 Chimpanzee APH1B antibody; Pan troglodytes APH1B antibody H2Q9J9 92.0%
ARP53807 Dog APH1B antibody; Canis familiaris APH1B antibody J9NV63 93.0%
ARP45011 Dog APH1B antibody; Canis familiaris APH1B antibody J9NV63 92.0%
ARP53808 Dog APH1B antibody; Canis familiaris APH1B antibody J9NV63 85.0%
ARP45011 Duckbill platypus APH1B antibody; Ornithorhynchus anatinus APH1B antibody F7D639 80.0%
ARP45011 Duckbill platypus APH1B antibody; Ornithorhynchus anatinus APH1B antibody F7D644 80.0%
ARP45011 European domestic ferret APH1B antibody; Mustela putorius furo APH1B antibody M3XNI3 92.0%
ARP53807 European domestic ferret APH1B antibody; Mustela putorius furo APH1B antibody M3XNI3 86.0%
ARP53808 European domestic ferret APH1B antibody; Mustela putorius furo APH1B antibody M3XNI3 85.0%
ARP53807 Giant panda APH1B antibody; Ailuropoda melanoleuca APH1B antibody G1L6B5 93.0%
ARP45011 Giant panda APH1B antibody; Ailuropoda melanoleuca APH1B antibody G1L6B5 92.0%
ARP53808 Giant panda APH1B antibody; Ailuropoda melanoleuca APH1B antibody G1L6B5 85.0%
ARP45011 Horse APH1B antibody; Equus caballus APH1B antibody A5YBM2 92.0%
ARP45011 Horse APH1B antibody; Equus caballus APH1B antibody F6TXJ8 92.0%
ARP53807 Human APH1B antibody; Homo sapiens APH1B antibody Q8WW43-2 100.0%
ARP53808 Human APH1B antibody; Homo sapiens APH1B antibody Q8WW43-2 100.0%
ARP53807 Human APH1B antibody; Homo sapiens APH1B antibody Q8WW43 100.0%
ARP53808 Human APH1B antibody; Homo sapiens APH1B antibody Q8WW43 100.0%
ARP53807 Human APH1B antibody; Homo sapiens APH1B antibody H0YKZ9 100.0%
ARP53807 Human APH1B antibody; Homo sapiens APH1B antibody H0YLT0 100.0%
ARP45011 Human APH1B antibody; Homo sapiens APH1B antibody Q8WW43 92.0%
ARP45011 Human APH1B antibody; Homo sapiens APH1B antibody H0YKZ9 92.0%
ARP45011 Human APH1B antibody; Homo sapiens APH1B antibody H0YLT0 92.0%
ARP53807 Mouse APH1B antibody; Mus musculus APH1B antibody Q8C7N7 93.0%
ARP53807 Mouse APH1B antibody; Mus musculus APH1B antibody F8WHK7 93.0%
ARP53807 Mouse APH1B antibody; Mus musculus APH1B antibody Q3TRQ2 93.0%
ARP53807 Mouse APH1B antibody; Mus musculus APH1B antibody Q8C7N7-2 93.0%
ARP53808 Mouse APH1B antibody; Mus musculus APH1B antibody Q8C7N7 92.0%
ARP53808 Mouse APH1B antibody; Mus musculus APH1B antibody F8WHK7 92.0%
ARP45011 Mouse APH1B antibody; Mus musculus APH1B antibody Q3TRQ2 92.0%
ARP45011 Mouse APH1B antibody; Mus musculus APH1B antibody Q8C7N7-2 92.0%
ARP45011 Mouse APH1B antibody; Mus musculus APH1B antibody Q8C7N7 92.0%
ARP53807 Pig APH1B antibody; Sus scrofa APH1B antibody F1S090 86.0%
ARP45011 Pig APH1B antibody; Sus scrofa APH1B antibody F1S090 83.0%
ARP53807 Rabbit APH1B antibody; Oryctolagus cuniculus APH1B antibody U3KNT9 100.0%
ARP53807 Rabbit APH1B antibody; Oryctolagus cuniculus APH1B antibody G1SM63 100.0%
ARP45011 Rabbit APH1B antibody; Oryctolagus cuniculus APH1B antibody G1SM63 92.0%
ARP53808 Rabbit APH1B antibody; Oryctolagus cuniculus APH1B antibody U3KNT9 85.0%
ARP53808 Rabbit APH1B antibody; Oryctolagus cuniculus APH1B antibody G1SM63 85.0%
ARP53807 Rat APH1B antibody; Rattus norvegicus APH1B antibody Q0PY50 93.0%
ARP53807 Rat APH1B antibody; Rattus norvegicus APH1B antibody Q4G070 93.0%
ARP45011 Rat APH1B antibody; Rattus norvegicus APH1B antibody Q0PY50 92.0%
ARP53808 Rat APH1B antibody; Rattus norvegicus APH1B antibody Q0PY50 92.0%
ARP45011 Rat APH1B antibody; Rattus norvegicus APH1B antibody Q4G070 92.0%
ARP53808 Rat APH1B antibody; Rattus norvegicus APH1B antibody Q4G070 92.0%
ARP53807 Rhesus macaque APH1B antibody; Macaca mulatta APH1B antibody F7DK04 100.0%
ARP53807 Rhesus macaque APH1B antibody; Macaca mulatta APH1B antibody F7FYY3 100.0%
ARP53807 Rhesus macaque APH1B antibody; Macaca mulatta APH1B antibody H9G0E6 100.0%
ARP45011 Rhesus macaque APH1B antibody; Macaca mulatta APH1B antibody F7DK04 92.0%
ARP53808 Rhesus macaque APH1B antibody; Macaca mulatta APH1B antibody F7DK04 92.0%
ARP53808 Rhesus macaque APH1B antibody; Macaca mulatta APH1B antibody F7FYY3 92.0%
ARP45011 Rhesus macaque APH1B antibody; Macaca mulatta APH1B antibody H9G0E6 92.0%
ARP53808 Rhesus macaque APH1B antibody; Macaca mulatta APH1B antibody H9G0E6 92.0%
ARP45011 Small-eared galago APH1B antibody; Otolemur garnettii APH1B antibody H0XHB9 92.0%
ARP53808 Small-eared galago APH1B antibody; Otolemur garnettii APH1B antibody H0XHB9 92.0%
ARP53807 Small-eared galago APH1B antibody; Otolemur garnettii APH1B antibody H0XHB9 86.0%
ARP53807 Sumatran orangutan APH1B antibody; Pongo abelii APH1B antibody Q5RDM3 100.0%
ARP45011 Sumatran orangutan APH1B antibody; Pongo abelii APH1B antibody Q5RDM3 92.0%
ARP53808 Sumatran orangutan APH1B antibody; Pongo abelii APH1B antibody Q5RDM3 92.0%
ARP45011 Tasmanian devil APH1B antibody; Sarcophilus harrisii APH1B antibody G3WYP3 83.0%
ARP53807 Thirteen-lined ground squirrel APH1B antibody; Spermophilus tridecemlineatus APH1B antibody I3MQU3 93.0%
ARP45011 Thirteen-lined ground squirrel APH1B antibody; Spermophilus tridecemlineatus APH1B antibody I3MQU3 92.0%
ARP53808 Thirteen-lined ground squirrel APH1B antibody; Spermophilus tridecemlineatus APH1B antibody I3MQU3 85.0%
ARP53807 White-tufted-ear marmoset APH1B antibody; Callithrix jacchus APH1B antibody U3BNX4 93.0%
ARP45011 White-tufted-ear marmoset APH1B antibody; Callithrix jacchus APH1B antibody U3BNX4 92.0%
ARP53808 White-tufted-ear marmoset APH1B antibody; Callithrix jacchus APH1B antibody U3BNX4 92.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas221036_s_at721_B_lymphoblasts7.85022.990Details
BioGPS Gene Atlas221036_s_atAdipocyte4.40022.990Details
BioGPS Gene Atlas221036_s_atAdrenalCortex4.55022.990Details
BioGPS Gene Atlas221036_s_atAdrenalgland4.85022.990Details
BioGPS Gene Atlas221036_s_atAmygdala4.60022.990Details
BioGPS Gene Atlas221036_s_atAppendix4.10022.990Details
BioGPS Gene Atlas221036_s_atAtrioventricularNode3.30022.990Details
BioGPS Gene Atlas221036_s_atBDCA4+_DentriticCells5.50022.990Details
BioGPS Gene Atlas221036_s_atBonemarrow4.30022.990Details
BioGPS Gene Atlas221036_s_atBronchialEpithelialCells4.35022.990Details
BioGPS Gene Atlas221036_s_atCD105+_Endothelial4.55022.990Details
BioGPS Gene Atlas221036_s_atCD14+_Monocytes9.70022.990Details
BioGPS Gene Atlas221036_s_atCD19+_BCells(neg._sel.)4.80022.990Details
BioGPS Gene Atlas221036_s_atCD33+_Myeloid9.25022.990Details
BioGPS Gene Atlas221036_s_atCD34+5.90022.990Details
BioGPS Gene Atlas221036_s_atCD4+_Tcells4.95022.990Details
BioGPS Gene Atlas221036_s_atCD56+_NKCells5.85022.990Details
BioGPS Gene Atlas221036_s_atCD71+_EarlyErythroid3.70022.990Details
BioGPS Gene Atlas221036_s_atCD8+_Tcells4.30022.990Details
BioGPS Gene Atlas221036_s_atCardiacMyocytes5.60022.990Details
BioGPS Gene Atlas221036_s_atCaudatenucleus3.90022.990Details
BioGPS Gene Atlas221036_s_atCerebellum3.70022.990Details
BioGPS Gene Atlas221036_s_atCerebellumPeduncles4.95022.990Details
BioGPS Gene Atlas221036_s_atCiliaryGanglion3.00022.990Details
BioGPS Gene Atlas221036_s_atCingulateCortex4.65022.990Details
BioGPS Gene Atlas221036_s_atColorectaladenocarcinoma4.20022.990Details
BioGPS Gene Atlas221036_s_atDorsalRootGanglion4.20022.990Details
BioGPS Gene Atlas221036_s_atFetalThyroid4.25022.990Details
BioGPS Gene Atlas221036_s_atFetalbrain4.35022.990Details
BioGPS Gene Atlas221036_s_atFetalliver3.85022.990Details
BioGPS Gene Atlas221036_s_atFetallung3.70022.990Details
BioGPS Gene Atlas221036_s_atGlobusPallidus3.15022.990Details
BioGPS Gene Atlas221036_s_atHeart5.05022.990Details
BioGPS Gene Atlas221036_s_atHypothalamus4.85022.990Details
BioGPS Gene Atlas221036_s_atKidney5.00022.990Details
BioGPS Gene Atlas221036_s_atLeukemia_chronicMyelogenousK-5623.95022.990Details
BioGPS Gene Atlas221036_s_atLeukemia_promyelocytic-HL-603.95022.990Details
BioGPS Gene Atlas221036_s_atLeukemialymphoblastic(MOLT-4)3.55022.990Details
BioGPS Gene Atlas221036_s_atLiver5.75022.990Details
BioGPS Gene Atlas221036_s_atLung4.85022.990Details
BioGPS Gene Atlas221036_s_atLymphnode4.25022.990Details
BioGPS Gene Atlas221036_s_atLymphoma_burkitts(Daudi)5.55022.990Details
BioGPS Gene Atlas221036_s_atLymphoma_burkitts(Raji)6.05022.990Details
BioGPS Gene Atlas221036_s_atMedullaOblongata4.10022.990Details
BioGPS Gene Atlas221036_s_atOccipitalLobe4.15022.990Details
BioGPS Gene Atlas221036_s_atOlfactoryBulb3.50022.990Details
BioGPS Gene Atlas221036_s_atOvary2.90022.990Details
BioGPS Gene Atlas221036_s_atPancreas3.50022.990Details
BioGPS Gene Atlas221036_s_atPancreaticIslet4.70022.990Details
BioGPS Gene Atlas221036_s_atParietalLobe4.85022.990Details
BioGPS Gene Atlas221036_s_atPituitary7.20022.990Details
BioGPS Gene Atlas221036_s_atPlacenta4.60022.990Details
BioGPS Gene Atlas221036_s_atPons4.20022.990Details
BioGPS Gene Atlas221036_s_atPrefrontalCortex5.50022.990Details
BioGPS Gene Atlas221036_s_atProstate5.25022.990Details
BioGPS Gene Atlas221036_s_atSalivarygland3.70022.990Details
BioGPS Gene Atlas221036_s_atSkeletalMuscle6.90022.990Details
BioGPS Gene Atlas221036_s_atSkin3.35022.990Details
BioGPS Gene Atlas221036_s_atSmoothMuscle5.35022.990Details
BioGPS Gene Atlas221036_s_atSpinalcord4.50022.990Details
BioGPS Gene Atlas221036_s_atSubthalamicNucleus4.00022.990Details
BioGPS Gene Atlas221036_s_atSuperiorCervicalGanglion4.85022.990Details
BioGPS Gene Atlas221036_s_atTemporalLobe3.80022.990Details
BioGPS Gene Atlas221036_s_atTestis469.30022.990Details
BioGPS Gene Atlas221036_s_atTestisGermCell290.45022.990Details
BioGPS Gene Atlas221036_s_atTestisIntersitial452.75022.990Details
BioGPS Gene Atlas221036_s_atTestisLeydigCell267.25022.990Details
BioGPS Gene Atlas221036_s_atTestisSeminiferousTubule145.55022.990Details
BioGPS Gene Atlas221036_s_atThalamus4.20022.990Details
BioGPS Gene Atlas221036_s_atThymus3.50022.990Details
BioGPS Gene Atlas221036_s_atThyroid5.50022.990Details
BioGPS Gene Atlas221036_s_atTongue4.25022.990Details
BioGPS Gene Atlas221036_s_atTonsil4.25022.990Details
BioGPS Gene Atlas221036_s_atTrachea3.75022.990Details
BioGPS Gene Atlas221036_s_atTrigeminalGanglion4.25022.990Details
BioGPS Gene Atlas221036_s_atUterus3.30022.990Details
BioGPS Gene Atlas221036_s_atUterusCorpus4.10022.990Details
BioGPS Gene Atlas221036_s_atWholeBlood6.40022.990Details
BioGPS Gene Atlas221036_s_atWholebrain3.45022.990Details
BioGPS Gene Atlas221036_s_atcolon4.50022.990Details
BioGPS Gene Atlas221036_s_atpineal_day6.16022.990Details
BioGPS Gene Atlas221036_s_atpineal_night6.98022.990Details
BioGPS Gene Atlas221036_s_atretina5.80022.990Details
BioGPS Gene Atlas221036_s_atsmall_intestine4.30022.990Details
BioGPS NCI60221036_s_at78624.85535.730Details
BioGPS NCI60221036_s_atA172102.42435.730Details
BioGPS NCI60221036_s_atA20446.38035.730Details
BioGPS NCI60221036_s_atA36138.19535.730Details
BioGPS NCI60221036_s_atA49824.29835.730Details
BioGPS NCI60221036_s_atA54949.62835.730Details
BioGPS NCI60221036_s_atACC316.22835.730Details
BioGPS NCI60221036_s_atACHN33.58935.730Details
BioGPS NCI60221036_s_atALVA3117.47735.730Details
BioGPS NCI60221036_s_atCAKI123.64135.730Details
BioGPS NCI60221036_s_atCCRT CEM25.06035.730Details
BioGPS NCI60221036_s_atCOLO20517.04235.730Details
BioGPS NCI60221036_s_atDLD122.15535.730Details
BioGPS NCI60221036_s_atDU14528.31135.730Details
BioGPS NCI60221036_s_atEKVX43.47635.730Details
BioGPS NCI60221036_s_atGM13340.15835.730Details
BioGPS NCI60221036_s_atGM160027.48835.730Details
BioGPS NCI60221036_s_atGM231326.38735.730Details
BioGPS NCI60221036_s_atGM234524.46535.730Details
BioGPS NCI60221036_s_atGM249318.21835.730Details
BioGPS NCI60221036_s_atGM9725.08535.730Details
BioGPS NCI60221036_s_atHCC299825.68135.730Details
BioGPS NCI60221036_s_atHCT11617.89335.730Details
BioGPS NCI60221036_s_atHCT1523.78035.730Details
BioGPS NCI60221036_s_atHEK 293 T-rex26.85135.730Details
BioGPS NCI60221036_s_atHEK 293T17.20035.730Details
BioGPS NCI60221036_s_atHEK29318.24235.730Details
BioGPS NCI60221036_s_atHELA58.07535.730Details
BioGPS NCI60221036_s_atHEPG218.09035.730Details
BioGPS NCI60221036_s_atHL6020.85135.730Details
BioGPS NCI60221036_s_atHOP6224.45335.730Details
BioGPS NCI60221036_s_atHOP9231.95635.730Details
BioGPS NCI60221036_s_atHS578T57.46235.730Details
BioGPS NCI60221036_s_atHSG16.77035.730Details
BioGPS NCI60221036_s_atHT108015.87135.730Details
BioGPS NCI60221036_s_atHT2924.92235.730Details
BioGPS NCI60221036_s_atIGROV116.95135.730Details
BioGPS NCI60221036_s_atIOSE8024.42135.730Details
BioGPS NCI60221036_s_atJURKAT24.42735.730Details
BioGPS NCI60221036_s_atK56225.46435.730Details
BioGPS NCI60221036_s_atKM1217.38335.730Details
BioGPS NCI60221036_s_atLN1836.94535.730Details
BioGPS NCI60221036_s_atLNCAP43.37835.730Details
BioGPS NCI60221036_s_atLOX IMVI31.00135.730Details
BioGPS NCI60221036_s_atM1424.27835.730Details
BioGPS NCI60221036_s_atMALME 3M25.40135.730Details
BioGPS NCI60221036_s_atMCF769.33535.730Details
BioGPS NCI60221036_s_atMD MB23124.42235.730Details
BioGPS NCI60221036_s_atMDA MB43524.60835.730Details
BioGPS NCI60221036_s_atMOLT422.77835.730Details
BioGPS NCI60221036_s_atNCI 46017.57735.730Details
BioGPS NCI60221036_s_atNCI H22637.55635.730Details
BioGPS NCI60221036_s_atNCI H2321.66535.730Details
BioGPS NCI60221036_s_atNCI H322M17.12735.730Details
BioGPS NCI60221036_s_atNCVADR RES18.89835.730Details
BioGPS NCI60221036_s_atOVCAR317.45635.730Details
BioGPS NCI60221036_s_atOVCAR423.64835.730Details
BioGPS NCI60221036_s_atOVCAR516.95535.730Details
BioGPS NCI60221036_s_atOVCAR815.76735.730Details
BioGPS NCI60221036_s_atPANC124.61535.730Details
BioGPS NCI60221036_s_atRL731.99935.730Details
BioGPS NCI60221036_s_atRPMI 822617.20235.730Details
BioGPS NCI60221036_s_atRS1184625.14135.730Details
BioGPS NCI60221036_s_atRXF39346.53435.730Details
BioGPS NCI60221036_s_atSAOS224.50835.730Details
BioGPS NCI60221036_s_atSF26820.45435.730Details
BioGPS NCI60221036_s_atSF29523.91235.730Details
BioGPS NCI60221036_s_atSF53928.61335.730Details
BioGPS NCI60221036_s_atSHSYSY+RA23.74535.730Details
BioGPS NCI60221036_s_atSHSYSY-RA24.22335.730Details
BioGPS NCI60221036_s_atSKMEL217.50135.730Details
BioGPS NCI60221036_s_atSKMEL2861.93135.730Details
BioGPS NCI60221036_s_atSKMEL551.49235.730Details
BioGPS NCI60221036_s_atSKOV328.25235.730Details
BioGPS NCI60221036_s_atSN12C62.01335.730Details
BioGPS NCI60221036_s_atSNB1923.39135.730Details
BioGPS NCI60221036_s_atSNB7518.47435.730Details
BioGPS NCI60221036_s_atSR30.77235.730Details
BioGPS NCI60221036_s_atSW62015.72035.730Details
BioGPS NCI60221036_s_atT2424.50135.730Details
BioGPS NCI60221036_s_atT3M416.58635.730Details
BioGPS NCI60221036_s_atTK1016.08235.730Details
BioGPS NCI60221036_s_atU118189.08535.730Details
BioGPS NCI60221036_s_atU138181.07635.730Details
BioGPS NCI60221036_s_atU20S24.09935.730Details
BioGPS NCI60221036_s_atU25124.02735.730Details
BioGPS NCI60221036_s_atU87103.02035.730Details
BioGPS NCI60221036_s_atUACC25727.66235.730Details
BioGPS NCI60221036_s_atUACC6217.24335.730Details
BioGPS NCI60221036_s_atUO3124.19935.730Details
BioGPS NCI60221036_s_atZR75_124.49035.730Details
BioGPS NCI60221036_s_atastrocytes16.82435.730Details
BioGPS NCI60221036_s_athuh-742.55135.730Details